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Referências encontradas : 363 [refinar]
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[PMID]:27774873
[Au] Autor:Gim J; Won S; Park T
[Ad] Endereço:* Institute of Health and Environment, Seoul National University, Gwanak-gu Seoul, 151-747, South Korea.
[Ti] Título:Conditional estimation of local pooled dispersion parameter in small-sample RNA-Seq data improves differential expression test.
[So] Source:J Bioinform Comput Biol;14(5):1644006, 2016 Oct.
[Is] ISSN:1757-6334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:High throughput sequencing technology in transcriptomics studies contribute to the understanding of gene regulation mechanism and its cellular function, but also increases a need for accurate statistical methods to assess quantitative differences between experiments. Many methods have been developed to account for the specifics of count data: non-normality, a dependence of the variance on the mean, and small sample size. Among them, the small number of samples in typical experiments is still a challenge. Here we present a method for differential analysis of count data, using conditional estimation of local pooled dispersion parameters. A comprehensive evaluation of our proposed method in the aspect of differential gene expression analysis using both simulated and real data sets shows that the proposed method is more powerful than other existing methods while controlling the false discovery rates. By introducing conditional estimation of local pooled dispersion parameters, we successfully overcome the limitation of small power and enable a powerful quantitative analysis focused on differential expression test with the small number of samples.
[Mh] Termos MeSH primário: Algoritmos
Análise de Sequência de RNA/métodos
[Mh] Termos MeSH secundário: Simulação por Computador
Interpretação Estatística de Dados
Bases de Dados Genéticas
Feminino
Regulação da Expressão Gênica
Projeto HapMap
Seres Humanos
Masculino
Modelos Genéticos
Tamanho da Amostra
Análise de Sequência de RNA/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE


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[PMID]:28640878
[Au] Autor:Byars SG; Huang QQ; Gray LA; Bakshi A; Ripatti S; Abraham G; Stearns SC; Inouye M
[Ad] Endereço:Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
[Ti] Título:Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.
[So] Source:PLoS Genet;13(6):e1006328, 2017 Jun.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals underlying coronary artery disease (CAD) in worldwide populations, using novel approaches to quantify relationships between polygenic selection signals and CAD genetic risk. We identified new candidate adaptive loci that appear to have been directly modified by disease pressures given their significant associations with CAD genetic risk. These candidates were all uniquely and consistently associated with many different male and female reproductive traits suggesting selection may have also targeted these because of their direct effects on fitness. We found that CAD loci are significantly enriched for lifetime reproductive success relative to the rest of the human genome, with evidence that the relationship between CAD and lifetime reproductive success is antagonistic. This supports the presence of antagonistic-pleiotropic tradeoffs on CAD loci and provides a novel explanation for the maintenance and high prevalence of CAD in modern humans. Lastly, we found that positive selection more often targeted CAD gene regulatory variants using HapMap3 lymphoblastoid cell lines, which further highlights the unique biological significance of candidate adaptive loci underlying CAD. Our study provides a novel approach for detecting selection on polygenic traits and evidence that modern human genomes have evolved in response to CAD-induced selection pressures and other early-life traits sharing pleiotropic links with CAD.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/genética
Loci Gênicos
Pleiotropia Genética
Seleção Genética
[Mh] Termos MeSH secundário: Aptidão Genética
Projeto HapMap
Seres Humanos
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006328


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[PMID]:28499414
[Au] Autor:Ka S; Lee S; Hong J; Cho Y; Sung J; Kim HN; Kim HL; Jung J
[Ad] Endereço:R&D center, Syntekabio, Inc., 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, South Korea.
[Ti] Título:HLAscan: genotyping of the HLA region using next-generation sequencing data.
[So] Source:BMC Bioinformatics;18(1):258, 2017 May 12.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several recent studies showed that next-generation sequencing (NGS)-based human leukocyte antigen (HLA) typing is a feasible and promising technique for variant calling of highly polymorphic regions. To date, however, no method with sufficient read depth has completely solved the allele phasing issue. In this study, we developed a new method (HLAscan) for HLA genotyping using NGS data. RESULTS: HLAscan performs alignment of reads to HLA sequences from the international ImMunoGeneTics project/human leukocyte antigen (IMGT/HLA) database. The distribution of aligned reads was used to calculate a score function to determine correctly phased alleles by progressively removing false-positive alleles. Comparative HLA typing tests using public datasets from the 1000 Genomes Project and the International HapMap Project demonstrated that HLAscan could perform HLA typing more accurately than previously reported NGS-based methods such as HLAreporter and PHLAT. In addition, the results of HLA-A, -B, and -DRB1 typing by HLAscan using data generated by NextGen were identical to those obtained using a Sanger sequencing-based method. We also applied HLAscan to a family dataset with various coverage depths generated on the Illumina HiSeq X-TEN platform. HLAscan identified allele types of HLA-A, -B, -C, -DQB1, and -DRB1 with 100% accuracy for sequences at ≥ 90× depth, and the overall accuracy was 96.9%. CONCLUSIONS: HLAscan, an alignment-based program that takes read distribution into account to determine true allele types, outperformed previously developed HLA typing tools. Therefore, HLAscan can be reliably applied for determination of HLA type across the whole-genome, exome, and target sequences.
[Mh] Termos MeSH primário: Antígenos HLA/genética
Teste de Histocompatibilidade/métodos
[Mh] Termos MeSH secundário: Alelos
Área Sob a Curva
Éxons
Genótipo
Antígenos HLA/química
Antígenos HLA/metabolismo
Antígenos HLA-A/química
Antígenos HLA-A/genética
Antígenos HLA-A/metabolismo
Antígenos HLA-B/química
Antígenos HLA-B/metabolismo
Cadeias HLA-DRB1/química
Cadeias HLA-DRB1/genética
Cadeias HLA-DRB1/metabolismo
Projeto HapMap
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Curva ROC
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA Antigens); 0 (HLA-A Antigens); 0 (HLA-B Antigens); 0 (HLA-DRB1 Chains)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1671-3


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[PMID]:28445522
[Au] Autor:Onuki R; Yamaguchi R; Shibuya T; Kanehisa M; Goto S
[Ad] Endereço:Bioinformatics Team, Advanced Analysis Center, National Agriculture and Food Research Organization (NARO), 2-1-2 Kannondai, Tsukuba, Ibaraki, Japan.
[Ti] Título:Revealing phenotype-associated functional differences by genome-wide scan of ancient haplotype blocks.
[So] Source:PLoS One;12(4):e0176530, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genome-wide scans for positive selection have become important for genomic medicine, and many studies aim to find genomic regions affected by positive selection that are associated with risk allele variations among populations. Most such studies are designed to detect recent positive selection. However, we hypothesize that ancient positive selection is also important for adaptation to pathogens, and has affected current immune-mediated common diseases. Based on this hypothesis, we developed a novel linkage disequilibrium-based pipeline, which aims to detect regions associated with ancient positive selection across populations from single nucleotide polymorphism (SNP) data. By applying this pipeline to the genotypes in the International HapMap project database, we show that genes in the detected regions are enriched in pathways related to the immune system and infectious diseases. The detected regions also contain SNPs reported to be associated with cancers and metabolic diseases, obesity-related traits, type 2 diabetes, and allergic sensitization. These SNPs were further mapped to biological pathways to determine the associations between phenotypes and molecular functions. Assessments of candidate regions to identify functions associated with variations in incidence rates of these diseases are needed in the future.
[Mh] Termos MeSH primário: Genoma Humano
Estudo de Associação Genômica Ampla
[Mh] Termos MeSH secundário: Bases de Dados Genéticas
Genética Populacional
Genótipo
Projeto HapMap
Haplótipos
Seres Humanos
Desequilíbrio de Ligação
Doenças Metabólicas/genética
Doenças Metabólicas/patologia
Método de Monte Carlo
Família Multigênica
Neoplasias/genética
Neoplasias/patologia
Doenças Neurodegenerativas/genética
Doenças Neurodegenerativas/patologia
Fenótipo
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176530


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[PMID]:28423003
[Au] Autor:Carvajal-Rodríguez A
[Ad] Endereço:Departamento de Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Spain.
[Ti] Título:HacDivSel: Two new methods (haplotype-based and outlier-based) for the detection of divergent selection in pairs of populations.
[So] Source:PLoS One;12(4):e0175944, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The detection of genomic regions involved in local adaptation is an important topic in current population genetics. There are several detection strategies available depending on the kind of genetic and demographic information at hand. A common drawback is the high risk of false positives. In this study we introduce two complementary methods for the detection of divergent selection from populations connected by migration. Both methods have been developed with the aim of being robust to false positives. The first method combines haplotype information with inter-population differentiation (FST). Evidence of divergent selection is concluded only when both the haplotype pattern and the FST value support it. The second method is developed for independently segregating markers i.e. there is no haplotype information. In this case, the power to detect selection is attained by developing a new outlier test based on detecting a bimodal distribution. The test computes the FST outliers and then assumes that those of interest would have a different mode. We demonstrate the utility of the two methods through simulations and the analysis of real data. The simulation results showed power ranging from 60-95% in several of the scenarios whilst the false positive rate was controlled below the nominal level. The analysis of real samples consisted of phased data from the HapMap project and unphased data from intertidal marine snail ecotypes. The results illustrate that the proposed methods could be useful for detecting locally adapted polymorphisms. The software HacDivSel implements the methods explained in this manuscript.
[Mh] Termos MeSH primário: Genética Populacional
Haplótipos
Modelos Genéticos
Seleção Genética
Caramujos/genética
Software
[Mh] Termos MeSH secundário: Migração Animal
Animais
Simulação por Computador
Ecossistema
Reações Falso-Positivas
Marcadores Genéticos
Projeto HapMap
Seres Humanos
Ondas de Maré
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175944


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[PMID]:28359046
[Au] Autor:Kidd KK; Speed WC; Pakstis AJ; Podini DS; Lagacé R; Chang J; Wootton S; Haigh E; Soundararajan U
[Ad] Endereço:Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8005, USA. Electronic address: kenneth.kidd@yale.edu.
[Ti] Título:Evaluating 130 microhaplotypes across a global set of 83 populations.
[So] Source:Forensic Sci Int Genet;29:29-37, 2017 Jul.
[Is] ISSN:1878-0326
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Today the primary DNA markers used in forensics are short tandem repeat (STR) polymorphisms (STRPs), initially selected because they are highly polymorphic. However, the increasingly common need to deal with samples with a mixture of DNA from two or more individuals sometimes is complicated by the inherent stutter involved with PCR amplification, especially in strongly unbalanced mixtures when the minor component coincides with the stutter range of the major component. Also, the STRPs in use provide little evidence of ancestry of a single source sample beyond broad "continental" resolution. Methodologies for analyzing DNA have become much more powerful in recent years. Massively parallel sequencing (MPS) is a new method being considered for routine use in forensics. Primarily to aid in mixture deconvolution and avoid the issue of stutter, we have begun to investigate a new type of forensic marker, microhaplotype loci, that will provide useful information on mixtures of DNA and on ancestry when typed using massively parallel sequencing (MPS). We have identified 130 loci and estimated their haplotype (allele) frequencies in 83 different population samples. Many of these loci are shown to be highly informative for individual identification and for mixture identification and deconvolution.
[Mh] Termos MeSH primário: Genética Populacional
Haplótipos
Sequenciamento de Nucleotídeos em Larga Escala
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Conjuntos de Dados como Assunto
Frequência do Gene
Projeto HapMap
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:28285767
[Au] Autor:Brynedal B; Choi J; Raj T; Bjornson R; Stranger BE; Neale BM; Voight BF; Cotsapas C
[Ad] Endereço:Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
[Ti] Título:Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation.
[So] Source:Am J Hum Genet;100(4):581-591, 2017 Apr 06.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Efforts to decipher the causal relationships between differences in gene regulation and corresponding differences in phenotype have been stymied by several basic technical challenges. Although detecting local, cis-eQTLs is now routine, trans-eQTLs, which are distant from the genes of origin, are far more difficult to find because millions of SNPs must currently be compared to thousands of transcripts. Here, we demonstrate an alternative approach: we looked for SNPs associated with the expression of many genes simultaneously and found that hundreds of trans-eQTLs each affect hundreds of transcripts in lymphoblastoid cell lines across three African populations. These trans-eQTLs target the same genes across the three populations and show the same direction of effect. We discovered that target transcripts of a high-confidence set of trans-eQTLs encode proteins that interact more frequently than expected by chance, are bound by the same transcription factors, and are enriched for pathway annotations indicative of roles in basic cell homeostasis. We thus demonstrate that our approach can uncover trans-acting transcriptional control circuits that affect co-regulated groups of genes: a key to understanding how cellular pathways and processes are orchestrated.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica
Locos de Características Quantitativas
Transcrição Genética
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Africano/genética
Algoritmos
Linhagem Celular
Perfilação da Expressão Gênica
Projeto HapMap
Seres Humanos
Polimorfismo de Nucleotídeo Único
Mapas de Interação de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:28249201
[Au] Autor:Li L; Wang Y; Yang S; Xia M; Yang Y; Wang J; Lu D; Pan X; Ma T; Jiang P; Yu G; Zhao Z; Ping Y; Zhou H; Zhao X; Sun H; Liu B; Jia D; Li C; Hu R; Lu H; Liu X; Chen W; Mi Q; Xue F; Su Y; Jin L; Li S
[Ad] Endereço:MOE Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Developmental Biology and School of Life Sciences, Fudan University, Shanghai, 200438, China.
[Ti] Título:Genome-wide screening for highly discriminative SNPs for personal identification and their assessment in world populations.
[So] Source:Forensic Sci Int Genet;28:118-127, 2017 May.
[Is] ISSN:1878-0326
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The applications of DNA profiling aim to identify perpetrators, missing family members and disaster victims in forensic investigations. Single nucleotide polymorphisms (SNPs) based forensic applications are emerging rapidly with a potential to replace short tandem repeats (STRs) based panels which are now being used widely, and there is a need for a well-designed SNP panel to meet such challenge for this transition. Here we present a panel of 175 SNP markers (referred to as Fudan ID Panel or FID), selected from ∼3.6 million SNPs, for the application of personal identification. We optimized and validated FID panel using 729 Chinese individuals using a next generation sequencing (NGS) technology. We showed that the SNPs in the panel possess very high heterozygosity as well as low within- and among-continent differentiations, enabling FID panel exhibit discrimination power in both regional and worldwide populations, with the average match probabilities ranging from 4.77×10 to 1.06×10 across 54 world populations. With the advent of biomedical research, the SNPs connecting physical anthropological, physiological, behavioral and phenotypic traits will be eventually added to the forensic panels that will revolutionize criminal investigation.
[Mh] Termos MeSH primário: Impressões Digitais de DNA/métodos
Genética Populacional
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Técnicas de Genotipagem
Projeto HapMap
Heterozigoto
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


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[PMID]:28198814
[Au] Autor:Zhou Y; Yuan K; Yu Y; Ni X; Xie P; Xing EP; Xu S
[Ad] Endereço:Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
[Ti] Título:Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with polynomial functions.
[So] Source:Heredity (Edinb);118(5):503-510, 2017 May.
[Is] ISSN:1365-2540
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To infer the histories of population admixture, one important challenge with methods based on the admixture linkage disequilibrium (ALD) is to remove the effect of source LD (SLD), which is directly inherited from source populations. In previous methods, only the decay curve of weighted LD between pairs of sites whose genetic distance were larger than a certain starting distance was fitted by single or multiple exponential functions, for the inference of recent single- or multiple-wave admixture. However, the effect of SLD has not been well defined and no tool has been developed to estimate the effect of SLD on weighted LD decay. In this study, we defined the SLD in the formularized weighted LD statistic under the two-way admixture model and proposed a polynomial spectrum (p-spectrum) to study the weighted SLD and weighted LD. We also found that reference populations could be used to reduce the SLD in weighted LD statistics. We further developed a method, iMAAPs, to infer multiple-wave admixture by fitting ALD using a p-spectrum. We evaluated the performance of iMAAPs under various admixture models in simulated data and applied iMAAPs to the analysis of genome-wide single nucleotide polymorphism data from the Human Genome Diversity Project and the HapMap Project. We showed that iMAAPs is a considerable improvement over other current methods and further facilitates the inference of histories of complex population admixtures.
[Mh] Termos MeSH primário: Genética Populacional/métodos
Desequilíbrio de Ligação
Modelos Genéticos
[Mh] Termos MeSH secundário: Algoritmos
Simulação por Computador
Genoma Humano
Projeto HapMap
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1038/hdy.2017.5


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[PMID]:28107422
[Au] Autor:de Vries PS; Sabater-Lleal M; Chasman DI; Trompet S; Ahluwalia TS; Teumer A; Kleber ME; Chen MH; Wang JJ; Attia JR; Marioni RE; Steri M; Weng LC; Pool R; Grossmann V; Brody JA; Venturini C; Tanaka T; Rose LM; Oldmeadow C; Mazur J; Basu S; Frånberg M; Yang Q; Ligthart S; Hottenga JJ; Rumley A; Mulas A; de Craen AJ; Grotevendt A; Taylor KD; Delgado GE; Kifley A; Lopez LM; Berentzen TL; Mangino M; Bandinelli S; Morrison AC; Hamsten A; Tofler G; de Maat MP; Draisma HH; Lowe GD; Zoledziewska M; Sattar N; Lackner KJ; Völker U; McKnight B; Huang J; Holliday EG
[Ad] Endereço:Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
[Ti] Título:Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.
[So] Source:PLoS One;12(1):e0167742, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were associated using both HapMap and 1000G imputation. One locus identified using HapMap imputation was not significant using 1000G imputation. The genome-wide significance threshold of 5×10-8 is based on the number of independent statistical tests using HapMap imputation, and 1000G imputation may lead to further independent tests that should be corrected for. When using a stricter Bonferroni correction for the 1000G GWA study (P-value < 2.5×10-8), the number of loci significant only using HapMap imputation increased to 4 while the number of loci significant only using 1000G decreased to 5. In conclusion, 1000G imputation enabled the identification of 20% more loci than HapMap imputation, although the advantage of 1000G imputation became less clear when a stricter Bonferroni correction was used. More generally, our results provide insights that are applicable to the implementation of other dense reference panels that are under development.
[Mh] Termos MeSH primário: Estudo de Associação Genômica Ampla
Projeto HapMap
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167742



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