Base de dados : MEDLINE
Pesquisa : G14.350.253 [Categoria DeCS]
Referências encontradas : 12120 [refinar]
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[PMID]:28459691
[Au] Autor:Maye A; Zhang D; Engel AK
[Ti] Título:Utilizing Retinotopic Mapping for a Multi-Target SSVEP BCI With a Single Flicker Frequency.
[So] Source:IEEE Trans Neural Syst Rehabil Eng;25(7):1026-1036, 2017 07.
[Is] ISSN:1558-0210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In brain-computer interfaces (BCIs) that use the steady-state visual evoked response (SSVEP), the user selects a control command by directing attention overtly or covertly to one out of several flicker stimuli. The different control channels are encoded in the frequency, phase, or time domain of the flicker signals. Here, we present a new type of SSVEP BCI, which uses only a single flicker stimulus and yet affords controlling multiple channels. The approach rests on the observation that the relative position between the stimulus and the foci of overt attention result in distinct topographies of the SSVEP response on the scalp. By classifying these topographies, the computer can determine at which position the user is gazing. Offline data analysis in a study on 12 healthy volunteers revealed that 9 targets can be recognized with about 95±3% accuracy, corresponding to an information transfer rate (ITR) of 40.8 ± 3.3 b/min on average. We explored how the classification accuracy is affected by the number of control channels, the trial length, and the number of EEG channels. Our findings suggest that the EEG data from five channels over parieto-occipital brain areas are sufficient for reliably classifying the topographies and that there is a large potential to improve the ITR by optimizing the trial length. The robust performance and the simple stimulation setup suggest that this approach is a prime candidate for applications on desktop and tablet computers.
[Mh] Termos MeSH primário: Atenção/fisiologia
Mapeamento Encefálico/métodos
Interfaces Cérebro-Computador
Potenciais Evocados Visuais/fisiologia
Fusão Flicker/fisiologia
Células Ganglionares da Retina/fisiologia
Córtex Visual/fisiologia
[Mh] Termos MeSH secundário: Adulto
Algoritmos
Eletroencefalografia/métodos
Feminino
Fixação Ocular/fisiologia
Seres Humanos
Masculino
Reconhecimento Automatizado de Padrão/métodos
Estimulação Luminosa/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1109/TNSRE.2017.2666479


  2 / 12120 MEDLINE  
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[PMID]:28930518
[Au] Autor:Vingolo EM; Napolitano G; Fragiotta S
[Ad] Endereço:Department of Medical-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, Sapienza University of Rome, Via Firenze 1, 04019, Terracina, Italy.
[Ti] Título:Microperimetric biofeedback training: fundamentals, strategies and perspectives.
[So] Source:Front Biosci (Schol Ed);10:48-64, 2018 01 01.
[Is] ISSN:1945-0524
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microperimetric biofeedback training (MBFT) is a visual rehabilitative strategy based on fixation stability improvement reinforcing or creating a new preferential fixation locus. The rationale consists in reeducating visual system to a new visual condition, promoting retina-brain transmission, and thus cortical plasticity. The use of MBFT found is major application in visual diseases involving central vision, but later it revealed promising functional outcomes even in myopia, inherited retinal degenerations and nystagmus. However, the use of microperimetric biofeedback is still limited due to poor knowledge of the procedure and inconsistent standards of practice, and thus an incipient skepticism on its efficacy. This review provides an overview of the rationale, current implications, procedures and future perspectives of microperimetric biofeedback training.
[Mh] Termos MeSH primário: Biorretroalimentação Psicológica/métodos
Baixa Visão/radioterapia
[Mh] Termos MeSH secundário: Biorretroalimentação Psicológica/fisiologia
Fixação Ocular/fisiologia
Seres Humanos
Retina/fisiopatologia
Baixa Visão/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


  3 / 12120 MEDLINE  
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[PMID]:29253883
[Au] Autor:Swanenburg J; Bäbler E; Adelsberger R; Straumann D; de Bruin ED
[Ad] Endereço:Physiotherapy and Occupational Therapy Research Center, Directorate of Research and Education, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[Ti] Título:Patients with chronic peripheral vestibular hypofunction compared to healthy subjects exhibit differences in gaze and gait behaviour when walking on stairs and ramps.
[So] Source:PLoS One;12(12):e0189037, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to compare gaze behaviour during stair and ramp walking between patients with chronic peripheral vestibular hypofunction and healthy human subjects. METHODS: Twenty four (24) patients with chronic peripheral vestibular hypofunction (14 unilateral and 10 bilateral) and 24 healthy subjects performed stair and ramp up and down walks at self-selected speed. The walks were repeated five times. A mobile eye tracker was used to record gaze behaviour (defined as time directed to pre-defined areas) and an insole measurement device assessed gait (speed, step time, step length). During each walk gaze behaviour relative to i) detection of first transition area "First TA", ii) detection of steps of the mid-staircase area and the handrail "Structure", iii) detection of second transition area "Second TA", and iv) looking elsewhere "Elsewhere" was assessed and expressed as a percentage of the walk duration. For all variables, a one-way ANOVA followed by contrast tests was conducted. RESULTS: Patients looked significantly longer at the "Structure" (p<0.001) and "Elsewhere" (p<0.001) while walking upstairs compared to walking downstairs (p<0.013). Patients looked significantly longer at the "Structure" (p<0.001) and "Elsewhere" (p<0.001) while walking upstairs compared to walking downstairs (p<0.013). No differences between groups were observed for the transition areas with exception of stair ascending. Patients were also slower going downstairs (p = 0.002) and presented with an increased step time (p = 0.003). Patients were walking faster up the ramp (p = 0.014) with longer step length (p = 0.008) compared to walking down the ramp (p = 0.050) with shorter step length (p = 0.024). CONCLUSIONS: Patients with chronic peripheral vestibular hypofunction differed in time directed to pre-defined areas during stair and ramp walking and looked longer at stair and ramp areas of interest during walking compared to healthy subjects. Patients did not differ in time directed to pre-defined areas during the stair-floor transition area while going downstairs, an area where accidents may frequently occur.
[Mh] Termos MeSH primário: Fixação Ocular
Marcha/fisiologia
Voluntários Saudáveis
Vestíbulo do Labirinto/fisiopatologia
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Idoso
Comportamento
Doença Crônica
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189037


  4 / 12120 MEDLINE  
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[PMID]:29196760
[Au] Autor:Barraza-Bernal MJ; Rifai K; Wahl S
[Ad] Endereço:Institute for Ophthalmic Research, Eberhard Karls University, Tuebingen, Germany.
[Ti] Título:Transfer of an induced preferred retinal locus of fixation to everyday life visual tasks.
[So] Source:J Vis;17(14):2, 2017 Dec 01.
[Is] ISSN:1534-7362
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Subjects develop a preferred retinal locus of fixation (PRL) under simulation of central scotoma. If systematic relocations are applied to the stimulus position, PRLs manifest at a location in favor of the stimulus relocation. The present study investigates whether the induced PRL is transferred to important visual tasks in daily life, namely pursuit eye movements, signage reading, and text reading. Fifteen subjects with normal sight participated in the study. To develop a PRL, all subjects underwent a scotoma simulation in a prior study, where five subjects were trained to develop the PRL in the left hemifield, five different subjects on the right hemifield, and the remaining five subjects could naturally chose the PRL location. The position of this PRL was used as baseline. Under central scotoma simulation, subjects performed a pursuit task, a signage reading task, and a reading-text task. In addition, retention of the behavior was also studied. Results showed that the PRL position was transferred to the pursuit task and that the vertical location of the PRL was maintained on the text reading task. However, when reading signage, a function-driven change in PRL location was observed. In addition, retention of the PRL position was observed over weeks and months. These results indicate that PRL positions can be induced and may further transferred to everyday life visual tasks, without hindering function-driven changes in PRL position.
[Mh] Termos MeSH primário: Fixação Ocular/fisiologia
Retina/fisiologia
Escotoma/fisiopatologia
Acuidade Visual
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Leitura
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1167/17.14.2


  5 / 12120 MEDLINE  
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[PMID]:28453952
[Au] Autor:Perea M; Rosa E; Marcet A
[Ad] Endereço:Universitat de València, Valencia, Spain. Electronic address: mperea@uv.es.
[Ti] Título:Where is the locus of the lowercase advantage during sentence reading?
[So] Source:Acta Psychol (Amst);177:30-35, 2017 Jun.
[Is] ISSN:1873-6297
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:While most models of visual word identification and reading posit that a word's visual codes are rapidly transformed onto case-invariant representations (i.e., table and TABLE would equally activate the word unit corresponding to "table"), a number of experiments have shown a lowercase advantage in various word identification and reading tasks. In the present experiment, we examined the locus of this lowercase advantage by comparing the pattern of eye movements when reading sentences in lowercase vs. uppercase. Each sentence contained a target word that was high or low in word-frequency. Overall, results showed faster reading times for lowercase than for uppercase sentences. More important, while the word-frequency effect was sizeable in the first-fixation durations on the target word, the lowercase advantage only arose in the gaze durations (i.e., the sum of durations of first-pass fixations on the target word, including refixations). Furthermore, we found an effect of word-frequency, but not of letter case, in the first-fixation duration on target words with multiple first-pass fixations. Taken together, these findings suggest that the lowercase advantage reflects operations that do not occur in the initial contact with the lexical entries.
[Mh] Termos MeSH primário: Compreensão/fisiologia
Impressão
Leitura
Semântica
[Mh] Termos MeSH secundário: Adulto
Movimentos Oculares/fisiologia
Feminino
Fixação Ocular/fisiologia
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  6 / 12120 MEDLINE  
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[PMID]:27773657
[Au] Autor:Matsumiya K; Sato M; Shioiri S
[Ad] Endereço:Research Institute of Electrical Communication, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. Electronic address: kmat@riec.tohoku.ac.jp.
[Ti] Título:Contrast dependence of saccadic blanking and landmark effects.
[So] Source:Vision Res;129:1-12, 2016 12.
[Is] ISSN:1878-5646
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two phenomena have been reported to affect the perceived displacement of a visual target during saccadic eye movements: the blanking effect and landmark effect. In the blanking effect, temporarily blanking the target after a saccade improves displacement judgments. In the landmark effect, illusory target displacement occurs when a continuously presented landmark is displaced during a saccade, and the target is temporarily blanked after the saccade without displacement. We show that the strengths of the blanking and landmark effects vary with stimulus contrast. In the blanking effect, target displacement detection rate increased with luminance contrast of the target. In the landmark effect, illusory target displacement decreased with luminance contrast of the target. Moreover, the landmark effect was found even for stimuli without luminance contrast (equiluminant color stimuli), while the blanking effect disappeared. These results can be attributed to a reduction in sensitivity of target displacement by a reduction of luminance contrast, which suggests that changes in luminance, or transient signals, play a critical role in visual stability across saccades.
[Mh] Termos MeSH primário: Sensibilidades de Contraste/fisiologia
Fixação Ocular/fisiologia
Movimentos Sacádicos/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Feminino
Seres Humanos
Iluminação
Estimulação Luminosa/métodos
Percepção Visual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  7 / 12120 MEDLINE  
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[PMID]:27771330
[Au] Autor:Rothkegel LO; Trukenbrod HA; Schütt HH; Wichmann FA; Engbert R
[Ad] Endereço:Department of Psychology & Cognitive Science Program, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany. Electronic address: lrothkeg@uni-potsdam.de.
[Ti] Título:Influence of initial fixation position in scene viewing.
[So] Source:Vision Res;129:33-49, 2016 12.
[Is] ISSN:1878-5646
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During scene perception our eyes generate complex sequences of fixations. Predictors of fixation locations are bottom-up factors such as luminance contrast, top-down factors like viewing instruction, and systematic biases, e.g., the tendency to place fixations near the center of an image. However, comparatively little is known about the dynamics of scanpaths after experimental manipulation of specific fixation locations. Here we investigate the influence of initial fixation position on subsequent eye-movement behavior on an image. We presented 64 colored photographs to participants who started their scanpaths from one of two experimentally controlled positions in the right or left part of an image. Additionally, we used computational models to predict the images' fixation locations and classified them as balanced images or images with high conspicuity on either the left or right side of a picture. The manipulation of the starting position influenced viewing behavior for several seconds and produced a tendency to overshoot to the image side opposite to the starting position. Possible mechanisms for the generation of this overshoot were investigated using numerical simulations of statistical and dynamical models. Our model comparisons show that inhibitory tagging is a viable mechanism for dynamical planning of scanpaths.
[Mh] Termos MeSH primário: Atenção/fisiologia
Fixação Ocular/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Feminino
Seres Humanos
Inibição (Psicologia)
Masculino
Estimulação Luminosa/métodos
Movimentos Sacádicos/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  8 / 12120 MEDLINE  
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[PMID]:29204647
[Au] Autor:Costela FM; Kajtezovic S; Woods RL
[Ad] Endereço:Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States.
[Ti] Título:The Preferred Retinal Locus Used to Watch Videos.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6073-6081, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Eccentric viewing is a common strategy used by people with central vision loss (CVL) to direct the eye such that the image falls onto functioning peripheral retina, known as the preferred retinal locus (PRL). It has been long acknowledged that we do not know whether the PRL used in a fixation test is also used when performing tasks. We present an innovative method to determine whether the same PRL observed during a fixation task was used to watch videos and whether poor resolution affects gaze location. Methods: The gaze of a group of 60 normal vision (NV) observers was used to define a democratic center of interest (COI) of video clips from movies and television. For each CVL participant (N = 20), we computed the gaze offsets from the COI across the video clips. The distribution of gaze offsets of the NV participants was used to define the limits of NV behavior. If the gaze offset was within this 95% degree confidence interval, we presumed that the same PRL was used for fixation and video watching. Another 15 NV participants watched the video clips with various levels of defocus blur. Results: CVL participants had wider gaze-offset distributions than NV participants (P < 0.001). Gaze offsets of 18/20 CVL participants were outside the NV confidence interval. Further, none of the 15 NV participants watching the same videos with spherical defocus blur had a gaze offset that was decentered (outside the NV confidence interval), suggesting that resolution was not the problem. Conclusions: This indicates that many CVL participants were using a PRL to view videos that differed from that found with a fixation task and that it was not caused by poor resolution alone. The relationship between these locations needs further investigation.
[Mh] Termos MeSH primário: Movimentos Oculares/fisiologia
Filmes Cinematográficos
Retina/fisiopatologia
Escotoma/fisiopatologia
Acuidade Visual
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Fixação Ocular
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21839


  9 / 12120 MEDLINE  
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[PMID]:29176901
[Au] Autor:Talk A; Antón-Méndez I; Pennefather B
[Ad] Endereço:Discipline of Psychology, School of Behavioural, Cognitive, and Social Sciences, University of New England, Armidale, New South Wales, Australia.
[Ti] Título:Graded expression of source memory revealed by analysis of gaze direction.
[So] Source:PLoS One;12(11):e0188727, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During source memory studies, knowledge of some detail about the context of a previously experienced item or event is tested. Here, participants attended to different objects presented at different quadrants on a screen. In a later test phase, a single object was presented in all four quadrants, and participants verbally reported whether the object was new or previously seen (item recognition), and if it was previously seen, they indicated the original screen location (source memory). We combined this test with eye-tracking to determine whether attention to an object during encoding would correlate with later recognition of the object and memory of its source location, and whether eye movements at test can reveal attention to the correct source location in the absence of correct explicit verbal responses. The amount of time spent looking at an object during encoding was not related to later object recognition or source recollection. However, we found that eye movements at test reveal retention of source information about an object in the absence of accurate retrieval of source information as assessed by verbal response. When participants correctly recognized an object but incorrectly indicated the source information, significantly more time was spent looking at the correct source location than to incorrect, non-selected locations. Moreover, when participants correctly recognized an object but said they could not remember the source information, significantly more time was spent looking at the correct source location. These results are consistent with the hypothesis that eye movements are sensitive to attention or other graded mental processes which can underlie the retrieval of source memories that can then be expressed verbally in a thresholded manner.
[Mh] Termos MeSH primário: Fixação Ocular/fisiologia
Memória/fisiologia
[Mh] Termos MeSH secundário: Movimentos Oculares/fisiologia
Feminino
Seres Humanos
Masculino
Estimulação Luminosa
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188727


  10 / 12120 MEDLINE  
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[PMID]:28449714
[Au] Autor:Gramatikov BI
[Ad] Endereço:Laboratory of Ophthalmic Instrument Development, The Krieger Children's Eye Center at the Wilmer Institute, Wilmer Eye Institute, 233, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287-9028, USA. bgramat@jhmi.edu.
[Ti] Título:Detecting central fixation by means of artificial neural networks in a pediatric vision screener using retinal birefringence scanning.
[So] Source:Biomed Eng Online;16(1):52, 2017 Apr 27.
[Is] ISSN:1475-925X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Reliable detection of central fixation and eye alignment is essential in the diagnosis of amblyopia ("lazy eye"), which can lead to blindness. Our lab has developed and reported earlier a pediatric vision screener that performs scanning of the retina around the fovea and analyzes changes in the polarization state of light as the scan progresses. Depending on the direction of gaze and the instrument design, the screener produces several signal frequencies that can be utilized in the detection of central fixation. The objective of this study was to compare artificial neural networks with classical statistical methods, with respect to their ability to detect central fixation reliably. METHODS: A classical feedforward, pattern recognition, two-layer neural network architecture was used, consisting of one hidden layer and one output layer. The network has four inputs, representing normalized spectral powers at four signal frequencies generated during retinal birefringence scanning. The hidden layer contains four neurons. The output suggests presence or absence of central fixation. Backpropagation was used to train the network, using the gradient descent algorithm and the cross-entropy error as the performance function. The network was trained, validated and tested on a set of controlled calibration data obtained from 600 measurements from ten eyes in a previous study, and was additionally tested on a clinical set of 78 eyes, independently diagnosed by an ophthalmologist. RESULTS: In the first part of this study, a neural network was designed around the calibration set. With a proper architecture and training, the network provided performance that was comparable to classical statistical methods, allowing perfect separation between the central and paracentral fixation data, with both the sensitivity and the specificity of the instrument being 100%. In the second part of the study, the neural network was applied to the clinical data. It allowed reliable separation between normal subjects and affected subjects, its accuracy again matching that of the statistical methods. CONCLUSION: With a proper choice of a neural network architecture and a good, uncontaminated training data set, the artificial neural network can be an efficient classification tool for detecting central fixation based on retinal birefringence scanning.
[Mh] Termos MeSH primário: Ambliopia/diagnóstico
Ambliopia/fisiopatologia
Diagnóstico por Computador/métodos
Fixação Ocular
Redes Neurais (Computação)
Retinoscopia/métodos
Seleção Visual/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Birrefringência
Criança
Pré-Escolar
Seres Humanos
Masculino
Refratometria/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s12938-017-0339-6



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