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  1 / 1596 MEDLINE  
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[PMID]:29254989
[Au] Autor:Grewal S
[Ad] Endereço:Reviews Editor, Development seema.grewal@biologists.com.
[Ti] Título:An interview with Claudio Stern.
[So] Source:Development;144(24):4473-4475, 2017 Dec 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Claudio Stern is the J. Z. Young Professor of Anatomy at University College London (UCL), UK. His lab studies the processes that regulate patterning and cell diversity in the early embryos of vertebrates, mostly in chick. Claudio, an elected fellow of the Royal Society, the UK Academy of Medical Sciences, and the Latin-American Academy of Medical Sciences, was awarded the 2006 Waddington Medal by the British Society of Developmental Biology, and he also served as President of the International Society for Developmental Biology (ISDB) from 2010-2013. At the 18th Congress of the ISDB (Singapore, June 2017), Claudio was awarded the ISDB's Ross Harrison Prize, which recognises an individual's outstanding contributions to developmental biology. We met with Claudio to ask him more about his career, his thoughts on the field, and his advice for early career researchers.
[Mh] Termos MeSH primário: Biologia do Desenvolvimento/história
Embriologia/história
[Mh] Termos MeSH secundário: Distinções e Prêmios
História do Século XX
História do Século XXI
[Pt] Tipo de publicação:AUTOBIOGRAPHY; HISTORICAL ARTICLE; INTERVIEW
[Ps] Nome de pessoa como assunto:Stern C
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1242/dev.160838


  2 / 1596 MEDLINE  
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[PMID]:28728678
[Au] Autor:den Hertog J; de Laat SW
[Ad] Endereço:Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. Electronic address: j.denhertog@hubrecht.eu.
[Ti] Título:Hubrecht Institute Centennial - From embryos to stem cells.
[So] Source:Dev Biol;428(2):261-263, 2017 08 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During the last 100 years, the Hubrecht Institute evolved from a small laboratory aimed at providing research material to the scientific community to a modern, fully equipped research institute with state-of-the-art infrastructure, performing research at the highest standard. The past 100 years have been eventful for the Hubrecht Institute with many glorious moments, but also threats to be shut down on several occasions. Here, we will briefly review the rich history of the Hubrecht Institute.
[Mh] Termos MeSH primário: Academias e Institutos
Embriologia
Células-Tronco
[Mh] Termos MeSH secundário: Academias e Institutos/história
Animais
Biologia do Desenvolvimento/história
Embriologia/história
História do Século XX
História do Século XXI
Seres Humanos
Países Baixos
Pesquisa com Células-Tronco/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE


  3 / 1596 MEDLINE  
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[PMID]:28625869
[Au] Autor:Tickle C
[Ad] Endereço:Department of Biology and Biochemistry, University of Bath, Bath, UK.
[Ti] Título:An historical perspective on the pioneering experiments of John Saunders.
[So] Source:Dev Biol;429(2):374-381, 2017 09 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis). This review looks in depth at some of his original papers and traces how he made the crucial findings about how limbs develop, considering these findings both in the context of contemporary knowledge at the time and also in terms of their immediate impact on the field.
[Mh] Termos MeSH primário: Embriologia/história
Embriologia/métodos
[Mh] Termos MeSH secundário: Animais
Padronização Corporal
Ectoderma/embriologia
Extremidades/embriologia
História do Século XX
Asas de Animais/embriologia
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Ps] Nome de pessoa como assunto:Saunders J
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


  4 / 1596 MEDLINE  
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[PMID]:28219632
[Au] Autor:Hildebrandt S; Czarnowski G
[Ad] Endereço:Boston Children's Hospital, Harvard Medical School, Div. General Pediatrics, Dep. Medicine, 333 Longwood Avenue-LO 234, Boston, MA 02115, USA. Electronic address: sabine.hildebrandt@childrens.harvard.edu.
[Ti] Título:Alfred Pischinger (1899-1983): An Austrian career in anatomy continuing through National Socialism to postwar leadership.
[So] Source:Ann Anat;211:104-113, 2017 May.
[Is] ISSN:1618-0402
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Despite intensified research efforts on the history of anatomy during National Socialism (NS), many aspects of this story still need further investigation. This study explores the life, work and politics of Alfred Pischinger, Chairman of the Institute for Embryology and Histology in Graz from 1936 to 1945, and in Vienna from 1958 to 1970, and is an addition to previous reports on careers in anatomy continuing through the Third Reich to the postwar period. Pischinger was an illegal NSDAP member in Austria, joined the SA in 1938, served as expert in racial hygiene, and as judge on the Genetic Health High Court of Graz. His research focus was histochemistry, but he became part of a scientific network at the University of Graz, which from 1939 on experimented on the bodies of pregnant women and their fetuses under the leadership of gynecologist Karl Ehrhardt. The researchers were among the many who took actively part in the complete exploitation and physical destruction of those considered to be "the enemy" by the NS regime. After the war, Pischinger received publicity for his work on the "scientific basis" of alternative and holistic approaches of medicine. His NS past and fetal experiments seem to have vanished from public knowledge. As systematic studies of the influence of the NS period on postwar medical education and the science of anatomy itself are still missing, this critical investigation of Alfred Pischinger's life within the relevant historic background aims to contribute to this body of knowledge.
[Mh] Termos MeSH primário: Embriologia/história
Eugenia (Ciência)/história
Ginecologia/história
Histocitoquímica/história
Experimentação Humana/história
Nacional-Socialismo/história
[Mh] Termos MeSH secundário: Áustria
História do Século XX
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


  5 / 1596 MEDLINE  
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[PMID]:28202827
[Au] Autor:Komiyama M
[Ad] Endereço:Department of Neuro-Intervention, Osaka City General Hospital.
[Ti] Título:[Cerebrovascular Diseases from the Perspective of Embryology, Anatomy, and Genetics].
[So] Source:No Shinkei Geka;45(2):103-115, 2017 Feb.
[Is] ISSN:0301-2603
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Vasos Sanguíneos/anormalidades
Encéfalo/crescimento & desenvolvimento
Transtornos Cerebrovasculares/genética
Transtornos Cerebrovasculares/patologia
Embriologia
Predisposição Genética para Doença
[Mh] Termos MeSH secundário: Animais
Vasos Sanguíneos/embriologia
Vasos Sanguíneos/patologia
Encéfalo/anatomia & histologia
Encéfalo/irrigação sanguínea
Transtornos Cerebrovasculares/diagnóstico
Embriologia/métodos
Seres Humanos
Mutação/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.11477/mf.1436203460


  6 / 1596 MEDLINE  
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[PMID]:28131856
[Au] Autor:Verheyden JM; Sun X
[Ad] Endereço:Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, United States.
[Ti] Título:Embryology meets molecular biology: Deciphering the apical ectodermal ridge.
[So] Source:Dev Biol;429(2):387-390, 2017 09 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:More than sixty years ago, while studying feather tracks on the shoulder of the chick embryo, Dr. John Saunders used Nile Blue dye to stain the tissue. There, he noticed a darkly stained line of cells that neatly rims the tip of the growing limb bud. Rather than ignoring this observation, he followed it up by removing this tissue and found that it led to a striking truncation of the limb skeletons. This landmark experiment marks the serendipitous discovery of the apical ectodermal ridge (AER), the quintessential embryonic structure that drives the outgrowth of the limb. Dr. Saunders continued to lead the limb field for the next fifty years, not just through his own work, but also by inspiring the next generation of researchers through his infectious love of science. Together, he and those who followed ushered in the discovery of fibroblast growth factor (FGF) as the AER molecule. The seamless marriage of embryology and molecular biology that led to the decoding of the AER serves as a shining example of how discoveries are made for the rest of the developmental biology field.
[Mh] Termos MeSH primário: Ectoderma/embriologia
Embriologia
Biologia Molecular
[Mh] Termos MeSH secundário: Animais
Padronização Corporal
Fatores de Crescimento de Fibroblastos/metabolismo
Técnicas de Inativação de Genes
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


  7 / 1596 MEDLINE  
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[PMID]:28049688
[Au] Autor:Craft AM; Johnson M
[Ad] Endereço:Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA april.craft@childrens.harvard.edu.
[Ti] Título:From stem cells to human development: a distinctly human perspective on early embryology, cellular differentiation and translational research.
[So] Source:Development;144(1):12-16, 2017 01 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over 100 scientists with common interests in human development, disease and regeneration gathered in late September 2016 for The Company of Biologists' second 'From Stem Cells to Human Development' meeting held in historic Southbridge. In this Meeting Review, we highlight some of the exciting new findings that were presented, and discuss emerging themes and convergences in human development and disease that arose during these discussions.
[Mh] Termos MeSH primário: Diferenciação Celular
Pesquisas com Embriões
Embriologia
Desenvolvimento Embrionário/fisiologia
Células-Tronco Embrionárias/fisiologia
Pesquisa Médica Translacional
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/genética
Embriologia/métodos
Embriologia/tendências
Seres Humanos
Pesquisa Médica Translacional/métodos
Pesquisa Médica Translacional/tendências
[Pt] Tipo de publicação:CONGRESSES
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1242/dev.142778


  8 / 1596 MEDLINE  
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[PMID]:27765265
[Au] Autor:Rabouille C; Deschamps J
[Ad] Endereço:Hubrecht Institute - Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Upsalalaan 8, 3584 CT Utrecht, The Netherlands. Electronic address: c.rabouille@hubrecht.eu.
[Ti] Título:On the shoulders of Hubrecht: From embryos to stem cells.
[So] Source:Dev Biol;428(2):264-272, 2017 08 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One hundred years of the Hubrecht Institute were celebrated in May 2016 with the organization of a one-day symposium "From embryos to stem cells" on the Uithof Campus, Utrecht, the Netherlands. Nine distinguished speakers were invited. They all represent a research branch originating from the passion of Institute founder, Ambrosius Hubrecht, for embryology:, regulation of gene expression, genome structure and function, embryonic and adult stem cells, nuclear reprogramming, and understanding cancer and other diseases using model organisms. The centennial symposium not only retraced the history of the Institute and of modern developmental biology, but was also a tribute to basic research. From there, avenues to therapeutics are being developed and implemented. The symposium was organized, introduced and chaired by Jeroen den Hertog and Alexander van Oudenaarden, the present Directors of the Institute, who also stand on Hubrecht's shoulders.
[Mh] Termos MeSH primário: Academias e Institutos
Embriologia
Células-Tronco
[Mh] Termos MeSH secundário: Academias e Institutos/história
Animais
Biologia do Desenvolvimento/história
Embriologia/história
Desenvolvimento Embrionário/genética
Genômica/história
História do Século XX
História do Século XXI
Seres Humanos
Oncologia/história
Países Baixos
Medicina Regenerativa/história
Pesquisa com Células-Tronco/história
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS; REVIEW
[Ps] Nome de pessoa como assunto:Hubrecht A
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


  9 / 1596 MEDLINE  
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[PMID]:28134042
[Au] Autor:Anton R
[Ad] Endereço:Nürtingen-Geislingen University of Economics and Environment.
[Ti] Título:On recent advances in human engineering Provocative trends in embryology, genetics, and regenerative medicine.
[So] Source:Politics Life Sci;35(2):54-68, 2016.
[Is] ISSN:1471-5457
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Advances in embryology, genetics, and regenerative medicine regularly attract attention from scientists, scholars, journalists, and policymakers, yet implications of these advances may be broader than commonly supposed. Laboratories culturing human embryos, editing human genes, and creating human-animal chimeras have been working along lines that are now becoming intertwined. Embryogenic methods are weaving traditional in vivo and in vitro distinctions into a new "in vivitro" (in life in glass) fabric. These and other methods known to be in use or thought to be in development promise soon to bring society to startling choices and discomfiting predicaments, all in a global effort to supply reliably rejuvenating stem cells, to grow immunologically non-provocative replacement organs, and to prevent, treat, cure, or even someday eradicate diseases having genetic or epigenetic mechanisms. With humanity's human-engineering era now begun, procedural prohibitions, funding restrictions, institutional controls, and transparency rules are proving ineffective, and business incentives are migrating into the most basic life-sciences inquiries, wherein lie huge biomedical potentials and bioethical risks. Rights, health, and heritage are coming into play with bioethical presumptions and formal protections urgently needing reassessment.
[Mh] Termos MeSH primário: Embriologia
Engenharia Genética/métodos
Genética
Medicina Regenerativa
[Mh] Termos MeSH secundário: Bioética
Sistemas CRISPR-Cas/fisiologia
Quimera/metabolismo
Edição de Genes/ética
Edição de Genes/métodos
Engenharia Genética/ética
Seres Humanos
Técnicas In Vitro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


  10 / 1596 MEDLINE  
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[PMID]:27796134
[Au] Autor:Brison DR
[Ad] Endereço:a Faculty of Biological, Medical and Human Sciences , University of Manchester , UK.
[Ti] Título:Professor Henry J Leese: honorary member of the European Society of Human Reproduction and Embryology.
[So] Source:Hum Fertil (Camb);19(4):220-221, 2016 Dec.
[Is] ISSN:1742-8149
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Embriologia/história
[Mh] Termos MeSH secundário: Inglaterra
História do Século XX
História do Século XXI
Seres Humanos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Leese HJ
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE



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