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[PMID]:28886097
[Au] Autor:Desvars-Larrive A; Pascal M; Gasqui P; Cosson JF; Benoît E; Lattard V; Crespin L; Lorvelec O; Pisanu B; Teynié A; Vayssier-Taussat M; Bonnet S; Marianneau P; Lacôte S; Bourhy P; Berny P; Pavio N; Le Poder S; Gilot-Fromont E; Jourdain E; Hammed A; Fourel I; Chikh F; Vourc'h G
[Ad] Endereço:Conservation Medicine, Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Austria.
[Ti] Título:Population genetics, community of parasites, and resistance to rodenticides in an urban brown rat (Rattus norvegicus) population.
[So] Source:PLoS One;12(9):e0184015, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brown rats are one of the most widespread urban species worldwide. Despite the nuisances they induce and their potential role as a zoonotic reservoir, knowledge on urban rat populations remains scarce. The main purpose of this study was to characterize an urban brown rat population from Chanteraines park (Hauts-de-Seine, France), with regards to haematology, population genetics, immunogenic diversity, resistance to anticoagulant rodenticides, and community of parasites. Haematological parameters were measured. Population genetics was investigated using 13 unlinked microsatellite loci. Immunogenic diversity was assessed for Mhc-Drb. Frequency of the Y139F mutation (conferring resistance to rodenticides) and two linked microsatellites were studied, concurrently with the presence of anticoagulant residues in the liver. Combination of microscopy and molecular methods were used to investigate the occurrence of 25 parasites. Statistical approaches were used to explore multiple parasite relationships and model parasite occurrence. Eighty-six rats were caught. The first haematological data for a wild urban R. norvegicus population was reported. Genetic results suggested high genetic diversity and connectivity between Chanteraines rats and surrounding population(s). We found a high prevalence (55.8%) of the mutation Y139F and presence of rodenticide residues in 47.7% of the sampled individuals. The parasite species richness was high (16). Seven potential zoonotic pathogens were identified, together with a surprisingly high diversity of Leptospira species (4). Chanteraines rat population is not closed, allowing gene flow and making eradication programs challenging, particularly because rodenticide resistance is highly prevalent. Parasitological results showed that co-infection is more a rule than an exception. Furthermore, the presence of several potential zoonotic pathogens, of which four Leptospira species, in this urban rat population raised its role in the maintenance and spread of these pathogens. Our findings should stimulate future discussions about the development of a long-term rat-control management program in Chanteraines urban park.
[Mh] Termos MeSH primário: Resistência a Medicamentos
Genética Populacional
Parasitos
Rodenticidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Biomarcadores
Contagem de Células Sanguíneas
França
Variação Genética
Genótipo
Geografia
Fenômenos Imunogenéticos
Repetições de Microssatélites
Parasitos/classificação
Parasitos/genética
Ratos
Saúde da População Urbana
Vitamina K Epóxido Redutases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Rodenticides); EC 1.17.4.4 (VKORC1 protein, rat); EC 1.17.4.4 (Vitamin K Epoxide Reductases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184015


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[PMID]:28542534
[Au] Autor:González-Andrade B; Santos-Lartigue R; Flores-Treviño S; Ramirez-Ochoa NS; Bocanegra-Ibarias P; Huerta-Torres FJ; Mendoza-Olazarán S; Villarreal-Treviño L; Camacho-Ortiz A; Villarreal-Vázquez H; Garza-González E
[Ad] Endereço:Servicio de Otorrinolaringología, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico.
[Ti] Título:The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population.
[So] Source:PLoS One;12(5):e0178115, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to estimate the relative contribution of immunogenetic and microbiological factors in the development of recurrent tonsillitis in a Mexican population. Patients (n = 138) with recurrent tonsillitis and an indication of tonsillectomy (mean age: 6.05 years ± 3.00; median age: 5 years, female: 58; age range: 1-15 years) and 195 non-related controls older than 18 years and a medical history free of recurrent tonsillitis were included. To evaluate the microbial contribution, tonsil swab samples from both groups and extracted tonsil samples from cases were cultured. Biofilm production of isolated bacteria was measured. To assess the immunogenetic component, DNA from peripheral blood was genotyped for the TNFA-308G/A single-nucleotide polymorphism (SNP) and for the IL1B -31C/T SNP. Normal microbiota, but no pathogens or potential pathogens, were identified from all control sample cultures. The most frequent pathogenic species detected in tonsils from cases were Staphylococcus aureus (48.6%, 67/138) and Haemophilus influenzae (31.9%, 44/138), which were found more frequently in patient samples than in samples from healthy volunteers (P < 0.0001). Importantly, 41/54 (75.9%) S. aureus isolates were biofilm producers (18 weak and 23 strong), whereas 17/25 (68%) H. influenzae isolates were biofilm producers (10 weak, and 7 strong biofilm producers). Patients with at least one copy of the IL1B-31*C allele had a higher risk of recurrent tonsillitis (OR = 4.03; 95% CI = 1.27-14.27; P = 0.013). TNFA-308 G/A alleles were not preferentially distributed among the groups. When considering the presence of IL1B-31*C plus S. aureus, IL1B-31*C plus S. aureus biofilm producer, IL1B-31*C plus H. influenzae or IL1B-31*C plus H. influenzae biofilm producer, the OR tended to infinite. Thus, the presence of IL1B-31*C allele plus the presence of S. aureus and/or H. influenzae could be related to the development of tonsillitis in this particular Mexican population.
[Mh] Termos MeSH primário: Portador Sadio/microbiologia
Infecções por Haemophilus/etiologia
Interleucina-1beta/genética
Infecções Estafilocócicas/etiologia
Tonsilite/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Alelos
Biofilmes
Portador Sadio/imunologia
Estudos de Casos e Controles
Criança
Pré-Escolar
Feminino
Infecções por Haemophilus/genética
Infecções por Haemophilus/microbiologia
Haemophilus influenzae/isolamento & purificação
Seres Humanos
Fenômenos Imunogenéticos
Lactente
Masculino
México
Microbiota
Meia-Idade
Recidiva
Fatores de Risco
Infecções Estafilocócicas/genética
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/isolamento & purificação
Tonsilite/genética
Tonsilite/microbiologia
Fator de Necrose Tumoral alfa/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL1B protein, human); 0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178115


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[PMID]:28288157
[Au] Autor:Vibert J; Thomas-Vaslin V
[Ad] Endereço:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Immunology-Immunopathology-Immunotherapy (I3) UMRS959; Paris, France.
[Ti] Título:Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background.
[So] Source:PLoS Comput Biol;13(3):e1005417, 2017 Mar.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell proliferation is the common characteristic of all biological systems. The immune system insures the maintenance of body integrity on the basis of a continuous production of diversified T lymphocytes in the thymus. This involves processes of proliferation, differentiation, selection, death and migration of lymphocytes to peripheral tissues, where proliferation also occurs upon antigen recognition. Quantification of cell proliferation dynamics requires specific experimental methods and mathematical modelling. Here, we assess the impact of genetics and aging on the immune system by investigating the dynamics of proliferation of T lymphocytes across their differentiation through thymus and spleen in mice. Our investigation is based on single-cell multicolour flow cytometry analysis revealing the active incorporation of a thymidine analogue during S phase after pulse-chase-pulse experiments in vivo, versus cell DNA content. A generic mathematical model of state transition simulates through Ordinary Differential Equations (ODEs) the evolution of single cell behaviour during various durations of labelling. It allows us to fit our data, to deduce proliferation rates and estimate cell cycle durations in sub-populations. Our model is simple and flexible and is validated with other durations of pulse/chase experiments. Our results reveal that T cell proliferation is highly heterogeneous but with a specific "signature" that depends upon genetic origins, is specific to cell differentiation stages in thymus and spleen and is altered with age. In conclusion, our model allows us to infer proliferation rates and cell cycle phase durations from complex experimental 5-ethynyl-2'-deoxyuridine (EdU) data, revealing T cell proliferation heterogeneity and specific signatures.
[Mh] Termos MeSH primário: Diferenciação Celular/genética
Proliferação Celular/genética
Senescência Celular/genética
Modelos Genéticos
Linfócitos T/citologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/imunologia
Células Cultivadas
Senescência Celular/imunologia
Simulação por Computador
Patrimônio Genético
Fenômenos Imunogenéticos/genética
Camundongos
Modelos Imunológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005417


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[PMID]:28135270
[Au] Autor:Wang S
[Ad] Endereço:Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California, United States of America.
[Ti] Título:Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.
[So] Source:PLoS Comput Biol;13(1):e1005336, 2017 Jan.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Affinity maturation is a Darwinian process in which B lymphocytes evolve potent antibodies to encountered antigens and generate immune memory. Highly mutable complex pathogens present an immense antigenic diversity that continues to challenge natural immunity and vaccine design. Induction of broadly neutralizing antibodies (bnAbs) against this diversity by vaccination likely requires multiple exposures to distinct but related antigen variants, and yet how affinity maturation advances under such complex stimulation remains poorly understood. To fill the gap, we present an in silico model of affinity maturation to examine two realistic new aspects pertinent to vaccine development: loss in B cell diversity across successive immunization periods against different variants, and the presence of distracting epitopes that entropically disfavor the evolution of bnAbs. We find these new factors, which introduce additional selection pressures and constraints, significantly influence antibody breadth development, in a way that depends crucially on the temporal pattern of immunization (or selection forces). Curiously, a less diverse B cell seed may even favor the expansion and dominance of cross-reactive clones, but only when conflicting selection forces are presented in series rather than in a mixture. Moreover, the level of frustration due to evolutionary conflict dictates the degree of distraction. We further describe how antigenic histories select evolutionary paths of B cell lineages and determine the predominant mode of antibody responses. Sequential immunization with mutationally distant variants is shown to robustly induce bnAbs that focus on conserved elements of the target epitope, by thwarting strain-specific and distracted lineages. An optimal range of antigen dose underlies a fine balance between efficient adaptation and persistent reaction. These findings provide mechanistic guides to aid in design of vaccine strategies against fast mutating pathogens.
[Mh] Termos MeSH primário: Vacinas contra a AIDS/imunologia
Diversidade de Anticorpos/genética
Diversidade de Anticorpos/imunologia
Linfócitos B/imunologia
Modelos Genéticos
Modelos Imunológicos
[Mh] Termos MeSH secundário: Vacinas contra a AIDS/genética
Anticorpos Neutralizantes/genética
Anticorpos Neutralizantes/imunologia
Afinidade de Anticorpos/genética
Afinidade de Anticorpos/imunologia
Reações Antígeno-Anticorpo/genética
Reações Antígeno-Anticorpo/imunologia
Linfócitos B/citologia
Evolução Biológica
Sobrevivência Celular/genética
Sobrevivência Celular/imunologia
Células Cultivadas
Simulação por Computador
Variação Genética
Seres Humanos
Imunização/métodos
Esquemas de Imunização
Fenômenos Imunogenéticos/genética
Modelos Estatísticos
Processos Estocásticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AIDS Vaccines); 0 (Antibodies, Neutralizing)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005336


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[PMID]:28067566
[Au] Autor:Callus R; Buttigieg J; Anastasi AA; Halawa A
[Ad] Endereço:Resident Specialist in Nephrology and General Medicine, Division of Nephrology, Department of Medicine, Mater Dei Hospital, Msida MSD2090, Malta and Faculty of Health and Science, Institute of Learning and Teaching, University of Liverpool, Liverpool.
[Ti] Título:Basic concepts in kidney transplant immunology.
[So] Source:Br J Hosp Med (Lond);78(1):32-37, 2017 Jan 02.
[Is] ISSN:1750-8460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Advances in the field of immunohistocompatibility and immunogenetics have been crucial for improvements in kidney transplant outcomes. This review provides a practical outline of these important breakthroughs for the general physician, at a time when demand for kidney transplants is increasing.
[Mh] Termos MeSH primário: Soro Antilinfocitário/imunologia
Antígenos HLA/imunologia
Falência Renal Crônica/cirurgia
Transplante de Rim
[Mh] Termos MeSH secundário: Testes Imunológicos de Citotoxicidade
Citometria de Fluxo
Antígenos HLA/genética
Teste de Histocompatibilidade
Seres Humanos
Fenômenos Imunogenéticos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antilymphocyte Serum); 0 (HLA Antigens)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.12968/hmed.2017.78.1.32


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[PMID]:27916969
[Au] Autor:Kovalchuka L; Cvetkova S; Trofimova J; Eglite J; Gintere S; Lucenko I; Oczko-Grzesik B; Viksna L; Krumina A
[Ad] Endereço:Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia. Lilija.Kovalcuka@bior.lv.
[Ti] Título:Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis.
[So] Source:Int J Environ Res Public Health;13(12), 2016 Dec 01.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.
[Mh] Termos MeSH primário: Genótipo
Cadeias HLA-DRB1/genética
Doença de Lyme/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Biomarcadores/sangue
Cadeias HLA-DRB1/metabolismo
Seres Humanos
Fenômenos Imunogenéticos
Incidência
Letônia/epidemiologia
Doença de Lyme/sangue
Doença de Lyme/microbiologia
Neuroborreliose de Lyme/sangue
Neuroborreliose de Lyme/epidemiologia
Neuroborreliose de Lyme/microbiologia
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (HLA-DRB1 Chains)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27612400
[Au] Autor:Wójtowicz A; Bochud PY
[Ad] Endereço:a Infectious Diseases Service, Department of Medicine, University Hospital (CHUV) and University of Lausanne , Lausanne , Switzerland.
[Ti] Título:Risk stratification and immunogenetic risk for infections following stem cell transplantation.
[So] Source:Virulence;7(8):917-929, 2016 Nov 16.
[Is] ISSN:2150-5608
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may be due, in part, to polymorphisms in immune genes. Thus, the identification of genetic factors influencing susceptibility to infections in HSCT recipients may lead to the development of individualized management strategies. However, studies are challenged by several issues, including the relative small size of existing cohorts, the frequent use of prophylactic or preemptive antimicrobial agents, and the fact that genes responsible for immune functions can be inherited either from the donor or the host. Consequently, the major challenge for today's researchers is to overcome these limitations and find associations that are robust enough to be translated into reliable risk stratification strategies for infectious diseases.
[Mh] Termos MeSH primário: Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Fenômenos Imunogenéticos
Infecção/imunologia
[Mh] Termos MeSH secundário: Feminino
Predisposição Genética para Doença
Seres Humanos
Imunossupressores
Infecção/etiologia
Infecção/genética
Masculino
Polimorfismo de Nucleotídeo Único
Medição de Risco/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170909
[Lr] Data última revisão:
170909
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE


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Werneck, Lineu Cesar
Texto completo SciELO Brasil
[PMID]:27556370
[Au] Autor:Werneck LC; Lorenzoni PJ; Arndt RC; Kay CS; Scola RH
[Ad] Endereço:Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brasil.
[Ti] Título:The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population.
[So] Source:Arq Neuropsiquiatr;74(8):607-16, 2016 Aug.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study the HLA of class 1and 2 in a multiple sclerosis (MS) population to verify the susceptibility for the disease in the Southern Brazil. METHODS: We analyzed patients with MS and controls, by direct sequencing of the genes related to HLA DRB1, DQB1, DPB1, A, B and C alleles with high resolution techniques. RESULTS: We found a lower frequency of all HLA alleles class 1 and 2 in MS and controls comparing to the European population. Several alleles had statistical correlation, but after Bonferroni correction, the only allele with significance was the HLA-DQB1*02:03, which has a positive association with MS. CONCLUSIONS: Our data have different frequency of HLA-alleles than the previous published papers in the Southeast Brazil and European population, possible due to several ethnic backgrounds.
[Mh] Termos MeSH primário: Predisposição Genética para Doença/genética
Antígenos de Histocompatibilidade Classe II/genética
Antígenos de Histocompatibilidade Classe I/genética
Esclerose Múltipla/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alelos
Brasil
Estudos de Casos e Controles
Grupo com Ancestrais do Continente Europeu
Feminino
Frequência do Gene
Genótipo
Seres Humanos
Fenômenos Imunogenéticos
Masculino
Meia-Idade
Esclerose Múltipla/etnologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histocompatibility Antigens Class I); 0 (Histocompatibility Antigens Class II)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


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Texto completo SciELO Brasil
[PMID]:27556368
[Au] Autor:Adoni T
[Ad] Endereço:Hospital Sírio-Libanês, São Paulo SP, Brasil.
[Ti] Título:Immunogenetics of multiple sclerosis: more questions than answers.
[So] Source:Arq Neuropsiquiatr;74(8):603-4, 2016 Aug.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Fenômenos Imunogenéticos
Esclerose Múltipla/genética
Esclerose Múltipla/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


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PubMed Central Texto completo
Texto completo
[PMID]:27419142
[Au] Autor:Granata S; Dalla Gassa A; Bellin G; Lupo A; Zaza G
[Ad] Endereço:Renal Unit, Department of Medicine, University Hospital of Verona, Piazzale Stefani 1, 37126 Verona, Italy.
[Ti] Título:Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease.
[So] Source:Biomed Res Int;2016:9290857, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic kidney disease (CKD) is an increasing and global health problem with a great economic burden for healthcare system. Therefore to slow down the progression of this condition is a main objective in nephrology. It has been extensively reported that microinflammation, immune system deregulation, and oxidative stress contribute to CKD progression. Additionally, dialysis worsens this clinical condition because of the contact of blood with bioincompatible dialytic devices. Numerous studies have shown the close link between immune system impairment and CKD but most have been performed using classical biomolecular strategies. These methodologies are limited in their ability to discover new elements and enable measuring the simultaneous influence of multiple factors. The "omics" techniques could overcome these gaps. For example, transcriptomics has revealed that mitochondria and inflammasome have a role in pathogenesis of CKD and are pivotal elements in the cellular alterations leading to systemic complications. We believe that a larger employment of this technique, together with other "omics" methodologies, could help clinicians to obtain new pathogenetic insights, novel diagnostic biomarkers, and therapeutic targets. Finally, transcriptomics could allow clinicians to personalize therapeutic strategies according to individual genetic background (nutrigenomic and pharmacogenomic). In this review, we analyzed the available transcriptomic studies involving CKD patients.
[Mh] Termos MeSH primário: Imunidade Inata/genética
Imunidade Inata/imunologia
Insuficiência Renal Crônica/genética
Insuficiência Renal Crônica/imunologia
Transcriptoma/genética
Transcriptoma/imunologia
[Mh] Termos MeSH secundário: Citocinas/genética
Citocinas/imunologia
Seres Humanos
Fenômenos Imunogenéticos/genética
Doenças Mitocondriais
Modelos Genéticos
Modelos Imunológicos
Herança Multifatorial/genética
Herança Multifatorial/imunologia
Estresse Oxidativo/genética
Estresse Oxidativo/imunologia
Espécies Reativas de Oxigênio/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE
[do] DOI:10.1155/2016/9290857



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