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  1 / 1908 MEDLINE  
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[PMID]:29029380
[Au] Autor:Santos ACC; Choueri RB; de Figueiredo Eufrasio Pauly G; Abessa D; Gallucci F
[Ad] Endereço:Centro de Estudos do Mar da Universidade Federal do Paraná, Av. Beira-mar, s/n 83255-976, Pontal do Sul, PR, Brazil; Centro de Biologia Marinha da Universidade de São Paulo, Rodovia Manoel Hypólito do Rego, km 131.5, São Sebastião, SP 11600-000, Brazil.
[Ti] Título:Is the microcosm approach using meiofauna community descriptors a suitable tool for ecotoxicological studies?
[So] Source:Ecotoxicol Environ Saf;147:945-953, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The usual approaches used in ecological risk assessment have been based on individual and population level standard procedures. Although these have been important tools to assess adverse effects on ecosystems, they are generally simplified and therefore lack ecological realism. Microcosm studies using meiobenthic communities offer a good compromise between the complexity of the ecosystem and the often highly artificial settings of laboratory experiments. An experiment was designed to investigate the potential of the microcosm approach using meiofauna as a tool for ecotoxicological studies. The experiment tested the ecological effects of exposure to sewage-impacted pore water simultaneously at the community level using meiofauna microcosms and at the individual level using laboratory fecundity tests with the copepod Nitokra sp. Specifically, the experiment tested the toxicity of pore water from three sites according to a contamination gradient. Both approaches were efficient in detecting differences in toxicity between the less and more contaminated sites. However, only multivariate data from community analysis detected differences in the gradient of contamination. In addition to information about toxicity, the community level microcosm experiment gave indications about sensitive and tolerant species, indirect ecological effects, as well as raised hypothesis about contamination routes and bioavailability to be tested. Considering the importance of meiofauna for benthic ecosystems, the microcosm approach using natural meiobenthic communities might be a valuable addition as a higher tier approach in ecological risk assessment, providing highly relevant ecological information on the toxicity of contaminated sediments.
[Mh] Termos MeSH primário: Copépodes/efeitos dos fármacos
Ecotoxicologia/métodos
Monitoramento Ambiental/métodos
Sedimentos Geológicos/microbiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Brasil
Ecologia
Ecossistema
Sedimentos Geológicos/análise
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  2 / 1908 MEDLINE  
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[PMID]:28968938
[Au] Autor:Rotini A; Gallo A; Parlapiano I; Berducci MT; Boni R; Tosti E; Prato E; Maggi C; Cicero AM; Migliore L; Manfra L
[Ad] Endereço:Department of Biology, University Tor Vergata, Rome, Italy; Institute for Environmental Protection and Research (ISPRA), Rome, Italy.
[Ti] Título:Insights into the CuO nanoparticle ecotoxicity with suitable marine model species.
[So] Source:Ecotoxicol Environ Saf;147:852-860, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Metal oxide nanoparticles, among them copper oxide nanoparticles (CuO NPs), are widely used in different applications (e.g. batteries, gas sensors, superconductors, plastics and metallic coatings), increasing their potential release in the environment. In aquatic matrix, the behavior of CuO NPs may strongly change, depending on their surface charge and some physical-chemical characteristics of the medium (e.g. ionic strength, salinity, pH and natural organic matter content). Ecotoxicity of CuO NPs to aquatic organisms was mainly studied on freshwater species, few tests being performed on marine biota. The aim of this study was to assess the toxicity of CuO NPs on suitable indicator species, belonging to the ecologically relevant level of consumers. The selected bioassays use reference protocols to identify Effect/Lethal Concentrations (E(L)C), by assessing lethal and sub-lethal endpoints. Mortality tests were performed on rotifer (Brachionus plicatilis), shrimp (Artemia franciscana) and copepod (Tigriopus fulvus). While moult release failure and fertilization rate were studied, as sub-lethal endpoints, on T. fulvus and sea urchin (Paracentrotus lividus), respectively. The size distribution and sedimentation rates of CuO NPs, together with the copper dissolution, were also analyzed in the exposure media. The CuO NP ecotoxicity assessment showed a concentration-dependent response for all species, indicating similar mortality for B. plicatilis (48hLC = 16.94 ± 2.68mg/l) and T. fulvus (96hLC = 12.35 ± 0.48mg/l), followed by A. franciscana (48hLC = 64.55 ± 3.54mg/l). Comparable EC values were also obtained for the sub-lethal endpoints in P. lividus (EC = 2.28 ± 0.06mg/l) and T. fulvus (EC = 2.38 ± 0.20mg/l). Copper salts showed higher toxicity than CuO NPs for all species, with common sensitivity trend as follows: P. lividus ≥ T. fulvus (sublethal endpoint) ≥ B. plicatilis >T. fulvus (lethal endpoint) >A. franciscana. CuO NP micrometric aggregates and high sedimentation rates were observed in the exposure media, with different particle size distributions depending on the medium. The copper dissolution was about 0.16% of the initial concentration, comparable to literature values. The integrated ecotoxicological-physicochemical approach was used to better describe CuO NP toxicity and behavior. In particular, the successful application of ecotoxicological reference protocols allowed to produce reliable L(E)C data useful to identify thresholds and assess potential environmental hazard due to NPs.
[Mh] Termos MeSH primário: Organismos Aquáticos/efeitos dos fármacos
Cobre/toxicidade
Nanopartículas Metálicas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Ecotoxicologia
Água Doce
Modelos Animais
Tamanho da Partícula
Salinidade
Especificidade da Espécie
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 789U1901C5 (Copper); V1XJQ704R4 (cupric oxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


  3 / 1908 MEDLINE  
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[PMID]:28942277
[Au] Autor:Pedrazzani R; Cavallotti I; Bollati E; Ferreri M; Bertanza G
[Ad] Endereço:Department of Mechanical and Industrial Engineering, Università degli Studi di Brescia, via Branze 38, I-25123 Brescia, Italy; MISTRAL c/o DSMC - Università degli Studi di Brescia, Viale Europa, 11, I-25123 Brescia, Italy. Electronic address: roberta.pedrazzani@unibs.it.
[Ti] Título:The role of bioassays in the evaluation of ecotoxicological aspects within the PEF/OEF protocols: The case of WWTPs.
[So] Source:Ecotoxicol Environ Saf;147:742-748, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The suitability evaluation of any industrial process should rely on economic, technical, social and, in particular, environmental aspects. The Commission Recommendation 2013/179/UE enables the improvement and the harmonization of the conventional evaluation of environmental footprints, such as LCA (Life Cycle Assessment), Carbon and Water Footprint, by suggesting the assessment of life cycle environmental performance of products and organisations (PEF, OEF). Novelty aspects reside in including new impact categories (namely, human toxicity cancer effects, human toxicity not-cancer effects and eco-toxicity). This paper presents an application of PEF/OEF protocol to the example case of an activated sludge wastewater treatment plant. Strengths and criticisms of this approach are discussed, by taking into consideration the possible final goal of the suitability assessment. Valuably, the adoption of bioassays (i.e., the input of their results in the models for calculating the life cycle environmental performance) for a more reliable evaluation of the impact on the ecosystem and human health is proposed.
[Mh] Termos MeSH primário: Bioensaio
Ecotoxicologia/métodos
Política Ambiental/legislação & jurisprudência
Regulamentação Governamental
Purificação da Água/normas
[Mh] Termos MeSH secundário: Bioensaio/métodos
Bioensaio/normas
Análise da Demanda Biológica de Oxigênio
Ecossistema
Ecotoxicologia/legislação & jurisprudência
União Europeia
Seres Humanos
Modelos Teóricos
Esgotos/análise
Testes de Toxicidade/normas
Águas Residuais/toxicidade
Poluentes Químicos da Água/toxicidade
Purificação da Água/legislação & jurisprudência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


  4 / 1908 MEDLINE  
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[PMID]:27775382
[Au] Autor:Huang Q; Wang H
[Ad] Endereço:Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada. email: qihua@ualberta.ca.
[Ti] Título:A toxin-mediated size-structured population model: Finite difference approximation and well-posedness.
[So] Source:Math Biosci Eng;13(4):697-722, 2016 08 01.
[Is] ISSN:1551-0018
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The question of the effects of environmental toxins on ecological communities is of great interest from both environmental and conservational points of view. Mathematical models have been applied increasingly to predict the effects of toxins on a variety of ecological processes. Motivated by the fact that individuals with different sizes may have different sensitivities to toxins, we develop a toxin-mediated size-structured model which is given by a system of first order fully nonlinear partial differential equations (PDEs). It is very possible that this work represents the first derivation of a PDE model in the area of ecotoxicology. To solve the model, an explicit finite difference approximation to this PDE system is developed. Existence-uniqueness of the weak solution to the model is established and convergence of the finite difference approximation to this unique solution is proved. Numerical examples are provided by numerically solving the PDE model using the finite difference scheme.
[Mh] Termos MeSH primário: Ecotoxicologia/métodos
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal
Meio Ambiente
Dinâmica Populacional
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3934/mbe.2016015


  5 / 1908 MEDLINE  
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[PMID]:28951039
[Au] Autor:Tato T; Salgueiro-González N; León VM; González S; Beiras R
[Ad] Endereço:Estación de Ciencias Mariñas de Toralla (ECIMAT), Universidade de Vigo, Illa de Toralla, 36331 Vigo, Galicia, Spain; Departamento de Ecoloxía e Bioloxía Animal, Universidade de Vigo, Campus Lagoas-Marcosende, 36200 Vigo, Galicia, Spain.
[Ti] Título:Ecotoxicological evaluation of the risk posed by bisphenol A, triclosan, and 4-nonylphenol in coastal waters using early life stages of marine organisms (Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus, and Acartia clausi).
[So] Source:Environ Pollut;232:173-182, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study assessed the environmental risk on coastal ecosystems posed by three phenolic compounds of special environmental and human health concern used in plastics and household products: bisphenol A (BPA), triclosan (TCS) and 4-nonylphenol (4-NP). These three chemicals are among the organic contaminants most frequently detected in wastewater. The most toxic compound tested was 4-NP, with 10% effective concentration at 11.1 µg L for Isochrysis galbana, 110.5 µg L for Mytilus galloprovincialis, 53.8 µg L for Paracentrotus lividus, and 29.0 µg L for Acartia clausi, followed by TCS (14.6 µg L for I. galbana, 149.8 µg L for M. galloprovincialis, 129.9 µg L for P. lividus, and 64.8 µg L for A. clausi). For all species tested, BPA was the less toxic chemical, with toxicity thresholds ranging between 400 and 1200 µg L except for A. clausi nauplii (186 µg L ). The relatively narrow range of variation in toxicity considering the broad physiological differences among the biological models used point at non-selective mechanisms of toxicity for these aromatic organics. Microalgae, the main primary producers in pelagic ecosystems, showed particularly high susceptibility to the chemicals tested. When the toxicity thresholds experimentally obtained were compared to the maximum environmental concentrations reported in coastal waters, the risk quotients obtained correspond to very low or low risk for BPA and TCS, and from low to high for 4-NP.
[Mh] Termos MeSH primário: Organismos Aquáticos/fisiologia
Compostos Benzidrílicos/toxicidade
Fenóis/toxicidade
Triclosan/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Copépodes
Ecotoxicologia
Monitoramento Ambiental
Haptófitas
Mytilus/efeitos dos fármacos
Paracentrotus
Plásticos
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Phenols); 0 (Plastics); 0 (Water Pollutants, Chemical); 4NM5039Y5X (Triclosan); I03GBV4WEL (4-nonylphenol); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  6 / 1908 MEDLINE  
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[PMID]:28958726
[Au] Autor:Pusceddu FH; Choueri RB; Pereira CDS; Cortez FS; Santos DRA; Moreno BB; Santos AR; Rogero JR; Cesar A
[Ad] Endereço:Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares, Universidade de São Paulo, São Paulo, SP, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, Santos, SP, Brazil. Electronic address: fabiohp@unisanta.br.
[Ti] Título:Environmental risk assessment of triclosan and ibuprofen in marine sediments using individual and sub-individual endpoints.
[So] Source:Environ Pollut;232:274-283, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The guidelines for the Environmental Risk Assessment (ERA) of pharmaceuticals and personal care products (PPCP) recommend the use of standard ecotoxicity assays and the assessment of endpoints at the individual level to evaluate potential effects of PPCP on biota. However, effects at the sub-individual level can also affect the ecological fitness of marine organisms chronically exposed to PPCP. The aim of the current study was to evaluate the environmental risk of two PPCP in marine sediments: triclosan (TCS) and ibuprofen (IBU), using sub-individual and developmental endpoints. The environmental levels of TCS and IBU were quantified in marine sediments from the vicinities of the Santos submarine sewage outfall (Santos Bay, São Paulo, Brazil) at 15.14 and 49.0 ng g , respectively. A battery (n = 3) of chronic bioassays (embryo-larval development) with a sea urchin (Lytechinus variegatus) and a bivalve (Perna perna) were performed using two exposure conditions: sediment-water interface and elutriates. Moreover, physiological stress through the Neutral Red Retention Time Assay (NRRT) was assessed in the estuarine bivalve Mytella charruana exposed to TCS and IBU spiked sediments. These compounds affected the development of L. variegatus and P. perna (75 ng g for TCS and 15 ng g for IBU), and caused a significant decrease in M. charruana lysosomal membrane stability at environmentally relevant concentrations (0.08 ng g for TCS and 0.15 ng g for IBU). Chemical and ecotoxicological data were integrated and the risk quotient estimated for TCS and IBU were higher than 1.0, indicating a high environmental risk of these compounds in sediments. These are the first data of sediment risk assessment of pharmaceuticals and personal care products of Latin America. In addition, the results suggest that the ERA based only on individual-level and standard toxicity tests may overlook other biological effects that can affect the health of marine organisms exposed to PPCP.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Sedimentos Geológicos/química
Ibuprofeno/análise
Triclosan/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos
Brasil
Ecotoxicologia
Perna (Organismo)
Medição de Risco
Esgotos
Testes de Toxicidade/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sewage); 0 (Water Pollutants, Chemical); 4NM5039Y5X (Triclosan); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


  7 / 1908 MEDLINE  
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[PMID]:28453253
[Au] Autor:Crump D; Williams KL; Chiu S; Zhang Y; Martin JW
[Ad] Endereço:Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University , Ottawa, Ontario K1A 0H3, Canada.
[Ti] Título:Athabasca Oil Sands Petcoke Extract Elicits Biochemical and Transcriptomic Effects in Avian Hepatocytes.
[So] Source:Environ Sci Technol;51(10):5783-5792, 2017 May 16.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Petroleum coke or "petcoke" is a granular carbonaceous material produced during the upgrading of heavy crude oils, including bitumen. Petcoke dust was recently reported as an environmental contaminant in the Athabasca oil sands region, but the ecotoxicological hazards posed by this complex bitumen-derived material-including those to avian species-have not been characterized. In this study, solvent extracts (x) of delayed and fluid petcoke (xDP and xFP) were prepared and dissolved in dimethyl sulfoxide. A water-accommodated fraction of delayed petcoke (waDP) was also prepared. Graded concentrations of xDP, xFP, and waDP were administered to chicken and double-crested cormorant hepatocytes to determine effects on 7-ethoxyresorufin-O-deethylase (EROD) activity, porphyrin accumulation, and mRNA expression. Polycyclic aromatic compounds (PACs) were characterized, and xDP, xFP, and waDP had total PAC concentrations of 93 000, 270, and 5.3 ng/mL. The rank order of biochemical and transcriptomic responses was xDP > xFP > waDP (e.g., EROD EC were lower for xDP compared to xFP and waDP). A total of 22, 18, and 4 genes were altered following exposure to the highest concentrations of xDP, xFP, and waDP, respectively, using a chicken PCR array comprising 27 AhR-related genes. To provide more exhaustive coverage of potential toxicity pathways being impacted, two avian ToxChip PCR arrays-chicken and double-crested cormorant-were utilized, and xDP altered the expression of more genes than xFP. Traditional PAC-related toxicity pathways and novel mechanisms of action were identified in two avian species following petcoke extract exposure. Extrapolation to real-world exposure scenarios must consider the bioavailability of the extracted PACs compared to those in exposed organisms.
[Mh] Termos MeSH primário: Aves
Coque/toxicidade
Perfilação da Expressão Gênica
Campos de Petróleo e Gás
Petróleo/toxicidade
[Mh] Termos MeSH secundário: Animais
Citocromo P-450 CYP1A1/efeitos dos fármacos
Citocromo P-450 CYP1A1/metabolismo
Ecotoxicologia
Hepatócitos/efeitos dos fármacos
Hepatócitos/metabolismo
Poluição por Petróleo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coke); 0 (Petroleum); EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b00767


  8 / 1908 MEDLINE  
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[PMID]:28799017
[Au] Autor:Archana G; Dhodapkar R; Kumar A
[Ad] Endereço:Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440010, India.
[Ti] Título:Ecotoxicological risk assessment and seasonal variation of some pharmaceuticals and personal care products in the sewage treatment plant and surface water bodies (lakes).
[So] Source:Environ Monit Assess;189(9):446, 2017 Aug 10.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper reports the seasonal variation and environmental quality control data for five fingerprint pharmaceuticals and personal care products (PPCPs) (acetaminophen ciprofloxacin, caffeine, irgasan and benzophenone) in the influent and the effluent of the sewage treatment plant (STP) and surface water bodies (six major lakes) in and around Nagpur, one of the "A class city" in the central India over a period of 1 year. The target compounds were analysed using developed offline solid-phase extraction (SPE) coupled with reversed phase high-performance liquid chromatography (RP-HPLC-PDA) method. All the five PPCPs were found in the influent, whereas four were found in the effluent of the STP. However, in the surface water bodies, three PPCPs were detected in all the seasons. Above PPCPs were present in the concentration range of 1-174 µg L in the surface water bodies, 12-373 µg L in the influent and 11-233 µg L in the effluent of the STP. Amongst the five PPCPs, caffeine was found to be in higher concentration as compared to others. The seasonal trends indicate higher concentrations of PPCPs in summer season and lowest in the rainy season. Additionally, physico-chemical characterisations (inorganic and organic parameters) of the collected samples were performed to access the anthropogenic pollution. Ecotoxicological risk assessment was done to appraise the degree of toxicity of the targeted compounds. Hazard quotient (HQ) values were found to be < 1 indicating no adverse effect on the targeted organism.
[Mh] Termos MeSH primário: Cosméticos/análise
Monitoramento Ambiental
Lagos/química
Preparações Farmacêuticas/análise
Eliminação de Resíduos Líquidos
Águas Residuais/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Benzofenonas
Carbanilidas
Cromatografia de Fase Reversa
Cidades
Ecotoxicologia
Índia
Medição de Risco
Estações do Ano
Esgotos/análise
Extração em Fase Sólida
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzophenones); 0 (Carbanilides); 0 (Cosmetics); 0 (Pharmaceutical Preparations); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical); 701M4TTV9O (benzophenone); I5ZZY3DC5G (cloflucarban)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6148-3


  9 / 1908 MEDLINE  
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[PMID]:28661217
[Au] Autor:Boyes WK; Thornton BLM; Al-Abed SR; Andersen CP; Bouchard DC; Burgess RM; Hubal EAC; Ho KT; Hughes MF; Kitchin K; Reichman JR; Rogers KR; Ross JA; Rygiewicz PT; Scheckel KG; Thai SF; Zepp RG; Zucker RM
[Ad] Endereço:a National Health and Environmental Effects Research Laboratory, Office of Research and Development , U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.
[Ti] Título:A comprehensive framework for evaluating the environmental health and safety implications of engineered nanomaterials.
[So] Source:Crit Rev Toxicol;47(9):767-810, 2017 Oct.
[Is] ISSN:1547-6898
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Engineered nanomaterials (ENM) are a growing aspect of the global economy, and their safe and sustainable development, use, and eventual disposal requires the capability to forecast and avoid potential problems. This review provides a framework to evaluate the health and safety implications of ENM releases into the environment, including purposeful releases such as for antimicrobial sprays or nano-enabled pesticides, and inadvertent releases as a consequence of other intended applications. Considerations encompass product life cycles, environmental media, exposed populations, and possible adverse outcomes. This framework is presented as a series of compartmental flow diagrams that serve as a basis to help derive future quantitative predictive models, guide research, and support development of tools for making risk-based decisions. After use, ENM are not expected to remain in their original form due to reactivity and/or propensity for hetero-agglomeration in environmental media. Therefore, emphasis is placed on characterizing ENM as they occur in environmental or biological matrices. In addition, predicting the activity of ENM in the environment is difficult due to the multiple dynamic interactions between the physical/chemical aspects of ENM and similarly complex environmental conditions. Others have proposed the use of simple predictive functional assays as an intermediate step to address the challenge of using physical/chemical properties to predict environmental fate and behavior of ENM. The nodes and interactions of the framework presented here reflect phase transitions that could be targets for development of such assays to estimate kinetic reaction rates and simplify model predictions. Application, refinement, and demonstration of this framework, along with an associated knowledgebase that includes targeted functional assay data, will allow better de novo predictions of potential exposures and adverse outcomes.
[Mh] Termos MeSH primário: Ecotoxicologia/métodos
Saúde Ambiental
Poluentes Ambientais/toxicidade
Nanoestruturas/toxicidade
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Teóricos
Medição de Risco
Segurança
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Environmental Pollutants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1080/10408444.2017.1328400


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[PMID]:28646766
[Au] Autor:Karami A
[Ad] Endereço:Laboratory of Aquatic Toxicology, Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Selangor, Malaysia. Electronic address: alikaramiv@gmail.com.
[Ti] Título:Gaps in aquatic toxicological studies of microplastics.
[So] Source:Chemosphere;184:841-848, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The contamination of aquatic environments with microplastics (MPs) has spurred an unprecedented interest among scientific communities to investigate their impacts on biota. Despite the rapid growth in the number of studies on the aquatic toxicology of MPs, controversy over the fate and biological impacts of MPs is increasingly growing mainly due to the absence of standardized laboratory bioassays. Given the complex features of MPs, such as the diversity of constituent polymers, additives, shapes and sizes, as well as continuous changes in the particle buoyancy as a result of fouling and defouling processes, it is necessary to modify conventional bioassay protocols before employing them for MP toxicity testings. Moreover, several considerations including quantification of chemicals on/in the MP particles, choice of test organisms, approaches for renewing the test solution, aggregation prevention, stock solution preparation, and units used to report MP concentration in the test solution should be taken into account. This critical review suggests some important strategies to help conduct environmentally-relevant MP bioassays.
[Mh] Termos MeSH primário: Ecotoxicologia
Plásticos/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Biota
Plásticos/química
Plásticos/toxicidade
Testes de Toxicidade
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plastics); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE



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