Base de dados : MEDLINE
Pesquisa : H01.158.273.343.335 [Categoria DeCS]
Referências encontradas : 30305 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 3031 ir para página                         

  1 / 30305 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29202706
[Au] Autor:Li J; Zeng W; Zhang Y; Ko AM; Li C; Zhu H; Fu Q; Zhou H
[Ad] Endereço:College of Life Science, Jilin University, Changchun, 130023, People's Republic of China.
[Ti] Título:Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese.
[So] Source:BMC Evol Biol;17(1):239, 2017 Dec 04.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese has been proposed, there is no evidence to support this view. Here we analyzed the human remains from an early Di-Qiang site (Mogou site dated ~4000 years old) and compared them to other ancient DNA across China, including an early Han-related site (Hengbei site dated ~3000 years old) to establish the underlying genetic relationship between the Di-Qiang and ancestors of Han Chinese. RESULTS: We found Mogou mtDNA haplogroups were highly diverse, comprising 14 haplogroups: A, B, C, D (D*, D4, D5), F, G, M7, M8, M10, M13, M25, N*, N9a, and Z. In contrast, Mogou males were all Y-DNA haplogroup O3a2/P201; specifically one male was further assigned to O3a2c1a/M117 using targeted unique regions on the non-recombining region of the Y-chromosome. We compared Mogou to 7 other ancient and 38 modern Chinese groups, in a total of 1793 individuals, and found that Mogou shared close genetic distances with Taojiazhai (a more recent Di-Qiang population), Hengbei, and Northern Han. We modeled their interactions using Approximate Bayesian Computation, and support was given to a potential admixture of ~13-18% between the Mogou and Northern Han around 3300-3800 years ago. CONCLUSIONS: Mogou harbors the earliest genetically identifiable Di-Qiang, ancestral to the Taojiazhai, and up to ~33% paternal and ~70% of its maternal haplogroups could be found in present-day Northern Han Chinese.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
DNA Antigo
Grupos Étnicos/genética
[Mh] Termos MeSH secundário: Teorema de Bayes
China
Cromossomos Humanos Y/genética
Simulação por Computador
DNA Mitocondrial/genética
Genética Populacional
Geografia
Haplótipos/genética
Seres Humanos
Masculino
Modelos Genéticos
Filogenia
Polimorfismo de Nucleotídeo Único/genética
Análise de Componente Principal
Probabilidade
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ancient); 0 (DNA, Mitochondrial)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-017-1082-0


  2 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29231017
[Au] Autor:Wang YL; Sheng X; Li M; Chen YL; Lin Y; Chen LQ
[Ad] Endereço:Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China.
[Ti] Título:[Forensic Application of HuaxiaTM Platinum Kit].
[So] Source:Fa Yi Xue Za Zhi;33(2):129-135, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To investigate the genetic polymorphism of 23 autosomal STR loci of Huaxia™ Platinum kit in Chinese Han population, and to evaluate the forensic efficiency of Huaxia™ Platinum kit. METHODS: A total of 500 unrelated healthy individuals from Han population were genotyped with Huaxia™ Platinum kit. The frequency distribution and the parameter of population genetics of STR loci were analysed statistically. Huaxia™ Platinum kit was compared with other 7 commercial STR kits commonly seen at home and abroad in the number of STR loci, interior label, fluorescent mark, total number of alleles in Ladder and system effectiveness. RESULTS: All the 23 autosomal STR loci were consistent with Hardy-Weinberg equilibrium ( >0.05). The discrimination power was 0.791 5-0.986 2. The polymorphism information content (PIC) was 0.559 0-0.914 0. The combined discrimination power (CDP) was 1-4.1×10⁻²8, while combined probability of paternity exclusion in trio (CPET) and in duo (CPED) were 1-4.1×10⁻¹° and 1-8.4×10⁻7, respectively. Compared with other 7 kits, Huaxia™ Platinum kit contained the most number of alleles within the Ladder. CONCLUSIONS: All the 23 autosomal STR loci of Huaxia™ Platinum kit with highly polymorphic in Han population can be used for paternity testing and individual identification. Compared with other 7 kits, it appears that Huaxia™ Platinum kit can provide more genetic information.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Genética Forense/métodos
Genética Populacional
Paternidade
Platina
Polimorfismo Genético
[Mh] Termos MeSH secundário: Alelos
Grupo com Ancestrais do Continente Asiático/etnologia
China
Frequência do Gene
Genótipo
Seres Humanos
Repetições de Microssatélites
Probabilidade
Kit de Reagentes para Diagnóstico
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reagent Kits, Diagnostic); 49DFR088MY (Platinum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.005


  3 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29205967
[Au] Autor:Liu YJ; Guo LH; Yue JT; Shi MS
[Ad] Endereço:Institute of Criminal Science and Technology, Xuchang Public Security Bureau, Xuchang 461000, China.
[Ti] Título:[Forensic Application of 16 X-STR Loci in Henan Han Population].
[So] Source:Fa Yi Xue Za Zhi;32(6):420-423, 2016 Dec.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To investigate the genetic data of 16 X-STR loci in Henan Han population and to assess the application value in forensic science. METHODS: The DNA of 326 unrelated individuals in Henan Han population were amplified using Golden ye™ DNA identification system 17X kit, and the PCR products were analyzed by electrophoresis through 3130xl genetic analyzer. The fragment sizes of alleles were analyzed subsequently by GeneMapper® ID-X. Allele frequencies and population genetics parameters of 16 X-STR loci were analyzed statistically and compared with the available data of other Han populations from different regions. RESULTS: Among the 16 X-STR loci, were found to be moderately polymorphic and the other 15 X-STR loci were highly polymorphic. The cumulative discrimination power in females and males were 0.999 999 999 999 992 and 0.999 999 996 577 712, respectively. The combined power of exclusion in trios and in duos were 0.999 999 971 and 0.999 992 574, respectively. CONCLUSIONS: The 16 X-STR loci meet the application requires of forensic genetics, especially for testing the special paternity cases.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Genética Forense
Repetições de Microssatélites
[Mh] Termos MeSH secundário: Alelos
China
DNA/análise
Feminino
Ciências Forenses
Frequência do Gene
Genética Populacional
Seres Humanos
Masculino
Reação em Cadeia da Polimerase
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.06.006


  4 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29205006
[Au] Autor:Zou Y; Guo JJ; Li QP; Zuo DH; Liu JS; Guo YD; Yan J; Zha L; Cai JF; Lan LM
[Ad] Endereço:Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, China.
[Ti] Título:Genetic Polymorphisms of 21 STR Loci in Hunan Province-based Han Population.
[So] Source:Fa Yi Xue Za Zhi;32(5):356-362, 2016 Oct.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To investigate the genetic polymorphisms of 21 short tandem repeat (STR) loci ( , , , , , , , , , , , , , , , , , , , and ). METHODS: A total of 560 blood samples were collected from unrelated healthy individuals of Han population in Hunan Province. Chelex-100 extraction method was applied to the extraction of genomic DNA, and an AGCU EX22 Kit and 9700 STR amplification was used in amplification reactions. The products were separated and analyzed on 310 Genetic Analyzer. RESULTS: A total of 248 alleles were observed, the allelic frequencies ranging from 0.001 to 0.518. Observation of genotype distributions for each locus showed no deviations from Hardy-Weinberg equilibrium except ( =0.023). The combined power of discrimination, combined power of exclusion, and combined matching probability of the 21 STR loci were approximately 0.999 999 999 999 999 999 999 999 8, 0.999 999 998, and 1.36×10⁻²5, respectively. CONCLUSIONS: The 21 STR loci show high polymorphisms in the Han population, which can provide valuable data and a theoretical basis for forensic individual identification and paternity testing.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Genética Populacional
Repetições de Microssatélites
Polimorfismo Genético
[Mh] Termos MeSH secundário: Alelos
China
Impressões Digitais de DNA
Frequência do Gene
Testes Genéticos
Genótipo
Seres Humanos
Reação em Cadeia da Polimerase
Probabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.05.010


  5 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29188666
[Au] Autor:He WZ; Ma XY; Xian JJ; Yuan TL; Li SY; Li SL; Liu HB; Li Q
[Ad] Endereço:Key Laboratory for Major Obstetric Diseases of Guangdong Province, Forensic Identification Institute of the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
[Ti] Título:[Genetic Polymorphisms of SNP Located in the 5' Region of VEGF Gene in Han Population in Guangdong].
[So] Source:Fa Yi Xue Za Zhi;32(4):257-260, 2016 Aug.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To investigate the genetic polymorphism of SNP located in the 5' region of the vascular endothelial growth factor (VEGF) gene in Han population in Guangdong and provide basic data for forensic application and population genetics research. METHODS: The genetic polymorphisms of 4 SNP loci (rs699947, rs1570360, rs833061, rs2010963) within 5' region of VEGF gene of 184 unrelated individuals in Han population in Guangdong were analyzed by DNA micro sequencing technology SNaPshot. The statistical analysis was carried out by PowerMarker v3.25 software. RESULTS: The genotype distributions of the 4 SNP loci within 5' region of VEGF gene of 184 unrelated individuals in Han population in Guangdong were in accordance with Hardy-Weinberg equilibrium ( >0.05) and 3 kinds of genotypes were detected from each loci. There was high linkage disequilibrium between the rs833061 and rs699947 SNP loci. Six haplotypes were observed, while the frequency of C-G-T-C, C-G-T-G, A-A-C-G and A-G-C-G were more than 10%, which were the main haplotypes. The discrimination probabilities (DP) of rs699947, rs833061, and rs2010963 loci were between 0.583 and 0.634, with the power of exclusion (PE) between 0.133 and 0.144. The DP and PE of haplotypes of 4 SNP were 0.868 and 0.438, respectively. CONCLUSIONS: There are great polymorphisms in the 5' region of VEGF gene in Han population in Guangdong, which could be used as genetic indexes for individual identification and paternity testing, as well as association analysis of the related diseases.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Polimorfismo de Nucleotídeo Único
Fator A de Crescimento do Endotélio Vascular/genética
[Mh] Termos MeSH secundário: China
Genética Populacional
Genótipo
Haplótipos
Seres Humanos
Desequilíbrio de Ligação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.04.005


  6 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28453670
[Au] Autor:Adams RH; Schield DR; Card DC; Blackmon H; Castoe TA
[Ad] Endereço:Department of Biology, The University of Texas at Arlington, Arlington, TX 76019, USA.
[Ti] Título:GppFst: genomic posterior predictive simulations of FST and dXY for identifying outlier loci from population genomic data.
[So] Source:Bioinformatics;33(9):1414-1415, 2017 May 01.
[Is] ISSN:1367-4811
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Summary: We introduce GppFst, an open source R package that generates posterior predictive distributions of FST and dx under a neutral coalescent model to identify putative targets of selection from genomic data. Availability and Implementation: GppFst is available at ( https://github.com/radamsRHA/GppFst ). Contact: todd.castoe@uta.edu. Supplementary information: Supplementary data are available at Bioinformatics online.
[Mh] Termos MeSH primário: Loci Gênicos
Genética Populacional/métodos
Modelos Genéticos
Polimorfismo de Nucleotídeo Único
Software
[Mh] Termos MeSH secundário: Algoritmos
Animais
Crotalus/genética
Genoma
Genômica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/bioinformatics/btw795


  7 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28453671
[Au] Autor:Krukov I; de Sanctis B; de Koning APJ
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
[Ti] Título:Wright-Fisher exact solver (WFES): scalable analysis of population genetic models without simulation or diffusion theory.
[So] Source:Bioinformatics;33(9):1416-1417, 2017 May 01.
[Is] ISSN:1367-4811
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Motivation: The simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. General computational approaches that do not require the assumptions of classical theory are therefore quite desirable. One such general approach is provided by the theory of absorbing Markov chains, which can be used to obtain exact results by directly analyzing population genetic Markov models, such as the classic bi-allelic Wright-Fisher model. Although these approaches are sometimes used, they are usually forgone in favor of simulation methods, due to the perception that they are too computationally burdensome. Here we show that, surprisingly, direct analysis of virtually any Markov chain model in population genetics can be made quite efficient by exploiting transition matrix sparsity and by solving restricted systems of linear equations, allowing a wide variety of exact calculations (within machine precision) to be easily and rapidly made on modern workstation computers. Results: We introduce Wright-Fisher Exact Solver (WFES), a fast and scalable method for direct analysis of Markov chain models in population genetics. WFES can rapidly solve for both long-term and transient behaviours including fixation and extinction probabilities, expected times to fixation or extinction, sojourn times, expected allele age and variance, and others. Our implementation requires only seconds to minutes of runtime on modern workstations and scales to biological population sizes ranging from humans to model organisms. Availability and Implementation: The code is available at https://github.com/dekoning-lab/wfes. Contact: jason.dekoning@ucalgary.ca. Supplementary information: Supplementary data are available at Bioinformatics online.
[Mh] Termos MeSH primário: Alelos
Genética Populacional/métodos
Modelos Genéticos
Software
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Cadeias de Markov
Densidade Demográfica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/bioinformatics/btw802


  8 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29246102
[Au] Autor:Montano V; Jombart T
[Ad] Endereço:School of Biology, University of St Andrews, Bute Building, St Andrews, KY16 9TS, UK. mirainoshojo@gmail.com.
[Ti] Título:An Eigenvalue test for spatial principal component analysis.
[So] Source:BMC Bioinformatics;18(1):562, 2017 Dec 16.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The spatial Principal Component Analysis (sPCA, Jombart (Heredity 101:92-103, 2008) is designed to investigate non-random spatial distributions of genetic variation. Unfortunately, the associated tests used for assessing the existence of spatial patterns (global and local test; (Heredity 101:92-103, 2008) lack statistical power and may fail to reveal existing spatial patterns. Here, we present a non-parametric test for the significance of specific patterns recovered by sPCA. RESULTS: We compared the performance of this new test to the original global and local tests using datasets simulated under classical population genetic models. Results show that our test outperforms the original global and local tests, exhibiting improved statistical power while retaining similar, and reliable type I errors. Moreover, by allowing to test various sets of axes, it can be used to guide the selection of retained sPCA components. CONCLUSIONS: As such, our test represents a valuable complement to the original analysis, and should prove useful for the investigation of spatial genetic patterns.
[Mh] Termos MeSH primário: Biologia Computacional/métodos
Variação Genética/genética
Genética Populacional/métodos
Análise de Componente Principal
[Mh] Termos MeSH secundário: Algoritmos
DNA Mitocondrial/genética
Seres Humanos
Grupos Populacionais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1988-y


  9 / 30305 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29216822
[Au] Autor:Ogundijo OE; Wang X
[Ad] Endereço:Department of Electrical Engineering, Columbia University, New York, 10027, USA.
[Ti] Título:Bayesian estimation of scaled mutation rate under the coalescent: a sequential Monte Carlo approach.
[So] Source:BMC Bioinformatics;18(1):541, 2017 Dec 08.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Samples of molecular sequence data of a locus obtained from random individuals in a population are often related by an unknown genealogy. More importantly, population genetics parameters, for instance, the scaled population mutation rate Θ=4N µ for diploids or Θ=2N µ for haploids (where N is the effective population size and µ is the mutation rate per site per generation), which explains some of the evolutionary history and past qualities of the population that the samples are obtained from, is of significant interest. RESULTS: In this paper, we present the evolution of sequence data in a Bayesian framework and the approximation of the posterior distributions of the unknown parameters of the model, which include Θ via the sequential Monte Carlo (SMC) samplers for static models. Specifically, we approximate the posterior distributions of the unknown parameters with a set of weighted samples i.e., the set of highly probable genealogies out of the infinite set of possible genealogies that describe the sampled sequences. The proposed SMC algorithm is evaluated on simulated DNA sequence datasets under different mutational models and real biological sequences. In terms of the accuracy of the estimates, the proposed SMC method shows a comparable and sometimes, better performance than the state-of-the-art MCMC algorithms. CONCLUSIONS: We showed that the SMC algorithm for static model is a promising alternative to the state-of-the-art approach for simulating from the posterior distributions of population genetics parameters.
[Mh] Termos MeSH primário: Biologia Computacional/métodos
Genética Populacional/métodos
Método de Monte Carlo
Taxa de Mutação
[Mh] Termos MeSH secundário: Algoritmos
Teorema de Bayes
Seres Humanos
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1948-6


  10 / 30305 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28455625
[Au] Autor:Balanovsky O
[Ad] Endereço:Vavilov Institute of General Genetics, Moscow, Russia. balanovsky@inbox.ru.
[Ti] Título:Toward a consensus on SNP and STR mutation rates on the human Y-chromosome.
[So] Source:Hum Genet;136(5):575-590, 2017 05.
[Is] ISSN:1432-1203
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The mutation rate on the Y-chromosome matters for estimating the time-to-the-most-recent-common-ancestor (TMRCA, i.e. haplogroup age) in population genetics, as well as for forensic, medical, and genealogical studies. Large-scale sequencing efforts have produced several independent estimates of Y-SNP mutation rates. Genealogical, or pedigree, rates tend to be slightly faster than evolutionary rates obtained from ancient DNA or calibrations using dated (pre)historical events. It is, therefore, suggested to report TMRCAs using an envelope defined by the average aDNA-based rate and the average pedigree-based rate. The current estimate of the "envelope rate" is 0.75-0.89 substitutions per billion base pairs per year. The available Y-SNP mutation rates can be applied to high-coverage data from the entire X-degenerate region, but other datasets may demand recalibrated rates. While a consensus on Y-SNP rates is approaching, the debate on Y-STR rates has continued for two decades, because multiple genealogical rates were consistent with each other but three times faster than the single evolutionary estimate. Applying Y-SNP and Y-STR rates to the same haplogroups recently helped to clarify the issue. Genealogical and evolutionary STR rates typically provide lower and upper bounds of the "true" (SNP-based) age. The genealogical rate often-but not always-works well for haplogroups less than 7000 years old. The evolutionary rate, although calibrated using recent events, inflates ages of young haplogroups and deflates the age of the entire Y-chromosomal tree, but often provides reasonable estimates for intermediate ages (old haplogroups). Future rate estimates and accumulating case studies should further clarify the Y-SNP rates.
[Mh] Termos MeSH primário: Cromossomos Humanos Y/genética
Repetições de Microssatélites
Taxa de Mutação
Mutação
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Genética Populacional
Haplótipos
Seres Humanos
Masculino
Linhagem
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s00439-017-1805-8



página 1 de 3031 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde