Base de dados : MEDLINE
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Referências encontradas : 375 [refinar]
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[PMID]:29199256
[Au] Autor:Saito N
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Tohoku University.
[Ti] Título:[Synthesis, Aggregation, Self-assembly, and Dynamic Properties of Helicene Oligomers].
[So] Source:Yakugaku Zasshi;137(12):1483-1490, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Biological systems exhibit dynamic phenomena at the macroscopic level as a result of the hierarchical integration of phenomena at the molecular level. For example, a number of amino acids compose actin proteins, which form three-dimensional structures determined by the sequence of amino acids. They form fibers by self-assembly, which then form ordered structures such as meshes, lyotropic liquid crystals (LCs), and bundles. The dynamic and reversible polymorphism between these nano- to centimeter-sized ordered structures is essential for biological functions such as cell division, contraction, and locomotion. To understand biological systems and create new functional materials, it is essential to develop a methodology to integrate phenomena at the molecular level into those at the macroscopic level using synthetic molecules. In this research, synthetic oligomers containing helicenes, which exhibit reversible structural transitions between cylindrical double helices and random coils in response to thermal stimuli, were employed as building blocks for the development of such a methodology. The properties of homo- and hetero-double helices at the molecular level were first controlled by taking advantage of the diversity of their molecular structures. Then, nano- to micrometer-sized structures were constructed by the self-assembly of hetero-double helices, which include fibers/gels, vesicles, and lyotropic LCs, and their dynamic properties were controlled by molecular design.
[Mh] Termos MeSH primário: Fenômenos Biológicos
Compostos Policíclicos
[Mh] Termos MeSH secundário: Animais
Disciplinas das Ciências Biológicas
Biopolímeros
Fenômenos Fisiológicos Celulares
Química Orgânica
Sequências Hélice-Alça-Hélice
Seres Humanos
Biologia Molecular
Estrutura Molecular
Nanopartículas
Compostos Policíclicos/química
Compostos Policíclicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biopolymers); 0 (Polycyclic Compounds); 0 (helicenes)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00130


  2 / 375 MEDLINE  
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[PMID]:28741915
[Ti] Título:Making a Titanium Surface Biologically Active.
[So] Source:J Calif Dent Assoc;44(9):538, 2016 Sep.
[Is] ISSN:1043-2256
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bivalves/metabolismo
Levodopa/fisiologia
Titânio
[Mh] Termos MeSH secundário: Animais
Fenômenos Biológicos
Levodopa/biossíntese
Propriedades de Superfície
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
46627O600J (Levodopa); D1JT611TNE (Titanium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  3 / 375 MEDLINE  
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[PMID]:28712921
[Au] Autor:Neme A; Seuter S; Carlberg C
[Ad] Endereço:School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
[Ti] Título:Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor.
[So] Source:Biochim Biophys Acta;1860(9):952-961, 2017 09.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH) D ). In THP-1 human monocytes we obtained a highly accurate VDR cistrome after 2 and 24h ligand stimulation comprising >11,600 genomic loci, 78% of which were detected exclusively after 24h. In contrast, a group of 510 persistent VDR sites occurred at all conditions and some 2100 VDR loci were only transiently occupied. Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. The 1,25(OH) D -dependent transcriptome of THP-1 cells comprised 587 genes, 311 of which were primary targets with main functions in the immune system. More than 97% of the latter genes were located within 1,25(OH) D -modulated topologically associated domains (TADs). The number of persistent and transient VDR sites was found to be the main discriminator for sorting these TADs into five classes carrying vitamin D target genes involved in distinct biological processes. In conclusion, specific regulation of biological processes by vitamin D depends on differences in time-dependent VDR binding.
[Mh] Termos MeSH primário: Receptores de Calcitriol/metabolismo
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: Linfócitos B/metabolismo
Fenômenos Biológicos
Linhagem Celular
Células Cultivadas
Regulação da Expressão Gênica/fisiologia
Seres Humanos
Monócitos/metabolismo
Ligação Proteica/fisiologia
Fatores de Transcrição/metabolismo
Transcriptoma/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Calcitriol); 0 (Transcription Factors); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE


  4 / 375 MEDLINE  
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[PMID]:28704373
[Au] Autor:Lee SW; Morishita Y
[Ad] Endereço:Laboratory for Developmental Morphogeometry, RIKEN Quantitative Biology Center, Kobe, Japan.
[Ti] Título:Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.
[So] Source:PLoS Comput Biol;13(7):e1005651, 2017 Jul.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell competition is a phenomenon originally described as the competition between cell populations with different genetic backgrounds; losing cells with lower fitness are eliminated. With the progress in identification of related molecules, some reports described the relevance of cell mechanics during elimination. Furthermore, recent live imaging studies have shown that even in tissues composed of genetically identical cells, a non-negligible number of cells are eliminated during growth. Thus, mechanical cell elimination (MCE) as a consequence of mechanical cellular interactions is an unavoidable event in growing tissues and a commonly observed phenomenon. Here, we studied MCE in a genetically-homogeneous tissue from the perspective of tissue growth efficiency and homeostasis. First, we propose two quantitative measures, cell and tissue fitness, to evaluate cellular competitiveness and tissue growth efficiency, respectively. By mechanical tissue simulation in a pure population where all cells have the same mechanical traits, we clarified the dependence of cell elimination rate or cell fitness on different mechanical/growth parameters. In particular, we found that geometrical (specifically, cell size) and mechanical (stress magnitude) heterogeneities are common determinants of the elimination rate. Based on these results, we propose possible mechanical feedback mechanisms that could improve tissue growth efficiency and density/stress homeostasis. Moreover, when cells with different mechanical traits are mixed (e.g., in the presence of phenotypic variation), we show that MCE could drive a drastic shift in cell trait distribution, thereby improving tissue growth efficiency through the selection of cellular traits, i.e. intra-tissue "evolution". Along with the improvement of growth efficiency, cell density, stress state, and phenotype (mechanical traits) were also shown to be homogenized through growth. More theoretically, we propose a mathematical model that approximates cell competition dynamics, by which the time evolution of tissue fitness and cellular trait distribution can be predicted without directly simulating a cell-based mechanical model.
[Mh] Termos MeSH primário: Fenômenos Biológicos
Fenômenos Biomecânicos/fisiologia
Fenômenos Fisiológicos Celulares/fisiologia
Aptidão Genética
Homeostase/fisiologia
[Mh] Termos MeSH secundário: Animais
Biologia Computacional
Drosophila
Epitélio
Modelos Biológicos
Desenvolvimento Vegetal
Xenopus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005651


  5 / 375 MEDLINE  
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[PMID]:28414779
[Au] Autor:Ye J; Wen B
[Ad] Endereço:Center for Integrative Conservation, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan, China.
[Ti] Título:Seed germination in relation to the invasiveness in spiny amaranth and edible amaranth in Xishuangbanna, SW China.
[So] Source:PLoS One;12(4):e0175948, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Both spiny and edible amaranths (Amaranthus spinosus and A. tricolor) are exotic annuals in China that produce numerous small seeds every year. Spiny amaranth has become a successful invader and a troublesome weed in Xishuangbanna, but edible amaranth has not, although it is widely grown as a vegetable there. As seed germination is one of the most important life-stages contributing to the ability of a plant to become invasive, we conducted experiments to compare the effects of high temperature and water stress on seed germination in two varieties each of spiny amaranth and edible amaranth. Overall, the seeds of both amaranth species exhibited adaptation to high temperature and water stress, including tolerance to ground temperatures of 70°C for air-dried seeds, which is consistent with their behavior in their native ranges in the tropics. As expected, the invasive spiny amaranth seeds exhibited higher tolerance to both continuous and daily periodic high-temperature treatment at 45°C, and to imbibition-desiccation treatment, compared to edible amaranth seeds. Unexpectedly, edible amaranth seeds exhibited higher germination at extreme temperatures (10°C, 15°C, and 40°C), and at lower water potential (below -0.6 MPa). It is likely that cultivation of edible amaranth has selected seed traits that include rapid germination and germination under stressful conditions, either of which, under natural conditions, may result in the death of most germinating edible amaranth seeds and prevent them from becoming invasive weeds in Xishuangbanna. This study suggests that rapid germination and high germination under stress conditions-excellent seed traits for crops and for many invasive species-might be a disadvantage under natural conditions if these traits are asynchronous with natural local conditions that support successful germination.
[Mh] Termos MeSH primário: Amaranthus/crescimento & desenvolvimento
Germinação/fisiologia
Plantas Daninhas/crescimento & desenvolvimento
Sementes/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Adaptação Fisiológica/fisiologia
Fenômenos Biológicos
China
Desidratação/fisiopatologia
Temperatura Alta
Espécies Introduzidas
Fenômenos Fisiológicos/fisiologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175948


  6 / 375 MEDLINE  
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[PMID]:28398362
[Au] Autor:Di Tano G; Clerico A
[Ad] Endereço:U.O. Cardiologia, Ospedale di Cremona, ASST, Cremona.
[Ti] Título:[The relationship between natriuretic peptides and neprilysin pathways: the clinical simplification against the complexity of biological systems].
[Ti] Título:Le relazioni tra peptidi natriuretici e antagonista della neprilisina: ovvero quando la semplificazione clinica affronta la complessità dei sistemi biologici..
[So] Source:G Ital Cardiol (Rome);18(2):95-100, 2017 Feb.
[Is] ISSN:1827-6806
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:A large body of evidence supports the use of natriuretic peptides (brain natriuretic peptide [BNP] and N-terminal proBNP [NT-proBNP]) for the evaluation and management of patients with heart failure over time. Elevated values reflect an enhanced counterregulatory response to hemodynamic stress and are indicative of heart failure severity, thus predicting prognosis. The clinical relevance and result interpretation of natriuretic peptides for monitoring therapy are still debated, and our understanding of their complex nature is still far from being complete. The new data about the clinical efficacy of LCZ696, a combination neprilysin inhibitor and angiotensin receptor blocker recently approved for the treatment of symptomatic chronic heart failure, showed a different susceptibility of BNP and NT-proBNP during therapy. The aim of this article is to discuss the controversial issues concerning the clinical use of cardiac natriuretic peptide measurement, the complex relationship with neprilysin pathways, and the practical implications of LCZ696 therapy for natriuretic peptide testing in clinical practice.
[Mh] Termos MeSH primário: Aminobutiratos/uso terapêutico
Antagonistas de Receptores de Angiotensina/uso terapêutico
Insuficiência Cardíaca/tratamento farmacológico
Peptídeo Natriurético Encefálico/sangue
Neprilisina/antagonistas & inibidores
Fragmentos de Peptídeos/sangue
Tetrazóis/uso terapêutico
[Mh] Termos MeSH secundário: Fenômenos Biológicos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminobutyrates); 0 (Angiotensin Receptor Antagonists); 0 (LCZ 696); 0 (Peptide Fragments); 0 (Tetrazoles); 0 (pro-brain natriuretic peptide (1-76)); 114471-18-0 (Natriuretic Peptide, Brain); EC 3.4.24.11 (Neprilysin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1714/2663.27294


  7 / 375 MEDLINE  
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[PMID]:28286014
[Au] Autor:Di Silvestre D; Brambilla F; Scardoni G; Brunetti P; Motta S; Matteucci M; Laudanna C; Recchia FA; Lionetti V; Mauri P
[Ad] Endereço:Institute for Biomedical Technologies - National Research Council (ITB-CNR), F.lli Cervi 93, 20090 Segrate, Milan, Italy.
[Ti] Título:Proteomics-based network analysis characterizes biological processes and pathways activated by preconditioned mesenchymal stem cells in cardiac repair mechanisms.
[So] Source:Biochim Biophys Acta;1861(5 Pt A):1190-1199, 2017 05.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We have demonstrated that intramyocardial delivery of human mesenchymal stem cells preconditioned with a hyaluronan mixed ester of butyric and retinoic acid (MSCp ) is more effective in preventing the decay of regional myocardial contractility in a swine model of myocardial infarction (MI). However, the understanding of the role of MSCp in proteomic remodeling of cardiac infarcted tissue is not complete. We therefore sought to perform a comprehensive analysis of the proteome of infarct remote (RZ) and border zone (BZ) of pigs treated with MSCp or unconditioned stem cells. METHODS: Heart tissues were analyzed by MudPIT and differentially expressed proteins were selected by a label-free approach based on spectral counting. Protein profiles were evaluated by using PPI networks and their topological analysis. RESULTS: The proteomic remodeling was largely prevented in MSCp group. Extracellular proteins involved in fibrosis were down-regulated, while energetic pathways were globally up-regulated. Cardioprotectant pathways involved in the production of keto acid metabolites were also activated. Additionally, we found that new hub proteins support the cardioprotective phenotype characterizing the left ventricular BZ treated with MSCp . In fact, the up-regulation of angiogenic proteins NCL and RAC1 can be explained by the increase of capillary density induced by MSCp . CONCLUSIONS: Our results show that angiogenic pathways appear to be uniquely positioned to integrate signaling with energetic pathways involving cardiac repair. GENERAL SIGNIFICANCE: Our findings prompt the use of proteomics-based network analysis to optimize new approaches preventing the post-ischemic proteomic remodeling that may underlie the limited self-repair ability of adult heart.
[Mh] Termos MeSH primário: Fenômenos Biológicos/efeitos dos fármacos
Células Mesenquimais Estromais/metabolismo
Miocárdio/metabolismo
Miócitos Cardíacos/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
Função Ventricular Esquerda/efeitos dos fármacos
Remodelação Ventricular/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Regulação para Baixo/efeitos dos fármacos
Fibrose/metabolismo
Seres Humanos
Cetoácidos/metabolismo
Masculino
Células Mesenquimais Estromais/efeitos dos fármacos
Infarto do Miocárdio/metabolismo
Miócitos Cardíacos/metabolismo
Neovascularização Patológica/metabolismo
Proteômica/métodos
Suínos
Tretinoína/farmacologia
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Keto Acids); 5688UTC01R (Tretinoin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


  8 / 375 MEDLINE  
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[PMID]:28166284
[Au] Autor:Cantor M; Pires MM; Marquitti FM; Raimundo RL; Sebastián-González E; Coltri PP; Perez SI; Barneche DR; Brandt DY; Nunes K; Daura-Jorge FG; Floeter SR; Guimarães PR
[Ad] Endereço:Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada.
[Ti] Título:Nestedness across biological scales.
[So] Source:PLoS One;12(2):e0171691, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biological networks pervade nature. They describe systems throughout all levels of biological organization, from molecules regulating metabolism to species interactions that shape ecosystem dynamics. The network thinking revealed recurrent organizational patterns in complex biological systems, such as the formation of semi-independent groups of connected elements (modularity) and non-random distributions of interactions among elements. Other structural patterns, such as nestedness, have been primarily assessed in ecological networks formed by two non-overlapping sets of elements; information on its occurrence on other levels of organization is lacking. Nestedness occurs when interactions of less connected elements form proper subsets of the interactions of more connected elements. Only recently these properties began to be appreciated in one-mode networks (where all elements can interact) which describe a much wider variety of biological phenomena. Here, we compute nestedness in a diverse collection of one-mode networked systems from six different levels of biological organization depicting gene and protein interactions, complex phenotypes, animal societies, metapopulations, food webs and vertebrate metacommunities. Our findings suggest that nestedness emerge independently of interaction type or biological scale and reveal that disparate systems can share nested organization features characterized by inclusive subsets of interacting elements with decreasing connectedness. We primarily explore the implications of a nested structure for each of these studied systems, then theorize on how nested networks are assembled. We hypothesize that nestedness emerges across scales due to processes that, although system-dependent, may share a general compromise between two features: specificity (the number of interactions the elements of the system can have) and affinity (how these elements can be connected to each other). Our findings suggesting occurrence of nestedness throughout biological scales can stimulate the debate on how pervasive nestedness may be in nature, while the theoretical emergent principles can aid further research on commonalities of biological networks.
[Mh] Termos MeSH primário: Fenômenos Biológicos
Modelos Biológicos
Redes Neurais (Computação)
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171691


  9 / 375 MEDLINE  
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[PMID]:28159781
[Au] Autor:Van JA; Scholey JW; Konvalinka A
[Ad] Endereço:Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; and julie.van@mail.utoronto.ca.
[Ti] Título:Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics.
[So] Source:J Am Soc Nephrol;28(4):1050-1061, 2017 Apr.
[Is] ISSN:1533-3450
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A number of proteomic and peptidomic analyses of urine from diabetic subjects have been published in the quest for a biomarker that predicts progression of nephropathy. Less attention has been paid to the relationships between urinary proteins and the underlying biological processes revealed by the analyses. In this review, we focus on the biological processes identified by studying urinary proteins and protein-protein interactions at each stage of diabetic nephropathy to provide an overview of the events underlying progression of kidney disease reflected in the urine. In uncomplicated diabetes, proteomic/peptidomic analyses indicate that early activation of fibrotic pathways in the kidney occurs before the onset of microalbuminuria. In incipient nephropathy, when albumin excretion rates are abnormal, proteomic/peptidomic analyses suggest that changes in glomerular permselectivity and tubular reabsorption account, at least in part, for the proteins and peptides that appear in the urine. Finally, overt nephropathy is characterized by proteins involved in wound healing, ongoing fibrosis, and inflammation. These findings suggest that there is a spectrum of biological processes in the diabetic kidney and that assessing protein networks may be more informative than individual markers with respect to the stage of disease and the risk of progression.
[Mh] Termos MeSH primário: Biologia Computacional
Nefropatias Diabéticas/urina
Proteômica
[Mh] Termos MeSH secundário: Fenômenos Biológicos
Nefropatias Diabéticas/diagnóstico
Nefropatias Diabéticas/etiologia
Nefropatias Diabéticas/fisiopatologia
Progressão da Doença
Seres Humanos
Hiperglicemia/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE
[do] DOI:10.1681/ASN.2016091018


  10 / 375 MEDLINE  
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[PMID]:28135687
[Au] Autor:Wang Y; Sheng Y; Liu Y; Pan B; Huang J; Warren A; Gao S
[Ad] Endereço:Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China.
[Ti] Título:N -methyladenine DNA modification in the unicellular eukaryotic organism Tetrahymena thermophila.
[So] Source:Eur J Protistol;58:94-102, 2017 Apr.
[Is] ISSN:1618-0429
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:N -methyladenine DNA (6mA) modification exists in both prokaryotes and eukaryotes in which it plays a crucial role in regulating numerous biological processes. In prokaryotes, 6mA is a marker to distinguish self from foreign DNA. Its role in eukaryotes, however, remains elusive. Ciliates were among the first eukaryotes reported to contain 6mA. In the model organism T. thermophila, cellular localization and features of 6mA have been extensively studied, especially in ribosomal DNA (rDNA) molecules. Here, we summarize the features and potential functions of 6mA in Tetrahymena thermophila and other ciliates, and the major findings and contributions of the Tetrahymena model in studies of 6mA methylation. We also discuss other questions in order to improve understanding of the function and evolution of 6mA in eukaryotes.
[Mh] Termos MeSH primário: Adenina/análogos & derivados
DNA de Protozoário/química
Tetrahymena thermophila/genética
[Mh] Termos MeSH secundário: Adenina/química
Adenina/metabolismo
Fenômenos Biológicos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Protozoan); JAC85A2161 (Adenine); W7IBY2BGAX (6-methyladenine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE



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