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[PMID]:28052844
[Au] Autor:Stafford N
[Ad] Endereço:Hamburg.
[Ti] Título:Daniel R Salomon.
[So] Source:BMJ;356:j22, 2017 Jan 04.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Reação Hospedeiro-Enxerto/imunologia
Transplante de Órgãos/história
[Mh] Termos MeSH secundário: Rejeição de Enxerto/imunologia
História do Século XX
História do Século XXI
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Salomon DR
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j22


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[PMID]:27697774
[Au] Autor:Mancusi A; Ruggeri L; Velardi A
[Ad] Endereço:Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
[Ti] Título:Haploidentical hematopoietic transplantation for the cure of leukemia: from its biology to clinical translation.
[So] Source:Blood;128(23):2616-2623, 2016 Dec 08.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present review describes the biology of human leukocyte antigen haplotype mismatched ("haploidentical") transplantation, its translation to clinical practice to cure leukemia, and the results of current transplantation protocols. The 1990s saw what had been major drawbacks of haploidentical transplantation, ie, very strong host-versus-graft and graft-versus-host alloresponses, which led respectively to rejection and graft-versus-host disease (GVHD), being overcome through transplantation of a "mega-dose" of T cell-depleted peripheral blood hematopoietic progenitor cells and no posttransplant pharmacologic immunosuppression. The absence of posttransplant immunosuppression was an opportunity to discover natural killer cell alloreactions that eradicated acute myeloid leukemia and improved survival. Furthermore, it also unveiled the benefits of transplantation from mother donors, a likely consequence of the mother-to-child interaction during pregnancy. More recent transplantation protocols use unmanipulated (without ex vivo T-cell depletion) haploidentical grafts combined with enhanced posttransplant immunosuppression to help prevent GVHD. Unmanipulated grafts substantially extended the use of haploidentical transplantation with results than even rival those of matched hematopoietic transplantation. In T cell-depleted haploidentical transplantation, recent advances were made by the adoptive transfer of regulatory and conventional T cells.
[Mh] Termos MeSH primário: Doença Enxerto-Hospedeiro
Transplante de Células-Tronco Hematopoéticas
Reação Hospedeiro-Enxerto/imunologia
Imunossupressão/métodos
Leucemia Mieloide Aguda
[Mh] Termos MeSH secundário: Transferência Adotiva/métodos
Aloenxertos
Doença Enxerto-Hospedeiro/imunologia
Doença Enxerto-Hospedeiro/prevenção & controle
Seres Humanos
Células Matadoras Naturais/imunologia
Leucemia Mieloide Aguda/imunologia
Leucemia Mieloide Aguda/terapia
Linfócitos T Reguladores/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27631233
[Au] Autor:Wen J; Xie K; Zhang M; Chen J; Zhang J; Cheng D; Li X; Ji S; Liu Z
[Ad] Endereço:National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, P. R. China.
[Ti] Título:HLA-DR, and not PLA2R, is expressed on the podocytes in kidney allografts in de novo membranous nephropathy.
[So] Source:Medicine (Baltimore);95(37):e4809, 2016 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Idiopathic membranous nephropathy (IMN) is known to be associated with antibodies acting on the M-type phospholipase A2 receptor (PLA2R) of the podocyte. However, the mechanism underlying de novo membranous nephropathy (dn MN) posttransplantation remains unclear. In this study, we aimed to elucidate the mechanism underlying dn MN.We selected 8 cases with dn MN and compared them to 20 IMN cases. Fifteen cases of stable grafts were selected as controls.Several differences between the dn MN group and the IMN group were detected. IgG4 showed negligible positive staining in patients with dn MN, while it was predominant in the IMN group (1/8 vs 20/20, P < 0.001). Serum anti-PLA2R antibodies and anti-PLA2R antibodies of the podocyte were very few in the dn MN patients; however, these antibodies were detected in most of the IMN patients (serum anti-PLA2R antibodies: 1/8 vs 16/20, P = 0.002, anti-PLA2R antibodies of the podocyte: 0/8 vs 17/20, P < 0.001). The dn MN patients also showed higher ratio of interstitial inflammation, peritubular capillaritis, and peritubular capillary C4d deposition. Importantly, human leukocyte antigens (HLA)-DR expression was detected on the podocytes in most of the dn MN patients, but none of the IMN patients and stable graft patients showed HLA-DR expression.These data suggested that the PLA2R pathway, which is known to play a role in IMN, was not involved in the mechanism underlying dn MN. On the contrary, dn MN might be associated with the alloimmune response directed against the podocyte.
[Mh] Termos MeSH primário: Glomerulonefrite Membranosa/imunologia
Antígenos HLA-DR/metabolismo
Podócitos/imunologia
Complicações Pós-Operatórias/imunologia
Receptores da Fosfolipase A2/metabolismo
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Glomerulonefrite Membranosa/metabolismo
Glomerulonefrite Membranosa/patologia
Reação Hospedeiro-Enxerto
Seres Humanos
Rim/patologia
Transplante de Rim
Masculino
Meia-Idade
Podócitos/metabolismo
Complicações Pós-Operatórias/metabolismo
Complicações Pós-Operatórias/patologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (HLA-DR Antigens); 0 (Receptors, Phospholipase A2)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004809


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[PMID]:27322252
[Au] Autor:Toldo S; Quader M; Salloum FN; Mezzaroma E; Abbate A
[Ad] Endereço:VCU Pauley Heart Center and Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA. Stefano.Toldo@vcuhealth.org.
[Ti] Título:Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death.
[So] Source:Int J Mol Sci;17(6), 2016 Jun 17.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Heart transplantation (HTx) is the ultimate treatment for end-stage heart failure. The number of patients on waiting lists for heart transplants, however, is much higher than the number of available organs. The shortage of donor hearts is a serious concern since the population affected by heart failure is constantly increasing. Furthermore, the long-term success of HTx poses some challenges despite the improvement in the management of the short-term complications and in the methods to limit graft rejection. Myocardial injury occurs during transplantation. Injury initiated in the donor as result of brain or cardiac death is exacerbated by organ procurement and storage, and is ultimately amplified by reperfusion injury at the time of transplantation. The innate immune system is a mechanism of first-line defense against pathogens and cell injury. Innate immunity is activated during myocardial injury and produces deleterious effects on the heart structure and function. Here, we briefly discuss the role of the innate immunity in the initiation of myocardial injury, with particular focus on the Toll-like receptors and inflammasome, and how to potentially expand the donor population by targeting the innate immune response.
[Mh] Termos MeSH primário: Morte
Transplante de Coração/efeitos adversos
Reação Hospedeiro-Enxerto/imunologia
Imunidade Inata
Obtenção de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Animais
Transplante de Coração/métodos
Seres Humanos
Obtenção de Tecidos e Órgãos/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27103077
[Au] Autor:Ileri T; Ünal Ince E; Çakmakli H; Uysal Z; Gençtürk Z; Ertem M
[Ad] Endereço:Department of Pediatric Hematology, Faculty of Medicine, Ankara University, Dikimevi, Ankara, Turkey.
[Ti] Título:Evaluation of engraftment syndrome in children following full-matched related donor hematopoietic stem cell transplantations.
[So] Source:Pediatr Transplant;20(4):581-9, 2016 Jun.
[Is] ISSN:1399-3046
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:The term "ES" has been widely used for describing a clinical condition consisting of skin rash, fever, and weight gain that occur during neutrophil recovery period following HSCT. In this study, the incidence, clinical features, risk factors, and outcomes of ES were evaluated in 169 children following allogeneic HSCT from full-matched related donor according to the Spitzer criteria. Seventeen patients (10.1%) presented with clinical conditions suggesting ES. In both univariate and multivariate analysis underlying malignant disease and early release of monocytes to the PB, and in univariate analysis using only CsA for GVHD prophylaxis were found to be the significant risk factors for the development of ES. Patients with ES experienced significantly higher incidence of acute and chronic GVHD and propensity toward a higher rate of TRM. OS did not differ between the patient groups. Thirteen of 17 patients received steroid therapy, and all but one patient responded to therapy. Monitoring for early detection of ES and early intervention with steroid therapy is the key for recovery. The most crucial approach for this purpose mainly is to find out and use the most useful and feasible diagnostic criteria for routine medical practice.
[Mh] Termos MeSH primário: Exantema/imunologia
Febre/imunologia
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Histocompatibilidade
Reação Hospedeiro-Enxerto/imunologia
Ganho de Peso/imunologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Exantema/diagnóstico
Exantema/epidemiologia
Exantema/etiologia
Feminino
Febre/diagnóstico
Febre/epidemiologia
Febre/etiologia
Seguimentos
Doença Enxerto-Hospedeiro/epidemiologia
Doença Enxerto-Hospedeiro/etiologia
Transplante de Células-Tronco Hematopoéticas/mortalidade
Seres Humanos
Incidência
Lactente
Doadores Vivos
Masculino
Avaliação de Resultados (Cuidados de Saúde)
Estudos Retrospectivos
Fatores de Risco
Síndrome
Transplante Homólogo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160423
[St] Status:MEDLINE
[do] DOI:10.1111/petr.12708


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[PMID]:26905198
[Au] Autor:Kawamura T; Miyagawa S; Fukushima S; Maeda A; Kashiyama N; Kawamura A; Miki K; Okita K; Yoshida Y; Shiina T; Ogasawara K; Miyagawa S; Toda K; Okuyama H; Sawa Y
[Ad] Endereço:Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
[Ti] Título:Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates.
[So] Source:Stem Cell Reports;6(3):312-20, 2016 Mar 08.
[Is] ISSN:2213-6711
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Induced pluripotent stem cells (iPSCs) can serve as a source of cardiomyocytes (CMs) to treat end-stage heart failure; however, transplantation of genetically dissimilar iPSCs even within species (allogeneic) can induce immune rejection. We hypothesized that this might be limited by matching the major histocompatibility complex (MHC) antigens between the donor and the recipient. We therefore transplanted fluorescence-labeled (GFP) iPSC-CMs donated from a macaque with homozygous MHC haplotypes into the subcutaneous tissue and hearts of macaques having heterozygous MHC haplotypes (MHC-matched; group I) or without identical MHC alleles (group II) in conjunction with immune suppression. Group I displayed a higher GFP intensity and less immune-cell infiltration in the graft than group II. However, MHC-matched transplantation with single or no immune-suppressive drugs still induced a substantial host immune response to the graft. Thus, the immunogenicity of allogeneic iPSC-CMs was reduced by MHC-matched transplantation although a requirement for appropriate immune suppression was retained for successful engraftment.
[Mh] Termos MeSH primário: Antígenos de Histocompatibilidade Classe I/imunologia
Reação Hospedeiro-Enxerto
Células-Tronco Pluripotentes Induzidas/transplante
Miócitos Cardíacos/transplante
Transplante de Células-Tronco
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Haplótipos
Heterozigoto
Células-Tronco Pluripotentes Induzidas/citologia
Células-Tronco Pluripotentes Induzidas/imunologia
Macaca
Masculino
Miócitos Cardíacos/citologia
Miócitos Cardíacos/imunologia
Transplante Homólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Histocompatibility Antigens Class I)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE


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[PMID]:26098894
[Au] Autor:Liu D; Suchard SJ; Nadler SG; Ford ML
[Ad] Endereço:Emory Transplant Center and Department of Surgery, Emory University, Atlanta, GA 30322, United States of America.
[Ti] Título:Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.
[So] Source:PLoS One;10(6):e0130490, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Programmed T cell differentiation is critically influenced by the complement of costimulatory and coinhibitory signals transmitted during initial antigen encounter. We previously showed that selective CD28 blockade with novel domain antibodies that leave CTLA-4-mediated coinhibitory signaling intact resulted in more profound attenuation of donor-reactive T cell responses and improved graft survival in a murine transplant model. Selective CD28 blockade was also associated with decreased ICOS expression on donor-reactive CD8+ T cell responses as compared to CTLA-4 Ig, but the functional importance of this reduced ICOS expression was not known. In this study, we created retrogenic donor-reactive CD8+ T cells that overexpress ICOS in order to determine whether reduced ICOS expression mechanistically underlies the increased efficacy of selective CD28 blockade in controlling graft-specific T cell responses as compared to conventional costimulation blockade with CTLA-4 Ig. Results indicated that the ability of selective CD28 blockade to blunt donor-reactive CD8+ T cell expansion following transplantation was independent of its ability to inhibit ICOS expression. Furthermore, we have previously published that 2B4 coinhibitory signals are functionally important for controlling graft-specific CD8+ T cell responses in mice treated with CD28 blockade. Here we used a co-adoptive transfer approach to determine that 2B4 coinhibitory signals on antigen-specific CD8+ T cells function in a cell-intrinsic manner to limit ICOS expression in the setting of selective CD28 blockade.
[Mh] Termos MeSH primário: Antígenos CD28/imunologia
Linfócitos T CD8-Positivos/imunologia
Proteína Coestimuladora de Linfócitos T Induzíveis/metabolismo
[Mh] Termos MeSH secundário: Animais
Antígenos CD28/antagonistas & inibidores
Reação Hospedeiro-Enxerto
Proteína Coestimuladora de Linfócitos T Induzíveis/genética
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (CD28 Antigens); 0 (Icos protein, mouse); 0 (Inducible T-Cell Co-Stimulator Protein)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0130490


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[PMID]:25962413
[Au] Autor:Bascom RA; Tao KS; Tollenaar SL; West LJ
[Ad] Endereço:Departments of Pediatrics, Surgery and Medical Microbiology/Immunology, Alberta Transplant Institute, University of Alberta, Edmonton, Canada.
[Ti] Título:Imaging Tolerance Induction in the Classic Medawar Neonatal Mouse Model: Active Roles of Multiple F1-Donor Cell Types.
[So] Source:Am J Transplant;15(9):2346-63, 2015 Sep.
[Is] ISSN:1600-6143
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The immature immune system is uniquely susceptible to tolerance induction and thus an attractive target for immunomodulation strategies for organ transplantation. Newborn mice injected with adult semi-allogeneic lymphohematopoietic cells accept transplants without immunosuppressive drugs. Early in vivo/in situ events leading to neonatal tolerance remain poorly understood. Here, we show by whole body/organ imaging that injected cells home to lymphoid organs and liver where various F1-donor cell types selectively alter neonatal immunity. In host thymus, F1-donor dendritic cells (DC) interact with developing thymocytes and regulatory T cells suggesting a role in negative selection. In spleen and lymph nodes, F1-donor regulatory T/B cells associate with host alloreactive cells and by themselves prolong cardiac allograft survival. In liver, F1-donor cells give rise to albumin-containing hepatocyte-like cells. The neonatal immune system is lymphopenic, Th-2 immunodeviated and contains immature DC, suggesting susceptibility to regulation by adult F1-donor cells. CD8a T cell inactivation greatly enhances chimerism, suggesting that variable emerging neonatal alloreactivity becomes a barrier to tolerance induction. This comprehensive qualitative imaging study systematically shows contribution of multiple in vivo processes leading simultaneously to robust tolerance. These insights into robust tolerance induction have important implications for development of strategies for clinical application.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Linfócitos T CD4-Positivos/imunologia
Células Dendríticas/imunologia
Reação Hospedeiro-Enxerto/imunologia
Tolerância Imunológica/imunologia
Baço/transplante
Linfócitos T Reguladores/imunologia
[Mh] Termos MeSH secundário: Aloenxertos
Animais
Animais Recém-Nascidos
Microscopia Crioeletrônica
Sobrevivência de Enxerto/imunologia
Transplante de Coração
Ativação Linfocitária
Cooperação Linfocítica
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C3H
Camundongos Endogâmicos C57BL
Baço/imunologia
Timócitos/imunologia
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150820
[Lr] Data última revisão:
150820
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150513
[St] Status:MEDLINE
[do] DOI:10.1111/ajt.13278


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[PMID]:25942348
[Au] Autor:Laftavi MR; Pankewycz O; Feng L; Said M; Patel S
[Ad] Endereço:Department of Surgery, SUNY at Buffalo , Buffalo, New York , USA and.
[Ti] Título:Combined induction therapy with rabbit antithymocyte globulin and rituximab in highly sensitized renal recipients.
[So] Source:Immunol Invest;44(4):373-84, 2015.
[Is] ISSN:1532-4311
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Compared to non-sensitized renal transplant recipients, patients with preformed alloantibodies are at greater risk of cellular and humoral rejection and premature graft failure. We explored the effects of adding B-cell depleting agent (rituximab) to standard rabbit anti-thymocyte globulin (rATG) induction regimen for patients with panel reactive antibody levels >50%. Following induction therapy, 14 recipients were given two doses of rituximab (375 mg/m(2)) within the first month post-transplantation. Their long-term outcomes were compared to a historical control group of 23 recipients who received rATG alone. Graft survival at 5 years was superior with combination therapy compared to induction therapy alone (92.9 versus 48.3%, respectively, p = 0.02). While 30% of the rATG alone group experienced cellular rejection and 26% humoral rejection, none of rituximab plus rATG renal transplant recipients group had rejection. Thus, addition of rituximab to rATG provided superior outcomes to rATG alone. This combination induction therapy should be considered for a high-risk population.
[Mh] Termos MeSH primário: Soro Antilinfocitário/uso terapêutico
Reação Hospedeiro-Enxerto/efeitos dos fármacos
Reação Hospedeiro-Enxerto/imunologia
Imunossupressores/uso terapêutico
Transplante de Rim
Rituximab/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Animais
Soro Antilinfocitário/administração & dosagem
Quimioterapia Combinada
Feminino
Rejeição de Enxerto/diagnóstico
Rejeição de Enxerto/imunologia
Rejeição de Enxerto/mortalidade
Rejeição de Enxerto/prevenção & controle
Seres Humanos
Imunossupressores/administração & dosagem
Estimativa de Kaplan-Meier
Transplante de Rim/efeitos adversos
Masculino
Meia-Idade
Infecções Oportunistas/etiologia
Projetos Piloto
Coelhos
Rituximab/administração & dosagem
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antilymphocyte Serum); 0 (Immunosuppressive Agents); 4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150506
[Lr] Data última revisão:
150506
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150506
[St] Status:MEDLINE
[do] DOI:10.3109/08820139.2015.1014097


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[PMID]:25840634
[Au] Autor:Manuyakorn W; Sinitkul R; Treepongkaruna S; Kamchaisatian W; Vilaiyuk S; Srisala S; Benjaponpitak S
[Ad] Endereço:Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
[Ti] Título:In vitro cytokine changes after pediatric liver transplantation.
[So] Source:Asian Pac J Allergy Immunol;33(1):52-8, 2015 Mar.
[Is] ISSN:0125-877X
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with chronic liver disease have been shown to have impaired immune statuses. Liver transplantation (LT) is the standard treatment for end-stage liver disease patients and immunosuppressive drugs are commonly used to prevent graft rejection. There is an increasing evidence of de novo food allergies post LT. OBJECTIVE: To investigate the cytokine response of peripheral blood mononuclear cells (PBMCs) of pediatric LT recipients before and six months after transplantation. METHOD: PBMCs collected before and six months after LT were stimulated with phytohemagglutinin (PHA), beta-lactoglobulin (BLG), tacrolimus (Tac), dexamethasone (Dex), and a combination of BLG and Dex (B+D), BLG and Tac (B+T), BLG and Tac plus Dex (B+T+D). Culture supernatants were measured for IL-5, IFN-γ and IL-10. Blood for liver function tests, complete blood counts, total IgE and specific IgE (sIgE) to cow's milk were recorded. RESULTS: A total of five pediatric LT recipients were enrolled in the study. There were no food allergy cases. Total IgE and sIgE to cow's milk decreased significantly after LT. After transplantation, there was a significant increase in IL-5, IFN-γ and IL-10 in culture supernatants of PHA-stimulated PBMCs. Among different stimulations in post transplantation's PBMCs, the level of IL-5 significantly increased in B+D was suppressed with the combination of B+T+D. The level of IL-10 significantly increased in all conditions containing BLG both before and after transplantation. CONCLUSION: There was an improvement of the in vitro-cytokine responses after liver transplantations. Immunosuppressive drugs used in post transplantation had an effect on the cytokine responses.
[Mh] Termos MeSH primário: Doença Hepática Terminal/cirurgia
Imunossupressores/uso terapêutico
Interferon gama/agonistas
Interleucina-10/agonistas
Interleucina-5/agonistas
Leucócitos Mononucleares/efeitos dos fármacos
Transplante de Fígado
[Mh] Termos MeSH secundário: Adulto
Pré-Escolar
Dexametasona/farmacologia
Doença Hepática Terminal/imunologia
Doença Hepática Terminal/patologia
Feminino
Reação Hospedeiro-Enxerto/efeitos dos fármacos
Reação Hospedeiro-Enxerto/imunologia
Seres Humanos
Imunoglobulina E/sangue
Lactente
Interferon gama/biossíntese
Interleucina-10/biossíntese
Interleucina-5/biossíntese
Lactoglobulinas/farmacologia
Leucócitos Mononucleares/citologia
Leucócitos Mononucleares/imunologia
Testes de Função Hepática
Masculino
Hipersensibilidade a Leite/sangue
Hipersensibilidade a Leite/imunologia
Hipersensibilidade a Leite/prevenção & controle
Fito-Hemaglutininas/farmacologia
Cultura Primária de Células
Tacrolimo/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (IL10 protein, human); 0 (IL5 protein, human); 0 (Immunosuppressive Agents); 0 (Interleukin-5); 0 (Lactoglobulins); 0 (Phytohemagglutinins); 130068-27-8 (Interleukin-10); 37341-29-0 (Immunoglobulin E); 7S5I7G3JQL (Dexamethasone); 82115-62-6 (Interferon-gamma); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150405
[St] Status:MEDLINE
[do] DOI:10.12932/AP0505.33.1.2015



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