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  1 / 2725 MEDLINE  
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[PMID]:29351554
[Au] Autor:Sabry AH; W Hasan WZ; Ab Kadir MZA; Radzi MAM; Shafie S
[Ad] Endereço:Department of Control and Automation, Faculty of Engineering, UPM, Serdang, Malaysia.
[Ti] Título:Field data-based mathematical modeling by Bode equations and vector fitting algorithm for renewable energy applications.
[So] Source:PLoS One;13(1):e0191478, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The power system always has several variations in its profile due to random load changes or environmental effects such as device switching effects when generating further transients. Thus, an accurate mathematical model is important because most system parameters vary with time. Curve modeling of power generation is a significant tool for evaluating system performance, monitoring and forecasting. Several numerical techniques compete to fit the curves of empirical data such as wind, solar, and demand power rates. This paper proposes a new modified methodology presented as a parametric technique to determine the system's modeling equations based on the Bode plot equations and the vector fitting (VF) algorithm by fitting the experimental data points. The modification is derived from the familiar VF algorithm as a robust numerical method. This development increases the application range of the VF algorithm for modeling not only in the frequency domain but also for all power curves. Four case studies are addressed and compared with several common methods. From the minimal RMSE, the results show clear improvements in data fitting over other methods. The most powerful features of this method is the ability to model irregular or randomly shaped data and to be applied to any algorithms that estimating models using frequency-domain data to provide state-space or transfer function for the model.
[Mh] Termos MeSH primário: Algoritmos
Modelos Teóricos
Energia Renovável/estatística & dados numéricos
[Mh] Termos MeSH secundário: Análise dos Mínimos Quadrados
Conceitos Matemáticos
Energia Solar/estatística & dados numéricos
Vento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191478


  2 / 2725 MEDLINE  
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[PMID]:29304144
[Au] Autor:Davis CL; Wahid R; Toapanta FR; Simon JK; Sztein MB
[Ad] Endereço:Natural Science Division, Pepperdine University, Malibu, CA, United States of America.
[Ti] Título:A clinically parameterized mathematical model of Shigella immunity to inform vaccine design.
[So] Source:PLoS One;13(1):e0189571, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We refine and clinically parameterize a mathematical model of the humoral immune response against Shigella, a diarrheal bacteria that infects 80-165 million people and kills an estimated 600,000 people worldwide each year. Using Latin hypercube sampling and Monte Carlo simulations for parameter estimation, we fit our model to human immune data from two Shigella EcSf2a-2 vaccine trials and a rechallenge study in which antibody and B-cell responses against Shigella's lipopolysaccharide (LPS) and O-membrane proteins (OMP) were recorded. The clinically grounded model is used to mathematically investigate which key immune mechanisms and bacterial targets confer immunity against Shigella and to predict which humoral immune components should be elicited to create a protective vaccine against Shigella. The model offers insight into why the EcSf2a-2 vaccine had low efficacy and demonstrates that at a group level a humoral immune response induced by EcSf2a-2 vaccine or wild-type challenge against Shigella's LPS or OMP does not appear sufficient for protection. That is, the model predicts an uncontrolled infection of gut epithelial cells that is present across all best-fit model parameterizations when fit to EcSf2a-2 vaccine or wild-type challenge data. Using sensitivity analysis, we explore which model parameter values must be altered to prevent the destructive epithelial invasion by Shigella bacteria and identify four key parameter groups as potential vaccine targets or immune correlates: 1) the rate that Shigella migrates into the lamina propria or epithelium, 2) the rate that memory B cells (BM) differentiate into antibody-secreting cells (ASC), 3) the rate at which antibodies are produced by activated ASC, and 4) the Shigella-specific BM carrying capacity. This paper underscores the need for a multifaceted approach in ongoing efforts to design an effective Shigella vaccine.
[Mh] Termos MeSH primário: Modelos Imunológicos
Vacinas contra Shigella/imunologia
[Mh] Termos MeSH secundário: Anticorpos Antibacterianos/biossíntese
Linfócitos B/imunologia
Ensaios Clínicos como Assunto
Simulação por Computador
Desenho de Drogas
Disenteria Bacilar/imunologia
Disenteria Bacilar/microbiologia
Disenteria Bacilar/prevenção & controle
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Imunidade Humoral
Conceitos Matemáticos
Método de Monte Carlo
Shigella/imunologia
Shigella/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Shigella Vaccines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189571


  3 / 2725 MEDLINE  
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[PMID]:29304161
[Au] Autor:Khan I; Ali Shah N; Tassaddiq A; Mustapha N; Kechil SA
[Ad] Endereço:Basic Engineering Sciences Department, College of Engineering Majmaah University, Majmaah, Saudi Arabia.
[Ti] Título:Natural convection heat transfer in an oscillating vertical cylinder.
[So] Source:PLoS One;13(1):e0188656, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper studies the heat transfer analysis caused due to free convection in a vertically oscillating cylinder. Exact solutions are determined by applying the Laplace and finite Hankel transforms. Expressions for temperature distribution and velocity field corresponding to cosine and sine oscillations are obtained. The solutions that have been obtained for velocity are presented in the forms of transient and post-transient solutions. Moreover, these solutions satisfy both the governing differential equation and all imposed initial and boundary conditions. Numerical computations and graphical illustrations are used in order to study the effects of Prandtl and Grashof numbers on velocity and temperature for various times. The transient solutions for both cosine and sine oscillations are also computed in tables. It is found that, the transient solutions are of considerable interest up to the times t = 15 for cosine oscillations and t = 1.75 for sine oscillations. After these moments, the transient solutions can be neglected and, the fluid moves according with the post-transient solutions.
[Mh] Termos MeSH primário: Convecção
Temperatura Alta
[Mh] Termos MeSH secundário: Transferência de Energia
Hidrodinâmica
Conceitos Matemáticos
Modelos Teóricos
Reologia
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188656


  4 / 2725 MEDLINE  
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[PMID]:29304085
[Au] Autor:Bai Z; Hui Y; Jiang D; Lv Z; Wong WK; Zheng S
[Ad] Endereço:KLASMOE and School of Mathematics and Statistics, Northeast Normal University, Changchun, China.
[Ti] Título:A new test of multivariate nonlinear causality.
[So] Source:PLoS One;13(1):e0185155, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The multivariate nonlinear Granger causality developed by Bai et al. (2010) (Mathematics and Computers in simulation. 2010; 81: 5-17) plays an important role in detecting the dynamic interrelationships between two groups of variables. Following the idea of Hiemstra-Jones (HJ) test proposed by Hiemstra and Jones (1994) (Journal of Finance. 1994; 49(5): 1639-1664), they attempt to establish a central limit theorem (CLT) of their test statistic by applying the asymptotical property of multivariate U-statistic. However, Bai et al. (2016) (2016; arXiv: 1701.03992) revisit the HJ test and find that the test statistic given by HJ is NOT a function of U-statistics which implies that the CLT neither proposed by Hiemstra and Jones (1994) nor the one extended by Bai et al. (2010) is valid for statistical inference. In this paper, we re-estimate the probabilities and reestablish the CLT of the new test statistic. Numerical simulation shows that our new estimates are consistent and our new test performs decent size and power.
[Mh] Termos MeSH primário: Causalidade
Análise Multivariada
Dinâmica não Linear
[Mh] Termos MeSH secundário: Simulação por Computador
Conceitos Matemáticos
Modelos Estatísticos
Processos Estocásticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185155


  5 / 2725 MEDLINE  
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[PMID]:27771344
[Au] Autor:Ramos FM; Rossato LT; Ramires BR; Pimentel GD; Venâncio LS; Orsatti FL; de Oliveira EP
[Ad] Endereço:Department of Public Health, Nutrition and Metabolism Center (CeMENutri), São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
[Ti] Título:Comparison of predictive equations of resting energy expenditure in older adults with chronic obstructive pulmonary disease.
[So] Source:Rev Port Pneumol (2006);23(1):40-42, 2017 Jan - Feb.
[Is] ISSN:2173-5115
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Metabolismo Basal
Doença Pulmonar Obstrutiva Crônica/metabolismo
[Mh] Termos MeSH secundário: Idoso
Metabolismo Energético
Feminino
Previsões
Seres Humanos
Masculino
Conceitos Matemáticos
[Pt] Tipo de publicação:COMPARATIVE STUDY; LETTER
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 2725 MEDLINE  
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[PMID]:29183937
[Au] Autor:Irvine KD; Shraiman BI
[Ad] Endereço:Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway NJ 08854, USA Irvine@waksman.rutgers.edu Shraiman@kitp.ucsb.edu.
[Ti] Título:Mechanical control of growth: ideas, facts and challenges.
[So] Source:Development;144(23):4238-4248, 2017 Dec 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In his classic book , D'Arcy Thompson discussed the necessity of a physical and mathematical approach to understanding the relationship between growth and form. The past century has seen extraordinary advances in our understanding of biological components and processes contributing to organismal morphogenesis, but the mathematical and physical principles involved have not received comparable attention. The most obvious entry of physics into morphogenesis is via tissue mechanics. In this Review, we discuss the fundamental role of mechanical interactions between cells induced by growth in shaping a tissue. Non-uniform growth can lead to accumulation of mechanical stress, which in the context of two-dimensional sheets of tissue can specify the shape it assumes in three dimensions. A special class of growth patterns - conformal growth - does not lead to the accumulation of stress and can generate a rich variety of planar tissue shapes. Conversely, mechanical stress can provide a regulatory feedback signal into the growth control circuit. Both theory and experiment support a key role for mechanical interactions in shaping tissues and, via mechanical feedback, controlling epithelial growth.
[Mh] Termos MeSH primário: Crescimento/fisiologia
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Proliferação Celular/fisiologia
Retroalimentação Fisiológica
Seres Humanos
Conceitos Matemáticos
Modelos Biológicos
Morfogênese/fisiologia
Organogênese/fisiologia
Transdução de Sinais
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1242/dev.151902


  7 / 2725 MEDLINE  
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[PMID]:28451760
[Au] Autor:Cardona G; Pons JC
[Ad] Endereço:Department of Mathematics and Computer Science, University of the Balearic Islands, 07122, Palma, Spain. gabriel.cardona@uib.es.
[Ti] Título:Reconstruction of LGT networks from tri-LGT-nets.
[So] Source:J Math Biol;75(6-7):1669-1692, 2017 Dec.
[Is] ISSN:1432-1416
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phylogenetic networks have gained attention from the scientific community due to the evidence of the existence of evolutionary events that cannot be represented using trees. A variant of phylogenetic networks, called LGT networks, models specifically lateral gene transfer events, which cannot be properly represented with generic phylogenetic networks. In this paper we treat the problem of the reconstruction of LGT networks from substructures induced by three leaves, which we call tri-LGT-nets. We first restrict ourselves to a class of LGT networks that are both mathematically treatable and biologically significant, called BAN-LGT networks. Then, we study the decomposition of such networks in subnetworks with three leaves and ask whether or not this decomposition determines the network. The answer to this question is negative, but if we further impose time-consistency (species involved in a later gene transfer must coexist) the answer is affirmative, up to some redundancy that can never be recovered but is fully characterized.
[Mh] Termos MeSH primário: Transferência Genética Horizontal
Modelos Genéticos
Filogenia
[Mh] Termos MeSH secundário: Simulação por Computador
Evolução Molecular
Redes Reguladoras de Genes
Conceitos Matemáticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00285-017-1131-8


  8 / 2725 MEDLINE  
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[PMID]:29104608
[Au] Autor:Burgess C; Burgess A; McMullen K
[Ad] Endereço:Ramboll Environ, Inc., Amherst, MA, USA.
[Ti] Título:Modelling Risk to US Military Populations from Stopping Blanket Mandatory Polio Vaccination.
[So] Source:Comput Math Methods Med;2017:7981645, 2017.
[Is] ISSN:1748-6718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objectives: Transmission of polio poses a threat to military forces when deploying to regions where such viruses are endemic. US-born soldiers generally enter service with immunity resulting from childhood immunization against polio; moreover, new recruits are routinely vaccinated with inactivated poliovirus vaccine (IPV), supplemented based upon deployment circumstances. Given residual protection from childhood vaccination, risk-based vaccination may sufficiently protect troops from polio transmission. Methods: This analysis employed a mathematical system for polio transmission within military populations interacting with locals in a polio-endemic region to evaluate changes in vaccination policy. Results: Removal of blanket immunization had no effect on simulated polio incidence among deployed military populations when risk-based immunization was employed; however, when these individuals reintegrated with their base populations, risk of transmission to nondeployed personnel increased by 19%. In the absence of both blanket- and risk-based immunization, transmission to nondeployed populations increased by 25%. The overall number of new infections among nondeployed populations was negligible for both scenarios due to high childhood immunization rates, partial protection against transmission conferred by IPV, and low global disease incidence levels. Conclusion: Risk-based immunization driven by deployment to polio-endemic regions is sufficient to prevent transmission among both deployed and nondeployed US military populations.
[Mh] Termos MeSH primário: Programas de Imunização
Militares
Poliomielite/prevenção & controle
Vacina Antipólio de Vírus Inativado/administração & dosagem
[Mh] Termos MeSH secundário: Biologia Computacional
Simulação por Computador
Seres Humanos
Incidência
Conceitos Matemáticos
Modelos Biológicos
Poliomielite/epidemiologia
Poliomielite/transmissão
Fatores de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Poliovirus Vaccine, Inactivated)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE
[do] DOI:10.1155/2017/7981645


  9 / 2725 MEDLINE  
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[PMID]:29081829
[Au] Autor:Ye Y; You W; Zhu W; Cui J; Chen K; Wang D
[Ad] Endereço:Shenzhen Second People's Hospital, 3002 Sungang West Rd, Shenzhen, Guangdong Province 518035, China.
[Ti] Título:The Applications of Finite Element Analysis in Proximal Humeral Fractures.
[So] Source:Comput Math Methods Med;2017:4879836, 2017.
[Is] ISSN:1748-6718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proximal humeral fractures are common and most challenging, due to the complexity of the glenohumeral joint, especially in the geriatric population with impacted fractures, that the development of implants continues because currently the problems with their fixation are not solved. Pre-, intra-, and postoperative assessments are crucial in management of those patients. Finite element analysis, as one of the valuable tools, has been implemented as an effective and noninvasive method to analyze proximal humeral fractures, providing solid evidence for management of troublesome patients. However, no review article about the applications and effects of finite element analysis in assessing proximal humeral fractures has been reported yet. This review article summarized the applications, contribution, and clinical significance of finite element analysis in assessing proximal humeral fractures. Furthermore, the limitations of finite element analysis, the difficulties of more realistic simulation, and the validation and also the creation of validated FE models were discussed. We concluded that although some advancements in proximal humeral fractures researches have been made by using finite element analysis, utility of this powerful tool for routine clinical management and adequate simulation requires more state-of-the-art studies to provide evidence and bases.
[Mh] Termos MeSH primário: Análise de Elementos Finitos
Fraturas do Ombro/fisiopatologia
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Biologia Computacional
Simulação por Computador
Seres Humanos
Conceitos Matemáticos
Modelos Anatômicos
Modelos Biológicos
Fraturas do Ombro/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171031
[St] Status:MEDLINE
[do] DOI:10.1155/2017/4879836


  10 / 2725 MEDLINE  
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[PMID]:29081830
[Au] Autor:Cioca G; Bacaita ES; Agop M; Lupascu Ursulescu C
[Ad] Endereço:Faculty of Medicine, Lucian Blaga University of Sibiu, Victoriei Bld. No. 10, 550024 Sibiu, Romania.
[Ti] Título:Anisotropy Influences on the Drug Delivery Mechanisms by Means of Joint Invariant Functions.
[So] Source:Comput Math Methods Med;2017:5748273, 2017.
[Is] ISSN:1748-6718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the frame of Higuchi's type functionality, this paper presents the anisotropy influences on the drug delivery mechanisms through the joint invariant functions to the simultaneous actions of the two SL(2R) isomorphic groups. Then, a new equation for drug delivery mechanism, independent of the type of polymer matrix and/or drug, is proposed.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos
[Mh] Termos MeSH secundário: Anisotropia
Materiais Biocompatíveis
Biologia Computacional
Simulação por Computador
Difusão
Sistemas de Liberação de Medicamentos/estatística & dados numéricos
Seres Humanos
Conceitos Matemáticos
Modelos Biológicos
Polímeros
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Polymers)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171031
[St] Status:MEDLINE
[do] DOI:10.1155/2017/5748273



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