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[PMID]:29319946
[Au] Autor:Food and Drug Administration, HHS.
[Ti] Título:Medical Devices; Hematology and Pathology Devices; Classification of a Cervical Intraepithelial Neoplasia Test System. Final order.
[So] Source:Fed Regist;83(2):232-4, 2018 Jan 03.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA or we) is classifying the cervical intraepithelial neoplasia (CIN) test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the CIN test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/diagnóstico
Segurança de Equipamentos/classificação
Histologia/classificação
Histologia/instrumentação
Patologia/classificação
Patologia/instrumentação
[Mh] Termos MeSH secundário: Biomarcadores Tumorais
Neoplasia Intraepitelial Cervical/patologia
Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:28576138
[Au] Autor:Nurdiana S; Goh YM; Ahmad H; Dom SM; Syimal'ain Azmi N; Noor Mohamad Zin NS; Ebrahimi M
[Ad] Endereço:Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia. nurdiana7251@salam.uitm.edu.my.
[Ti] Título:Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin.
[So] Source:BMC Complement Altern Med;17(1):290, 2017 Jun 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The potential application of Ficus deltoidea and vitexin for the management of symptomatologies associated with diabetes mellitus (DM) has gained much attention. However, less firm evidence comes from data to augment our understanding of the role of F. deltoidea and vitexin in protecting pancreatic ß-cells. The aim of this study was to assess histological and oxidative stress changes in the pancreas of streptozotocin (STZ)-induced diabetic rats following F. deltoidea extract and vitexin treatment. METHODS: F. deltoidea and vitexin was administrated orally to six-weeks STZ-induced diabetic rats over 8 weeks period. The glucose and insulin tolerances were assessed by intraperitoneal glucose (2 g/kg) tolerance test (IPGTT) and intraperitoneal insulin (0.65 U/kg) tolerance test (IPITT), respectively. Subsequently, insulin resistance was assessed by homeostasis assessment model of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and the insulin/triglyceride-derived McAuley index. The histological changes in the pancreas were then observed by hematoxylin-eosin (H&E) staining. Further, the pattern of fatty acid composition and infrared (IR) spectra of the serum and pancreas were monitored by gas chromatography (GC) method and Fourier Transform Infrared (FT-IR) spectroscopy. RESULTS: F. deltoidea and vitexin increased pancreatic antioxidant enzymes and promoted islet regeneration. However, a significant increase in insulin secretion was observed only in rats treated with F. deltoidea. More importantly, reduction of fasting blood glucose is consistent with reduced FT-IR peaks at 1200-1000 cm . CONCLUSIONS: These results accentuate that F. deltoidea and vitexin could be a potential agent to attenuate pancreatic oxidative damage and advocate their therapeutic potential for treating DM.
[Mh] Termos MeSH primário: Apigenina/administração & dosagem
Diabetes Mellitus Experimental/tratamento farmacológico
Ficus/química
Hipoglicemiantes/administração & dosagem
Insulina/secreção
Pâncreas/secreção
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Glicemia/metabolismo
Diabetes Mellitus Experimental/metabolismo
Histologia
Seres Humanos
Masculino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 7V515PI7F6 (Apigenin); 9VP70K75OK (vitexin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1762-8


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[PMID]:28472600
[Au] Autor:Vázquez-Velasco M; González-Torres L; García-Fernández RA; Méndez MT; Bastida S; Benedí J; González-Muñoz MJ; Sánchez-Muniz FJ
[Ad] Endereço:1 Department of Nutrition and Food Science (I) Nutrition, School of Pharmacy, Complutense University , Madrid, Spain .
[Ti] Título:Glucomannan or Glucomannan Plus Spirulina-Enriched Squid-Surimi Diets Reduce Histological Damage to Liver and Heart in Zucker fa/fa Rats Fed a Cholesterol-Enriched and Non-Cholesterol-Enriched Atherogenic Diet.
[So] Source:J Med Food;20(6):618-625, 2017 Jun.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN-93M rodent diet plus six versions of 30% squid surimi for 7 weeks: control (C), glucomannan (G), and glucomannan plus spirulina (GS). The cholesterol-control (HC), cholesterol-glucomannan (HG), and cholesterol-glucomannan plus spirulina (HGS) groups were given similar diets that were enriched with 2% cholesterol and 0.4% cholic acid. G and GS diets versus C diet significantly inhibited weight gain and lowered plasma alanine aminotransferase and aspartate aminotransferase, liver steatosis, lipogranulomas, and total inflammation and alteration scores. The hypercholesterolemic agent significantly increased the harmful effects of the C diet. Liver weight, the hepatosomatic index, all damage markers, and total histological scoring rose for HC versus C (at least P < .05). The addition of glucomannan (HG vs. HC) improved these biomarkers, and non-additional effects from spirulina were observed except for the total liver alteration score. In conclusion, glucomannan and glucomannan plus spirulina blocked the highly saturated-hyper-energetic diet negative effects both with and without added cholesterol. Results suggest the usefulness of including these functional ingredients in fish products.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Colesterol na Dieta/efeitos adversos
Dieta Aterogênica/efeitos adversos
Produtos Pesqueiros/efeitos adversos
Fígado/metabolismo
Mananas/metabolismo
Miocárdio/metabolismo
Spirulina/metabolismo
[Mh] Termos MeSH secundário: Animais
Decapodiformes/metabolismo
Produtos Pesqueiros/análise
Coração/anatomia & histologia
Histologia
Fígado/anatomia & histologia
Masculino
Ratos
Ratos Zucker
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholesterol, Dietary); 0 (Mannans); 36W3E5TAMG ((1-6)-alpha-glucomannan)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0157


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[PMID]:28325446
[Au] Autor:Hernández-Morera P; Travieso-González CM; Castaño-González I; Mompeó-Corredera B; Ortega-Santana F
[Ad] Endereço:IUMA Information and Communication Systems, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira, 35017 - Las Palmas de Gran Canaria, Spain; Department of Telematic Engineering, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira, 35017 - Las Palmas de Gran C
[Ti] Título:Segmentation of elastic fibres in images of vessel wall sections stained with Weigert's resorcin-fuchsin.
[So] Source:Comput Methods Programs Biomed;142:43-54, 2017 Apr.
[Is] ISSN:1872-7565
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: The elastic fibres are an essential component of the extracellular matrix in blood vessel walls that allows a long-range of deformability and passive recoil without energy input. The quantitative determination of elastic fibres will provide information on the state of the vascular wall and to determine the role and behaviour of this key structural element in different physiological and pathological vascular processes. METHODS: We present a segmentation method to identify and quantify elastic fibres based on a local threshold technique and some morphological characteristics measured on the segmented objects that facilitate the discrimination between elastic fibres and other image components. The morphological characteristics analysed are the thickness and the length of an object. RESULTS: The segmentation method was evaluated using an image database of vein sections stained with Weigert's resorcin-fuchsin. The performance results are based on a ground truth generated manually resulting in values of sensitivity greater than 80% with the exception in two samples, and specificity values above 90% for all samples. Medical specialists carried out a visual evaluation where the observations indicate a general agreement on the segmentation results' visual quality, and the consistency between the methodology proposed and the subjective observation of the doctors for the evaluation of pathological changes in vessel wall. CONCLUSIONS: The proposed methodology provides more objective measurements than the qualitative methods traditionally used in the histological analysis, with a significant potential for this method to be used as a diagnostic aid for many other vascular pathological conditions and in similar tissues such as skin and mucous membranes.
[Mh] Termos MeSH primário: Tecido Elástico/diagnóstico por imagem
Veia Safena/patologia
Coloração e Rotulagem/métodos
Doenças Vasculares/diagnóstico
[Mh] Termos MeSH secundário: Algoritmos
Cadáver
Feminino
Histologia
Seres Humanos
Processamento de Imagem Assistida por Computador
Masculino
Modelos Estatísticos
Plastificantes/química
Resorcinóis/química
Corantes de Rosanilina/química
Sensibilidade e Especificidade
Software
Estireno/química
Xilenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasticizers); 0 (Resorcinols); 0 (Rosaniline Dyes); 0 (Xylenes); 44LJ2U959V (Styrene); YUL4LO94HK (resorcinol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:27848036
[Au] Autor:Avincsal MO; Zen Y
[Ad] Endereço:Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Kobe, 650-0017, Japan.
[Ti] Título:The Histopathology of IgG4-Related Disease.
[So] Source:Curr Top Microbiol Immunol;401:45-60, 2017.
[Is] ISSN:0070-217X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:IgG4-related disease is a multi-organ immune-mediated chronic fibroinflammatory condition characterized by elevated serum IgG4 concentrations, tumefaction, and tissue infiltration by IgG4-positive plasma cells. The exact etiology of IgG4-related disease remains unclear with no known role of the IgG4 molecule itself being identified. Although the pancreas and salivary glands are the main organs affected, the involvement of other organs has also been reported. This multi-organ disease mimics a large number of malignant, infectious, and inflammatory disorders; therefore, a prompt differential diagnosis is important for selecting the right therapeutic strategy. Early steroid therapy assists in preventing tissue fibrosis, parenchymal extinction, and severe functional impairments in the affected organs. The definitive and prompt diagnosis of IgG4-related disease requires both histopathological confirmation and clinicopathological correlations. A histopathological examination is mandatory to exclude neoplastic or inflammatory conditions that mimic IgG4-related disease. The histological changes that occur are basically similar in any organ manifestation, with several site-specific findings being recognized. This chapter summarizes general rules for the pathological examination of IgG4-related disease, as well as the histopathological features and differential diagnoses of major organ manifestations.
[Mh] Termos MeSH primário: Imunoglobulina G/sangue
Inflamação/patologia
[Mh] Termos MeSH secundário: Animais
Diagnóstico Diferencial
Histologia
Seres Humanos
Imunoglobulina G/imunologia
Inflamação/sangue
Inflamação/diagnóstico
Inflamação/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1007/82_2016_38


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[PMID]:27845202
[Au] Autor:Steinhoff PO; Sombke A; Liedtke J; Schneider JM; Harzsch S; Uhl G
[Ad] Endereço:Zoological Institute and Museum, General and Systematic Zoology, University of Greifswald, Anklamer Straße 20, 17489 Greifswald, Germany. Electronic address: philipsteinhoff@gmail.com.
[Ti] Título:The synganglion of the jumping spider Marpissa muscosa (Arachnida: Salticidae): Insights from histology, immunohistochemistry and microCT analysis.
[So] Source:Arthropod Struct Dev;46(2):156-170, 2017 Mar.
[Is] ISSN:1873-5495
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Jumping spiders are known for their extraordinary cognitive abilities. The underlying nervous system structures, however, are largely unknown. Here, we explore and describe the anatomy of the brain in the jumping spider Marpissa muscosa (Clerck, 1757) by means of paraffin histology, X-ray microCT analysis and immunohistochemistry as well as three-dimensional reconstruction. In the prosoma, the CNS is a clearly demarcated mass that surrounds the esophagus. The anteriormost neuromere, the protocerebrum, comprises nine bilaterally paired neuropils, including the mushroom bodies and one unpaired midline neuropil, the arcuate body. Further ventrally, the synganglion comprises the cheliceral (deutocerebrum) and pedipalpal neuropils (tritocerebrum). Synapsin-immunoreactivity in all neuropils is generally strong, while allatostatin-immunoreactivity is mostly present in association with the arcuate body and the stomodeal bridge. The most prominent neuropils in the spider brain, the mushroom bodies and the arcuate body, were suggested to be higher integrating centers of the arthropod brain. The mushroom body in M. muscosa is connected to first and second order visual neuropils of the lateral eyes, and the arcuate body to the second order neuropils of the anterior median eyes (primary eyes) through a visual tract. The connection of both, visual neuropils and eyes and arcuate body, as well as their large size corroborates the hypothesis that these neuropils play an important role in cognition and locomotion control of jumping spiders. In addition, we show that the architecture of the brain of M. muscosa and some previously investigated salticids differs significantly from that of the wandering spider Cupiennius salei, especially with regard to structure and arrangement of visual neuropils and mushroom body. Thus, we need to explore the anatomical conformities and specificities of the brains of different spider taxa in order to understand evolutionary transformations of the arthropod brain.
[Mh] Termos MeSH primário: Aranhas/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/anatomia & histologia
Encéfalo/citologia
Feminino
Gânglios/anatomia & histologia
Gânglios/citologia
Histologia
Imuno-Histoquímica
Microscopia Confocal
Neurópilo/citologia
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE


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[PMID]:27458988
[Au] Autor:Byram JN; Seifert MF; Brooks WS; Fraser-Cotlin L; Thorp LE; Williams JM; Wilson AB
[Ad] Endereço:Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana.
[Ti] Título:Using generalizability analysis to estimate parameters for anatomy assessments: A multi-institutional study.
[So] Source:Anat Sci Educ;10(2):109-119, 2017 Mar.
[Is] ISSN:1935-9780
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With integrated curricula and multidisciplinary assessments becoming more prevalent in medical education, there is a continued need for educational research to explore the advantages, consequences, and challenges of integration practices. This retrospective analysis investigated the number of items needed to reliably assess anatomical knowledge in the context of gross anatomy and histology. A generalizability analysis was conducted on gross anatomy and histology written and practical examination items that were administered in a discipline-based format at Indiana University School of Medicine and in an integrated fashion at the University of Alabama School of Medicine and Rush University Medical College. Examination items were analyzed using a partially nested design s×(i:o) in which items were nested within occasions (i:o) and crossed with students (s). A reliability standard of 0.80 was used to determine the minimum number of items needed across examinations (occasions) to make reliable and informed decisions about students' competence in anatomical knowledge. Decision study plots are presented to demonstrate how the number of items per examination influences the reliability of each administered assessment. Using the example of a curriculum that assesses gross anatomy knowledge over five summative written and practical examinations, the results of the decision study estimated that 30 and 25 items would be needed on each written and practical examination to reach a reliability of 0.80, respectively. This study is particularly relevant to educators who may question whether the amount of anatomy content assessed in multidisciplinary evaluations is sufficient for making judgments about the anatomical aptitude of students. Anat Sci Educ 10: 109-119. © 2016 American Association of Anatomists.
[Mh] Termos MeSH primário: Anatomia/educação
Educação de Graduação em Medicina/métodos
Avaliação Educacional/métodos
Generalização (Psicologia)
Histologia/educação
Teoria Psicológica
Estudantes de Medicina/psicologia
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Currículo
Escolaridade
Seres Humanos
Psicometria
Reprodutibilidade dos Testes
Estudos Retrospectivos
Faculdades de Medicina
Fatores de Tempo
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE
[do] DOI:10.1002/ase.1631


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[PMID]:27955651
[Au] Autor:Sahota M; Leung B; Dowdell S; Velan GM
[Ad] Endereço:Department of Pathology, School of Medical Sciences, Faculty of Medicine, UNSW Australia, Sydney, Australia.
[Ti] Título:Learning pathology using collaborative vs. individual annotation of whole slide images: a mixed methods trial.
[So] Source:BMC Med Educ;16(1):311, 2016 Dec 12.
[Is] ISSN:1472-6920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Students in biomedical disciplines require understanding of normal and abnormal microscopic appearances of human tissues (histology and histopathology). For this purpose, practical classes in these disciplines typically use virtual microscopy, viewing digitised whole slide images in web browsers. To enhance engagement, tools have been developed to enable individual or collaborative annotation of whole slide images within web browsers. To date, there have been no studies that have critically compared the impact on learning of individual and collaborative annotations on whole slide images. METHODS: Junior and senior students engaged in Pathology practical classes within Medical Science and Medicine programs participated in cross-over trials of individual and collaborative annotation activities. Students' understanding of microscopic morphology was compared using timed online quizzes, while students' perceptions of learning were evaluated using an online questionnaire. RESULTS: For senior medical students, collaborative annotation of whole slide images was superior for understanding key microscopic features when compared to individual annotation; whilst being at least equivalent to individual annotation for junior medical science students. Across cohorts, students agreed that the annotation activities provided a user-friendly learning environment that met their flexible learning needs, improved efficiency, provided useful feedback, and helped them to set learning priorities. Importantly, these activities were also perceived to enhance motivation and improve understanding. CONCLUSION: Collaborative annotation improves understanding of microscopic morphology for students with sufficient background understanding of the discipline. These findings have implications for the deployment of annotation activities in biomedical curricula, and potentially for postgraduate training in Anatomical Pathology.
[Mh] Termos MeSH primário: Educação de Pós-Graduação em Medicina
Histologia/educação
Microscopia/métodos
Patologia/educação
Estudantes de Medicina
Ensino
[Mh] Termos MeSH secundário: Instrução por Computador
Currículo
Avaliação Educacional
Seres Humanos
Aprendizagem
Avaliação de Programas e Projetos de Saúde
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


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[PMID]:27833990
[Au] Autor:Wincewicz A
[Ad] Endereço:Department of Pathology, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland; ruahpolin@yahoo.com, andwinc@gmail.com.
[Ti] Título:Pro Memoria. Professor Boleslaw Jalowy (1906-1943): Mortui viventes obligant - the livings are obligated to the dead.
[So] Source:Rom J Morphol Embryol;57(2 Suppl):899-901, 2016.
[Is] ISSN:1220-0522
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:Professor Boleslaw Jalowy (1906-1943) was a chairman of Department of Histology and Embryology at Faculty of Medicine of King John Casimir University (Polish: Universytet Jana Kazimierza: UJK) in Lvov. He succeeded Professor Wladyslaw Szymonowicz (1869-1939) who held this position for decades. As the most skillful followers of his tutor, Boleslaw Jalowy was a great investigator of physiology of human tissue, embryogenesis, histological consequences of female sex hormones on blood clotting action as well as regeneration of nerves in addition to description of silver staining technique for reticulin fibers of skin. He was a hard working person with gentle attitude to such a subtle matter as microscopic structure of human body. However, he happened to live in brutal conditions of nationalistic struggles. His example shows how much a dedicated scientist could do in a very short time as his life was tragically ended with murdering him during World War Two. His story is a great lesson for generations of academic workers how to meet high moral standards with efficient and creative scientific work in evil and destructive, nationalistic climate that occurs usually in wartime.
[Mh] Termos MeSH primário: Histologia/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Jalowy B
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161112
[St] Status:MEDLINE


  10 / 1196 MEDLINE  
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[PMID]:27828738
[Au] Autor:Ellis H
[Ad] Endereço:Emeritus Professor of Surgery, Guy's, King's and St Thomas' School of Biomedical Sciences, London SE1 1UL.
[Ti] Título:Sir William Bowman: a histologist and an ophthalmic surgeon.
[So] Source:Br J Hosp Med (Lond);77(11):661, 2016 Nov 02.
[Is] ISSN:1750-8460
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Histologia/história
Oftalmologia/história
[Mh] Termos MeSH secundário: História do Século XIX
Seres Humanos
Reino Unido
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE



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