[PMID]: | 29244826 |
[Au] Autor: | Baldow C; Salentin S; Schroeder M; Roeder I; Glauche I |
[Ad] Endereço: | Institute for Medical Informatics and Biometry, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. |
[Ti] Título: | MAGPIE: Simplifying access and execution of computational models in the life sciences. |
[So] Source: | PLoS Comput Biol;13(12):e1005898, 2017 12. |
[Is] ISSN: | 1553-7358 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Over the past decades, quantitative methods linking theory and observation became increasingly important in many areas of life science. Subsequently, a large number of mathematical and computational models has been developed. The BioModels database alone lists more than 140,000 Systems Biology Markup Language (SBML) models. However, while the exchange within specific model classes has been supported by standardisation and database efforts, the generic application and especially the re-use of models is still limited by practical issues such as easy and straight forward model execution. MAGPIE, a Modeling and Analysis Generic Platform with Integrated Evaluation, closes this gap by providing a software platform for both, publishing and executing computational models without restrictions on the programming language, thereby combining a maximum on flexibility for programmers with easy handling for non-technical users. MAGPIE goes beyond classical SBML platforms by including all models, independent of the underlying programming language, ranging from simple script models to complex data integration and computations. We demonstrate the versatility of MAGPIE using four prototypic example cases. We also outline the potential of MAGPIE to improve transparency and reproducibility of computational models in life sciences. A demo server is available at magpie.imb.medizin.tu-dresden.de. |
[Mh] Termos MeSH primário: |
Disciplinas das Ciências Biológicas/estatística & dados numéricos Modelos Biológicos Software
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[Mh] Termos MeSH secundário: |
Biologia Computacional Simulação por Computador Seres Humanos Modelos Estatísticos Linguagens de Programação Reprodutibilidade dos Testes Biologia de Sistemas
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Em] Mês de entrada: | 1801 |
[Cu] Atualização por classe: | 180123 |
[Lr] Data última revisão:
| 180123 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 171216 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1371/journal.pcbi.1005898 |
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