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  1 / 74424 MEDLINE  
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[PMID]:29335539
[Au] Autor:Eimon PM; Ghannad-Rezaie M; De Rienzo G; Allalou A; Wu Y; Gao M; Roy A; Skolnick J; Yanik MF
[Ad] Endereço:Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. peter.eimon@gmail.com.
[Ti] Título:Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects.
[So] Source:Nat Commun;9(1):219, 2018 01 15.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurological drugs are often associated with serious side effects, yet drug screens typically focus only on efficacy. We demonstrate a novel paradigm utilizing high-throughput in vivo electrophysiology and brain activity patterns (BAPs). A platform with high sensitivity records local field potentials (LFPs) simultaneously from many zebrafish larvae over extended periods. We show that BAPs from larvae experiencing epileptic seizures or drug-induced side effects have substantially reduced complexity (entropy), similar to reduced LFP complexity observed in Parkinson's disease. To determine whether drugs that enhance BAP complexity produces positive outcomes, we used light pulses to trigger seizures in a model of Dravet syndrome, an intractable genetic epilepsy. The highest-ranked compounds identified by BAP analysis exhibit far greater anti-seizure efficacy and fewer side effects during subsequent in-depth behavioral assessment. This high correlation with behavioral outcomes illustrates the power of brain activity pattern-based screens and identifies novel therapeutic candidates with minimal side effects.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Fenômenos Eletrofisiológicos
Psicotrópicos/farmacologia
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Eletrofisiologia/métodos
Epilepsias Mioclônicas/diagnóstico
Epilepsias Mioclônicas/fisiopatologia
Seres Humanos
Larva/efeitos dos fármacos
Larva/genética
Larva/fisiologia
Psicotrópicos/toxicidade
Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Psychotropic Drugs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02404-4


  2 / 74424 MEDLINE  
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[PMID]:29253878
[Au] Autor:Asam K; Staniszewski A; Zhang H; Melideo SL; Mazzeo A; Voronkov M; Huber KL; Pérez E; Stock M; Stock JB; Arancio O; Nicholls RE
[Ad] Endereço:Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America.
[Ti] Título:Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.
[So] Source:PLoS One;12(12):e0189413, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soluble forms of oligomeric beta-amyloid (Aß) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation of methylation of the serine/threonine protein phosphatase, PP2A, was recently shown to alter the sensitivity of mice to AD-related impairments resulting from acute exposure to elevated levels of Aß. In addition, eicosanoyl-5-hydroxytryptamide (EHT), a naturally occurring component from coffee beans that modulates PP2A methylation, was shown to confer therapeutic benefits in rodent models of AD and Parkinson's disease. Here, we tested the hypothesis that EHT protects animals from the pathological effects of exposure to elevated levels of soluble oligomeric Aß. We treated mice with EHT-containing food at two different doses and assessed the sensitivity of these animals to Aß-induced behavioral and electrophysiological impairments. We found that EHT administration protected animals from Aß-induced cognitive impairments in both a radial-arm water maze and contextual fear conditioning task. We also found that both chronic and acute EHT administration prevented Aß-induced impairments in long-term potentiation. These data add to the accumulating evidence suggesting that interventions with pharmacological agents, such as EHT, that target PP2A activity may be therapeutically beneficial for AD and other neurological conditions.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Peptídeos beta-Amiloides/química
Transtornos Cognitivos/prevenção & controle
Serotonina/análogos & derivados
[Mh] Termos MeSH secundário: Doença de Alzheimer/patologia
Animais
Café
Cognição/efeitos dos fármacos
Condicionamento (Psicologia)
Modelos Animais de Doenças
Eletrofisiologia
Medo
Feminino
Potenciação de Longa Duração
Masculino
Aprendizagem em Labirinto
Metilação
Camundongos
Camundongos Endogâmicos C57BL
Doenças do Sistema Nervoso/tratamento farmacológico
Doenças do Sistema Nervoso/patologia
Plasticidade Neuronal
Fosforilação
Serotonina/farmacologia
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Coffee); 0 (eicosanoyl-5-hydroxytryptamide); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189413


  3 / 74424 MEDLINE  
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[PMID]:29397523
[Au] Autor:Robson AG; Nilsson J; Li S; Jalali S; Fulton AB; Tormene AP; Holder GE; Brodie SE
[Ad] Endereço:Department of Electrophysiology, Moorfields Eye Hospital, 162 City Road, London, UK. anthony.robson@moorfields.nhs.uk.
[Ti] Título:ISCEV guide to visual electrodiagnostic procedures.
[So] Source:Doc Ophthalmol;136(1):1-26, 2018 02.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Clinical electrophysiological testing of the visual system incorporates a range of noninvasive tests and provides an objective indication of function relating to different locations and cell types within the visual system. This document developed by the International Society for Clinical Electrophysiology of Vision provides an introduction to standard visual electrodiagnostic procedures in widespread use including the full-field electroretinogram (ERG), the pattern electroretinogram (pattern ERG or PERG), the multifocal electroretinogram (multifocal ERG or mfERG), the electrooculogram (EOG) and the cortical-derived visual evoked potential (VEP). The guideline outlines the basic principles of testing. Common clinical presentations and symptoms are described with illustrative examples and suggested investigation strategies.
[Mh] Termos MeSH primário: Eletrodiagnóstico/normas
Eletroculografia
Eletrofisiologia/organização & administração
Eletrorretinografia/métodos
Potenciais Evocados Visuais
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Agências Internacionais
Doenças do Nervo Óptico/diagnóstico
Doenças Retinianas/diagnóstico
Sociedades Médicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180205
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9621-y


  4 / 74424 MEDLINE  
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[PMID]:28469099
[Au] Autor:Lu YY; Lyu H; Jin SQ; Zuo YH; Liu J; Wang ZX; Zhang W; Yuan Y
[Ad] Endereço:Department of Neurology, Peking University First Hospital, Beijing 100034, China.
[Ti] Título:Clinical and Genetic Features of Chinese X-linked Charcot-Marie-Tooth Type 1 Disease.
[So] Source:Chin Med J (Engl);130(9):1049-1054, 2017 May 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: X-linked Charcot-Marie-Tooth type 1 (CMT1X) disease is one of the most common forms of inherited neuropathy caused by mutations in the gap junction beta-1 protein (GJB1) gene (also known as connexin 32). This study presented the clinical and genetic features of a series of Chinese patients with GJB1 gene mutations. METHODS: A total of 22 patients from unrelated families, who were referred to Department of Neurology, Peking University First Hospital from January 2005 to January 2016, were identified with GJB1 mutations. Their clinical records and laboratory findings were retrospectively collected and reviewed. Mutations in the GJB1 gene were analyzed by targeted next-generation sequencing (NGS). Nucleotide alternations were confirmed with Sanger sequencing. RESULTS: The CMT1X patients predominantly showed distal muscle weakness of lower limbs with mild sensory disturbance. The mean age of onset was 15.6 ± 8.7 years (ranging from 1 year to 42 years). The sudden onset of cerebral symptoms appeared in four patients (18.2%); two were initial symptoms. One case had constant central nervous system (CNS) signs. There were 19 different heterozygous mutations, including 15 known mutations and four novel mutations (c.115G>T, c.380T>A, c.263C>A, and c.818_819insGGGCT). Among the 22 Chinese patients with CMT1X, the frequency of the GJB1 mutation was 4.5% in transmembrane domain 1 (TM1), 4.5% in TM2, 22.7% in TM3, 9.1% in TM4, 4.5% in extracellular 1 (EC1), 27.3% in EC2, 9.1% in intracellular loop, 13.6% in the N-terminal domain, and 4.5% in the C-terminal domain. CMT1X with CNS impairment appeared in five (22.7%) of these patients. CONCLUSIONS: This study indicated that CNS impairment was not rare in Chinese CMT1X patients. Mutations in the EC2 domain of the GJB1 gene were hotspot in Chinese CMT1X patients.
[Mh] Termos MeSH primário: Doença de Charcot-Marie-Tooth/genética
Conexinas/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Sistema Nervoso Central/metabolismo
Doença de Charcot-Marie-Tooth/patologia
Criança
Pré-Escolar
Análise Mutacional de DNA
Eletrofisiologia
Feminino
Genótipo
Seres Humanos
Lactente
Masculino
Mutação
Fenótipo
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexins); 0 (connexin 32)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.204925


  5 / 74424 MEDLINE  
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[PMID]:28459685
[Au] Autor:Dhamala J; Arevalo HJ; Sapp J; Horacek M; Wu KC; Trayanova NA; Wang L
[Ti] Título:Spatially Adaptive Multi-Scale Optimization for Local Parameter Estimation in Cardiac Electrophysiology.
[So] Source:IEEE Trans Med Imaging;36(9):1966-1978, 2017 09.
[Is] ISSN:1558-254X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To obtain a patient-specific cardiac electro-physiological (EP) model, it is important to estimate the 3-D distributed tissue properties of the myocardium. Ideally, the tissue property should be estimated at the resolution of the cardiac mesh. However, such high-dimensional estimation faces major challenges in identifiability and computation. Most existing works reduce this dimension by partitioning the cardiac mesh into a pre-defined set of segments. The resulting low-resolution solutions have a limited ability to represent the underlying heterogeneous tissue properties of varying sizes, locations, and distributions. In this paper, we present a novel framework that, going beyond a uniform low-resolution approach, is able to obtain a higher resolution estimation of tissue properties represented by spatially non-uniform resolution. This is achieved by two central elements: 1) a multi-scale coarse-to-fine optimization that facilitates higher resolution optimization using the lower resolution solution and 2) a spatially adaptive decision criterion that retains lower resolution in homogeneous tissue regions and allows higher resolution in heterogeneous tissue regions. The presented framework is evaluated in estimating the local tissue excitability properties of a cardiac EP model on both synthetic and real data experiments. Its performance is compared with optimization using pre-defined segments. Results demonstrate the feasibility of the presented framework to estimate local parameters and to reveal heterogeneous tissue properties at a higher resolution without using a high number of unknowns.
[Mh] Termos MeSH primário: Eletrofisiologia
[Mh] Termos MeSH secundário: Coração
Seres Humanos
Miocárdio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1109/TMI.2017.2697820


  6 / 74424 MEDLINE  
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[PMID]:29368462
[Au] Autor:Bertucci P
[Ti] Título:Shocking Subjects: Human Experiments and the Material Culture of Medical Electricity in Eighteenth-Century England.
[So] Source:Clio Med;95:111-38, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Eletricidade/história
Eletrofisiologia/história
Eletrochoque/história
Experimentação Humana/história
[Mh] Termos MeSH secundário: Pesquisa Biomédica/história
Estimulação Elétrica
Inglaterra
História do Século XVIII
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  7 / 74424 MEDLINE  
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[PMID]:28458358
[Au] Autor:Sasaki T; Nishimura Y; Ikegaya Y
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, The University of Tokyo.
[Ti] Título:Simultaneous Recordings of Central and Peripheral Bioelectrical Signals in a Freely Moving Rodent.
[So] Source:Biol Pharm Bull;40(5):711-715, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Understanding physiological interactions between the central and peripheral nervous systems requires an experimental strategy to simultaneously monitor activity patterns of the brain and peripheral organs. In this study, we developed a novel method to record extracellular field potential signals from a wide range of brain regions together with electrocardiograms, electromyograms, and breathing signals from a freely moving rodent. This method collects all recorded signals into a single device mounted on an animal's head, allowing the reduction of experimental costs and the simplification of data processing. The methodological concept is applicable to a number of biological research issues of how the brain-body association is altered in response to various environmental changes, emotional challenges, and acute and chronic dysfunction of internal organs.
[Mh] Termos MeSH primário: Sistema Nervoso Central/fisiologia
Eletrofisiologia/métodos
Sistema Nervoso Periférico/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Eletrocardiografia
Eletrodos Implantados
Eletromiografia
Fenômenos Eletrofisiológicos
Eletrofisiologia/instrumentação
Emoções
Espaço Extracelular/fisiologia
Masculino
Ratos
Ratos Wistar
Respiração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b17-00070


  8 / 74424 MEDLINE  
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[PMID]:29253887
[Au] Autor:Jensen R
[Ad] Endereço:Research Service, VA Boston Healthcare System, Boston, Massachusetts, United States of America.
[Ti] Título:Effects of GABACR and mGluR1 antagonists on contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells.
[So] Source:PLoS One;12(12):e0189980, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The GABACR antagonist TPMPA and the mGluR1 antagonist JNJ16259685 have been shown previously to alter the sensitivity of retinal ganglion cells (RGCs) in the Sprague-Dawley (SD) rat and P23H rat (animal model of retinitis pigmentosa) to brief flashes of light. In order to better understand the effects of these antagonists on the visual responses of SD and P23H rat RGCs, I examined the responses of RGCs to a drifting sinusoidal grating of various contrasts. Multielectrode array recordings were made from RGCs to a drifting sinusoidal grating of a spatial frequency of 1 cycle/mm and a temporal frequency of 2 cycles/s. In both SD and P23H rat retinas, contrast response functions were found to have a variable shape across cells. Some cells showed saturation of responses at high contrast levels while others did not. Whereas 49% of SD rat RGCs exhibited response saturation, only 14% of P23H rat RGCs showed response saturation. TPMPA decreased the responses of saturating SD rat RGCs to low (6% to 13%) grating contrasts but increased the response to the highest contrast (83%) tested. JNJ16259685 did not significantly affect the contrast response functions of either saturating or non-saturating SD rat RGCs. In contrast, both TPMPA and JNJ16259685 increased the responses of saturating and non-saturating P23H rat RGCs to all grating contrasts. Neither TPMPA nor JNJ16259685 affected the contrast thresholds of SD rat RGCs, but both antagonists lowered the contrast thresholds of P23H rat RGCs. Overall, the findings show that GABACR and mGluR1 antagonists have differential effects on the contrast response functions of SD and P23H rat RGCs. Notably, these receptor antagonists increase the responsiveness of P23H rat RGCs to both low and high contrast visual stimuli.
[Mh] Termos MeSH primário: Receptores de GABA/metabolismo
Receptores de Glutamato Metabotrópico/antagonistas & inibidores
Células Ganglionares da Retina/metabolismo
Retinite Pigmentosa/metabolismo
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Calibragem
Modelos Animais de Doenças
Eletrodos
Eletrofisiologia
Feminino
Homozigoto
Masculino
Ratos
Ratos Sprague-Dawley
Receptores de Glutamato Metabotrópico/metabolismo
Retina/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-C receptor); 0 (Receptors, GABA); 0 (Receptors, Metabotropic Glutamate); 0 (metabotropic glutamate receptor type 1)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189980


  9 / 74424 MEDLINE  
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[PMID]:28449392
[Au] Autor:Saraiva GFR; Ferreira AS; Souza GM
[Ad] Endereço:Graduate Program in Agronomy, Western São Paulo University, (PPGA/UNOESTE), Presidente Prudente, Brazil.
[Ti] Título:Osmotic stress decreases complexity underlying the electrophysiological dynamic in soybean.
[So] Source:Plant Biol (Stuttg);19(5):702-708, 2017 Sep.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Studies on plant electrophysiology are mostly focused on specific traits of single cells. Inspired by the complexity of the signalling network in plants, and by analogy with neurons in human brains, we sought evidence of high complexity in the electrical dynamics of plant signalling and a likely relationship with environmental cues. An EEG-like standard protocol was adopted for high-resolution measurements of the electrical signal in Glycine max seedlings. The signals were continuously recorded in the same plants before and after osmotic stimuli with a -2 MPa mannitol solution. Non-linear time series analyses methods were used as follows: auto-correlation and cross-correlation function, power spectra density function, and complexity of the time series estimated as Approximate Entropy (ApEn). Using Approximate Entropy analysis we found that the level of temporal complexity of the electrical signals was affected by the environmental conditions, decreasing when the plant was subjected to a low osmotic potential. Electrical spikes observed only after stimuli followed a power law distribution, which is indicative of scale invariance. Our results suggest that changes in complexity of the electrical signals could be associated with water stress conditions in plants. We hypothesised that the power law distribution of the spikes could be explained by a self-organised critical state (SOC) after osmotic stress.
[Mh] Termos MeSH primário: Eletrofisiologia/métodos
Pressão Osmótica/fisiologia
Feijão de Soja/metabolismo
[Mh] Termos MeSH secundário: Feijão de Soja/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12576


  10 / 74424 MEDLINE  
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[PMID]:29252999
[Au] Autor:Yang S; Govindaiah G; Lee SH; Yang S; Cox CL
[Ad] Endereço:Department of Nano-bioengineering, Incheon National University, Incheon, Korea.
[Ti] Título:Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin.
[So] Source:PLoS One;12(12):e0189690, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.
[Mh] Termos MeSH primário: Axônios/fisiologia
Córtex Cerebral/fisiologia
Dendritos/fisiologia
Neurônios/fisiologia
Tálamo/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletrofisiologia
Feminino
Neurônios GABAérgicos/fisiologia
Corpos Geniculados/fisiologia
Potenciais Pós-Sinápticos Inibidores
Cinética
Masculino
Inibição Neural/fisiologia
Terminações Pré-Sinápticas/fisiologia
Domínios Proteicos
Ratos
Ratos Sprague-Dawley
Núcleos Talâmicos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189690



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