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  1 / 18555 MEDLINE  
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[PMID]:28743422
[Au] Autor:Bond PJ; Verma CS
[Ad] Endereço:Bioinformatics Institute (A∗STAR), 30 Biopolis Street, #07-01 Matrix, 138671 Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore. Electronic address: peterjb@bii.a-star.edu.sg.
[Ti] Título:Editorial.
[So] Source:Prog Biophys Mol Biol;128:1-2, 2017 09.
[Is] ISSN:1873-1732
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Biofísica
Biologia Molecular
[Mh] Termos MeSH secundário: Proteínas/química
Proteínas/metabolismo
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  2 / 18555 MEDLINE  
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[PMID]:28466098
[Au] Autor:Kozelka J
[Ad] Endereço:Department of Condensed Matter Physics, Faculty of Science, Masaryk University, Kotlárská 2, 61137, Brno, Czech Republic. kozelka.jiri@gmail.com.
[Ti] Título:Lone pair-π interactions in biological systems: occurrence, function, and physical origin.
[So] Source:Eur Biophys J;46(8):729-737, 2017 Dec.
[Is] ISSN:1432-1017
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Lone pair-π interactions are now recognized as a supramolecular bond whose existence in biological systems is documented by a growing number of examples. They are commonly attributed to electrostatic forces. This review attempts to highlight some recent discoveries evidencing the important role which lone pair-π interactions, and anion-π interactions in particular, play in stabilizing the structure and affecting the function of biomolecules. Special attention is paid to studies exploring the physical origin of these at first glance counterintuitive interactions between a lone pair of electrons of one residue and the π-cloud of another. Recent theoretical work went beyond the popular electrostatic model and inquired the extent to which orbital interactions have to be taken into account. In at least one biologically relevant case-that of anion-flavin interactions-a substantial charge-transfer component has been shown to operate.
[Mh] Termos MeSH primário: Biofísica
Elétrons
[Mh] Termos MeSH secundário: Modelos Moleculares
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s00249-017-1210-1


  3 / 18555 MEDLINE  
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[PMID]:29020053
[Au] Autor:Yamamoto A; Nakamoto H; Yamaji T; Ootaka H; Bessho Y; Nakamura R; Ono R
[Ad] Endereço:Department of Community Health Science, Graduate School of Health Science, Kobe University, Kobe, Hyogo, Japan.
[Ti] Título:Method for measuring tri-axial lumbar motion angles using wearable sheet stretch sensors.
[So] Source:PLoS One;12(10):e0183651, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Body movements, such as trunk flexion and rotation, are risk factors for low back pain in occupational settings, especially in healthcare workers. Wearable motion capture systems are potentially useful to monitor lower back movement in healthcare workers to help avoid the risk factors. In this study, we propose a novel system using sheet stretch sensors and investigate the system validity for estimating lower back movement. METHODS: Six volunteers (female:male = 1:1, mean age: 24.8 ± 4.0 years, height 166.7 ± 5.6 cm, weight 56.3 ± 7.6 kg) participated in test protocols that involved executing seven types of movements. The movements were three uniaxial trunk movements (i.e., trunk flexion-extension, trunk side-bending, and trunk rotation) and four multiaxial trunk movements (i.e., flexion + rotation, flexion + side-bending, side-bending + rotation, and moving around the cranial-caudal axis). Each trial lasted for approximately 30 s. Four stretch sensors were attached to each participant's lower back. The lumbar motion angles were estimated using simple linear regression analysis based on the stretch sensor outputs and compared with those obtained by the optical motion capture system. RESULTS: The estimated lumbar motion angles showed a good correlation with the actual angles, with correlation values of r = 0.68 (SD = 0.35), r = 0.60 (SD = 0.19), and r = 0.72 (SD = 0.18) for the flexion-extension, side bending, and rotation movements, respectively (all P < 0.05). The estimation errors in all three directions were less than 3°. CONCLUSION: The stretch sensors mounted on the back provided reasonable estimates of the lumbar motion angles. The novel motion capture system provided three directional angles without capture space limits. The wearable system possessed great potential to monitor the lower back movement in healthcare workers and helping prevent low back pain.
[Mh] Termos MeSH primário: Biofísica/instrumentação
Biofísica/métodos
Vértebras Lombares/fisiologia
Amplitude de Movimento Articular/fisiologia
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Feminino
Seres Humanos
Masculino
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183651


  4 / 18555 MEDLINE  
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[PMID]:28941613
[Au] Autor:Giacomazza D; Viappiani C; Cera ED; Musio C
[Ad] Endereço:CNR Institute of Biophysics, Unit at Palermo, Via U. La Malfa 153, Palermo, I.
[Ti] Título:SIBPA under the Tuscan sun: Introduction to the SIBPA XXIII Special Issue.
[So] Source:Biophys Chem;229:1-4, 2017 Oct.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The Italian Society for Pure and Applied Biophysics (SIBPA) held its XXIII National Congress in the gorgeous Tuscan town of Cortona, Italy, on September 18-21, 2016. This special issue features a selection of contributions from the Congress in the areas of molecular, applied, cellular and computational biophysics. Cutting-edge developments in nanoscale biophysics were introduced for the first time in the program. SIBPA continues its successful promotion of biophysical disciplines at the national and international levels, with added strength from its partnership with Biophysical Chemistry and Elsevier.
[Mh] Termos MeSH primário: Biofísica
[Mh] Termos MeSH secundário: Nanotecnologia
Sociedades Científicas
[Pt] Tipo de publicação:CONGRESSES; EDITORIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


  5 / 18555 MEDLINE  
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[PMID]:28710769
[Au] Autor:Koivuniemi A
[Ad] Endereço:The Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland.
[Ti] Título:The biophysical properties of plasmalogens originating from their unique molecular architecture.
[So] Source:FEBS Lett;591(18):2700-2713, 2017 Sep.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plasmalogens are a unique class of phospholipids that are present in many organisms. Their presence in cell membranes has intrigued researchers for decades due to their unique molecular structure, namely the vinyl-ether bond at the sn-1 position, and their association with brain related disorders. Apparently, based on their amount in the cell membranes, their function is to provide exclusive structural and dynamical properties to these complex molecular assemblies. Yet, many of their physiological roles manifested through their biophysical properties have been challenging to identify. In this review, the biophysical properties of plasmalogens are discussed and compared to other lipid species. The role of plasmalogens is examined in the context of cell membrane function, and some future directions are given.
[Mh] Termos MeSH primário: Biofísica
Plasmalogênios/química
[Mh] Termos MeSH secundário: Animais
Membrana Celular/metabolismo
Seres Humanos
Estrutura Molecular
Plasmalogênios/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plasmalogens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12754


  6 / 18555 MEDLINE  
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[PMID]:28705333
[Au] Autor:Montagnini L
[Ad] Endereço:Biblioteche di Roma, Italy. Electronic address: leonemontagnini@katamail.com.
[Ti] Título:Interdisciplinarity in Norbert Wiener, a mathematician-philosopher of our time.
[So] Source:Biophys Chem;229:173-180, 2017 Oct.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The paper focuses on interdisciplinarity in Norbert Wiener looking at his scientific work from a unitary point of view. It begins with a bird's-eye view of the history of the term "interdisciplinarity", pointing out how the word was the result of a movement of ideas that took place in US science along the whole Twentieth century. This way, the Wiener's conceptions and practices concerning interdisciplinarity are compared with their historical context, showing analogies and peculiarities. For Wiener, interdisciplinary research by very small groups whose members have a very broad interdisciplinary basis is an essential prerequisite for new fundamental ideas for invention and discoveries. On the contrary, in his opinion, mass attacks by large well financed interdisciplinary research groups with a big number of overspecialized member is useful only in a second phase in which invention and discoveries need to be implemented by designers and developers. Finally, through a conceptual matching between Wiener's ideas and the ones of José Ortega y Gasset, it appears how the Wienerian small interdisciplinary group would fit better with the Kuhnian revolutionary phase in science, while the big interdisciplinary group would fit better to the Kuhnian normal science.
[Mh] Termos MeSH primário: Biofísica/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


  7 / 18555 MEDLINE  
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[PMID]:28678160
[Au] Autor:Khan MS; Dosoky NS; Patel D; Weimer J; Williams JD
[Ad] Endereço:Electrical and Computer Engineering Department, University of Alabama in Huntsville, Huntsville, AL 35899, USA. mskhan7@illinois.edu.
[Ti] Título:Lipid Bilayer Membrane in a Silicon Based Micron Sized Cavity Accessed by Atomic Force Microscopy and Electrochemical Impedance Spectroscopy.
[So] Source:Biosensors (Basel);7(3), 2017 Jul 05.
[Is] ISSN:2079-6374
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Supported lipid bilayers (SLBs) are widely used in biophysical research to probe the functionality of biological membranes and to provide diagnoses in high throughput drug screening. Formation of SLBs at below phase transition temperature ( ) has applications in nano-medicine research where low temperature profiles are required. Herein, we report the successful production of SLBs at above-as well as below-the of the lipids in an anisotropically etched, silicon-based micro-cavity. The Si-based cavity walls exhibit controlled temperature which assist in the quick and stable formation of lipid bilayer membranes. Fusion of large unilamellar vesicles was monitored in real time in an aqueous environment inside the Si cavity using atomic force microscopy (AFM), and the lateral organization of the lipid molecules was characterized until the formation of the SLBs. The stability of SLBs produced was also characterized by recording the electrical resistance and the capacitance using electrochemical impedance spectroscopy (EIS). Analysis was done in the frequency regime of 10 -105 Hz at a signal voltage of 100 mV and giga-ohm sealed impedance was obtained continuously over four days. Finally, the cantilever tip in AFM was utilized to estimate the bilayer thickness and to calculate the rupture force at the interface of the tip and the SLB. We anticipate that a silicon-based, micron-sized cavity has the potential to produce highly-stable SLBs below their . The membranes inside the Si cavity could last for several days and allow robust characterization using AFM or EIS. This could be an excellent platform for nanomedicine experiments that require low operating temperatures.
[Mh] Termos MeSH primário: Membrana Celular/química
Bicamadas Lipídicas/química
Nanomedicina
Fosfatidilcolinas/isolamento & purificação
[Mh] Termos MeSH secundário: Anisotropia
Biofísica
Espectroscopia Dielétrica/métodos
Seres Humanos
Bicamadas Lipídicas/isolamento & purificação
Microscopia de Força Atômica/métodos
Transição de Fase
Fosfatidilcolinas/química
Silício/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipid Bilayers); 0 (Phosphatidylcholines); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


  8 / 18555 MEDLINE  
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[PMID]:28658992
[Au] Autor:Genick CC; Wright SK
[Ad] Endereço:a Novartis Pharma AG, Novartis Institutes for BioMedical Research, Chemical Biology and Therapeutics , Protein Sciences , Basel , Switzerland.
[Ti] Título:Biophysics: for HTS hit validation, chemical lead optimization, and beyond.
[So] Source:Expert Opin Drug Discov;12(9):897-907, 2017 Sep.
[Is] ISSN:1746-045X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: There are many challenges to the drug discovery process, including the complexity of the target, its interactions, and how these factors play a role in causing the disease. Traditionally, biophysics has been used for hit validation and chemical lead optimization. With its increased throughput and sensitivity, biophysics is now being applied earlier in this process to empower target characterization and hit finding. Areas covered: In this article, the authors provide an overview of how biophysics can be utilized to assess the quality of the reagents used in screening assays, to validate potential tool compounds, to test the integrity of screening assays, and to create follow-up strategies for compound characterization. They also briefly discuss the utilization of different biophysical methods in hit validation to help avoid the resource consuming pitfalls caused by the lack of hit overlap between biophysical methods. Expert opinion: The use of biophysics early on in the drug discovery process has proven crucial to identifying and characterizing targets of complex nature. It also has enabled the identification and classification of small molecules which interact in an allosteric or covalent manner with the target. By applying biophysics in this manner and at the early stages of this process, the chances of finding chemical leads with novel mechanisms of action are increased. In the future, focused screens with biophysics as a primary readout will become increasingly common.
[Mh] Termos MeSH primário: Desenho de Drogas
Descoberta de Drogas/métodos
Ensaios de Triagem em Larga Escala/métodos
[Mh] Termos MeSH secundário: Biofísica/métodos
Seres Humanos
Preparações Farmacêuticas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1080/17460441.2017.1349096


  9 / 18555 MEDLINE  
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[PMID]:28620037
[Au] Autor:Hill FR; Monachino E; van Oijen AM
[Ad] Endereço:Centre for Medical and Medicinal Bioscience, Illawarra Health and Medical Research Institute and School of Chemistry, University of Wollongong, Wollongong, NSW, Australia.
[Ti] Título:The more the merrier: high-throughput single-molecule techniques.
[So] Source:Biochem Soc Trans;45(3):759-769, 2017 Jun 15.
[Is] ISSN:1470-8752
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The single-molecule approach seeks to understand molecular mechanisms by observing biomolecular processes at the level of individual molecules. These methods have led to a developing understanding that for many processes, a diversity of behaviours will be observed, representing a multitude of pathways. This realisation necessitates that an adequate number of observations are recorded to fully characterise this diversity. The requirement for large numbers of observations to adequately sample distributions, subpopulations, and rare events presents a significant challenge for single-molecule techniques, which by their nature do not typically provide very high throughput. This review will discuss many developing techniques which address this issue by combining nanolithographic approaches, such as zero-mode waveguides and DNA curtains, with single-molecule fluorescence microscopy, and by drastically increasing throughput of force-based approaches such as magnetic tweezers and laminar-flow techniques. These methods not only allow the collection of large volumes of single-molecule data in single experiments, but have also made improvements to ease-of-use, accessibility, and automation of data analysis.
[Mh] Termos MeSH primário: Biofísica
Nanotecnologia/métodos
[Mh] Termos MeSH secundário: DNA
Microscopia de Fluorescência/métodos
Proteínas
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Proteins); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1042/BST20160137


  10 / 18555 MEDLINE  
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[PMID]:28600219
[Au] Autor:Takahashi T; Kim SJ; Naruse M
[Ad] Endereço:Department of Behavioral Science, Research and Education Center for Brain Sciences (RECBS), Center for Experimental Research in Social Sciences (CERSS), Hokkaido University, Kita 10, Nishi 7, Kita-ku, Sapporo, 060-0810, Japan. Electronic address: taikitakahashi@gmail.com.
[Ti] Título:A note on the roles of quantum and mechanical models in social biophysics.
[So] Source:Prog Biophys Mol Biol;130(Pt A):103-105, 2017 Nov.
[Is] ISSN:1873-1732
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Recent advances in the applications of quantum models into various disciplines such as cognitive science, social sciences, economics, and biology witnessed enormous achievements and possible future progress. In this paper, we propose one of the most promising directions in the applications of quantum models: the combination of quantum and mechanical models in social biophysics. The possible resulting discipline may be called as experimental quantum social biophysics and could foster our understandings of the relationships between the society and individuals.
[Mh] Termos MeSH primário: Biofísica/métodos
Fenômenos Mecânicos
Teoria Quântica
Ciências Sociais/métodos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE



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