Base de dados : MEDLINE
Pesquisa : H01.158.273.343.249 [Categoria DeCS]
Referências encontradas : 2669 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 267 ir para página                         

  1 / 2669 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28745446
[Au] Autor:Chartier KG; Hesselbrock MN; Hesselbrock VM
[Ad] Endereço:School of Social Work, Virginia Commonwealth University, Richmond, Virginia.
[Ti] Título:Conclusion: Special issue on genetic and alcohol use disorder research with diverse racial/ethnic groups: Key findings and potential next steps.
[So] Source:Am J Addict;26(5):532-537, 2017 Aug.
[Is] ISSN:1521-0391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: This special issue brings together papers focusing on a wide range of topics relevant to the research and understanding of the role of race/ethnicity and genetic variation for the susceptibility of developing an alcohol use disorder (AUD). METHODS: The key findings from the issue's 10 articles are reviewed and organized here around three topics: I: addictive behaviors and potential environmental influences; II: a focus on four racial/ethnic groups; and III: special methodologies. RESULTS: Several potential next steps in improving effective research strategies are highlighted: (1) implementing best practices for outreach and community engagement may reduce reluctance to participate; (2) recruiting adequately sized and racially/ethnically diverse samples will require new collaborations with investigators who successfully work in diverse communities; (3) identifying and assessing environmental influences that are both unique to, and common among, racial/ethnic groups may inform preventions for AUD; (4) use of standardized measures will facilitate the generation of larger samples and meta-analysis of research findings; and (5) use of better analytic approaches and experimental methods will improve replication in gene finding research and help advance new areas of research. CONCLUSIONS: Genetic research of AUD in diverse racial/ethnic populations is advancing. The articles in this issue examined the general theme of including diverse population groups in genetic studies and offered potential strategies for addressing some common problems. SCIENTIFIC SIGNIFICANCE: Greater inclusion of diverse racial/ethnic populations in this research is important to ensure that the benefits of new knowledge and technology are equally shared. (Am J Addict 2017;26:532-537).
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Álcool/genética
Transtornos Relacionados ao Uso de Álcool/psicologia
Previsões
[Mh] Termos MeSH secundário: Grupos Étnicos
Pesquisa em Genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/ajad.12585


  2 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29191896
[Au] Autor:Emerson C; James S; Littler K; Randazzo FF
[Ad] Endereço:Institute on Ethics and Policy for Innovation, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
[Ti] Título:Principles for gene drive research.
[So] Source:Science;358(6367):1135-1136, 2017 12 01.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Tecnologia de Impulso Genético/ética
Tecnologia de Impulso Genético/normas
Pesquisa em Genética/ética
Guias como Assunto
[Mh] Termos MeSH secundário: Controle de Doenças Transmissíveis/métodos
Seres Humanos
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1126/science.aap9026


  3 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29178651
[Au] Autor:Laurino MY; Truitt AR; Tenney L; Fisher D; Lindor NM; Veenstra D; Jarvik GP; Newcomb PA; Fullerton SM
[Ad] Endereço:Cancer Prevention Program, Seattle Cancer Care Alliance, Seattle, Washington, USA.
[Ti] Título:Clinical verification of genetic results returned to research participants: findings from a Colon Cancer Family Registry.
[So] Source:Mol Genet Genomic Med;5(6):700-708, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The extent to which participants act to clinically verify research results is largely unknown. This study examined whether participants who received Lynch syndrome (LS)-related findings pursued researchers' recommendation to clinically verify results with testing performed by a CLIA-certified laboratory. METHODS: The Fred Hutchinson Cancer Research Center site of the multinational Colon Cancer Family Registry offered non-CLIA individual genetic research results to select registry participants (cases and their enrolled relatives) from 2011 to 2013. Participants who elected to receive results were counseled on the importance of verifying results at a CLIA-certified laboratory. Twenty-six (76.5%) of the 34 participants who received genetic results completed 2- and 12-month postdisclosure surveys; 42.3% of these (11/26) participated in a semistructured follow-up interview. RESULTS: Within 12 months of result disclosure, only 4 (15.4%) of 26 participants reported having verified their results in a CLIA-certified laboratory; of these four cases, all research and clinical results were concordant. Reasons for pursuing clinical verification included acting on the recommendation of the research team and informing future clinical care. Those who did not verify results cited lack of insurance coverage and limited perceived personal benefit of clinical verification as reasons for inaction. CONCLUSION: These findings suggest researchers will need to address barriers to seeking clinical verification in order to ensure that the intended benefits of returning genetic research results are realized.
[Mh] Termos MeSH primário: Neoplasias Colorretais Hereditárias sem Polipose/diagnóstico
Testes Genéticos
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias Colorretais Hereditárias sem Polipose/genética
Neoplasias Colorretais Hereditárias sem Polipose/psicologia
Proteínas de Ligação a DNA/genética
Família
Feminino
Pesquisa em Genética
Testes Genéticos/normas
Seres Humanos
Cobertura do Seguro
Laboratórios/normas
Masculino
Meia-Idade
Endonuclease PMS2 de Reparo de Erro de Pareamento/genética
Proteína 1 Homóloga a MutL/genética
Proteína 2 Homóloga a MutS/genética
Sistema de Registros
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (MLH1 protein, human); 0 (Msh6 protein, mouse); EC 3.6.1.- (PMS2 protein, human); EC 3.6.1.3 (MSH2 protein, human); EC 3.6.1.3 (Mismatch Repair Endonuclease PMS2); EC 3.6.1.3 (MutL Protein Homolog 1); EC 3.6.1.3 (MutS Homolog 2 Protein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.328


  4 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28457162
[Au] Autor:Richmond-Rakerd LS; Belsky DW
[Ad] Endereço:From the Department of Psychological Sciences, University of Missouri, Columbia, M.O.; and the Department of Medicine, Duke University School of Medicine, the Center for the Study of Aging and Human Development, Duke University, and Duke University Population Research Institute, Durham, N.C.
[Ti] Título:Swedish Register Analysis of Divorce and Alcohol Use Disorder Highlights Social Relationships as a Target for Preventive Psychiatry and Genetic Research.
[So] Source:Am J Psychiatry;174(5):411-413, 2017 05 01.
[Is] ISSN:1535-7228
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Divórcio
Psiquiatria Preventiva
[Mh] Termos MeSH secundário: Alcoolismo
Pesquisa em Genética
Seres Humanos
Suécia
[Pt] Tipo de publicação:EDITORIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1176/appi.ajp.2017.17020170


  5 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28777832
[Au] Autor:Grammaticos PC; Antoniou DE
[Ad] Endereço:Hermou 51 str., P.C 54623, Thessaloniki, Makedonia, Greece. fgrammat@auth.gr.
[Ti] Título:Endless research II. The genomic era. Neohippocratic Medicine.
[So] Source:Hell J Nucl Med;20(2):107-109, 2017 May-Aug.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The great progress of genetics research, during 2015-2017, will certainly influence all medical specialties including nuclear medicine. In nuclear medicine there are still problems to solve as to differentiate between infection, inflammation and cancer etc. Furthermore, in dosimetry and radiation protection there are worldwide problems. It has been reported that Cu-cetuximab immune-PET represented EGFR expression levels in ESCC tumors and that Lu-cetuximab radioimmunotherapy effectively inhibited the tumor growth. Recent important research findings and few related suggestions for further research are mentioned related to Gastroenterology, Neohippocratic Medicine, the Respiratory System, Neurology and the Hayflick phenomenon. Perhaps we now live in the genetics transformation era, the Genomie's Era.
[Mh] Termos MeSH primário: Pesquisa em Genética
Neoplasias/genética
Neoplasias/radioterapia
Medicina Nuclear/tendências
Medicina de Precisão/tendências
Radioimunoterapia/tendências
[Mh] Termos MeSH secundário: Medicina Baseada em Evidências
Juramento Hipocrático
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  6 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28686700
[Au] Autor:Zereyesus YA; Dalton TJ
[Ad] Endereço:Department of Agricultural Economics, Kansas State University, Manhattan, Kansas, United States of America.
[Ti] Título:Rates of return to sorghum and millet research investments: A meta-analysis.
[So] Source:PLoS One;12(7):e0180414, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sorghum and millet grow in some of the most heterogeneous and austere agroecologies around the world. These crops are amongst the top five cereal sources of food and feed. Yet, few studies document the impact of sorghum and millet genetic enhancement. The Internal Rate of Return (ROR) is one of the most popular metrics used to measure the economic return on investment on agricultural research and development (R&D). This study conducted a meta-analysis of 59 sorghum and millet ROR estimates obtained from 25 sources published between 1958 and 2015. The average rate of return to sorghum and millet R&D investment is between 54-76 percent per year. All studies computed social rather than private RORs because the technologies were developed using public funds originating from host country National Agricultural Research Systems (NARS) and international organizations such as the INTSORMIL CRSP, ICRISAT and others. Nearly three quarter of the studies focused only on sorghum (72 percent) and around one tenth of the studies (8 percent) on millet. Regression models analyzed the determinants of variation in the reported RORs. Results show that ex-ante type and self-evaluated type of analyses are positively and significantly associated with the ROR estimates. Compared to estimates conducted by a university, results from international institutions and other mixed organizations provided significantly smaller estimates. Estimates conducted at national level also are significantly lower than those conducted at sub-national levels. The ROR is higher for studies conducted in the United States and for those conducted more recently. The study also reconstructed modified internal rate of return (MIRR) for a sub-sample of the reported RORs following recent methods from the literature. These results show that the MIRR estimates are significantly smaller than the reported ROR estimates. Both results indicate that investment in sorghum and millet research generates high social rates of return.
[Mh] Termos MeSH primário: Análise Custo-Benefício
Produtos Agrícolas/economia
Pesquisa em Genética/economia
Milhetes/genética
Melhoramento Vegetal/economia
Sorghum/genética
[Mh] Termos MeSH secundário: Grãos Comestíveis/economia
Grãos Comestíveis/genética
Grãos Comestíveis/crescimento & desenvolvimento
Seres Humanos
Investimentos em Saúde/estatística & dados numéricos
Milhetes/crescimento & desenvolvimento
Análise de Regressão
Sorghum/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180414


  7 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28630366
[Au] Autor:Cooper-Jones B; Verstraten K
[Ad] Endereço:Vancouver, British Columbia.
[Ti] Título:A game-changer for hereditary cancer patients.
[So] Source:CMAJ;189(24):E843-E844, 2017 06 19.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Pesquisa em Genética
Síndrome de Li-Fraumeni/genética
[Mh] Termos MeSH secundário: Feminino
Genes p53/genética
Genética Médica
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.1095411


  8 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28421887
[Au] Autor:Christensen KD; Savage SK; Huntington NL; Weitzman ER; Ziniel SI; Bacon PL; Cacioppo CN; Green RC; Holm IA
[Ad] Endereço:1 Brigham and Women's Hospital, Boston, MA, USA.
[Ti] Título:Preferences for the Return of Individual Results From Research on Pediatric Biobank Samples.
[So] Source:J Empir Res Hum Res Ethics;12(2):97-106, 2017 Apr.
[Is] ISSN:1556-2654
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Discussions about disclosing individual genetic research results include calls to consider participants' preferences. In this study, parents of Boston Children's Hospital patients set preferences for disclosure based on disease preventability and severity, and could exclude mental health, developmental, childhood degenerative, and adult-onset disorders. Participants reviewed hypothetical reports and reset preferences, if desired. Among 661 participants who initially wanted all results (64%), 1% reset preferences. Among 336 participants who initially excluded at least one category (36%), 38% reset preferences. Participants who reset preferences added 0.9 categories, on average; and their mean satisfaction on 0 to 10 scales increased from 4.7 to 7.2 ( p < .001). Only 2% reduced the number of categories they wanted disclosed. Findings demonstrate the benefits of providing examples of preference options and the tendency of participants to want results disclosed. Findings also suggest that preference-setting models that do not provide specific examples of results could underestimate participants' desires for information.
[Mh] Termos MeSH primário: Bancos de Espécimes Biológicos
Compreensão
Revelação
Pesquisa em Genética
Testes Genéticos
Pais/psicologia
Preferência do Paciente/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Predisposição Genética para Doença
Genômica
Hospitais
Seres Humanos
Masculino
Massachusetts
Meia-Idade
Satisfação do Paciente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1177/1556264617697839


  9 / 2669 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28399922
[Au] Autor:Hurlimann T; Jaitovich Groisman I; Godard B
[Ad] Endereço:Institut de recherche en santé publique (IRSPUM), Omics-Ethics Research Group, University of Montreal, PO Box 6128, Station Centre-ville, Montreal, QC, H3C 3 J7, Canada.
[Ti] Título:The elusive ideal of inclusiveness: lessons from a worldwide survey of neurologists on the ethical issues raised by whole-genome sequencing.
[So] Source:BMC Med Ethics;18(1):28, 2017 Apr 11.
[Is] ISSN:1472-6939
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The anticipation of ethical issues that may arise with the clinical use of genomic technologies is crucial to envision their future implementation in a manner sensitive to local contexts. Yet, populations in low- and middle-income countries are underrepresented in studies that aim to explore stakeholders' perspectives on the use of such technologies. Within the framework of a research project entitled "Personalized medicine in the treatment of epilepsy", we sought to increase inclusiveness by widening the reach of our survey, inviting neurologists from around the world to share their views and practices regarding the use of whole-genome sequencing in clinical neurology and its associated ethics. We discuss herein the compelling scientific and ethical reasons that led us to attempt to recruit neurologists worldwide, despite the lack, in many low- or middle-income countries, of access to genomic technologies. Recruitment procedures and their results are presented and discussed, as well as the barriers we faced. We conclude that inclusive recruitment remains a challenging, albeit necessary and legitimate, endeavour.
[Mh] Termos MeSH primário: Atitude do Pessoal de Saúde
Países em Desenvolvimento
Pesquisa em Genética/ética
Genômica
Neurologistas
Análise de Sequência de DNA
Justiça Social
[Mh] Termos MeSH secundário: Temas Bioéticos
Tecnologia Biomédica
Assistência à Saúde
Epilepsia/genética
Ética em Pesquisa
Seres Humanos
Medicina de Precisão/ética
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1186/s12910-017-0187-8


  10 / 2669 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28220724
[Au] Autor:Miller VA; Werner-Lin A; Walser SA; Biswas S; Bernhardt BA
[Ad] Endereço:1 The Children's Hospital of Philadelphia, PA, USA.
[Ti] Título:An Observational Study of Children's Involvement in Informed Consent for Exome Sequencing Research.
[So] Source:J Empir Res Hum Res Ethics;12(1):6-13, 2017 Feb.
[Is] ISSN:1556-2654
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to examine children's involvement in consent sessions for exome sequencing research and associations of involvement with provider and parent communication. Participants included 44 children (8-17 years) from five cohorts who were offered participation in an exome sequencing study. The consent sessions were audiotaped, transcribed, and coded. Providers attempted to facilitate the child's involvement in the majority (73%) of sessions, and most (75%) children also verbally participated. Provider facilitation was strongly associated with likelihood of child participation. These findings underscore that strategies such as asking for children's opinions and soliciting their questions show respect for children and may increase the likelihood that they are engaged and involved in decisions about research participation.
[Mh] Termos MeSH primário: Tomada de Decisões
Exoma
Pesquisa em Genética
Consentimento Informado por Menores
Participação do Paciente
Análise de Sequência de DNA
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Comunicação
Feminino
Pessoal de Saúde
Seres Humanos
Consentimento Livre e Esclarecido
Masculino
Pais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1177/1556264616674096



página 1 de 267 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde