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  1 / 1743 MEDLINE  
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[PMID]:29297215
[Au] Autor:Rosso AM
[Ti] Título:Alexandria, An emporium in the Silk Road, and the Traffic of Unusual Medicines.
[So] Source:Vesalius;22(2 Suppl):26-52, 2016 Dec.
[Is] ISSN:1373-4857
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:In Ancient times, an active trade of exotic and peculiar drugs tool place along the Silk Road. Coming through China, India, Central Asia, Armenia, including Colchis, Arabia, Nubia as far as Greece and Rome, it was centered during Ptolemaic and Roman times in Alexandria, the world Emporium, remarkably advanced in scientific medicine. Physicians required a variety of active ingredients for their pharmacotherapy, following various related branches of medicine. These included: 1) herbal remedies: including toxic plants 2) polypharmacy: missing together all kind of drugs 3) dreckapotheke or copropharmacy, employing unclean materials 4) organic therapy, using exotic or domestic animal products 5) aromatherapy, lined to essential oils and perfumes 6) 'medical astrology and botany', regarding the laws of sympathy in the natural world 7) alchemy and magic medicine: with occult knowledge
[Mh] Termos MeSH primário: Comércio/história
Mundo Grego/história
Medicina Tradicional/história
Farmácia/história
Mundo Romano/história
Seda/história
[Mh] Termos MeSH secundário: Cidades
Egito
Medicina Herbária/história
História Antiga
Polimedicação
Seda/economia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Silk)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


  2 / 1743 MEDLINE  
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[PMID]:29188968
[Au] Autor:Koulu M; Örmä S; Liljeblad A; Niemelä P
[Ti] Título:Artemisaiae as medicinal and herbal medicinal plants from ancient times to the present day.
[So] Source:Duodecim;132(19):1763-70, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:The 2015 Nobel Prize in Physiology and Medicine was awarded to Chinese Youyou Tu for her work on an antimalarial drug that she isolated from sweet wormwood (Artemisia annua L) and absinthe (Artemisia absinthium L) belonging to the genus of Artemisia. In this article we deal with the use of Artemisiae as medicinal plants through the ages, and several pharmacologically active compounds can be obtained from species of the genus Artemisia. We will particularly focus on two medicinally interesting species of Artemisiae - sweet wormwood and absinthe - as well as two pharmacologically significant compounds found in them, artemisin and thujone.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Artemisia
Medicina Herbária
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antimalarials); 0 (Neuroprotective Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  3 / 1743 MEDLINE  
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[PMID]:29191194
[Au] Autor:Agyei-Baffour P; Kudolo A; Quansah DY; Boateng D
[Ad] Endereço:School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[Ti] Título:Integrating herbal medicine into mainstream healthcare in Ghana: clients' acceptability, perceptions and disclosure of use.
[So] Source:BMC Complement Altern Med;17(1):513, 2017 Dec 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although there are current efforts to integrate herbal medicine (HM) into mainstream healthcare in Ghana, there is paucity of empirical evidence on the acceptability and concurrent use of HM, in the formal health facilities in Ghana. This study sought to determine client perception, disclosure and acceptability of integrating herbal medicine in mainstream healthcare in Kumasi, Ghana. METHODS: A cross-sectional study was conducted from May to August, 2015. Five hundred patients presenting at the outpatient departments of Kumasi South, Suntreso and Tafo Government Hospitals in Kumasi were randomly selected. Interviews were conducted with the use of structured questionnaires. A logistic regression analysis, using backward selection, was conducted to determine the influence of socio-demographic and facility related factors on the odds of using HM at the facility. All statistical tests were two-sided and considered significant at a p-value of <0.05. RESULTS: Majority of the study respondents were females (64.8%) and the median age was 36 years. Less than half, 42.2%, of the respondents utilized HM services when they visited the health facility. Reasons for using HM at the facility level included 'being effective' (24.4%), 'easy to access' (25.3%) and 'being comparatively cheaper' (16%). About 86% never disclosed previous use of HM to their health care providers. Socio-economic status and perception of service provision influenced use of herbal medicines. Respondents who rated themselves wealthy had increased odds of using herbal medicines at the health facility as compared to those who rated themselves poor (OR = 4.9; 95%CI = 1.6-15.3). CONCLUSION: This study shows that integration of herbal medicine is feasible and herbal medicines may be generally accepted as a formal source of healthcare in Ghana. The results of this study might serve as a basis for improvement and upscale of the herbal medicine integration programme in Ghana.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Aceitação pelo Paciente de Cuidados de Saúde
Fitoterapia/psicologia
Fitoterapia/utilização
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Gana
Medicina Herbária
Seres Humanos
Masculino
Meia-Idade
Satisfação do Paciente
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2025-4


  4 / 1743 MEDLINE  
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[PMID]:28915268
[Au] Autor:Huang C; Yang Y; Chen X; Wang C; Li Y; Zheng C; Wang Y
[Ad] Endereço:Bioinformatics Center, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
[Ti] Título:Large-scale cross-species chemogenomic platform proposes a new drug discovery strategy of veterinary drug from herbal medicines.
[So] Source:PLoS One;12(9):e0184880, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Veterinary Herbal Medicine (VHM) is a comprehensive, current, and informative discipline on the utilization of herbs in veterinary practice. Driven by chemistry but progressively directed by pharmacology and the clinical sciences, drug research has contributed more to address the needs for innovative veterinary medicine for curing animal diseases. However, research into veterinary medicine of vegetal origin in the pharmaceutical industry has reduced, owing to questions such as the short of compatibility of traditional natural-product extract libraries with high-throughput screening. Here, we present a cross-species chemogenomic screening platform to dissect the genetic basis of multifactorial diseases and to determine the most suitable points of attack for future veterinary medicines, thereby increasing the number of treatment options. First, based on critically examined pharmacology and text mining, we build a cross-species drug-likeness evaluation approach to screen the lead compounds in veterinary medicines. Second, a specific cross-species target prediction model is developed to infer drug-target connections, with the purpose of understanding how drugs work on the specific targets. Third, we focus on exploring the multiple targets interference effects of veterinary medicines by heterogeneous network convergence and modularization analysis. Finally, we manually integrate a disease pathway to test whether the cross-species chemogenomic platform could uncover the active mechanism of veterinary medicine, which is exemplified by a specific network module. We believe the proposed cross-species chemogenomic platform allows for the systematization of current and traditional knowledge of veterinary medicine and, importantly, for the application of this emerging body of knowledge to the development of new drugs for animal diseases.
[Mh] Termos MeSH primário: Doenças dos Animais/tratamento farmacológico
Doenças dos Animais/genética
Descoberta de Drogas
Medicina Herbária
Drogas Veterinárias
[Mh] Termos MeSH secundário: Animais
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Veterinary Drugs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184880


  5 / 1743 MEDLINE  
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[PMID]:28891095
[Au] Autor:Guo BJ; Bian ZX; Qiu HC; Wang YT; Wang Y
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, China.
[Ti] Título:Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease.
[So] Source:Ann N Y Acad Sci;1401(1):37-48, 2017 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that includes Crohn's disease (CD) and ulcerative colitis (UC). Homeostasis of various regulatory factors involved with intestinal immunity is disrupted in IBD, including the intestinal epithelial barrier, macrophages, and cellular mediators such as cytokines and chemokines. No successful treatment is currently available for the management of IBD. Natural products and herbal medicines have exhibited efficacy for UC and CD in experimental models and clinical trials with the following activities: (1) maintenance of integrity of the intestinal epithelial barrier, (2) regulation of macrophage activation, (3) modulation of innate and adaptive immune response, and (4) inhibition of TNF-α activity. Here, we discuss the major factors involved in the pathogenesis of IBD and the current development of natural products and herbs for the treatment of IBD.
[Mh] Termos MeSH primário: Produtos Biológicos/uso terapêutico
Medicina Herbária/métodos
Doenças Inflamatórias Intestinais/tratamento farmacológico
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Produtos Biológicos/química
Produtos Biológicos/farmacologia
Medicina Herbária/tendências
Seres Humanos
Doenças Inflamatórias Intestinais/metabolismo
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/metabolismo
Fitoterapia/métodos
Preparações de Plantas/química
Preparações de Plantas/farmacologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Plant Preparations)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13414


  6 / 1743 MEDLINE  
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[PMID]:28851456
[Au] Autor:Moein E; Hajimehdipoor H; Toliyat T; Choopani R; Hamzeloo-Moghadam M
[Ad] Endereço:Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method.
[So] Source:Daru;25(1):19, 2017 Aug 29.
[Is] ISSN:2008-2231
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Currently, people are more interested to traditional medicine. The traditional formulations should be converted to modern drug delivery systems to be more acceptable for the patients. In the present investigation, a poly herbal medicine "Ayarij-e-Faiqra" (AF) based on Iranian traditional medicine (ITM) has been formulated and its quality control parameters have been developed. METHODS: The main ingredients of AF including barks of Cinnamomum zeylanicum Blume and Cinnamomum cassia J. Presl, the rhizomes of Nardostachys jatamansi DC., the fruits of Piper cubeba L.f., the flowers of Rosa damascena Herrm., the oleo gum resin of Pistacia terebinthus L. and Aloe spp. dried juice were powdered and used for preparing seven tablet formulations of the herbal mixture. Flowability of the different formulated powders was examined and the best formulations were selected (F6&F7). The tablets were prepared from the selected formulations compared according to the physical characteristics and finally, F7 was selected and coated. Physicochemical characters of core and coated AF tablets were determined and the HPLC method for quantitation of aloin as a marker of tablets was selected and verified according to selectivity, linearity, precision, recovery, LOD and LOQ. RESULTS: The results showed that core and coated AF tablets were in agreement with USP requirements for herbal drugs. They had acceptable appearance, disintegration time, friability, hardness, dissolution behavior, weight variation and content uniformity. The amount of aloin in tablets was found 123.1 mg/tab. The HPLC method for aloin determination in AF tablets was verified according to selectivity, linearity (5-500 µg/ml, r :0.9999), precision (RSD: 1.62%), recovery (108.0%), LOD & LOQ (0.0053 & 0.0161 µg/ml). CONCLUSIONS: The formulated tablets could be a good substitute for powder and capsules of AF in ITM clinics with a feasible and precise method for its quality control. Ayarij-e-Faiqra formulation.
[Mh] Termos MeSH primário: Aloe
Medicina Tradicional
Fitoterapia
[Mh] Termos MeSH secundário: Cinnamomum
Composição de Medicamentos
Emodina/análogos & derivados
Emodina/análise
Emodina/uso terapêutico
Flores
Frutas
Medicina Herbária/métodos
Irã (Geográfico)
Medicina Tradicional/métodos
Nardostachys
Fitoterapia/métodos
Piper
Pistacia
Casca de Planta
Rizoma
Rosa
Comprimidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tablets); KA46RNI6HN (Emodin); W41H6S09F4 (alloin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1186/s40199-017-0185-x


  7 / 1743 MEDLINE  
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[PMID]:28778156
[Au] Autor:Ishtiaq S; Akram M; Kamran SH; Hanif U; Afridi MSK; Sajid-Ur-Rehman; Afzal A; Asif A; Younus M; Akbar S
[Ad] Endereço:Punjab University College of Pharmacy, University of the Punjab Allama Iqbal Campus, Lahore, 54000, Pakistan. saiqa.pharmacy@pu.edu.pk.
[Ti] Título:Acute and sub-acute toxicity study of a Pakistani polyherbal formulation.
[So] Source:BMC Complement Altern Med;17(1):387, 2017 Aug 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Herbology is the prevailing system among the nationally-accepted alternative or complementary systems of medicine. The system is due to its general and patient-oriented methodology, is widely used in the general population exposing them to the risk of the side effects of the herbal medicines. METHOD: The aim of study was to assess the acute and sub-acute toxicity of the polyherbal formulation Hab-e-Kabad Noshadri tablets. In the acute arm of the study, a single dose of 2000 mg/kg was administered to Swiss Albino mice which were observed for physical symptoms and behavioral changes for 72 h. In sub-acute toxicity study repeated doses of the polyherbal preparation was administered to Wistar rats of both genders, separately. The animals received three doses of polyherbal product (50 mg/kg/day, 100 mg/kg/day and 200 mg/kg/day) for a period of 28 days. On 28th day of experiment, blood sampling of animals was done for hematological and biochemical analysis i.e. liver and renal function parameters, lipid profile and then sacrificed for histopathological examination of liver and kidney. RESULT: There was no morbidity and mortality noticed with single dose administration in acute toxicity study in mice. In sub-acute toxicity study, morphological changes with some damage in liver and kidney tissues of male and female animals were recorded at dose of 100 mg/kg/day and 200 mg/kg/day. CONCLUSIONS: It was found that prolonged use at higher dose i.e. 200 mg/kg/day of this polyherbal formulation should be avoided and practitioners should cautiously prescribe this formulation in patients with hepatic and renal impairment.
[Mh] Termos MeSH primário: Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
Magnoliopsida
Fitoterapia/efeitos adversos
Extratos Vegetais/efeitos adversos
Plantas Medicinais
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Combinação de Medicamentos
Feminino
Medicina Herbária
Masculino
Camundongos
Paquistão
Extratos Vegetais/administração & dosagem
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1889-7


  8 / 1743 MEDLINE  
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[PMID]:28774308
[Au] Autor:Ahmed M; Fatima H; Qasim M; Gul B; Ihsan-Ul-Haq
[Ad] Endereço:Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
[Ti] Título:Polarity directed optimization of phytochemical and in vitro biological potential of an indigenous folklore: Quercus dilatata Lindl. ex Royle.
[So] Source:BMC Complement Altern Med;17(1):386, 2017 Aug 03.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis. Brine shrimp lethality, SRB and MTT assays were employed to test cytotoxicity against Artemia salina and human cancer cell lines respectively. Antileishmanial activity was determined using standard MTT protocol. Glucose modulation was assessed by α-amylase inhibition assay while disc diffusion assay was used to establish protein kinase inhibitory and antifungal spectrum. RESULTS: Among 14 extracts of aerial parts, distilled water-acetone extract demonstrated maximum extract recovery (10.52% w/w), phenolic content (21.37 ± 0.21 µg GAE/mg dry weight (DW)), total antioxidant capacity (4.81 ± 0.98 µg AAE/mg DW) and reducing power potential (20.03 ± 2.4 µg/mg DW). On the other hand, Distilled water extract proficiently extracted flavonoid content (4.78 ± 0.51 µg QE/mg DW). RP-HPLC analysis revealed the presence of significant amounts of phenolic metabolites (0.049 to 15.336 µg/mg extract) including, pyrocatechol, gallic acid, catechin, chlorogenic acid, p-coumaric acid, ferulic acid and quercetin. Highest free radical scavenging capacity was found in Methanol-Ethyl acetate extract (IC 8.1 ± 0.5 µg/ml). In the brine shrimp toxicity assay, most of the tested extracts (57%) showed high cytotoxicity. Among these, Chloroform-Methanol extract had highest cytotoxicity against THP-1 cell line (IC 3.88 ± 0.53 µg/ml). About 50% of the extracts were found to be moderately antiproliferative against Hep G2 cell line. Methanol extract exhibited considerable protein kinase inhibitory activity against Streptomyces 85E strain (28 ± 0.35 mm bald phenotype at 100 µg/disc; MIC = 12.5 µg/ disc) while, Chloroform extract displayed maximum antidiabetic activity (α-amylase inhibition of 21.61 ± 1.53% at 200 µg/ml concentration). The highest antileishmanial potential was found in Ethyl acetate-Acetone extract (12.91 ± 0.02% at 100 µg/ml concentration), while, Q. dilatata extracts also showed a moderate antifungal activity. CONCLUSION: This study proposes that multiple-solvent system is a crucial variable to elucidate pharmacological potential of Q. dilatata and the results of the present findings prospects its potential as a resource for the discovery of novel anticancer, antidiabetic, antileishmanial and antioxidant agents.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Inibidores de Proteínas Quinases/farmacologia
Quercus/química
Tripanossomicidas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/uso terapêutico
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Células Hep G2
Medicina Herbária
Seres Humanos
Leishmania/efeitos dos fármacos
Medicina Tradicional
Neoplasias/tratamento farmacológico
Fenóis/isolamento & purificação
Fenóis/farmacologia
Fenóis/uso terapêutico
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Solventes
Streptomyces/efeitos dos fármacos
alfa-Amilases/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Phenols); 0 (Plant Extracts); 0 (Protein Kinase Inhibitors); 0 (Solvents); 0 (Trypanocidal Agents); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1894-x


  9 / 1743 MEDLINE  
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[PMID]:28758992
[Au] Autor:Li FS; Weng JK
[Ad] Endereço:Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, Massachusetts 02142, USA.
[Ti] Título:Demystifying traditional herbal medicine with modern approach.
[So] Source:Nat Plants;3:17109, 2017 Jul 31.
[Is] ISSN:2055-0278
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plants have long been recognized for their therapeutic properties. For centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of maladies. By contrast, the rise of the modern pharmaceutical industry in the past century has been based on exploiting individual active compounds with precise modes of action. This surge has yielded highly effective drugs that are widely used in the clinic, including many plant natural products and analogues derived from these products, but has fallen short of delivering effective cures for complex human diseases with complicated causes, such as cancer, diabetes, autoimmune disorders and degenerative diseases. While the plant kingdom continues to serve as an important source for chemical entities supporting drug discovery, the rich traditions of herbal medicine developed by trial and error on human subjects over thousands of years contain invaluable biomedical information just waiting to be uncovered using modern scientific approaches. Here we provide an evolutionary and historical perspective on why plants are of particular significance as medicines for humans. We highlight several plant natural products that are either in the clinic or currently under active research and clinical development, with particular emphasis on their mechanisms of action. Recent efforts in developing modern multi-herb prescriptions through rigorous molecular-level investigations and standardized clinical trials are also discussed. Emerging technologies, such as genomics and synthetic biology, are enabling new ways for discovering and utilizing the medicinal properties of plants. We are entering an exciting era where the ancient wisdom distilled into the world's traditional herbal medicines can be reinterpreted and exploited through the lens of modern science.
[Mh] Termos MeSH primário: Medicina Herbária
Plantas Medicinais
[Mh] Termos MeSH secundário: Evolução Biológica
Produtos Biológicos
Indústria Farmacêutica/tendências
Medicina Herbária/história
Medicina Herbária/tendências
História Antiga
Seres Humanos
Medicina Tradicional Chinesa
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1038/nplants.2017.109


  10 / 1743 MEDLINE  
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[PMID]:28667389
[Au] Autor:Samuels N; Ben-Arye E; Maimon Y; Berger R
[Ad] Endereço:Tal Center for Integrative Oncology, Institute of Oncology, Sheba Medical Center, 2 Derech Sheba Road, Tel-Hashomer, 52621, Ramat Gan, Israel. noah.samuels@sheba.health.gov.il.
[Ti] Título:Unmonitored use of herbal medicine by patients with breast cancer: reframing expectations.
[So] Source:J Cancer Res Clin Oncol;143(11):2267-2273, 2017 Nov.
[Is] ISSN:1432-1335
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To identify the unmonitored use of herbal medicine by female patients with breast cancer, examining the impact of an integrative physician (IP) consultation on this practice. METHODS: The files of 269 female patients with breast cancer following an IP consultation were surveyed retrospectively for use of herbal medicine for cancer-related goals. Expectations from the IP consultation and adherence to the IP-guided treatments were examined as well. RESULTS: Among the cohort, 111 (41.3%) reported using herbal medicine for cancer-related goals, unmonitored by their oncology healthcare professional. Factors predicting herbal medicine use were the adoption of dietary changes (odds ratio = 13.6, p < 0.001, CI 7.16-26.0) and the expectation that the IP consultation and treatments would address cancer-related goals (odds ratio = 3.29, p = 0.001, CI 1.64-6.6). Patients with metastatic disease were more likely to be using herbal medicine than non-users (34.5 vs. 22.8%; p = 0.088), as were those who had consulted with a complementary/alternative medicine practitioner (54.9 vs. 20.8%; p = 0.005). The IP advised 17 patients (15.3%) to stop taking specific herbal products due to safety-related concerns; and 10 patients to take dietary supplements for relief of specific symptoms. Herbal medicine users were less likely than non-users to adhere to the IP-recommended treatment program (34.7 vs. 48.3%; p = 0.037). CONCLUSIONS: Unmonitored use of herbal medicine by patients with breast cancer is more frequent among those adopting dietary changes for cancer-related goals. Integrative physicians provide evidence-based guidance on the safe and effective use of herbal products, and reframe patient expectations from cancer-related goals to reducing symptoms and improving quality of life.
[Mh] Termos MeSH primário: Neoplasias da Mama/terapia
Terapias Complementares/utilização
Medicina Herbária/métodos
Cooperação do Paciente
Qualidade de Vida
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Seres Humanos
Meia-Idade
Invasividade Neoplásica
Metástase Neoplásica
Médicos
Fitoterapia
Prognóstico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.1007/s00432-017-2471-x



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