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  1 / 2206 MEDLINE  
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[PMID]:28457509
[Au] Autor:Fracasso NCA; de Andrade ES; Wiezel CEV; Andrade CCF; Zanão LR; da Silva MS; Marano LA; Donadi EA; C Castelli E; Simões AL; Mendes-Junior CT
[Ad] Endereço:Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900, Ribeirão Preto-SP, Brazil. Electronic address: nadiadeaguiar@gmail.com.
[Ti] Título:Haplotypes from the SLC45A2 gene are associated with the presence of freckles and eye, hair and skin pigmentation in Brazil.
[So] Source:Leg Med (Tokyo);25:43-51, 2017 Mar.
[Is] ISSN:1873-4162
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The Solute Carrier Family 45, Member 2 (SLC45A2) gene encodes the Membrane-Associated Transporter Protein (MATP), which mediates melanin synthesis by tyrosinase trafficking and proton transportation to melanosomes. At least two SLC45A2 coding SNPs [E272K (rs26722) and L374F (rs16891982)] were reported influencing normal variation of human pigmentation. Here we aimed at evaluating the influence of haplotypes of 12 SNPs within SLC45A2 in the determination of eye, hair and skin pigmentation in a highly admixed population sample and comparing their frequencies with the ones found in data retrieved from the 1000 Genomes Project. To achieve this goal, 12 SLC45A2 SNPs were evaluated in 288 unrelated individuals from the Ribeirão Preto city area, Southeastern Brazil. SNPs were genotyped by PCR-RFLP or Allele-specific PCR, followed by polyacrylamide gel electrophoresis. Haplotypes of each individual were inferred by two independent computational methods, PHASE and Partition-Ligation-Expectation-Maximization (PL-EM) algorithms, and 34 different haplotypes were identified. The hp9 haplotype was the most frequent (58.3%) and was associated with the presence of blond/red hair, pale skin, blue eyes and freckles. All haplotypes significantly associated with dark or light pigmentation features harbor the 374L and 374F alleles, respectively. These results emphasize the role played by haplotypes at SLC45A2 in the determination of pigmentation aspects of human populations and reinforce the relevance of SNP L374F in human pigmentation.
[Mh] Termos MeSH primário: Cor de Olho/genética
Cor de Cabelo/genética
Haplótipos/genética
Melanose/genética
Pigmentação da Pele/genética
[Mh] Termos MeSH secundário: Alelos
Brasil
Frequência do Gene
Projeto Genoma Humano
Seres Humanos
Polimorfismo de Fragmento de Restrição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  2 / 2206 MEDLINE  
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[PMID]:28748670
[Au] Autor:Taye M; Lee W; Caetano-Anolles K; Dessie T; Hanotte O; Mwai OA; Kemp S; Cho S; Oh SJ; Lee HK; Kim H
[Ad] Endereço:Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
[Ti] Título:Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance.
[So] Source:Anim Sci J;88(12):1889-1901, 2017 Dec.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light-colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross-population composite likelihood ratio (XP-CLR) and cross-population extended haplotype homozygosity (XP-EHH) statistical methods. We identified 296 (XP-EHH) and 327 (XP-CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study.
[Mh] Termos MeSH primário: Bovinos/genética
Bovinos/fisiologia
Estudos de Associação Genética/veterinária
Genoma/genética
Seleção Genética/genética
Termotolerância/genética
[Mh] Termos MeSH secundário: Animais
Ingestão de Alimentos/genética
Ontologia Genética
Cor de Cabelo/genética
Haplótipos/genética
Resposta ao Choque Térmico/genética
Homozigoto
Temperatura Alta
Pressão Osmótica
Estresse Oxidativo/genética
Glândulas Sudoríparas
Sudorese/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12851


  3 / 2206 MEDLINE  
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[PMID]:29284020
[Au] Autor:Frost P; Kleisner K; Flegr J
[Ad] Endereço:Department of Anthropology, Université Laval, Quebec City, Canada.
[Ti] Título:Health status by gender, hair color, and eye color: Red-haired women are the most divergent.
[So] Source:PLoS One;12(12):e0190238, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Red hair is associated in women with pain sensitivity. This medical condition, and perhaps others, seems facilitated by the combination of being red-haired and female. We tested this hypothesis by questioning a large sample of Czech and Slovak respondents about the natural redness and darkness of their hair, their natural eye color, their physical and mental health (24 categories), and other personal attributes (height, weight, number of children, lifelong number of sexual partners, frequency of smoking). Red-haired women did worse than other women in ten health categories and better in only three, being particularly prone to colorectal, cervical, uterine, and ovarian cancer. Red-haired men showed a balanced pattern, doing better than other men in three health categories and worse in three. Number of children was the only category where both male and female redheads did better than other respondents. We also confirmed earlier findings that red hair is naturally more frequent in women than in men. Of the 'new' hair and eye colors, red hair diverges the most from the ancestral state of black hair and brown eyes, being the most sexually dimorphic variant not only in population frequency but also in health status. This divergent health status may have one or more causes: direct effects of red hair pigments (pheomelanins) or their by-products; effects of other genes that show linkage with genes involved in pheomelanin production; excessive prenatal exposure to estrogen (which facilitates expression of red hair during fetal development and which, at high levels, may cause health problems later in life); evolutionary recentness of red hair and corresponding lack of time to correct negative side effects; or genetic incompatibilities associated with the allele Val92Met, which seems to be of Neanderthal origin and is one of the alleles that can cause red hair.
[Mh] Termos MeSH primário: Cor de Olho
Cor de Cabelo
Nível de Saúde
Fatores Sexuais
[Mh] Termos MeSH secundário: República Tcheca
Feminino
Seres Humanos
Masculino
Eslováquia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190238


  4 / 2206 MEDLINE  
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[PMID]:29362773
[Au] Autor:Abalem MF; Rao PK; Rao RC
[Ad] Endereço:Department of Ophthalmology, Faculty of Medicine, University of São Paulo, Brazil.
[Ti] Título:Nystagmus and Platinum Hair.
[So] Source:JAMA;319(4):399-400, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Albinismo Oculocutâneo/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Albinismo Oculocutâneo/complicações
Diagnóstico Diferencial
Feminino
Fundo de Olho
Cor de Cabelo
Seres Humanos
Nistagmo Patológico/etiologia
Transtornos da Pigmentação/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.20673


  5 / 2206 MEDLINE  
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[PMID]:28985494
[Au] Autor:Dannemann M; Kelso J
[Ad] Endereço:Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
[Ti] Título:The Contribution of Neanderthals to Phenotypic Variation in Modern Humans.
[So] Source:Am J Hum Genet;101(4):578-589, 2017 Oct 05.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. Using baseline phenotypes collected for 112,000 individuals by the UK Biobank, we can now elaborate on previous findings that identified associations between signatures of positive selection on Neanderthal DNA and various modern human traits but not any specific phenotypic consequences. Here, we show that Neanderthal DNA affects skin tone and hair color, height, sleeping patterns, mood, and smoking status in present-day Europeans. Interestingly, multiple Neanderthal alleles at different loci contribute to skin and hair color in present-day Europeans, and these Neanderthal alleles contribute to both lighter and darker skin tones and hair color, suggesting that Neanderthals themselves were most likely variable in these traits.
[Mh] Termos MeSH primário: Evolução Biológica
Grupo com Ancestrais do Continente Europeu/genética
Homem de Neandertal/genética
Fenótipo
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Animais
Estudos de Coortes
Frequência do Gene
Genoma Humano
Cor de Cabelo
Haplótipos
Seres Humanos
Desequilíbrio de Ligação
Filogenia
Pigmentação da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  6 / 2206 MEDLINE  
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[PMID]:28627318
[Au] Autor:Sugaya K
[Ad] Endereço:a Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics , National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST) , Chiba , Japan.
[Ti] Título:Effects of gamma rays on the regeneration of murine hair follicles in the natural hair cycle.
[So] Source:Int J Radiat Biol;93(9):937-946, 2017 Sep.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This review evaluates the effects of γ-rays on the regeneration of murine hair follicles in the natural hair cycle. A series of studies were performed to investigate this issue, in which the whole bodies of C57BL/10JHir mice in the 1st telogen phase of the hair cycle were irradiated with γ-rays. RESULTS: The dermis of the irradiated skin showed a decrease in hair follicle density and induction of curved hair follicles along with the presence of white hairs and hypopigmented hair bulbs in the 2nd and 3rd anagen phases. An increased frequency of hypopigmented hair bulbs was still observed in the later hair cycle at postnatal day 200. There was no significant difference in the number of stem cells in the hair bulge region between control and irradiated skin. CONCLUSIONS: These results show that the effects of γ-rays on the pigmentation of murine hair follicles are persistently carried over to later hair cycles, although those on the number and structure of hair follicles appear to be hidden by the effects of aging. Our findings may be important for understanding the mechanisms of the actions of stem cells on hair regeneration in connection with age-related phenotypes.
[Mh] Termos MeSH primário: Raios gama
Cor de Cabelo/fisiologia
Cor de Cabelo/efeitos da radiação
Folículo Piloso/crescimento & desenvolvimento
Folículo Piloso/efeitos da radiação
Regeneração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta à Radiação
Folículo Piloso/citologia
Camundongos
Camundongos Endogâmicos C57BL
Dose de Radiação
Regeneração/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1080/09553002.2017.1344362


  7 / 2206 MEDLINE  
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[PMID]:28577553
[Au] Autor:Johansson MK; Jäderkvist Fegraeus K; Lindgren G; Ekesten B
[Ad] Endereço:Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, -750 07, Uppsala, SE, Sweden. mariakjoh@hotmail.com.
[Ti] Título:The refractive state of the eye in Icelandic horses with the Silver mutation.
[So] Source:BMC Vet Res;13(1):153, 2017 Jun 02.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The syndrome Multiple Congenital Ocular Anomalies (MCOA) is a congenital eye disorder in horses. Both the MCOA syndrome and the Silver coat colour in horses are caused by the same missense mutation in the premelanosome protein (PMEL) gene. Horses homozygous for the Silver mutation (TT) are affected by multiple ocular defects causing visual impairment or blindness. Horses heterozygous for the Silver mutation (CT) have less severe clinical signs, usually cysts arising from the ciliary body iris or retina temporally. It is still unknown if the vision is impaired in horses heterozygous for the Silver mutation. A recent study reported that Comtois horses carrying the Silver mutation had significantly deeper anterior chambers of the eye compared to wild-type horses. This could potentially cause refractive errors. The purpose of the present study was to investigate if Icelandic horses with the Silver mutation have refractive errors compared to wild-type horses. One hundred and fifty-two Icelandic horses were included in the study, 71 CT horses and five TT horses. All horses were genotyped for the missense mutation in PMEL. Each CT and TT horse was matched by a wild-type (CC) horse of the same age ± 1 year. Skiascopy and a brief ophthalmic examination were performed in all horses. Association between refraction and age, eye, genotype and sex was tested by linear mixed-effect model analysis. TT horses with controls were not included in the statistical analyses as they were too few. RESULTS: The interaction between age and genotype had a significant impact on the refractive state (P = 0.0001). CT horses older than 16 years were on average more myopic than wild-type horses of the same age. No difference in the refractive state could be observed between genotypes (CT and CC) in horses younger than 16 years. TT horses were myopic (-2 D or more) in one or both eyes regardless of age. CONCLUSION: Our results indicate that an elderly Icelandic horse (older than 16 years) carrying the Silver mutation is more likely to be myopic than a wild-type horse of the same age.
[Mh] Termos MeSH primário: Oftalmopatias/veterinária
Doenças dos Cavalos/congênito
Mutação de Sentido Incorreto
Refração Ocular/genética
[Mh] Termos MeSH secundário: Animais
Oftalmopatias/congênito
Oftalmopatias/genética
Feminino
Cor de Cabelo/genética
Heterozigoto
Homozigoto
Doenças dos Cavalos/genética
Cavalos
Masculino
Fenótipo
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1059-7


  8 / 2206 MEDLINE  
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[PMID]:28532438
[Au] Autor:Jespersen A; Jensen HE; Agger JF; Heegaard PMH; Damborg P; Aalbæk B; Hammer AS
[Ad] Endereço:Kopenhagen Fur, Langagervej 60, DK-2600, Glostrup, Denmark. ajes@sund.ku.dk.
[Ti] Título:The effect of color type on early wound healing in farmed mink (Neovison vison).
[So] Source:BMC Vet Res;13(1):135, 2017 May 22.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Individual differences of mink, including color type, are speculated to affect the course of wound healing, thereby impacting wound assessment and management on the farms, as well as the assessment of wounds in forensic cases. In this study, we examined the effect of color type on early wound healing in farmed mink. Full thickness excisional wounds (2 × 2 cm) were made on the back in 18 mink of the color types Brown, Silverblue and Blue Iris. Gross and microscopic pathology of the wounds was evaluated 2 days post-wounding together with degree of wound size reduction, presence of bacteria and blood analyses. RESULTS: Pathological examination on day 2 showed the greatest mean wound size reduction in Brown mink (11.0%) followed by Blue Iris (7.9%) and Silverblue (1.6%). Bacteria were cultured from all wounds, and predominantly Staphylococcus species were recovered in mixed or pure culture. Histopathology from day 2 wounds showed a scab overlying necrotic wound edges, which were separated from underlying vital tissue by a demarcation zone rich in polymorphonuclear leukocytes. Fibroblasts and plump endothelial cells were more numerous in the deeper tissues. Complete blood count parameters were within normal ranges in most cases, however, the mink showed mildly to markedly decreased hematocrit and six mink of the color types Silverblue and Blue Iris showed moderately elevated numbers of circulating segmented neutrophils on day 2. There was a marked increase in concentration of serum amyloid A from day 0 to day 2 in all color types. CONCLUSIONS: We have described differences in early wound healing between mink of the color types Brown, Silverblue and Blue Iris by use of an experimental wound model in farmed mink. The most pronounced difference pertained to the degree of wound size reduction which was greatest in Brown mink, followed by Blue Iris and Silverblue, respectively.
[Mh] Termos MeSH primário: Cor de Cabelo
Vison
Cicatrização
Ferimentos e Lesões/veterinária
[Mh] Termos MeSH secundário: Animais
Masculino
Ferimentos e Lesões/microbiologia
Ferimentos e Lesões/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1052-1


  9 / 2206 MEDLINE  
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[PMID]:28525626
[Au] Autor:Lin BM; Li WQ; Curhan SG; Stankovic KM; Qureshi AA; Curhan GC
[Ti] Título:Skin Pigmentation and Risk of Hearing Loss in Women.
[So] Source:Am J Epidemiol;186(1):1-10, 2017 Jul 01.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Black individuals have a lower risk of hearing loss than do whites, possibly because of differences in cochlear melanocytes. Previous studies have suggested that darker-skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are important in generating the endocochlear potential. We investigated the relationship between self-reported hearing loss and skin pigmentation by using hair color, skin tanning ability, and skin reaction to prolonged sun exposure as surrogate measures of pigmentation among 49,323 white women in the Nurses' Health Study. Cox proportional hazards regression models were used to adjust for potential confounders. During 1,190,170 person-years of follow-up (1982-2012), there was no association between risk of hearing loss and hair color (for black hair vs. red or blonde hair, multivariable-adjusted relative risk (RR) = 0.99, 95% confidence interval (CI): 0.90, 1.09), skin tanning ability (for dark tan vs. no tan, multivariable-adjusted RR = 0.98, 95% CI: 0.92, 1.05), skin reaction to prolonged sun exposure (for painful burn with blisters vs. practically no reaction, multivariable-adjusted RR = 1.01, 95% CI: 0.93, 1.08), or Fitzpatrick skin phototype (for type IV vs. type I, multivariable-adjusted RR = 0.99, 95% CI: 0.92, 1.05). In our cohort of white women, surrogates for skin pigmentation were not associated with risk of hearing loss.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Europeu
Perda Auditiva/epidemiologia
Pigmentação da Pele
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Consumo de Bebidas Alcoólicas/epidemiologia
Índice de Massa Corporal
Surdez/epidemiologia
Diabetes Mellitus Tipo 2/epidemiologia
Dieta
Exercício
Feminino
Cor de Cabelo
Seres Humanos
Hipertensão/epidemiologia
Meia-Idade
Doenças Mitocondriais/epidemiologia
Modelos de Riscos Proporcionais
Fumar/epidemiologia
Bronzeado
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kwx024


  10 / 2206 MEDLINE  
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[PMID]:28500464
[Au] Autor:Walsh S; Chaitanya L; Breslin K; Muralidharan C; Bronikowska A; Pospiech E; Koller J; Kovatsi L; Wollstein A; Branicki W; Liu F; Kayser M
[Ad] Endereço:Department of Biology, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA. walshsus@iupui.edu.
[Ti] Título:Global skin colour prediction from DNA.
[So] Source:Hum Genet;136(7):847-863, 2017 Jul.
[Is] ISSN:1432-1203
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Human skin colour is highly heritable and externally visible with relevance in medical, forensic, and anthropological genetics. Although eye and hair colour can already be predicted with high accuracies from small sets of carefully selected DNA markers, knowledge about the genetic predictability of skin colour is limited. Here, we investigate the skin colour predictive value of 77 single-nucleotide polymorphisms (SNPs) from 37 genetic loci previously associated with human pigmentation using 2025 individuals from 31 global populations. We identified a minimal set of 36 highly informative skin colour predictive SNPs and developed a statistical prediction model capable of skin colour prediction on a global scale. Average cross-validated prediction accuracies expressed as area under the receiver-operating characteristic curve (AUC) ± standard deviation were 0.97 ± 0.02 for Light, 0.83 ± 0.11 for Dark, and 0.96 ± 0.03 for Dark-Black. When using a 5-category, this resulted in 0.74 ± 0.05 for Very Pale, 0.72 ± 0.03 for Pale, 0.73 ± 0.03 for Intermediate, 0.87±0.1 for Dark, and 0.97 ± 0.03 for Dark-Black. A comparative analysis in 194 independent samples from 17 populations demonstrated that our model outperformed a previously proposed 10-SNP-classifier approach with AUCs rising from 0.79 to 0.82 for White, comparable at the intermediate level of 0.63 and 0.62, respectively, and a large increase from 0.64 to 0.92 for Black. Overall, this study demonstrates that the chosen DNA markers and prediction model, particularly the 5-category level; allow skin colour predictions within and between continental regions for the first time, which will serve as a valuable resource for future applications in forensic and anthropologic genetics.
[Mh] Termos MeSH primário: DNA/genética
Polimorfismo de Nucleotídeo Único
Pigmentação da Pele/genética
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Africano/genética
Grupo com Ancestrais do Continente Europeu/genética
Feminino
Marcadores Genéticos
Genótipo
Técnicas de Genotipagem
Cor de Cabelo/genética
Seres Humanos
Modelos Logísticos
Masculino
Modelos Genéticos
Modelos Estatísticos
Fenótipo
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1007/s00439-017-1808-5



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