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Pesquisa : H01.158.273.180.350.349 [Categoria DeCS]
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[PMID]:29376303
[Au] Autor:Lapik IA; Gapparova KM; Chekhonina YG; Sorikina EY; Borodina SV
[Ti] Título:[Current trends in nutrigenomics of obesity].
[So] Source:Vopr Pitan;85(6):6-13, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:One of the most general chronic illness in the world is obesity, which lead to progression of cardiovascular diseases, diabetes mellitus type 2, metabolic syndrome and other diseases. Slow body weight gain, that leads to overweight, is a long-term aftereffect of a long-term positive energy balance, which occurs as a result of physical activity reduction and calorie intake increasing. Trend in the reduction of physical activity and increasing the caloric value of food intake is probably the main reason of increasing patients with obesity, but it's necessary to mention that this tendency occurs because of genetic variation in population. The volume of scientific information, relevant to the problem of genetic predisposition testing to obesity, is highly increasing. This article provides an overview of recent data on the genetics of obesity and the role of genetic testing of candidate genes polymorphisms, as well as genes associated with carbohydrate and lipid metabolism disorders (FTO, ADRB2, ADRB3, PPARG and a number of others). The role of nutrigenomics in personalization of diet treatment for obesity.
[Mh] Termos MeSH primário: Nutrigenômica
Obesidade
Polimorfismo Genético
[Mh] Termos MeSH secundário: Dioxigenase FTO Dependente de alfa-Cetoglutarato/genética
Dioxigenase FTO Dependente de alfa-Cetoglutarato/metabolismo
Animais
Seres Humanos
Nutrigenômica/métodos
Nutrigenômica/tendências
Obesidade/genética
Obesidade/metabolismo
PPAR gama/genética
PPAR gama/metabolismo
Receptores Adrenérgicos beta 2/genética
Receptores Adrenérgicos beta 2/metabolismo
Receptores Adrenérgicos beta 3/genética
Receptores Adrenérgicos beta 3/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (ADRB2 protein, human); 0 (ADRB3 protein, human); 0 (PPAR gamma); 0 (Receptors, Adrenergic, beta-2); 0 (Receptors, Adrenergic, beta-3); EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO); EC 1.14.11.33 (FTO protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:27771938
[Au] Autor:Lucock M; Beckett E; Martin C; Jones P; Furst J; Yates Z; Jablonski NG; Chaplin G; Veysey M
[Ad] Endereço:School of Environmental and Life Sciences, University of Newcastle, PO Box 127, Brush Rd, Ourimbah, NSW, 2258, Australia.
[Ti] Título:UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes.
[So] Source:Am J Hum Biol;29(2), 2017 Mar.
[Is] ISSN:1520-6300
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this study was to examine whether UV exposure alters folate status according to C677T-MTHFR genotype, and to consider the relevance of this to human health and the evolutionary model of skin pigmentation. METHODS: Total Ozone Mapping Spectrometer (TOMS) satellite data were used to examine surface UV-irradiance, as a marker of UV exposure, in a large (n = 649) Australian cross-sectional study population. PCR/RFLP analysis was used to genotype C677T-MTHFR. RESULTS: Overall, cumulative UV-irradiance (42 and 120 days pre-clinic) was significantly negatively related to red cell folate (RCF) levels. When the cohort was stratified by MTHFR-C677T genotype, the relationship between UV-irradiance (42 days pre-clinic) and RCF remained significant only in the cohorts containing carriers of the T allele. Statistically significant z-score statistics and interaction terms from genotype and UV-irradiance (p-interaction) demonstrated that genotype did modify the effect of UV-irradiance on RCF, with the largest effect of UV being demonstrated in the 677TT-MTHFR subjects. CONCLUSIONS: Data provide strong evidence that surface UV-irradiance reduces long-term systemic folate levels, and that this is influenced by the C677T-MTHFR gene variant. We speculate this effect may be due to 677TT-MTHFR individuals containing more 5,10CH -H PteGlu, and that this folate form may be particularly UV labile. Since UV-irradiance lowers RCF in an MTHFR genotype-specific way, there are likely implications for human health and the evolution of skin pigmentation.
[Mh] Termos MeSH primário: Ácido Fólico/metabolismo
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Ácido Fólico/efeitos da radiação
Genótipo
Seres Humanos
Masculino
Metilenotetra-Hidrofolato Redutase (NADPH2)/genética
Metilenotetra-Hidrofolato Redutase (NADPH2)/metabolismo
New South Wales
Nutrigenômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
935E97BOY8 (Folic Acid); EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/ajhb.22929


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[PMID]:28831952
[Au] Autor:Sosa-Castillo E; Rodríguez-Cruz M; Moltó-Puigmartí C
[Ad] Endereço:Laboratorio de Nutrición Molecular,Unidad de Investigación Médica en Nutrición,Hospital de Pediatría,Centro Médico Nacional Siglo XXI,Instituto Mexicano del Seguro Social,06725 Ciudad de México,Mexico.
[Ti] Título:Genomics of lactation: role of nutrigenomics and nutrigenetics in the fatty acid composition of human milk.
[So] Source:Br J Nutr;118(3):161-168, 2017 Aug.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human milk covers the infant's nutrient requirements during the first 6 months of life. The composition of human milk progressively changes during lactation and it is influenced by maternal nutritional factors. Nowadays, it is well known that nutrients have the ability to interact with genes and modulate molecular mechanisms impacting physiological functions. This has led to a growing interest among researchers in exploring nutrition at a molecular level and to the development of two fields of study: nutrigenomics, which evaluates the influence of nutrients on gene expression, and nutrigenetics, which evaluates the heterogeneous individual response to nutrients due to genetic variation. Fatty acids are one of the nutrients most studied in relation to lactation given their biologically important roles during early postnatal life. Fatty acids modulate transcription factors involved in the regulation of lipid metabolism, which in turn causes a variation in the proportion of lipids in milk. This review focuses on understanding, on the one hand, the gene transcription mechanisms activated by maternal dietary fatty acids and, on the other hand, the interaction between dietary fatty acids and genetic variation in genes involved in lipid metabolism. Both of these mechanisms affect the fatty acid composition of human milk.
[Mh] Termos MeSH primário: Ácidos Graxos/análise
Lactação/genética
Metabolismo dos Lipídeos/genética
Leite Humano/química
Nutrigenômica
[Mh] Termos MeSH secundário: Bases de Dados Factuais
Dieta
Gorduras na Dieta/análise
Feminino
Seres Humanos
Glândulas Mamárias Humanas/metabolismo
Fenômenos Fisiológicos da Nutrição Materna
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001854


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[PMID]:28723948
[Au] Autor:Abernathy J; Brezas A; Snekvik KR; Hardy RW; Overturf K
[Ad] Endereço:Hagerman Fish Culture Experiment Station, USDA-ARS, Hagerman, Idaho, United States of America.
[Ti] Título:Integrative functional analyses using rainbow trout selected for tolerance to plant diets reveal nutrigenomic signatures for soy utilization without the concurrence of enteritis.
[So] Source:PLoS One;12(7):e0180972, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Finding suitable alternative protein sources for diets of carnivorous fish species remains a major concern for sustainable aquaculture. Through genetic selection, we created a strain of rainbow trout that outperforms parental lines in utilizing an all-plant protein diet and does not develop enteritis in the distal intestine, as is typical with salmonids on long-term plant protein-based feeds. By incorporating this strain into functional analyses, we set out to determine which genes are critical to plant protein utilization in the absence of gut inflammation. After a 12-week feeding trial with our selected strain and a control trout strain fed either a fishmeal-based diet or an all-plant protein diet, high-throughput RNA sequencing was completed on both liver and muscle tissues. Differential gene expression analyses, weighted correlation network analyses and further functional characterization were performed. A strain-by-diet design revealed differential expression ranging from a few dozen to over one thousand genes among the various comparisons and tissues. Major gene ontology groups identified between comparisons included those encompassing central, intermediary and foreign molecule metabolism, associated biosynthetic pathways as well as immunity. A systems approach indicated that genes involved in purine metabolism were highly perturbed. Systems analysis among the tissues tested further suggests the interplay between selection for growth, dietary utilization and protein tolerance may also have implications for nonspecific immunity. By combining data from differential gene expression and co-expression networks using selected trout, along with ontology and pathway analyses, a set of 63 candidate genes for plant diet tolerance was found. Risk loci in human inflammatory bowel diseases were also found in our datasets, indicating rainbow trout selected for plant-diet tolerance may have added utility as a potential biomedical model.
[Mh] Termos MeSH primário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Aquicultura/métodos
Dieta
Enterite/etiologia
Oncorhynchus mykiss/fisiologia
Proteínas de Vegetais Comestíveis/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Carnivoridade
Sequenciamento de Nucleotídeos em Larga Escala
Nutrigenômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vegetable Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180972


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[PMID]:28715990
[Au] Autor:Schork NJ; Goetz LH
[Ad] Endereço:Translational Genomics Research Institute, Phoenix, Arizona 85004; email: nschork@tgen.org.
[Ti] Título:Single-Subject Studies in Translational Nutrition Research.
[So] Source:Annu Rev Nutr;37:395-422, 2017 Aug 21.
[Is] ISSN:1545-4312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a great deal of interest in personalized, individualized, or precision interventions for disease and health-risk mitigation. This is as true of nutrition-based intervention and prevention strategies as it is for pharmacotherapies and pharmaceutical-oriented prevention strategies. Essentially, technological breakthroughs have enabled researchers to probe an individual's unique genetic, biochemical, physiological, behavioral, and exposure profile, allowing them to identify very specific and often nuanced factors that an individual might possess, which may make it more or less likely that he or she responds favorably to a particular intervention (e.g., nutrient supplementation) or disease prevention strategy (e.g., specific diet). However, as compelling and intuitive as personalized nutrition might be in the current era in which data-intensive biomedical characterization of individuals is possible, appropriately and objectively vetting personalized nutrition strategies is not trivial and requires novel study designs and data analytical methods. These designs and methods must consider a very integrated use of the multiple contemporary biomedical assays and technologies that motivate them, which adds to their complexity. Single-subject or N-of-1 trials can be used to assess the utility of personalized interventions and, in addition, can be crafted in such a way as to accommodate the necessarily integrated use of many emerging biomedical technologies and assays. In this review, we consider the motivation, design, and implementation of N-of-1 trials in translational nutrition research that are meant to assess the utility of personalized nutritional strategies. We provide a number of example studies, discuss appropriate analytical methods given the complex data they generate and require, and consider how such studies could leverage integration of various biomarker assays and clinical end points. Importantly, we also consider the development of strategies and algorithms for matching nutritional needs to individual biomedical profiles and the issues surrounding them. Finally, we discuss the limitations of personalized nutrition studies, possible extensions of N-of-1 nutritional intervention studies, and areas of future research.
[Mh] Termos MeSH primário: Dieta
Nutrigenômica
Medicina de Precisão
Pesquisa Médica Translacional
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-nutr-071816-064717


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[PMID]:28594817
[Au] Autor:Maharjan RP; Ferenci T
[Ad] Endereço:School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
[Ti] Título:A shifting mutational landscape in 6 nutritional states: Stress-induced mutagenesis as a series of distinct stress input-mutation output relationships.
[So] Source:PLoS Biol;15(6):e2001477, 2017 Jun.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental stresses increase genetic variation in bacteria, plants, and human cancer cells. The linkage between various environments and mutational outcomes has not been systematically investigated, however. Here, we established the influence of nutritional stresses commonly found in the biosphere (carbon, phosphate, nitrogen, oxygen, or iron limitation) on both the rate and spectrum of mutations in Escherichia coli. We found that each limitation was associated with a remarkably distinct mutational profile. Overall mutation rates were not always elevated, and nitrogen, iron, and oxygen limitation resulted in major spectral changes but no net increase in rate. Our results thus suggest that stress-induced mutagenesis is a diverse series of stress input-mutation output linkages that is distinct in every condition. Environment-specific spectra resulted in the differential emergence of traits needing particular mutations in these settings. Mutations requiring transpositions were highest under iron and oxygen limitation, whereas base-pair substitutions and indels were highest under phosphate limitation. The unexpected diversity of input-output effects explains some important phenomena in the mutational biases of evolving genomes. The prevalence of bacterial insertion sequence transpositions in the mammalian gut or in anaerobically stored cultures is due to environmentally determined mutation availability. Likewise, the much-discussed genomic bias towards transition base substitutions in evolving genomes can now be explained as an environment-specific output. Altogether, our conclusion is that environments influence genetic variation as well as selection.
[Mh] Termos MeSH primário: DNA Bacteriano
Escherichia coli K12/fisiologia
Interação Gene-Ambiente
Modelos Genéticos
Mutagênese
Mutação
Estresse Fisiológico
[Mh] Termos MeSH secundário: Carboidratos Epimerases/genética
Carboidratos Epimerases/metabolismo
Células Clonais
Análise por Conglomerados
DNA Bacteriano/metabolismo
Escherichia coli K12/genética
Escherichia coli K12/crescimento & desenvolvimento
Escherichia coli K12/isolamento & purificação
Proteínas de Escherichia coli/genética
Proteínas de Escherichia coli/metabolismo
Fermentação
Perfilação da Expressão Gênica
Regulação Bacteriana da Expressão Gênica
Mutação INDEL
Mutagênese Insercional
Taxa de Mutação
Mutação de Sentido Incorreto
Nutrigenômica/métodos
Mutação Puntual
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Escherichia coli Proteins); EC 5.1.3.- (Carbohydrate Epimerases); EC 5.1.3.4 (L-ribulosephosphate 4-epimerase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001477


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[PMID]:28488677
[Au] Autor:Janssens ACJ; Bunnik EM; Burke W; Schermer MH
[Ad] Endereço:Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
[Ti] Título:Uninformed consent in nutrigenomic research.
[So] Source:Eur J Hum Genet;25(7):789-790, 2017 Jun.
[Is] ISSN:1476-5438
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Genetic testing for personalizing diet and wellness programs is performed without extensive counseling that informs about the potential implications of knowing one's genotype status. Genetic counseling seems redundant for genes that impact the effect of diet on biomarkers such as cholesterol and blood pressure, but the same genes may have pleiotropic effects that cannot be ignored. A well-known example is the APOE gene, which is implicated in cholesterol regulation and is a major risk factor for Alzheimer's disease. Not fully informing participants about the major pleiotropic effects of genes has ethical implications and invalidates informed consent.
[Mh] Termos MeSH primário: Consentimento Livre e Esclarecido/ética
Nutrigenômica/ética
[Mh] Termos MeSH secundário: Apolipoproteínas E/genética
Dieta
Aconselhamento Genético/ética
Aconselhamento Genético/normas
Seres Humanos
Consentimento Livre e Esclarecido/normas
Nutrigenômica/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ApoE protein, human); 0 (Apolipoproteins E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1038/ejhg.2017.63


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[PMID]:28387720
[Au] Autor:Heianza Y; Qi L
[Ad] Endereço:Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. yheianza@tulane.edu.
[Ti] Título:Gene-Diet Interaction and Precision Nutrition in Obesity.
[So] Source:Int J Mol Sci;18(4), 2017 Apr 07.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients. This review summarized data from recent studies of gene-diet interactions, and discussed integration of research of metabolomics and gut microbiome, as well as potential application of the findings in precision nutrition.
[Mh] Termos MeSH primário: Restrição Calórica/métodos
Variação Genética
Nutrigenômica/métodos
Obesidade/dietoterapia
[Mh] Termos MeSH secundário: Comportamento Alimentar
Predisposição Genética para Doença
Seres Humanos
Redes e Vias Metabólicas
Estado Nutricional
Obesidade/genética
Estilo de Vida Sedentário
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170507
[Lr] Data última revisão:
170507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE


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[PMID]:28383492
[Au] Autor:Murgia C; Adamski MM
[Ad] Endereço:Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC 3168, Australia. chiara.murgia@monash.edu.
[Ti] Título:Translation of Nutritional Genomics into Nutrition Practice: The Next Step.
[So] Source:Nutrients;9(4), 2017 Apr 06.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Genetics is an important piece of every individual health puzzle. The completion of the Human Genome Project sequence has deeply changed the research of life sciences including nutrition. The analysis of the genome is already part of clinical care in oncology, pharmacology, infectious disease and, rare and undiagnosed diseases. The implications of genetic variations in shaping individual nutritional requirements have been recognised and conclusively proven, yet routine use of genetic information in nutrition and dietetics practice is still far from being implemented. This article sets out the path that needs to be taken to build a framework to translate gene-nutrient interaction studies into best-practice guidelines, providing tools that health professionals can use to understand whether genetic variation affects nutritional requirements in their daily clinical practice.
[Mh] Termos MeSH primário: Interação Gene-Ambiente
Nutrigenômica
Fenômenos Fisiológicos da Nutrição
[Mh] Termos MeSH secundário: Dietética
Variação Genética
Genoma Humano
Seres Humanos
Necessidades Nutricionais/genética
Estado Nutricional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE


  10 / 568 MEDLINE  
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[PMID]:28340087
[Au] Autor:Tremblay BL; Rudkowska I
[Ad] Endereço:Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec City, Quebec, Canada.
[Ti] Título:Nutrigenomic point of view on effects and mechanisms of action of ruminant trans fatty acids on insulin resistance and type 2 diabetes.
[So] Source:Nutr Rev;75(3):214-223, 2017 03 01.
[Is] ISSN:1753-4887
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Evidence from observational studies suggests beneficial effects of ruminant trans fatty acids (rTFA) on insulin resistance (IR) and type 2 diabetes (T2D). However, beneficial effects of rTFA are not always observed in cell, animal, and human studies. This narrative review presents potential mechanisms of action of rTFA using nutrigenomics and microRNA results in an integrative model. In addition, the review presents factors, including measures of IR and T2D, dose and duration of studies, as well as health status, ethnicity, and genotypes of subjects, that may help explain the heterogeneity in response to rTFA supplementation. Future studies should consider these factors, as well as research in nutritional genomics, to better understand the effects of rTFA on IR and T2D.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2
Resistência à Insulina
Nutrigenômica
Ácidos Graxos Trans/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Suplementos Nutricionais
Modelos Animais de Doenças
Seres Humanos
MicroRNAs/genética
MicroRNAs/metabolismo
Estudos Observacionais como Assunto
Ruminantes
Ácidos Graxos Trans/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Trans Fatty Acids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1093/nutrit/nuw066



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