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[PMID]:29496812
[Au] Autor:Costa-Silva D; Côrtes JA; Bachinski RF; Spiegel CN; Alves GG
[Ad] Endereço:Ms. Costa-Silva is a Master's in Science and Biotechnology student, Fluminense Federal University, Niteroi, Brazil; Ms. Côrtes is a doctoral fellow in Science and Biotechnology at Fluminense Federal University, Niteroi, Brazil; Dr. Bachinski is Director of the 1RNet Institute, Rio de Janeiro, Brazil
[Ti] Título:Teaching Cell Biology to Dental Students with a Project-Based Learning Approach.
[So] Source:J Dent Educ;82(3):322-331, 2018 Mar.
[Is] ISSN:1930-7837
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although the discipline of cell biology (CB) is part of the curricula of predoctoral dental schools, students often fail to recognize its practical relevance. The aim of this study was to assess the effectiveness of a practical-theoretical project-based course in closing the gaps among CB, scientific research, and dentistry for dental students. A project-based learning course was developed with nine sequential lessons to evaluate 108 undergraduate dental students enrolled in CB classes of a Brazilian school of dentistry during 2013-16. To highlight the relevance of in vitro studies in the preclinical evaluation of dental materials at the cellular level, the students were challenged to complete the process of drafting a protocol and performing a cytocompatibility assay for a bone substitute used in dentistry. Class activities included small group discussions, scientific database search and article presentations, protocol development, lab experimentation, and writing of a final scientific report. A control group of 31 students attended only one laboratory class on the same theme, and the final reports were compared between the two groups. The results showed that the project-based learning students had superior outcomes in acknowledging the relevance of in vitro methods during biocompatibility testing. Moreover, they produced scientifically sound reports with more content on methodological issues, the relationship with dentistry, and the scientific literature than the control group (p<0.05). The project-based learning students also recognized a higher relevance of scientific research and CB to dental practice. These results suggest that a project-based approach can help contextualize scientific research in dental curricula.
[Mh] Termos MeSH primário: Biologia Celular/educação
Educação em Odontologia/métodos
Ensino
[Mh] Termos MeSH secundário: Currículo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:180303
[St] Status:MEDLINE
[do] DOI:10.21815/JDE.018.032


  2 / 3300 MEDLINE  
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[PMID]:29189794
[Ti] Título:A day in the life of a cell biologist.
[So] Source:Nature;551(7682):S182, 2017 11 30.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Biologia Celular
Pesquisadores
[Mh] Termos MeSH secundário: Pesquisa Interdisciplinar
Fusão de Membrana
Microscopia
Sinaptotagmina I/metabolismo
[Pt] Tipo de publicação:INTERVIEW
[Nm] Nome de substância:
0 (Synaptotagmin I)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1038/d41586-017-07563-4


  3 / 3300 MEDLINE  
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[PMID]:29253402
[Au] Autor:Lew JB; Simms KT; Smith MA; Hall M; Kang YJ; Xu XM; Caruana M; Velentzis LS; Bessell T; Saville M; Hammond I; Canfell K
[Ad] Endereço:Cancer Council NSW, Cancer Research Division, Sydney, NSW, Australia.
[Ti] Título:Primary HPV testing versus cytology-based cervical screening in women in Australia vaccinated for HPV and unvaccinated: effectiveness and economic assessment for the National Cervical Screening Program.
[So] Source:Lancet Public Health;2(2):e96-e107, 2017 Feb.
[Is] ISSN:2468-2667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Australia's National Cervical Screening Program currently recommends cytological screening every 2 years for women aged 18-69 years. Human papillomavirus (HPV) vaccination was implemented in 2007 with high population coverage, and falls in high-grade lesions in young women have been reported extensively. This decline prompted a major review of the National Cervical Screening Program and new clinical management guidelines, for which we undertook this analysis. METHODS: We did effectiveness modelling and an economic assessment of potential new screening strategies, using a model of HPV transmission, vaccination, natural history, and cervical screening. First, we evaluated 132 screening strategies, including those based on cytology and primary HPV testing. Second, after a recommendation was made to adopt primary HPV screening with partial genotyping and direct referral to colposcopy of women positive for HPV16/18, we evaluated the final effect of HPV screening after incorporating new clinical guidelines for women positive for HPV. Both evaluations considered both unvaccinated and vaccinated cohorts. FINDINGS: Strategies entailing HPV testing every 5 years and either partial genotyping for HPV16/18 or cytological co-testing were the most effective. One of the most effective and cost-effective strategies comprised primary HPV screening with referral of women positive for oncogenic HPV16/18 direct to colposcopy, with reflex cytological triage for women with other oncogenic types and direct referral for those in this group with high-grade cytological findings. After incorporating detailed clinical guidelines recommendations, this strategy is predicted to reduce cervical cancer incidence and mortality by 31% and 36%, respectively, in unvaccinated cohorts, and by 24% and 29%, respectively, in cohorts offered vaccination. Furthermore, this strategy is predicted to reduce costs by up to 19% for unvaccinated cohorts and 26% for cohorts offered vaccination, compared with the current programme. INTERPRETATION: Primary HPV screening every 5 years with partial genotyping is predicted to be substantially more effective and potentially cost-saving compared with the current cytology-based screening programme undertaken every 2 years. These findings underpin the decision to transition to primary HPV screening with partial genotyping in the Australian National Cervical Screening Program, which will occur in May, 2017. FUNDING: Department of Health, Australia.
[Mh] Termos MeSH primário: Detecção Precoce de Câncer/economia
Detecção Precoce de Câncer/métodos
Infecções por Papillomavirus/diagnóstico
Vacinas contra Papillomavirus/administração & dosagem
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Austrália
Biologia Celular/economia
Análise Custo-Benefício
Testes Diagnósticos de Rotina/economia
Feminino
Seres Humanos
Meia-Idade
Infecções por Papillomavirus/prevenção & controle
Prevenção Primária/economia
Avaliação de Programas e Projetos de Saúde
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:28743585
[Au] Autor:Torday JS; Miller WB
[Ad] Endereço:Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Electronic address: jtorday@labiomed.org.
[Ti] Título:The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism.
[So] Source:Prog Biophys Mol Biol;131:288-297, 2017 Dec.
[Is] ISSN:1873-1732
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Boundary conditions enable cellular life through negentropy, chemiosmosis, and homeostasis as identifiable First Principles of Physiology. Self-referential awareness of status arises from this organized state to sustain homeostatic imperatives. Preferred homeostatic status is dependent upon the appraisal of information and its communication. However, among living entities, sources of information and their dissemination are always imprecise. Consequently, living systems exist within an innate state of ambiguity. It is presented that cellular life and evolutionary development are a self-organizing cellular response to uncertainty in iterative conformity with its basal initiating parameters. Viewing the life circumstance in this manner permits a reasoned unification between Western rational reductionism and Eastern holism.
[Mh] Termos MeSH primário: Biologia Celular
Células/citologia
Filosofia
Ocidente
[Mh] Termos MeSH secundário: Animais
Comunicação Celular
Células/metabolismo
Epigênese Genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  5 / 3300 MEDLINE  
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[PMID]:28461555
[Ti] Título:Cell scientist to watch - Mitchell Guttman.
[So] Source:J Cell Sci;130(9):1497-1499, 2017 May 01.
[Is] ISSN:1477-9137
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mitchell received a bachelor's degree in molecular and computational biology and a master's degree in computational biology and bioinformatics from the University of Pennsylvania. He then joined the laboratory of Eric Lander at the Broad Institute of MIT and Harvard and was awarded his PhD in 2012. The same year he was named in the Forbes '30 under 30: science and healthcare' list of rising stars and received an NIH early independence award. Mitchell subsequently moved to the California Institute of Technology as an Assistant Professor to establish his own laboratory. He has received numerous awards, including being named a Robertson Investigator of the New York Stem Cell Foundation, an Investigator at the Heritage Medical Research Institute and a Pew-Stewart scholar for cancer research in 2015. Having identified and characterised a new class of functional large non-coding RNA (lncRNA) genes, his laboratory aims to understand the mechanisms by which lncRNAs act to control cellular functions through regulation of proteins, binding to genomic DNA targets and contributing to nuclear organisation.
[Mh] Termos MeSH primário: Biologia Celular/história
Pesquisadores
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
[Pt] Tipo de publicação:AUTOBIOGRAPHY; BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Guttman M
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1242/jcs.203976


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[PMID]:29183934
[Au] Autor:Coen E; Kennaway R; Whitewoods C
[Ad] Endereço:Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK enrico.coen@jic.ac.uk.
[Ti] Título:On genes and form.
[So] Source:Development;144(23):4203-4213, 2017 Dec 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mechanisms by which organisms acquire their sizes and shapes through growth was a major focus of D'Arcy Thompson's book By applying mathematical and physical principles to a range of biological forms, Thompson achieved fresh insights, such as the notion that diverse biological shapes could be related through simple deformations of a coordinate system. However, Thompson considered genetics to lie outside the scope of his work, even though genetics was a growing discipline at the time the book was published. Here, we review how recent advances in cell, developmental, evolutionary and computational biology allow Thompson's ideas to be integrated with genes and the processes they influence to provide a deeper understanding of growth and morphogenesis. We consider how genes interact with subcellular-, cellular- and tissue-level processes in plants to yield patterns of growth that underlie the developmental and evolutionary shape transformations Thompson so eloquently described.
[Mh] Termos MeSH primário: Morfogênese/genética
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Padronização Corporal/genética
Biologia Celular
Biologia Computacional
Biologia do Desenvolvimento
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1242/dev.151910


  7 / 3300 MEDLINE  
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[PMID]:29096079
[Au] Autor:Terenzio M; Schiavo G; Fainzilber M
[Ad] Endereço:Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
[Ti] Título:Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience.
[So] Source:Neuron;96(3):667-679, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells.
[Mh] Termos MeSH primário: Biologia Celular/tendências
Citoesqueleto/fisiologia
Neurônios/fisiologia
Neurociências/tendências
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Neurociências/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


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[PMID]:28875992
[Au] Autor:Sahl SJ; Hell SW; Jakobs S
[Ad] Endereço:Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics, Am Fassberg 11, 37077 Göttingen, Germany.
[Ti] Título:Fluorescence nanoscopy in cell biology.
[So] Source:Nat Rev Mol Cell Biol;18(11):685-701, 2017 Nov.
[Is] ISSN:1471-0080
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fluorescence nanoscopy uniquely combines minimally invasive optical access to the internal nanoscale structure and dynamics of cells and tissues with molecular detection specificity. While the basic physical principles of 'super-resolution' imaging were discovered in the 1990s, with initial experimental demonstrations following in 2000, the broad application of super-resolution imaging to address cell-biological questions has only more recently emerged. Nanoscopy approaches have begun to facilitate discoveries in cell biology and to add new knowledge. One current direction for method improvement is the ambition to quantitatively account for each molecule under investigation and assess true molecular colocalization patterns via multi-colour analyses. In pursuing this goal, the labelling of individual molecules to enable their visualization has emerged as a central challenge. Extending nanoscale imaging into (sliced) tissue and whole-animal contexts is a further goal. In this Review we describe the successes to date and discuss current obstacles and possibilities for further development.
[Mh] Termos MeSH primário: Imagem Molecular/métodos
[Mh] Termos MeSH secundário: Biologia Celular
Microscopia de Fluorescência/métodos
Imagem Molecular/instrumentação
Imagem Molecular/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1038/nrm.2017.71


  9 / 3300 MEDLINE  
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[PMID]:28819013
[Au] Autor:O'Donnell MA
[Ti] Título:Yaron Fuchs: Exploring the mysterious mixture of life and death.
[So] Source:J Cell Biol;216(9):2600-2601, 2017 Sep 04.
[Is] ISSN:1540-8140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fuchs studies how cell death controls stem cell-driven processes.
[Mh] Termos MeSH primário: Apoptose
Pesquisa Biomédica/história
Biologia Celular/história
Regeneração
Células-Tronco
[Mh] Termos MeSH secundário: Escolha da Profissão
Proliferação Celular
Autorrenovação Celular
História do Século XX
História do Século XXI
Seres Humanos
Liderança
Mentores/história
Células-Tronco/patologia
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; INTERVIEW; PORTRAITS
[Ps] Nome de pessoa como assunto:Fuchs Y
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1083/jcb.201708079


  10 / 3300 MEDLINE  
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[PMID]:28726246
[Au] Autor:Wagner J; Schaffer M; Fernández-Busnadiego R
[Ad] Endereço:Max Planck Institute of Biochemistry, Martinsried, Germany.
[Ti] Título:Cryo-electron tomography-the cell biology that came in from the cold.
[So] Source:FEBS Lett;591(17):2520-2533, 2017 Sep.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cryo-electron tomography (cryo-ET) provides high-resolution 3D views into cells pristinely preserved by vitrification. Recent technical advances such as direct electron detectors, the Volta phase plate and cryo-focused ion beam milling have dramatically pushed image quality and expanded the range of cryo-ET applications. Cryo-ET not only allows mapping the positions and interactions of macromolecules within their intact cellular context, but can also reveal their in situ structure at increasing resolution. Here, we review how recent work using cutting-edge cryo-ET technologies is starting to provide fresh views into different aspects of cellular biology at an unprecedented level of detail. We anticipate that these developments will soon make cryo-ET a fundamental technique in cell biology.
[Mh] Termos MeSH primário: Biologia Celular
Tomografia com Microscopia Eletrônica/métodos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Imagem Tridimensional
Substâncias Macromoleculares/química
Substâncias Macromoleculares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Macromolecular Substances)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12757



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