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Pesquisa : H01.158.273.610 [Categoria DeCS]
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  1 / 2003 MEDLINE  
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[PMID]:29096071
[Au] Autor:Südhof TC
[Ad] Endereço:Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, 265 Campus Drive, CA 94305-5453, USA. Electronic address: tcs1@stanford.edu.
[Ti] Título:Molecular Neuroscience in the 21 Century: A Personal Perspective.
[So] Source:Neuron;96(3):536-541, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Neurobiologia/tendências
Plasticidade Neuronal/fisiologia
Neurociências/tendências
[Mh] Termos MeSH secundário: Animais
Encéfalo/citologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


  2 / 2003 MEDLINE  
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[PMID]:28850647
[Au] Autor:Worley J
[Ti] Título:The Role of Pleasure Neurobiology and Dopamine in Mental Health Disorders.
[So] Source:J Psychosoc Nurs Ment Health Serv;55(9):17-21, 2017 Sep 01.
[Is] ISSN:0279-3695
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent evidence and research has demonstrated that the pleasure response and associated neurotransmitters and brain circuits play a significant role in substance use disorders (SUDs). It was thought that negative behaviors associated with SUDs resulted from negative choices, but it is now known that chemical changes in the brain drive those behaviors. Several mental health disorders (e.g., eating disorders, non-suicidal self-injury, compulsive sex behaviors, internet gaming, gambling) are also thought to involve those same pleasure responses, neurotransmitters, and brain regions. Studies have shown that the use of naltrexone, a dopamine antagonist, can reduce symptoms of these disorders. It is important for nurses to understand the underlying physiology of mental health disorders that are thought to have an addictive or craving component. This understanding can help reduce stigma. Educating patients about likely neurobiological causes for their disorders can also help reduce guilt and shame. Nurses should educate patients about these disorders and evidence-based treatments, including off-label use of naltrexone. [Journal of Psychosocial Nursing and Mental Health Services, 55(9), 17-21.].
[Mh] Termos MeSH primário: Dopamina/farmacologia
Transtornos Mentais/tratamento farmacológico
Neurobiologia
Prazer/efeitos dos fármacos
[Mh] Termos MeSH secundário: Comportamento Aditivo/fisiopatologia
Encéfalo
Dopamina/metabolismo
Seres Humanos
Naltrexona/uso terapêutico
Antagonistas de Entorpecentes/uso terapêutico
Uso Off-Label
Enfermagem Psiquiátrica
Transtornos Relacionados ao Uso de Substâncias/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Narcotic Antagonists); 5S6W795CQM (Naltrexone); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.3928/02793695-20170818-09


  3 / 2003 MEDLINE  
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[PMID]:28689641
[Au] Autor:Ciabatti E; González-Rueda A; Mariotti L; Morgese F; Tripodi M
[Ad] Endereço:Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK.
[Ti] Título:Life-Long Genetic and Functional Access to Neural Circuits Using Self-Inactivating Rabies Virus.
[So] Source:Cell;170(2):382-392.e14, 2017 Jul 13.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neural networks are emerging as the fundamental computational unit of the brain and it is becoming progressively clearer that network dysfunction is at the core of a number of psychiatric and neurodegenerative disorders. Yet, our ability to target specific networks for functional or genetic manipulations remains limited. Monosynaptically restricted rabies virus facilitates the anatomical investigation of neural circuits. However, the inherent cytotoxicity of the rabies largely prevents its implementation in long-term functional studies and the genetic manipulation of neural networks. To overcome this limitation, we developed a self-inactivating ΔG-rabies virus (SiR) that transcriptionally disappears from the infected neurons while leaving permanent genetic access to the traced network. SiR provides a virtually unlimited temporal window for the study of network dynamics and for the genetic and functional manipulation of neural circuits in vivo without adverse effects on neuronal physiology and circuit function.
[Mh] Termos MeSH primário: Vias Neurais
Neurobiologia/métodos
Vírus da Raiva/genética
[Mh] Termos MeSH secundário: Animais
Camundongos
Neurônios/metabolismo
Sinapses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE


  4 / 2003 MEDLINE  
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[PMID]:28389130
[Au] Autor:Müller CP; Kornhuber J
[Ad] Endereço:Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address: Christian.Mueller@uk-erlangen.de.
[Ti] Título:Biological Evidence for Paradoxical Improvement of Psychiatric Disorder Symptoms by Addictive Drugs.
[So] Source:Trends Pharmacol Sci;38(6):501-502, 2017 Jun.
[Is] ISSN:1873-3735
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Addiction biology has focused on the mechanisms of the positive and negative reinforcing actions of addictive drugs but neglected potential benefits. Two new studies provide the first insights into a neurobiology of psychoactive drug instrumentalization. This may help us design better models for addiction neuroscience and opens a new dimension for the development of personalized pharmacotherapy of drug addiction.
[Mh] Termos MeSH primário: Comportamento Aditivo/psicologia
Comportamento de Procura de Droga/fisiologia
Psicotrópicos/administração & dosagem
Transtornos Relacionados ao Uso de Substâncias/psicologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Neurobiologia
Teoria Psicológica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Psychotropic Drugs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE


  5 / 2003 MEDLINE  
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[PMID]:28372547
[Au] Autor:Arguello JR; Benton R
[Ad] Endereço:Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015, Lausanne, Switzerland.
[Ti] Título:Open questions: Tackling Darwin's "instincts": the genetic basis of behavioral evolution.
[So] Source:BMC Biol;15(1):26, 2017 Apr 03.
[Is] ISSN:1741-7007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:All of us have marveled at the remarkable diversity of animal behaviors in nature.None of us has much idea of how these have evolved.
[Mh] Termos MeSH primário: Comportamento
Evolução Biológica
Fenômenos Genéticos
Instinto
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Neurobiologia
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1186/s12915-017-0369-3


  6 / 2003 MEDLINE  
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[PMID]:28165279
[Au] Autor:Deater-Deckard K; Sturge-Apple ML
[Ad] Endereço:Department of Psychological and Brain Sciences, University of Massachusetts Amherst.
[Ti] Título:Introduction to the special section: Mind and matter: New insights on the role of parental cognitive and neurobiological functioning in process models of parenting.
[So] Source:J Fam Psychol;31(1):5-7, 2017 Feb.
[Is] ISSN:1939-1293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This is an introduction to the special section on neurobiological and neurocognitive factors in parenting. The collection of 11 papers are published in 2 serial subsections of consecutive issues of the journal. The science they present captures the leading edge of work examining the interface of cognitive, emotional, behavioral, and physiological self-regulation in parenting and how these operate to protect or increment risk for poorer parenting among families who face chronic stressors (e.g., poverty, single parenthood, homelessness, mood disorders). Samples span the poor to the affluent, many ethnicities, several nationalities, and a wide variety of geographic locations. The studies also are diverse in the methods employed, spanning behavioral and questionnaire indicators of executive function and effortful control, attentional and social-cognitive biases, and psychophysiology. Taken together, the papers present clear and compelling evidence for the crucial role of parental neurobiological and neurocognitive deficits and strengths in the etiology of distressed and resilient parenting. (PsycINFO Database Record
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Cognição/fisiologia
Poder Familiar/psicologia
Pais/psicologia
[Mh] Termos MeSH secundário: Emoções
Função Executiva
Feminino
Seres Humanos
Masculino
Neurobiologia
Resolução de Problemas
Comportamento Social
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1037/fam0000300


  7 / 2003 MEDLINE  
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[PMID]:28082597
[Au] Autor:Henke K
[Ad] Endereço:Katharina Henke is a professor at the Institute of Psychology and the Center for Cognition, Learning and Memory at the University of Bern. Send your career story to SciCareerEditor@aaas.org.
[Ti] Título:Choosing the hard road.
[So] Source:Science;355(6321):218, 2017 01 13.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Estudos Interdisciplinares
Neurobiologia/educação
Psicologia/educação
[Mh] Termos MeSH secundário: Encéfalo/fisiologia
Seres Humanos
Memória/fisiologia
Suíça
[Pt] Tipo de publicação:JOURNAL ARTICLE; PERSONAL NARRATIVES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1126/science.355.6321.218


  8 / 2003 MEDLINE  
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[PMID]:28065680
[Au] Autor:Brain PF
[Ad] Endereço:College of Science, Swansea University, Swansea SA2 8PP, United Kingdom. Electronic address: profpbrain@gmail.com.
[Ti] Título:Bob Blanchard: A neurobiological legacy and appreciation.
[So] Source:Neurosci Biobehav Rev;76(Pt A):2-3, 2017 05.
[Is] ISSN:1873-7528
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neurobiologia/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; EDITORIAL; HISTORICAL ARTICLE
[Ps] Nome de pessoa como assunto:Blanchard B
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


  9 / 2003 MEDLINE  
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[PMID]:28057302
[Au] Autor:Chakravarti L; Moscato EH; Kayser MS
[Ad] Endereço:Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
[Ti] Título:Unraveling the Neurobiology of Sleep and Sleep Disorders Using Drosophila.
[So] Source:Curr Top Dev Biol;121:253-285, 2017.
[Is] ISSN:1557-8933
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep disorders in humans are increasingly appreciated to be not only widespread but also detrimental to multiple facets of physical and mental health. Recent work has begun to shed light on the mechanistic basis of sleep disorders like insomnia, restless legs syndrome, narcolepsy, and a host of others, but a more detailed genetic and molecular understanding of how sleep goes awry is lacking. Over the past 15 years, studies in Drosophila have yielded new insights into basic questions regarding sleep function and regulation. More recently, powerful genetic approaches in the fly have been applied toward studying primary human sleep disorders and other disease states associated with dysregulated sleep. In this review, we discuss the contribution of Drosophila to the landscape of sleep biology, examining not only fundamental advances in sleep neurobiology but also how flies have begun to inform pathological sleep states in humans.
[Mh] Termos MeSH primário: Drosophila/fisiologia
Neurobiologia
Transtornos do Sono-Vigília/patologia
Sono
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Seres Humanos
Genética Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE


  10 / 2003 MEDLINE  
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[PMID]:28035782
[Au] Autor:Ravizza T; Onat FY; Brooks-Kayal AR; Depaulis A; Galanopoulou AS; Mazarati A; Numis AL; Sankar R; Friedman A
[Ad] Endereço:Department of Neuroscience, IRCCS-"Mario Negri" Institute for Pharmacological Research, Milano, Italy.
[Ti] Título:WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities.
[So] Source:Epilepsia;58(3):331-342, 2017 Mar.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurologic and psychiatric comorbidities are common in patients with epilepsy. Diagnostic, predictive, and pharmacodynamic biomarkers of such comorbidities do not exist. They may share pathogenetic mechanisms with epileptogenesis/ictogenesis, and as such are an unmet clinical need. The objectives of the subgroup on biomarkers of comorbidities at the XIII Workshop on the Neurobiology of Epilepsy (WONOEP) were to present the state-of-the-art recent research findings in the field that highlighting potential biomarkers for comorbidities in epilepsy. We review recent progress in the field, including molecular, imaging, and genetic biomarkers of comorbidities as discussed during the WONOEP meeting on August 31-September 4, 2015, in Heybeliada Island (Istanbul, Turkey). We further highlight new directions and concepts from studies on comorbidities and potential new biomarkers for the prediction, diagnosis, and treatment of epilepsy-associated comorbidities. The activation of various molecular signaling pathways such as the "Janus Kinase/Signal Transducer and Activator of Transcription," "mammalian Target of Rapamycin," and oxidative stress have been shown to correlate with the presence and severity of subsequent cognitive abnormalities. Furthermore, dysfunction in serotonergic transmission, hyperactivity of the hypothalamic-pituitary-adrenocortical axis, the role of the inflammatory cytokines, and the contributions of genetic factors have all recently been regarded as relevant for understanding epilepsy-associated depression and cognitive deficits. Recent evidence supports the utility of imaging studies as potential biomarkers. The role of such biomarker may be far beyond the diagnosis of comorbidities, as accumulating clinical data indicate that comorbidities can predict epilepsy outcomes. Future research is required to reveal whether molecular changes in specific signaling pathways or advanced imaging techniques could be detected in the clinical settings and correlate with epilepsy-associated comorbidities. A reliable biomarker will allow a more accurate diagnosis and improved treatment of epilepsy-associated comorbidities.
[Mh] Termos MeSH primário: Biomarcadores
Epilepsia/epidemiologia
Transtornos Mentais/epidemiologia
Doenças do Sistema Nervoso/epidemiologia
[Mh] Termos MeSH secundário: Animais
Comorbidade
Seres Humanos
Neurobiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13652



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