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[PMID]:29378653
[Au] Autor:Kalyana Sundaram I; Sarangi DD; Sundararajan V; George S; Sheik Mohideen S
[Ad] Endereço:Department of Biotechnology, Dayanandasagar College of Engineering, Kumaraswamy Layout, Bangalore, 560078, Karnataka, India.
[Ti] Título:Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging.
[So] Source:BMC Complement Altern Med;18(1):33, 2018 Jan 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Extrinsic factors that affect skin aging such as UV radiation can also cause malignant melanoma. Here we selected four medicinal plant materials, namely, leaves of Nyctanthes arbor-tristis, unripe and ripe Aegle marmelos fruit pulp and the terminal meristem of Musa paradisiaca flower and investigated their anti-aging properties and cytotoxicity in vitro individually as well as in a poly herbal formulation containing the four plant extracts in different ratios. METHODS: The phytochemical contents of the plant extracts were investigated for radical scavenging activity and total reducing power. Based upon its anti-oxidant properties, a poly herbal formulation containing leaves of Nyctanthes arbor-tristis, unripe and ripe fruit pulp of Aegle marmelos, and the terminal meristem of Musa paradisiaca flower in the ratio 6:2:1:1 (Poly Herbal Formulation 1) and 1:1:1:1 (Poly Herbal Formulation 2), respectively were formulated. RESULT: It has been observed that the Poly Herbal Formulation 1 was more potent than Poly Herbal Formulation 2 due to better anti-oxidant and anti-elastase activities in NIH3T3 fibroblast cells. In addition Poly Herbal formulation 1 also had better anti-cancer activity in human malignant melanoma cells. CONCLUSION: Based on these results these beneficial plant extracts were identified for its potential application as an anti-aging agent in skin creams as well as an anti-proliferation compound against cancer cells.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Elastase Pancreática/antagonistas & inibidores
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Aegle/química
Animais
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Camundongos
Células NIH 3T3
Óxido Nítrico/metabolismo
Oleaceae/química
Plantas Medicinais/química
Espécies Reativas de Oxigênio/metabolismo
Envelhecimento da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 31C4KY9ESH (Nitric Oxide); EC 3.4.21.36 (Pancreatic Elastase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2097-9


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[PMID]:29382339
[Au] Autor:Lee HJ; Im AR; Kim SM; Kang HS; Lee JD; Chae S
[Ad] Endereço:Department of Microbiology, Disivion of Natural Science, Pusan National University, Busan, 609-735, South Korea.
[Ti] Título:The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways.
[So] Source:BMC Complement Altern Med;18(1):39, 2018 Jan 30.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation. This study was designed to evaluate the efficacy of hesperidin against photoaging of dorsal skin in hairless mice. METHODS: Hairless male mice (6-week-old) were divided into three groups (n = 7): control, UVB-treated vehicle, and UVB-treated hesperidin groups. UVB-irradiated mice from hesperidin group were orally administered 0.1 mL of water containing 100 mg/kg body weight per day hesperidin. RESULTS: The mean length and depth of wrinkles in the UVB-treated hesperidin group significantly improved after the oral administration of hesperidin, which significantly inhibited the increase in epidermal thickness and epidermal hypertrophy (P < 0.05). UVB irradiation of mice induced epidermal barrier dysfunction including an increase in the transepidermal water loss (TEWL); however, hesperidin decreased the TEWL. UVB irradiation increased the expression of MMP-9 and pro-inflammatory cytokines whereas UVB-treated hesperidin group showed reduced expression. These results indicate that hesperidin showed anti-photoaging activity in the UVB-irradiated hairless mice. In conclusion, hesperidin inhibited the UVB-induced increase in skin thickness, wrinkle formation, and collagen fiber loss in male hairless mice. CONCLUSIONS: These results suggest that hesperidin shows potent anti-photoaging activity by regulating MMP-9 expression through the suppression of MAPK-dependent signaling pathways.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Hesperidina/farmacologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Metaloproteinase 9 da Matriz/metabolismo
Envelhecimento da Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Regulação para Baixo/efeitos dos fármacos
Epiderme/efeitos dos fármacos
Epiderme/efeitos da radiação
Imuno-Histoquímica
Masculino
Camundongos
Camundongos Pelados
Envelhecimento da Pele/efeitos da radiação
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); E750O06Y6O (Hesperidin); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2058-8


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[PMID]:29384737
[Au] Autor:Rezende Machado AL; Dezem TU; Bruni AT; Alves da Silva RH
[Ad] Endereço:Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Curso de Graduação em Odontologia (Iniciação Científica), Brasil.
[Ti] Título:Age estimation by facial analysis based on applications available for smartphones.
[So] Source:J Forensic Odontostomatol;2(35):61-70, 2017 Dec 01.
[Is] ISSN:2219-6749
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Forensic Dentistry has an important role in the human identification cases and, among the analyses that can be performed, age estimation has an important value in establishing an anthropological profile. Modern technology invests for new mechanisms of age estimation: software apps, based on special algorithms, because there is not interference based on personal knowledge, cultural and personal experiences for facial recognition. MATERIALS AND METHODS: This research evaluated the use of two different apps: "How Old Do I Look? - Age Camera" and "How Old Am I? - Age Camera, Do You Look Like in Selfie Face Pic?", for age estimation analysis in a sample of 100 people (50 females and 50 males). Univariate and multivariate statistical methods were used to evaluate data. RESULTS: A great reliability was seen when used for the male volunteers. However, for females, no equivalence was found between the real age and the estimated age. CONCLUSION: These applications presented satisfactory results as an auxiliary method, in male images.
[Mh] Termos MeSH primário: Face/anatomia & histologia
Aplicativos Móveis
Envelhecimento da Pele
Smartphone
[Mh] Termos MeSH secundário: Feminino
Antropologia Forense
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE


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[PMID]:29369878
[Au] Autor:Kirkland-Kyhn H; Zaratkiewicz S; Teleten O; Young HM
[Ad] Endereço:Holly Kirkland-Kyhn is the director of wound care in the Patient Care Services Department of the University of California, Davis, Medical Center in Sacramento, where Oleg Teleten is a wound care specialist. Sunniva Zaratkiewicz is the director of clinical education, nursing research, and accreditation at Harborview Medical Center, University of Washington, Seattle. Heather M. Young is dean of the Betty Irene Moore School of Nursing at the University of California, Davis, and associate vice chancellor for nursing at UC Davis Health. Contact author: Holly Kirkland-Kyhn, kirklandwalsh@ucdavis.edu. The authors have disclosed no potential conflicts of interest, financial or otherwise.
[Ti] Título:Caring for Aging Skin.
[So] Source:Am J Nurs;118(2):60-63, 2018 02.
[Is] ISSN:1538-7488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:: This article is part of a series, Supporting Family Caregivers: No Longer Home Alone, published in collaboration with the AARP Public Policy Institute. Results of focus groups, conducted as part of the AARP Public Policy Institute's No Longer Home Alone video project, supported evidence that family caregivers aren't given the information they need to manage the complex care regimens of family members. This series of articles and accompanying videos aims to help nurses provide caregivers with the tools they need to manage their family member's health care at home.The articles in this new installment of the series provide simple and useful instructions that nurses should reinforce with family caregivers who perform wound care tasks. Each article also includes an informational tear sheet-Information for Family Caregivers-that contains links to instructional videos. To use this series, nurses should read the article first, so they understand how best to help family caregivers, and then encourage caregivers to watch the videos and ask questions. For additional information, see Resources for Nurses.
[Mh] Termos MeSH primário: Envelhecimento da Pele/fisiologia
Higiene da Pele/enfermagem
[Mh] Termos MeSH secundário: Dieta
Emolientes/uso terapêutico
Seres Humanos
Lesão por Pressão/terapia
Dermatopatias/fisiopatologia
Dermatopatias/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; PATIENT EDUCATION HANDOUT
[Nm] Nome de substância:
0 (Emollients)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/01.NAJ.0000530249.91452.4e


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[PMID]:29176034
[Au] Autor:Jobeili L; Rousselle P; Béal D; Blouin E; Roussel AM; Damour O; Rachidi W
[Ad] Endereço:Cell and Tissue Bank of Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
[Ti] Título:Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion.
[So] Source:Aging (Albany NY);9(11):2302-2315, 2017 Nov 25.
[Is] ISSN:1945-4589
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Skin is constantly exposed to environmental factors such as pollutants, chemicals and ultra violet radiation (UV), which can induce premature skin aging and increase the risk of skin cancer. One strategy to reduce the effect of oxidative stress produced by environmental exposure is the application of antioxidant molecules. Among the endogenous antioxidants, selenoproteins play a key role in antioxidant defense and in maintaining a reduced cellular environment. Selenium, essential for the activity of selenoproteins, is a trace element that is not synthesized by organisms and must be supplied by diet or supplementation. The aim of this study is to evaluate the effect of Selenium supplementation on skin aging, especially on keratinocytes, the main cells of the epidermis. Our results demonstrate for the first time to our knowledge, the major role of Selenium on the replicative life span of keratinocytes and on aging skin. Selenium protects keratinocyte stem cells (KSCs) against senescence via preservation of their stemness phenotype through adhesion to the basement membrane. Additionally, Selenium supplementation maintains the homeostasis of skin during chronological aging in our senescent skin equivalent model. Controlled supplementation with Selenium could be a new strategy to protect skin against aging.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Adesão Celular/efeitos dos fármacos
Diferenciação Celular/efeitos dos fármacos
Senescência Celular/efeitos dos fármacos
Epiderme/efeitos dos fármacos
Queratinócitos/efeitos dos fármacos
Envelhecimento da Pele/efeitos dos fármacos
Selenito de Sódio/farmacologia
Células-Tronco/efeitos dos fármacos
[Mh] Termos MeSH secundário: Membrana Basal/efeitos dos fármacos
Membrana Basal/metabolismo
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Relação Dose-Resposta a Droga
Epiderme/metabolismo
Seres Humanos
Queratinócitos/metabolismo
Fenótipo
Células-Tronco/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); HIW548RQ3W (Sodium Selenite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.18632/aging.101322


  6 / 6676 MEDLINE  
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[PMID]:29186250
[Au] Autor:Silva SAME; Michniak-Kohn B; Leonardi GR
[Ad] Endereço:Medicine Department - Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
[Ti] Título:An overview about oxidation in clinical practice of skin aging.
[So] Source:An Bras Dermatol;92(3):367-374, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Estresse Oxidativo/efeitos dos fármacos
Envelhecimento da Pele/efeitos dos fármacos
Dermatopatias/tratamento farmacológico
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  7 / 6676 MEDLINE  
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[PMID]:29186248
[Au] Autor:Addor FAS
[Ad] Endereço:Private clinic - São Paulo (SP), Brazil.
[Ti] Título:Antioxidants in dermatology.
[So] Source:An Bras Dermatol;92(3):356-362, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The skin cells continuously produce, through cellular respiration, metabolic processes or under external aggressions, highly reactive molecules oxidation products, generally called free radicals. These molecules are immediately neutralized by enzymatic and non-enzymatic systems in a physiological and dynamic balance. In situations where this balance is broken, various cellular structures, such as the cell membrane, nuclear or mitochondrial DNA may suffer structural modifications, triggering or worsening skin diseases. several substances with alleged antioxidant effects has been offered for topical or oral use, but little is known about their safety, possible associations and especially their mechanism of action. The management of topical and oral antioxidants can help dermatologist to intervene in the oxidative processes safely and effectively, since they know the mechanisms, limitations and potential risks of using these molecules as well as the potential benefits of available associations.
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Envelhecimento da Pele/efeitos dos fármacos
Dermatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Radicais Livres/metabolismo
Seres Humanos
Estresse Oxidativo/efeitos dos fármacos
Envelhecimento da Pele/fisiologia
Higiene da Pele/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radicals)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


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[PMID]:29186249
[Au] Autor:Sumita JM; Leonardi GR; Bagatin E
[Ad] Endereço:Dermatology Department of the Paulista Medical School - Universidade Federal de São Paulo (EPM - UNIFESP) - São Paulo (SP), Brazil.
[Ti] Título:Tretinoin peel: a critical view.
[So] Source:An Bras Dermatol;92(3):363-366, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The tretinoin peel, also known as retinoic acid peel, is a superficial peeling often performed in dermatological clinics in Brazil. The first study on this was published in 2001, by Cuce et al., as a treatment option for melasma. Since then, other studies have reported its applicability with reasonable methodology, although without a consistent scientific background and consensus. Topical tretinoin is used for the treatment of various dermatoses such as acne, melasma, scars, skin aging and non-melanoma skin cancer. The identification of retinoids cellular receptors was reported in 1987, but a direct cause-effect relation has not been established. This article reviews studies evaluating the use of topical tretinoin as agent for superficial chemical peel. Most of them have shown benefits in the treatment of melasma and skin aging. A better quality methodology in the study design, considering indication and intervention is indispensable regarding concentration, vehicle and treatment regimen (interval and number of applications). Additionally, more controlled and randomized studies comparing the treatment with tretinoin cream versus its use as a peeling agent, mainly for melasma and photoaging, are necessary.
[Mh] Termos MeSH primário: Abrasão Química/métodos
Ceratolíticos/administração & dosagem
Envelhecimento da Pele/efeitos dos fármacos
Dermatopatias/tratamento farmacológico
Tretinoína/administração & dosagem
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Keratolytic Agents); 5688UTC01R (Tretinoin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


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[PMID]:29244934
[Au] Autor:Gorkun AA; Kozhina KV; Zurina IM; Kosheleva NV; Saburina IN
[Ti] Título:Pathophysiological and molecular mechanisms of extracellular matrix protein resorption during skin aging, and the ways to their restoration.
[So] Source:Patol Fiziol Eksp Ter;60(4):128-33, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The article is a short review of the most studied molecular mechanisms leading to skin aging. It considers mechanisms of cellular aging, oxidative stress, development of chronic inflammation, as well as synthesis and degradation of extracellular matrix proteins. The review also contains examples of extracellular matrix restoration using cell and pharmacological technologies.
[Mh] Termos MeSH primário: Proteínas da Matriz Extracelular/metabolismo
Matriz Extracelular/metabolismo
Envelhecimento da Pele
[Mh] Termos MeSH secundário: Matriz Extracelular/patologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Extracellular Matrix Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:29284244
[Au] Autor:Sagan D; Stepniak J; Gesing A; Lewinski A; Karbownik-Lewinska M
[Ad] Endereço:Department of Oncological Endocrinology, Medical University of Lodz, Lodz, Poland.
[Ti] Título:Melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers - A study in postmenopausal women.
[So] Source:Ann Agric Environ Med;24(4):659-666, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION AND OBJECTIVE: Protective antioxidative effects of melatonin have been repeatedly documented in experimental and clinical studies. One of the most spectacular exogenous prooxidative agents is cigarette smoking. The aim of the study was to evaluate the level of oxidative damage to membrane lipids (lipid peroxidation; LPO) in blood serum, and in epidermis exfoliated during microdermabrasion collected from former-smokers who were treated with melatonin. MATERIAL AND METHODS: The study was performed in postmenopausal women. Ninety (90) female volunteers, aged 46-67 years, were enrolled. Two major groups, i.e. never-smokers (n=44) and former-smokers (n=46), were divided into: Control, melatonin topical skin application, Restructurer (containing antioxidants) topical skin application, and melatonin oral treatment. Microdermabrasion was performed at point '0', after 2 weeks, and after 4 weeks of treatment. The following parameters were measured: LPO in blood serum, LPO in epidermis exfoliated during microdermabrasion, and skin biophysical characteristics, such as sebum, moisture, elasticity, and pigmentation. Malondialdehyde+4-hydroxyalkenals level (LPO index) was measured spectrophotometrically. RESULTS: Melatonin oral treatment significantly reversed the increased serum LPO level in former-smokers already after 2 weeks of treatment. In a univariate regression model, LPO blood level constituted the only independent factor negatively associated with melatonin oral treatment. After 4 weeks of treatment, melatonin given orally increased skin sebum, moisture and elasticity levels, and melatonin applied topically increased sebum level. CONCLUSIONS: Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Melatonina/administração & dosagem
Lipídeos de Membrana/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Pós-Menopausa/metabolismo
Envelhecimento da Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Antioxidantes/metabolismo
Feminino
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Meia-Idade
Pós-Menopausa/efeitos dos fármacos
Pele/efeitos dos fármacos
Pele/metabolismo
Fumantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Membrane Lipids); 4Y8F71G49Q (Malondialdehyde); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE



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