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[PMID]:29273907
[Au] Autor:Ghiasvand AR; Nouriasl K; Yazdankhah F
[Ad] Endereço:Department of Chemistry, Lorestan University, Khoramabad, Lorestan Province, 6713817133, Iran. a_ghiasvand@yahoo.com.
[Ti] Título:Comparison of the atmospheric- and reduced-pressure HS-SPME strategies for analysis of residual solvents in commercial antibiotics using a steel fiber coated with a multiwalled carbon nanotube/polyaniline nanocomposite.
[So] Source:Anal Bioanal Chem;410(2):361-371, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A low-cost, sensitive and reliable reduced-pressure headspace solid-phase microextraction (HS-SPME) setup was developed and evaluated for direct extraction of residual solvents in commercial antibiotics, followed by determination by gas chromatography with flame ionization detection (GC-FID). A stainless steel narrow wire was made porous and adhesive by platinization by a modified electrophoretic deposition method and coated with a polyaniline/multiwalled carbon nanotube nanocomposite. All experimental variables affecting the extraction efficiency were investigated for both atmospheric-pressure and reduced-pressure conditions. Comparison of the optimal experimental conditions and the results demonstrated that the reduced-pressure strategy leads to a remarkable increase in the extraction efficiency and reduction of the extraction time and temperature (10 min, 25 °Ï¹ vs 20 min, 40 °Ï¹). Additionally, the reduced-pressure strategy showed better analytical performances compared with those obtained by the conventional HS-SPME-GC-FID method. Limit of detections, linear dynamic ranges, and relative standard deviations of the reduced-pressure HS-SPME procedure for benzene, toluene, ethylbenzene, and xylene (BTEX) in injectable solid drugs were obtained over the ranges of 20-100 pg g , 0.02-40 µg g , and 2.8-10.2%, respectively. The procedure developed was successful for the analysis of BTEX in commercial containers of penicillin, ampicillin, ceftriaxone, and cefazolin. Graphical abstract Schematic representation of the developed RP-HS-SPME setup.
[Mh] Termos MeSH primário: Compostos de Anilina/química
Antibacterianos/análise
Nanocompostos/química
Nanotubos de Carbono/química
Microextração em Fase Sólida/instrumentação
Solventes/análise
Xilenos/análise
[Mh] Termos MeSH secundário: Pressão Atmosférica
Contaminação de Medicamentos
Desenho de Equipamento
Nanocompostos/ultraestrutura
Nanotubos de Carbono/ultraestrutura
Solventes/isolamento & purificação
Aço/química
Xilenos/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Anti-Bacterial Agents); 0 (Nanotubes, Carbon); 0 (Solvents); 0 (Xylenes); 0 (polyaniline); 12597-69-2 (Steel)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0726-7


  2 / 6618 MEDLINE  
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[PMID]:29406111
[Au] Autor:Duo B; Cui L; Wang Z; Li R; Zhang L; Fu H; Chen J; Zhang H; Qiong A
[Ad] Endereço:Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China; Department of Chemistry & Environmental Science, Tibet University, Lhasa 850000, China.
[Ti] Título:Observations of atmospheric pollutants at Lhasa during 2014-2015: Pollution status and the influence of meteorological factors.
[So] Source:J Environ Sci (China);63:28-42, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Atmospheric pollutants including SO , NO , CO, O and inhalable particulate matter (PM and PM ) were monitored continuously from March 2014 to February 2015 to investigate characteristics of air pollution at Lhasa, Tibetan Plateau. Species exhibited similar seasonal variations except O , with the peaks in winter but low valleys in summer. The maximum O concentration was observed in spring, followed by summer, autumn, and winter. The positive correlation between O and PM in spring indicated similar sources of them, and was assumed to be turbulent transport. Temperature was the dominant meteorological factor for most species in spring. High temperature accelerates O photochemistry, and favors air disturbance which is conductive to dust resuspension in spring. Relative humidity (RH) and atmospheric pressure were the main meteorological factors in summer. RH showed negative correlations with species, while atmospheric pressure posed opposite situation. Wind speed (WS) was the dominant meteorological factor in autumn, the negative correlations between WS and species indicated diffusion by wind. Most species showed non-significant correlations with meteorological factors in winter, indicating the dependence of pollution on source emission rather than restriction by meteorology. Pollution weather character indicated that emissions were from biomass burning and dust suspension, and meteorological factors also played an important role. Air stream injection from the stratosphere was observed during O pollution period. Air parcels from Southwest Asia were observed during air pollution period in winter. An enhancement in air pollutants such as O would be expected in the future, more attention should be given to countermeasures for prevention of air pollution in the future.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Monitoramento Ambiental
Conceitos Meteorológicos
[Mh] Termos MeSH secundário: Poluição do Ar/estatística & dados numéricos
Atmosfera/química
Pressão Atmosférica
Poeira
Estações do Ano
Temperatura Ambiente
Tibet
Vento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Dust)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29370217
[Au] Autor:Rahne T; Köppke R; Nehring M; Plontke SK; Fischer HG
[Ad] Endereço:University Hospital Halle (Saale), Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
[Ti] Título:Does ambient noise or hypobaric atmosphere influence olfactory and gustatory function?
[So] Source:PLoS One;13(1):e0190837, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multidimensional food perception is based mainly on gustatory and olfactory function. Recent research has demonstrated that hypobaric pressure impairs gustatory function and that background noise or distracting auditory stimulation impairs olfactory function. Using a hypobaric chamber, the odor identification, discrimination, and thresholds as well as taste identification and threshold scores were measured in 16 healthy male volunteers under normal and hypobaric (6380 ft) conditions using clinically validated tests. In both conditions, background noise was either canceled out or replaced by white noise presentation (70 dB sound pressure level). Olfactory sensitivity for n-butanol and gustatory sensitivity were impaired in a hypobaric atmosphere. White noise did not influence the odor test results. White noise stimulation impaired sensitivity for sour and sweet but not for bitter or salty tastants. We conclude that hypobaric or noisy environments could impair gustatory and olfactory sensitivity selectively for particular tastants and odorants.
[Mh] Termos MeSH primário: Pressão Atmosférica
Ruído/efeitos adversos
Olfato/fisiologia
Paladar/fisiologia
[Mh] Termos MeSH secundário: 1-Butanol
Adulto
Aeronaves
Altitude
Voluntários Saudáveis
Seres Humanos
Masculino
Odorantes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8PJ61P6TS3 (1-Butanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190837


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[PMID]:28745648
[Au] Autor:Yang HC; Chang CH; Urban PL
[Ad] Endereço:Department of Applied Chemistry, National Chiao Tung University.
[Ti] Título:Fizzy Extraction of Volatile Organic Compounds Combined with Atmospheric Pressure Chemical Ionization Quadrupole Mass Spectrometry.
[So] Source:J Vis Exp;(125), 2017 Jul 14.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemical analysis of volatile and semivolatile compounds dissolved in liquid samples can be challenging. The dissolved components need to be brought to the gas phase, and efficiently transferred to a detection system. Fizzy extraction takes advantage of the effervescence phenomenon. First, a carrier gas (here, carbon dioxide) is dissolved in the sample by applying overpressure and stirring the sample. Second, the sample chamber is decompressed abruptly. Decompression leads to the formation of numerous carrier gas bubbles in the sample liquid. These bubbles assist the release of the dissolved analyte species from the liquid to the gas phase. The released analytes are immediately transferred to the atmospheric pressure chemical ionization interface of a triple quadrupole mass spectrometer. The ionizable analyte species give rise to mass spectrometric signals in the time domain. Because the release of the analyte species occurs over short periods of time (a few seconds), the temporal signals have high amplitudes and high signal-to-noise ratios. The amplitudes and areas of the temporal peaks can then be correlated with concentrations of the analytes in the liquid samples subjected to fizzy extraction, which enables quantitative analysis. The advantages of fizzy extraction include: simplicity, speed, and limited use of chemicals (solvents).
[Mh] Termos MeSH primário: Espectrometria de Massas/métodos
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Pressão Atmosférica
Dióxido de Carbono/química
Gases/química
Espectrometria de Massas/instrumentação
Razão Sinal-Ruído
Gravação em Vídeo
Compostos Orgânicos Voláteis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gases); 0 (Volatile Organic Compounds); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.3791/56008


  5 / 6618 MEDLINE  
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[PMID]:28463779
[Au] Autor:Tessema EN; Gebre-Mariam T; Schmelzer CEH; Neubert RHH
[Ad] Endereço:Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle Saale, Germany.
[Ti] Título:Isolation and structural characterization of glucosylceramides from Ethiopian plants by LC/APCI-MS/MS.
[So] Source:J Pharm Biomed Anal;141:241-249, 2017 Jul 15.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chronic skin conditions such as atopic dermatitis, psoriasis and aged skin are characterized by defective skin barrier and dryness which are associated with reduced levels of skin ceramides (CERs). The beneficial effects of plant-derived CERs for skin hydration and skin barrier recovery have been shown in several studies. Although plenty of glucosylceramide (GlcCER)-based dietary supplements meant for skin barrier improvement have been marketed, there are limited commercial sources of plant GlcCERs. In an attempt to explore alternative GlcCER sources, a reversed phase LC-MS/MS method with atmospheric pressure chemical ionization (APCI) interface was developed for separation and structural identification of GlcCERs isolated from three plants. The GlcCERs were extracted from the seeds of grass pea (Lathyrus sativus L.), Ethiopian mustard (Brassica carinata) and haricot bean (Phaseolus vulgaris) and purified by column chromatography and preparative LC-MS. The individual GlcCER species were further separated and qualitatively analyzed by LC/APCI-MS/MS. The amount of GlcCERs in each plant was quantified by HPTLC. All GlcCER species detected in the three plants consisted of C18 di/trihydroxy sphingoid bases amide linked with hydroxy fatty acids (C14-C24). The trihydroxy SBs were acylated with very long chain FAs (C22-C24). The major GlcCERs derived from grass pea, Ethiopian mustard and haricot bean are composed of sphingenine (d18:1) linked to hydroxypalmitic acid (h16:0), 4-hydroxy-8-sphingenine (t18:1) coupled with hydroxynervonic acid (h24:1) and sphingadienine (d18:2) joined with h16:0, respectively. The GlcCERs contents in haricot bean (161.2mg/kg) and grass pea (130.0mg/kg) were found to be higher compared to Ethiopian mustard (71.8mg/kg). This qualitative and quantitative information suggests that the two plants of the Fabaceae family (haricot bean and grass pea) are potential alternative sources of GlcCERs for their use in products meant for the recovery of skin barrier function. The LC/APCI-MS/MS method described here has proven to be reliable for the screening of other potential plants containing GlcCERs.
[Mh] Termos MeSH primário: Glucosilceramidas/análise
[Mh] Termos MeSH secundário: Pressão Atmosférica
Cromatografia Líquida
Plantas
Esfingosina/análogos & derivados
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-hydroxy-8-sphingenine); 0 (Glucosylceramides); NGZ37HRE42 (Sphingosine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  6 / 6618 MEDLINE  
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[PMID]:28464556
[Au] Autor:Zhong W; Bobbink FD; Fei Z; Dyson PJ
[Ad] Endereço:College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, P. R. China.
[Ti] Título:Polyimidazolium Salts: Robust Catalysts for the Cycloaddition of Carbon Dioxide into Carbonates in Solvent-Free Conditions.
[So] Source:ChemSusChem;10(13):2728-2735, 2017 07 10.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:There is a growing interest in sustainable heterogeneous catalysts based on organic polymers. Here, we describe a series of polyimidazolium salt catalysts, prepared from the direct reaction of arene-bridged bis- and tris-alkyl halides with trimethylsilylimidazole. The polyimidazolium salts were characterized by spectroscopic and analytical techniques and it was found that their morphology and porosity could be controlled by adjusting the steric parameters of the spacer in the alkyl-halide starting materials. Moreover, the polymers are excellent heterogeneous organocatalysts for the cycloaddition of CO to epoxides to afford cyclic carbonates at atmospheric pressure under solvent-free conditions. The polymer catalysts exhibit long-term stability and may be recycled and reused at least 10 times.
[Mh] Termos MeSH primário: Dióxido de Carbono/química
Carbonatos/química
Carbonatos/síntese química
Reação de Cicloadição
Imidazóis/química
[Mh] Termos MeSH secundário: Pressão Atmosférica
Catálise
Reciclagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbonates); 0 (Imidazoles); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700570


  7 / 6618 MEDLINE  
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[PMID]:28449122
[Au] Autor:Sussmilch FC; Brodribb TJ; McAdam SAM
[Ad] Endereço:School of Biological Sciences, University of Tasmania, Hobart, TAS, Australia.
[Ti] Título:Up-regulation of NCED3 and ABA biosynthesis occur within minutes of a decrease in leaf turgor but AHK1 is not required.
[So] Source:J Exp Bot;68(11):2913-2918, 2017 05 17.
[Is] ISSN:1460-2431
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A major environmental signal influencing day-time stomatal aperture is the vapour pressure deficit between the leaf and atmosphere (VPD). In angiosperms, increased VPD triggers biosynthesis of abscisic acid (ABA), prompting rapid stomatal closure. Altered cell turgor has been proposed as the trigger for ABA biosynthesis, but the timing and nature of the genetic signals linking these processes have remained uncertain. We investigated this in Arabidopsis by examining changes induced by a decrease in leaf turgor, simulating a natural increase in VPD. We found that the rate-limiting gene within the de novo ABA biosynthesis pathway, 9-cis-epoxycarotenoid dioxygenase 3 (NCED3), was induced and ABA levels increased within just 5 min of decreased leaf turgor. This rapid induction matches the time-frame for initiation of stomatal closure in response to a doubling in VPD. We further examined Arabidopsis histidine kinase1 (AHK1) as the most likely candidate for the turgor-sensing receptor involved, but found no significant difference between wild-type and an ahk1 null mutant in the induction of ABA-biosynthetic genes, ABA production, or stomatal behaviour. We show that decreased leaf turgor triggers de novo ABA biosynthesis within the time-frame of the stomatal response to VPD, but that AHK1 does not fulfil a critical role as a turgor-sensing receptor within this pathway.
[Mh] Termos MeSH primário: Ácido Abscísico/biossíntese
Proteínas de Arabidopsis/fisiologia
Arabidopsis/metabolismo
Dioxigenases/genética
Regulação da Expressão Gênica de Plantas
Histidina Quinase/fisiologia
Folhas de Planta/metabolismo
Proteínas de Plantas/genética
[Mh] Termos MeSH secundário: Arabidopsis/genética
Proteínas de Arabidopsis/genética
Pressão Atmosférica
Dioxigenases/metabolismo
Histidina Quinase/genética
Proteínas de Plantas/metabolismo
Estômatos de Plantas/metabolismo
Transpiração Vegetal/genética
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Plant Proteins); 72S9A8J5GW (Abscisic Acid); EC 1.13.11.- (Dioxygenases); EC 1.13.11.51 (9-cis-epoxy-carotenoid dioxygenase); EC 2.7.13.1 (AHK1 protein, Arabidopsis); EC 2.7.13.1 (Histidine Kinase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180114
[Lr] Data última revisão:
180114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1093/jxb/erx124


  8 / 6618 MEDLINE  
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[PMID]:28792953
[Au] Autor:Telfer S; Obradovich N
[Ad] Endereço:Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States of America.
[Ti] Título:Local weather is associated with rates of online searches for musculoskeletal pain symptoms.
[So] Source:PLoS One;12(8):e0181266, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Weather conditions are commonly believed to influence musculoskeletal pain, however the evidence for this is mixed. This study aimed to examine the relationship between local meteorological conditions and online search trends for terms related to knee pain, hip pain, and arthritis. Five years of relative online search volumes for these terms were obtained for the 50 most populous cities in the contiguous United States, along with corresponding local weather data for temperature, relative humidity, barometric pressure, and precipitation. Methods from the climate econometrics literature were used to assess the casual impact of these meteorological variables on the relative volumes of searches for pain. For temperatures between -5°C and 30°C, search volumes for hip pain increased by 12 index points, and knee pain increased by 18 index points. Precipitation had a negative effect on search volumes for these terms. At temperatures >30°C, search volumes for arthritis related pain decreased by 7 index points. These patterns were not seen for pain searches unrelated to the musculoskeletal system. In summary, selected local weather conditions are significantly associated with online search volumes for specific musculoskeletal pain symptoms. We believe the predominate driver for this to be the relative changes in physical activity levels associated with meteorological conditions.
[Mh] Termos MeSH primário: Internet/estatística & dados numéricos
Internet/tendências
Dor Musculoesquelética/patologia
Tempo (Meteorologia)
[Mh] Termos MeSH secundário: Pressão Atmosférica
Clima
Seres Humanos
Medição da Dor
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181266


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[PMID]:28763985
[Au] Autor:Jung S; Lee CW; Lee J; Yong HI; Yum SJ; Jeong HG; Jo C
[Ad] Endereço:Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address: samooel@cnu.ac.kr.
[Ti] Título:Increase in nitrite content and functionality of ethanolic extracts of Perilla frutescens following treatment with atmospheric pressure plasma.
[So] Source:Food Chem;237:191-197, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the effect of atmospheric pressure plasma (APP) treatment on nitrite content and functionality of plant extracts. Ethanolic extracts of Perilla frutescens (EEP) were prepared and treated with APP for 60min. Nitrite content increased from 0 to 45.8mg/l in EEP after APP treatment for 60min. Antimicrobial activity of EEP against Clostridium perfringens and Salmonella Typhimurium was increased by APP with no influence on antioxidative activity (p<0.05). Lyophilized EEP (LEEP) treated with APP for 60min contained 3.74mg/g nitrite. The control (LEEP without APP) contained no nitrite. The minimum inhibitory concentration (MIC) of LEEP for C. perfringens was 200µg/ml. The control did not inhibit C. perfringens growth between 25 and 1000µg/ml. MICs of LEEP and the control against S. Typhimurium were 25 and 50µg/ml, respectively. New nitrite sources with increased antimicrobial activity can be produced from natural plants by APP treatment.
[Mh] Termos MeSH primário: Perilla frutescens
[Mh] Termos MeSH secundário: Pressão Atmosférica
Etanol
Nitritos
Extratos Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrites); 0 (Plant Extracts); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  10 / 6618 MEDLINE  
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[PMID]:28720196
[Ti] Título:This Month in Aerospace Medicine History.
[So] Source:Aerosp Med Hum Perform;88(8):802, 2017 Aug 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Medicina Aeroespacial/história
Medicina Militar/história
[Mh] Termos MeSH secundário: Astronautas
Pressão Atmosférica
Aviação
Comunicação
Descompressão
Mergulho
História do Século XX
Seres Humanos
Hipóxia/prevenção & controle
Hipóxia/terapia
Cooperação Internacional
Linguagem
Oxigenoterapia
Voo Espacial
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4940.2017



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