Base de dados : MEDLINE
Pesquisa : H01.158.201.636 [Categoria DeCS]
Referências encontradas : 20111 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2012 ir para página                         

  1 / 20111 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29368838
[Au] Autor:Alekseenko IV; Pleshkan VV; Monastyrskaya GS; Kuzmich AI; Snezhkov EV; Didych DA; Sverdlov ED
[Ti] Título:[Fundamentally low reproducibility in molecular genetic cancer research].
[So] Source:Genetika;52(7):745-60, 2016 Jul.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.
[Mh] Termos MeSH primário: Biologia Molecular
Neoplasias/genética
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Neoplasias/patologia
Neoplasias/terapia
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29319937
[Au] Autor:Food and Drug Administration, HHS.
[Ti] Título:Medical Devices; Clinical Chemistry and Clinical Toxicology Devices; Classification of the Reagents for Molecular Diagnostic Instrument Test Systems. Final order.
[So] Source:Fed Regist;82(247):61162-3, 2017 Dec 27.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA or we) is classifying the reagents for molecular diagnostic instrument test systems into class I (general controls). We are taking this action because we have determined that classifying the device into class I (general controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
[Mh] Termos MeSH primário: Testes de Química Clínica/classificação
Testes de Química Clínica/instrumentação
Segurança de Equipamentos/classificação
Indicadores e Reagentes/classificação
Biologia Molecular/classificação
Biologia Molecular/instrumentação
Kit de Reagentes para Diagnóstico/classificação
[Mh] Termos MeSH secundário: DNA Polimerase Dirigida por DNA/classificação
Seres Humanos
Ácidos Nucleicos/classificação
Nucleotídeos/classificação
DNA Polimerase Dirigida por RNA/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indicators and Reagents); 0 (Nucleic Acids); 0 (Nucleotides); 0 (Reagent Kits, Diagnostic); EC 2.7.7.49 (RNA-Directed DNA Polymerase); EC 2.7.7.7 (DNA-Directed DNA Polymerase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


  3 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29272285
[Au] Autor:Konini S; Janse van Rensburg EJ
[Ad] Endereço:Mathematics & Statistics, York University, Toronto, Ontario, M3J 1P3, Canada.
[Ti] Título:Mean field analysis of algorithms for scale-free networks in molecular biology.
[So] Source:PLoS One;12(12):e0189866, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The sampling of scale-free networks in Molecular Biology is usually achieved by growing networks from a seed using recursive algorithms with elementary moves which include the addition and deletion of nodes and bonds. These algorithms include the Barabási-Albert algorithm. Later algorithms, such as the Duplication-Divergence algorithm, the Solé algorithm and the iSite algorithm, were inspired by biological processes underlying the evolution of protein networks, and the networks they produce differ essentially from networks grown by the Barabási-Albert algorithm. In this paper the mean field analysis of these algorithms is reconsidered, and extended to variant and modified implementations of the algorithms. The degree sequences of scale-free networks decay according to a powerlaw distribution, namely P(k) ∼ k-γ, where γ is a scaling exponent. We derive mean field expressions for γ, and test these by numerical simulations. Generally, good agreement is obtained. We also found that some algorithms do not produce scale-free networks (for example some variant Barabási-Albert and Solé networks).
[Mh] Termos MeSH primário: Algoritmos
Biologia Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189866


  4 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29267315
[Au] Autor:Jafari M; Ansari-Pour N; Azimzadeh S; Mirzaie M
[Ad] Endereço:Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
[Ti] Título:A logic-based dynamic modeling approach to explicate the evolution of the central dogma of molecular biology.
[So] Source:PLoS One;12(12):e0189922, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is nearly half a century past the age of the introduction of the Central Dogma (CD) of molecular biology. This biological axiom has been developed and currently appears to be all the more complex. In this study, we modified CD by adding further species to the CD information flow and mathematically expressed CD within a dynamic framework by using Boolean network based on its present-day and 1965 editions. We show that the enhancement of the Dogma not only now entails a higher level of complexity, but it also shows a higher level of robustness, thus far more consistent with the nature of biological systems. Using this mathematical modeling approach, we put forward a logic-based expression of our conceptual view of molecular biology. Finally, we show that such biological concepts can be converted into dynamic mathematical models using a logic-based approach and thus may be useful as a framework for improving static conceptual models in biology.
[Mh] Termos MeSH primário: Modelos Biológicos
Biologia Molecular
[Mh] Termos MeSH secundário: Biologia de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189922


  5 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29251435
[Au] Autor:Chenette EJ
[Ad] Endereço:The FEBS Journal Editorial Office, Cambridge, UK.
[Ti] Título:Announcing the winners of our 50th Anniversary Science Communication Competition.
[So] Source:FEBS J;284(24):4172-4173, 2017 Dec.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The FEBS Journal is pleased to announce the three winners of its 50th Anniversary Science Communication Competition. Read on to see their prize-winning entries!
[Mh] Termos MeSH primário: Distinções e Prêmios
Disciplinas das Ciências Biológicas/história
Sociedades Científicas
[Mh] Termos MeSH secundário: Recursos Audiovisuais
Europa (Continente)
História do Século XXI
México
Biologia Molecular/história
Filmes Cinematográficos
Neurociências/história
Pôsteres como Assunto
Singapura
[Pt] Tipo de publicação:BIOGRAPHY; EDITORIAL; HISTORICAL ARTICLE
[Ps] Nome de pessoa como assunto:Fong A; Estrada-Rivadeneyra D; Mitheera V
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1111/febs.14329


  6 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29199256
[Au] Autor:Saito N
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Tohoku University.
[Ti] Título:[Synthesis, Aggregation, Self-assembly, and Dynamic Properties of Helicene Oligomers].
[So] Source:Yakugaku Zasshi;137(12):1483-1490, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Biological systems exhibit dynamic phenomena at the macroscopic level as a result of the hierarchical integration of phenomena at the molecular level. For example, a number of amino acids compose actin proteins, which form three-dimensional structures determined by the sequence of amino acids. They form fibers by self-assembly, which then form ordered structures such as meshes, lyotropic liquid crystals (LCs), and bundles. The dynamic and reversible polymorphism between these nano- to centimeter-sized ordered structures is essential for biological functions such as cell division, contraction, and locomotion. To understand biological systems and create new functional materials, it is essential to develop a methodology to integrate phenomena at the molecular level into those at the macroscopic level using synthetic molecules. In this research, synthetic oligomers containing helicenes, which exhibit reversible structural transitions between cylindrical double helices and random coils in response to thermal stimuli, were employed as building blocks for the development of such a methodology. The properties of homo- and hetero-double helices at the molecular level were first controlled by taking advantage of the diversity of their molecular structures. Then, nano- to micrometer-sized structures were constructed by the self-assembly of hetero-double helices, which include fibers/gels, vesicles, and lyotropic LCs, and their dynamic properties were controlled by molecular design.
[Mh] Termos MeSH primário: Fenômenos Biológicos
Compostos Policíclicos
[Mh] Termos MeSH secundário: Animais
Disciplinas das Ciências Biológicas
Biopolímeros
Fenômenos Fisiológicos Celulares
Química Orgânica
Sequências Hélice-Alça-Hélice
Seres Humanos
Biologia Molecular
Estrutura Molecular
Nanopartículas
Compostos Policíclicos/química
Compostos Policíclicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biopolymers); 0 (Polycyclic Compounds); 0 (helicenes)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00130


  7 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743422
[Au] Autor:Bond PJ; Verma CS
[Ad] Endereço:Bioinformatics Institute (A∗STAR), 30 Biopolis Street, #07-01 Matrix, 138671 Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore. Electronic address: peterjb@bii.a-star.edu.sg.
[Ti] Título:Editorial.
[So] Source:Prog Biophys Mol Biol;128:1-2, 2017 09.
[Is] ISSN:1873-1732
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Biofísica
Biologia Molecular
[Mh] Termos MeSH secundário: Proteínas/química
Proteínas/metabolismo
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  8 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28453505
[Au] Autor:Esparza-López J; Escobar-Arriaga E; Soto-Germes S; Ibarra-Sánchez MJ
[Ad] Endereço:Biochemistry Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
[Ti] Título:Breast Cancer Intra-Tumor Heterogeneity: One Tumor, Different Entities.
[So] Source:Rev Invest Clin;69(2):66-76, 2017 Mar-Apr.
[Is] ISSN:0034-8376
[Cp] País de publicação:Mexico
[La] Idioma:eng
[Ab] Resumo:In recent years, it has become evident that intra-tumor heterogeneity of breast cancer is a big challenge for the diagnosis, treatment, and clinical course of tumor-bearing patients. The advances in molecular biology and other technologies have led to the knowledge that a breast cancer tumor is comprised of multiple cellular entities. Here we review the two theories that have been described, trying to explain the origin of intra-tumor heterogeneity: clonal evolution and cancer stem cells. The first one considers that a single cell gives rise to many subpopulations through the accumulation of multiple aberrations, while the cancer stem cells theory foresees a hierarchical tumor evolution where only a few cells with self-renewal capacity give rise to different subpopulations. We also analyze the genetic, epigenetic, and microenvironment contributions to breast cancer intra-tumor heterogeneity. Finally, the clinical and therapeutic impact of intra-tumor heterogeneity on the outcome of breast cancer patients is discussed.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Evolução Clonal/fisiologia
Células-Tronco Neoplásicas/citologia
[Mh] Termos MeSH secundário: Neoplasias da Mama/diagnóstico
Neoplasias da Mama/terapia
Autorrenovação Celular/fisiologia
Epigênese Genética/fisiologia
Feminino
Seres Humanos
Biologia Molecular/métodos
Microambiente Tumoral/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  9 / 20111 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28864201
[Au] Autor:Xu G; Ma T; Zang T; Sun W; Wang Q; Ma J
[Ad] Endereço:School of Life Sciences, Tsinghua University, Beijing 100084, China.
[Ti] Título:OPUS-DOSP: A Distance- and Orientation-Dependent All-Atom Potential Derived from Side-Chain Packing.
[So] Source:J Mol Biol;429(20):3113-3120, 2017 Oct 13.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report a new distance- and orientation-dependent, all-atom statistical potential derived from side-chain packing, named OPUS-DOSP, for protein structure modeling. The framework of OPUS-DOSP is based on OPUS-PSP, previously developed by us [JMB (2008), 376, 288-301], with refinement and new features. In particular, distance or orientation contribution is considered depending on the range of contact distance. A new auxiliary function in energy function is also introduced, in addition to the traditional Boltzmann term, in order to adjust the contributions of extreme cases. OPUS-DOSP was tested on 11 decoy sets commonly used for statistical potential benchmarking. Among 278 native structures, 239 and 249 native structures were recognized by OPUS-DOSP without and with the auxiliary function, respectively. The results show that OPUS-DOSP has an increased decoy recognition capability comparing with those of other relevant potentials to date.
[Mh] Termos MeSH primário: Química/métodos
Biologia Computacional/métodos
Modelos Moleculares
Biologia Molecular/métodos
[Mh] Termos MeSH secundário: Modelos Estatísticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


  10 / 20111 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28736230
[Au] Autor:Alexeev V; Salas-Alanis JC; Palisson F; Mukhtarzada L; Fortuna G; Uitto J; South A; Igoucheva O
[Ad] Endereço:Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
[Ti] Título:Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration.
[So] Source:J Invest Dermatol;137(11):2298-2308, 2017 Nov.
[Is] ISSN:1523-1747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to blistering skin and to more advanced skin lesions remains a challenge. Here, we analyzed cytokines and chemokines in blister fluids of patients affected by dystrophic, junctional, and simplex EB. Our analysis revealed high levels of CXCR1, CXCR2, CCR2, and CCR4 ligands, particularly dominant in dystrophic and junctional EB. In vitro migration assays demonstrated the preferential recruitment of CCR4 lymphocytes and CXCR1 , CXCR2 , and CCR2 myeloid cells toward EB-derived blister fluids. Immunophenotyping of skin-infiltrating leukocytes confirmed substantial infiltration of EB-affected skin with resting (CD45RA ) and activated (CD45RO ) T cells and CXCR2 CD11b cells, many of which were identified as CD16b neutrophils. Our studies also showed that abundance of CXCR2 ligand in blister fluids also creates a favorable milieu for the recruitment of the CXCR2 stem cells, as validated by in vitro and in-matrix migration assays. Collectively, this study identified several chemotactic pathways that control the recruitment of leukocytes to the EB-associated skin lesions. These chemotactic axes could be explored for the refinement of the cutaneous homing of the therapeutic stem cells.
[Mh] Termos MeSH primário: Quimiocinas/genética
Citocinas/genética
Epidermólise Bolhosa/genética
Epidermólise Bolhosa/patologia
Receptores CXCR/genética
[Mh] Termos MeSH secundário: Vesícula/patologia
Movimento Celular/genética
Células Cultivadas
Progressão da Doença
Feminino
Regulação da Expressão Gênica
Seres Humanos
Leucócitos/metabolismo
Leucócitos/patologia
Masculino
Biologia Molecular
Prognóstico
Amostragem
Sensibilidade e Especificidade
Células-Tronco/metabolismo
Células-Tronco/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokines); 0 (Cytokines); 0 (Receptors, CXCR)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE



página 1 de 2012 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde