Base de dados : MEDLINE
Pesquisa : G13.750 [Categoria DeCS]
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[PMID]:29339793
[Au] Autor:Hua Q; Sun J; Liu H; Bao R; Yu R; Zhai J; Pan C; Wang ZL
[Ad] Endereço:CAS Center for Excellence in Nanoscience, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
[Ti] Título:Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing.
[So] Source:Nat Commun;9(1):244, 2018 01 16.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mechanosensation electronics (or Electronic skin, e-skin) consists of mechanically flexible and stretchable sensor networks that can detect and quantify various stimuli to mimic the human somatosensory system, with the sensations of touch, heat/cold, and pain in skin through various sensory receptors and neural pathways. Here we present a skin-inspired highly stretchable and conformable matrix network (SCMN) that successfully expands the e-skin sensing functionality including but not limited to temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity. The actualized specific expandable sensor units integrated on a structured polyimide network, potentially in three-dimensional (3D) integration scheme, can also fulfill simultaneous multi-stimulus sensing and achieve an adjustable sensing range and large-area expandability. We further construct a personalized intelligent prosthesis and demonstrate its use in real-time spatial pressure mapping and temperature estimation. Looking forward, this SCMN has broader applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies.
[Mh] Termos MeSH primário: Fenômenos Mecânicos
Sensação/fisiologia
Fenômenos Fisiológicos da Pele
Pele/metabolismo
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/instrumentação
Técnicas Biossensoriais/métodos
Seres Humanos
Umidade
Campos Magnéticos
Mecanotransdução Celular/fisiologia
Microscopia Eletrônica de Varredura
Pressão
Pele/citologia
Pele/ultraestrutura
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02685-9


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[PMID]:29369282
[Au] Autor:Newbern S
[Ad] Endereço:Stacy Newbern is a wound care clinic supervisor at Central Peninsula Hospital in Soldotna, Alaska.
[Ti] Título:Why your facility needs a full-time certified wound care nurse.
[So] Source:Nursing;48(2):66-68, 2018 Feb.
[Is] ISSN:1538-8689
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Instalações de Saúde
Necessidades e Demandas de Serviços de Saúde
Admissão e Escalonamento de Pessoal
Ferimentos e Lesões/enfermagem
[Mh] Termos MeSH secundário: Certificação
Seres Humanos
Descrição de Cargo
Guias de Prática Clínica como Assunto
Melhoria de Qualidade
Fenômenos Fisiológicos da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/01.NURSE.0000529914.98433.76


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[PMID]:29429507
[Au] Autor:Léauté-Labrèze C
[Ad] Endereço:Unité de dermatologie pédiatrique et centre de référence des maladies rares de la peau, hôpital Pellegrin-Enfants, CHU de Bordeaux, 33076 Bordeaux Cedex, France. Electronic address: christine.labreze@chu-bordeaux.fr.
[Ti] Título:[What's new in pediatric dermatology?]
[Ti] Título:Quoi de neuf en dermatologie pédiatrique ?.
[So] Source:Ann Dermatol Venereol;143 Suppl 3:S29-S36, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The association of a birth defect and a segmental hemangioma is well established, a consensus concerning evaluation and monitoring of infants with PHACE or LUMBAR syndromes has been published. The efficacy of propranolol in infantile hemangioma is proven; however there were still unresolved issues concerning the safety in children; after 8 years of use on thousands of children safety data collection did not show any unexpected side effects. Topical treatment of infantile hemangiomas with beta-blockers, such as timolol, is very popular, but recent publications revealed a significant systemic absorption that could be responsible for severe side effects, such as bradycardia, in low birthweight infants. As a consequence, this therapeutic option should be considered with caution. In the last 2 years mTOR inhibitors have been tested in low-flow vascular malformations with varying success, but progress remains to be done in the treatment of vascular abnormalities. Today, genetics has led to advances in the understanding of the pathophysiology and in the future targeted therapies could probably be feasible. Skin barrier deficiency is responsible for the development of allergic phenomena in atopic patients, since it has been shown that sensibilisation, even to food, could probably be induced by skin contact. Unfortunately, the topical treatment with crisaborole, a phosphodiesterase 4 inhibitor, does not look like a revolution in children atopic dermatitis, its efficacy seems equivalent to emollient application. In the field of infectious diseases, changes in viral outbreaks are the most reported. Furthermore epidemic Zika virus, enteroviruses are responsible for expanded dermatological manifestations and also severe meningoencephalitis. Paraviral character of various eruptions, such as gloves and socks syndrome or eruptive pseudoangiomatosis is challenged.
[Mh] Termos MeSH primário: Dermatopatias
[Mh] Termos MeSH secundário: Coartação Aórtica/terapia
Doenças Autoimunes/genética
Criança
Dermatologia
Anormalidades do Olho/terapia
Hipersensibilidade Alimentar/imunologia
Hemangioma/terapia
Seres Humanos
Síndromes Neurocutâneas/terapia
Pediatria
Fator de Transcrição STAT3/genética
Dermatopatias/diagnóstico
Dermatopatias/etiologia
Dermatopatias/terapia
Fenômenos Fisiológicos da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (STAT3 Transcription Factor); 0 (STAT3 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29391860
[Au] Autor:Galor A; Small L; Feuer W; Levitt RC; Sarantopoulos KD; Yosipovitch G
[Ad] Endereço:Miami Veterans Administration Medical Center, Miami, Florida (Dr Galor); Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida (Dr Galor, Dr Small, Mr Feuer); and Department of Anesthesiology, Perioperative Medicine and Pain Management (Dr Levitt, Dr Sarantopo
[Ti] Título:The Relationship Between Ocular Itch, Ocular Pain, and Dry Eye Symptoms (An American Ophthalmological Society Thesis).
[So] Source:Trans Am Ophthalmol Soc;115:T5, 2017 Aug.
[Is] ISSN:1545-6110
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate associations between sensations of ocular itch and dry eye (DE) symptoms, including ocular pain, and DE signs. Methods: A cross-sectional study of 324 patients seen in the Miami Veterans Affairs eye clinic was performed. The evaluation consisted of questionnaires regarding ocular itch, DE symptoms, descriptors of neuropathic-like ocular pain (NOP), and evoked pain sensitivity testing on the forehead and forearm, followed by a comprehensive ocular surface examination including corneal mechanical sensitivity testing. Analyses were performed to examine for differences between those with and without subjective complaints of ocular itch. Results: The mean age was 62 years with 92% being male. Symptoms of DE and NOP were more frequent in patients with moderate-severe ocular itch compared to those with no or mild ocular itch symptoms. With the exception of ocular surface inflammation (abnormal matrix metalloproteinase 9 testing) which was less common in those with moderate-severe ocular itch symptoms, DE signs were not related to ocular itch. Individuals with moderate-severe ocular itch also demonstrated greater sensitivity to evoked pain on the forearm and had higher non-ocular pain, depression, and post-traumatic stress disorders scores, compared to those with no or mild itch symptoms. Conclusions: Subjects with moderate-severe ocular itch symptoms have more severe symptoms of DE, NOP, non-ocular pain and demonstrate abnormal somatosensory testing in the form of increased sensitivity to evoked pain at a site remote from the eye, consistent with generalized hypersensitivity.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/diagnóstico
Oftalmopatias/diagnóstico
Dor Ocular/diagnóstico
Prurido/diagnóstico
[Mh] Termos MeSH secundário: Córnea/fisiologia
Estudos Transversais
Síndromes do Olho Seco/fisiopatologia
Oftalmopatias/fisiopatologia
Dor Ocular/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Oftalmologia/organização & administração
Medição da Dor
Prurido/fisiopatologia
Qualidade de Vida
Fenômenos Fisiológicos da Pele
Sociedades Médicas
Inquéritos e Questionários
Lágrimas/fisiologia
Estados Unidos
Veteranos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29394019
[Au] Autor:Wei KS; Stella C; Wehmeyer KR; Christman J; Altemeier A; Spruell R; Wimalasena RL; Fadayel GM; Reilman RA; Motlagh S; Stoffolano PJ; Benzing K; Wickett RR
[Ti] Título:Effects of season stratum corneum barrier function and skin biomarkers.
[So] Source:J Cosmet Sci;67(3):185-203, 2016 May-Jun.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The skin on the lower legs of 25 female subjects was evaluated first in the winter, and then again in the summer of the same subjects. Barrier function was determined by measuring transepidermal water loss (TEWL), and skin hydration and dryness were evaluated by electrical measurements (Corneometer ® CM825) and visual grading. Stratum corneum (SC) was sampled using 10 sequential D-Squame sampling discs and analyzed for 2-pyrrolidone-5-carboxylic acid (PCA), keratin-1,10,11, interleukin 1α (IL-1α), interleukin 1 receptor antagonist (IL-1ra), selected ceramides, cholesterol, cholesterol sulfate, and selected free fatty acids. TEWL as well as the visual dryness grades were significantly lower in the summer while hydration was higher. PCA was significantly higher in the summer as were the keratins. The ratio IL-1ra:IL-1α, an indicator of skin inflammation, was significantly lower in the summer. The amount of protein removed by the tape strips was also significantly lower in summer indicating better SC cohesion. Among the SC lipids measured, total ceramides, individual ceramides, total fatty acids, and cholesterol were higher in summer compared to winter. Stearic acid and cholesterol sulfate were not significantly different between winter and summer.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Epiderme/fisiologia
Pele/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Meia-Idade
Estações do Ano
Fenômenos Fisiológicos da Pele
Perda Insensível de Água
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29394018
[Au] Autor:Yuanxi L; Wei H; Lidan X; Li L
[Ti] Título:Comparison of skin hydration in combination and single use of common moisturizers (cream, toner, and spray water).
[So] Source:J Cosmet Sci;67(3):175-83, 2016 May-Jun.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aims to assess the moisturization in combination or single use (including seven general applications) of three common moisturizers: cream, toner, and spray water. Groups were set as C: cream only; T: toner only; C+T, T+C: cream or toner applied successively within a few minutes; C-T, C-S: cream applied with repeated toner or spray water every 2 h; T-T: toner applied with repeated toner every 2 h; and N: untreated group. Outcomes were the change in skin hydration from baseline at 2, 4, 6, and 8 h after applications. All treated zones displayed a significantly higher degree of hydration compared with the untreated zone ( p < 0.05). For normal skin (hydration value at baseline >35 a.u.), C-T led to greatest hydration change rate compared with others, followed by C+T, T+C, and C. Those three applications exhibited analogous hydration at each test point ( p > 0.05). The hydration rate of C-S differed slightly from T-T, followed by those four mentioned above, with T being the last. For dry skin (hydration value at baseline <35 a.u.), no statistical significance could be detected between C-T zone and C+T, T+C, and C zones ( p > 0.05), the other results were identical. When cream and toner were applied successively, the application order has little effect on skin hydration. The application of cream only was an effective and brief way to achieve favorable moisturization especially for dry skin. As a complement, repeated application of toner rather than spray water is efficacious for skin hydration.
[Mh] Termos MeSH primário: Emolientes/uso terapêutico
Dermatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Emolientes/administração & dosagem
Emolientes/farmacologia
Feminino
Seres Humanos
Dermatopatias/fisiopatologia
Fenômenos Fisiológicos da Pele
Perda Insensível de Água
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Emollients)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29394015
[Au] Autor:Gillece T; McMullen RL; Fares H; Senak L; Ozkan S; Foltis L
[Ti] Título:Probing the textures of composite skin care formulations using large amplitude oscillatory shear.
[So] Source:J Cosmet Sci;67(3):121-59, 2016 May-Jun.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Identifying meaningful and measurable rheological parameters that shadow the dynamic shear stresses sustained in the initial application and subsequent spreading of structured cosmetic formulations onto the skin is quite challenging. When applied to non-Newtonian soft solids, traditional oscillatory rheological testing tends to best correlate with the "at-rest" state, or, more fundamentally, with the initial and thermodynamically reversible perturbations in the physiochemical networking that binds components of the amalgamated microstructure. In addition, after yielding, as an applied film is further thinned while spreading on the skin surface, shear rates during flow processes may rapidly and dynamically increase to 104 s⁻¹ , which is a magnitude that is not practically simulated with a standard rotational rheometer. Realistically speaking, it is rare that a single rheological measurement or resultant parameter predicts the sensorial appeal of a complex fluid during the entire scope of a spreading process. Large amplitude oscillatory shear (LAOS) methodology is an augmentation of standard oscillatory rheology, or small amplitude oscillatory shear (SAOS), and delivers a means to dynamically probe the deforming microstructure of a soft solid as it rheologically transitioned from a viscoplastic material to a structured fluid. LAOS rheology was performed on four different prototypes having different skincare textures to produce Bowditch­Lissajous plots (henceforth truncated to Lissajous in the remainder of the document) for subsequent association with previously measured sensorial properties. Insights into the shapes of the curves and their relation to paralleled sensorial analyses are primarily based on the performance of the composite prototypes rather than speculating on the individual contribution of each constituent to the dynamics of the adapting microstructure. Therefore, transitions in the Lissajous trajectories may be used to visually describe changes in the bulk rheology as the physical components of the local viscoelastic environment are controllably sheared. In this work, Lissajous profiles are amassed with smooth and rough surfaces data utilizing standard rheological techniques, including oscillatory SAOS, stress ramps, Brookfield viscometry, and the manifestation of interfacial or complex flow properties, such as wall-slip and shear-banding phenomena. Practical influences on the human stratum corneum, including thermal softening and electrostatic shielding, are also considered. Additionally, outcomes from texture profile analysis are reported and contrasted with the accompanying results. Ultimately, the objective is to make meaningful connections between trends in Lissajous trajectories and paralleled sensorial analyses conducted by a trained expert panel. For the reader, a basic level of rheological knowledge is assumed.
[Mh] Termos MeSH primário: Cosméticos/química
[Mh] Termos MeSH secundário: Composição de Medicamentos
Seres Humanos
Reologia
Higiene da Pele
Fenômenos Fisiológicos da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:27776996
[Au] Autor:Holm HJ; Skugor S; Bjelland AK; Radunovic S; Wadsworth S; Koppang EO; Evensen Ø
[Ad] Endereço:Faculty of Veterinary Medicine and Biosciences, Department of Basic Sciences and Aquatic Medicine, Sea Lice Research Centre, Norwegian University of Life Sciences, Oslo, Norway. Electronic address: Helle.Holm@nmbu.no.
[Ti] Título:Contrasting expression of immune genes in scaled and scaleless skin of Atlantic salmon infected with young stages of Lepeophtheirus salmonis.
[So] Source:Dev Comp Immunol;67:153-165, 2017 02.
[Is] ISSN:1879-0089
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Atlantic salmon skin tissues with and without scales were taken from two preferred sites of salmon louse (Lepeophtheirus salmonis) attachment, behind the dorsal fin (scaled) and from the top of the head (scaleless), respectively. Tissues were profiled by qPCR of 32 genes to study responses to copepodids, 4 days post infection (dpi), and during the moult of copepodids to the chalimus stage, at 8 dpi. Basal/constitutive differences were found for many immune-related genes between the two skin sites; e.g., mannose binding protein C was over 100 fold higher expressed in the scaled skin from the back in comparison to the skin without scales from the head. With lice-infection, at 4 dpi most genes in both tissues showed lower values than in the non-infected control. By 8 dpi, the majority of responses increased towards the control levels, including cytokines of Th1, Th17 and Th2 pathways. Immunohistochemistry of three immune factors revealed an even distribution of MHC class II positive cells throughout epidermis, including the top layer of keratinocytes, marked compartmentalization of Mx and CD8α cells close to stratum basale, and an increase in numbers of CD8α cells in response to infection. In conclusion, suppression of immune genes during the copepodid stage likely sets off a beneficial situation for the parasite. At the moult to chalimus stage 8 dpi, only few genes surpassed the non-infected control levels, including CD8α. The gene expression pattern was reflected in the increased number of CD8α expressing cells, thus revealing a relatively minor activation of skin T-cell defenses in Atlantic salmon in response to L. salmonis infection.
[Mh] Termos MeSH primário: Escamas de Animais/fisiologia
Copépodes/imunologia
Proteínas de Peixes/metabolismo
Infestações por Piolhos/imunologia
Lectina de Ligação a Manose/metabolismo
Salmo salar/imunologia
Pele/imunologia
[Mh] Termos MeSH secundário: Escamas de Animais/parasitologia
Animais
Células Cultivadas
Citocinas/metabolismo
Proteínas de Peixes/genética
Imunidade/genética
Infestações por Piolhos/genética
Estágios do Ciclo de Vida
Lectina de Ligação a Manose/genética
Salmo salar/parasitologia
Pele/parasitologia
Fenômenos Fisiológicos da Pele/genética
Células Th1/imunologia
Células Th17/imunologia
Células Th2/imunologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Fish Proteins); 0 (MBL2 protein, human); 0 (Mannose-Binding Lectin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28931040
[Au] Autor:Reis ZSN; Vitral GLN; de Souza IMF; Rego MAS; Guimaraes RN
[Ad] Endereço:Center of Health Informatics, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
[Ti] Título:Newborn skin reflection: Proof of concept for a new approach for predicting gestational age at birth. A cross-sectional study.
[So] Source:PLoS One;12(9):e0184734, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Current methods to assess the gestational age during prenatal care or at birth are a global challenge. Disadvantages, such as low accessibility, high costs, and imprecision of clinical tests and ultrasonography measurements, may compromise health decisions at birth, based on the gestational age. Newborns' organs and tissues can indirectly indicate their physical maturity, and we hypothesized that evolutionary changes in their skin, detected using an optoelectronic device meter, may aid in estimating the gestational age. This study analyzed the feasibility of using newborn skin reflectance to estimate the gestational age at birth noninvasively. METHODS AND FINDINGS: A cross-sectional study evaluated the skin reflectance of selected infants, preferably premature, at birth. The first-trimester ultrasound was the reference for gestational age. A prototype of a new noninvasive optoelectronic device measured the backscattering of light from the skin, using a light emitting diode at wavelengths of 470 nm, 575 nm, and 630 nm. Univariate and multivariate regression analysis models were employed to predict gestational age, combining skin reflectance with clinical variables for gestational age estimation. The gestational age at birth of 115 newborns from 24.1 to 41.8 weeks of gestation correlated with the light at 630 nm wavelength reflectance 3.3 mm/6.5 mm ratio distant of the sensor, at the forearm and sole (Pearson's correlation = 0.505, P < 0.001 and 0.710, P < 0.001, respectively). The best-combined variables to predict the gold standard gestational age at birth was the skin reflectance at wavelengths of 630 nm and 470 nm in combination with birth weight, phototherapy, and adjusted to include incubator stay, and sex (R2 = 0.828, P < 0.001). The main limitation of the study is that it was very specific to the premature population we studied and needs to be studied in a broader spectrum of newborns. CONCLUSIONS: A novel automated skin reflectometer device, in combination with clinical variables, was able to predict the gestational age and could be useful when the information is in doubt or is unknown. Multivariable predictive models associated the skin reflectance with easy to obtain clinical parameters, at the birth scenario. External validation needs to be proven in an actual population with the real incidence of premature infants.
[Mh] Termos MeSH primário: Idade Gestacional
Recém-Nascido Prematuro
Óptica e Fotônica/métodos
Pele/fisiopatologia
[Mh] Termos MeSH secundário: Peso ao Nascer
Estudos Transversais
Feminino
Seres Humanos
Recém-Nascido
Óptica e Fotônica/instrumentação
Gravidez
Fenômenos Fisiológicos da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184734


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[PMID]:28919421
[Au] Autor:Kim YJ; Yoo SM; Park HH; Lim HJ; Kim YL; Lee S; Seo KW; Kang KS
[Ad] Endereço:Stem Cells and Regenerative Bioengineering Institute, Kangstem Biotech CO., LTD., 2nd Floor, Biotechnology Center, #81 Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea.
[Ti] Título:Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin.
[So] Source:Biochem Biophys Res Commun;493(2):1102-1108, 2017 Nov 18.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Moreover, we evaluated skin permeation of USC-CM Exos by using human skin tissues. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 h. Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics.
[Mh] Termos MeSH primário: Exossomos/metabolismo
Sangue Fetal/citologia
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Peptídeos e Proteínas de Sinalização Intercelular/farmacologia
Células Mesenquimais Estromais/metabolismo
Rejuvenescimento
Fenômenos Fisiológicos da Pele
[Mh] Termos MeSH secundário: Adulto
Células Cultivadas
Colágeno/metabolismo
Cosméticos
Elastina/metabolismo
Exossomos/química
Feminino
Sangue Fetal/química
Sangue Fetal/metabolismo
Fibroblastos/citologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Seres Humanos
Peptídeos e Proteínas de Sinalização Intercelular/isolamento & purificação
Peptídeos e Proteínas de Sinalização Intercelular/farmacocinética
Células Mesenquimais Estromais/química
Células Mesenquimais Estromais/citologia
Absorção Cutânea
Fenômenos Fisiológicos da Pele/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics); 0 (Intercellular Signaling Peptides and Proteins); 9007-34-5 (Collagen); 9007-58-3 (Elastin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE



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