Base de dados : MEDLINE
Pesquisa : H01.158.610 [Categoria DeCS]
Referências encontradas : 6199 [refinar]
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[PMID]:29208230
[Au] Autor:Schlegel P; Costa M; Jefferis GS
[Ad] Endereço:Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
[Ti] Título:Learning from connectomics on the fly.
[So] Source:Curr Opin Insect Sci;24:96-105, 2017 Dec.
[Is] ISSN:2214-5753
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Parallels between invertebrates and vertebrates in nervous system development, organisation and circuits are powerful reasons to use insects to study the mechanistic basis of behaviour. The last few years have seen the generation in Drosophila melanogaster of very large light microscopy data sets, genetic driver lines and tools to report or manipulate neural activity. These resources in conjunction with computational tools are enabling large scale characterisation of neuronal types and their functional properties. These are complemented by 3D electron microscopy, providing synaptic resolution data. A whole brain connectome of the fly larva is approaching completion based on manual reconstruction of electron-microscopy data. An adult whole brain dataset is already publicly available and focussed reconstruction is under way, but its 40× greater volume would require ∼500-5000 person-years of manual labour. Nevertheless rapid technical improvements in imaging and especially automated segmentation will likely deliver a complete adult connectome in the next 5 years. To enhance our understanding of the circuit basis of behaviour, light and electron microscopy outputs must be integrated with functional and physiological information into comprehensive databases. We review presently available data, tools and opportunities in Drosophila. We then consider the limits and potential of future progress and how this may impact neuroscience in rich model systems provided by larger insects and vertebrates.
[Mh] Termos MeSH primário: Conectoma
Drosophila melanogaster/anatomia & histologia
Drosophila melanogaster/fisiologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/fisiologia
Drosophila melanogaster/crescimento & desenvolvimento
Larva/anatomia & histologia
Larva/crescimento & desenvolvimento
Larva/fisiologia
Neurônios/fisiologia
Neurociências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  2 / 6199 MEDLINE  
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[PMID]:29251435
[Au] Autor:Chenette EJ
[Ad] Endereço:The FEBS Journal Editorial Office, Cambridge, UK.
[Ti] Título:Announcing the winners of our 50th Anniversary Science Communication Competition.
[So] Source:FEBS J;284(24):4172-4173, 2017 Dec.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The FEBS Journal is pleased to announce the three winners of its 50th Anniversary Science Communication Competition. Read on to see their prize-winning entries!
[Mh] Termos MeSH primário: Distinções e Prêmios
Disciplinas das Ciências Biológicas/história
Sociedades Científicas
[Mh] Termos MeSH secundário: Recursos Audiovisuais
Europa (Continente)
História do Século XXI
México
Biologia Molecular/história
Filmes Cinematográficos
Neurociências/história
Pôsteres como Assunto
Singapura
[Pt] Tipo de publicação:BIOGRAPHY; EDITORIAL; HISTORICAL ARTICLE
[Ps] Nome de pessoa como assunto:Fong A; Estrada-Rivadeneyra D; Mitheera V
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1111/febs.14329


  3 / 6199 MEDLINE  
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[PMID]:29216458
[Au] Autor:Gleeson P; Davison AP; Silver RA; Ascoli GA
[Ad] Endereço:Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
[Ti] Título:A Commitment to Open Source in Neuroscience.
[So] Source:Neuron;96(5):964-965, 2017 Dec 06.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Modern neuroscience increasingly relies on custom-developed software, but much of this is not being made available to the wider community. A group of researchers are pledging to make code they produce for data analysis and modeling open source, and are actively encouraging their colleagues to follow suit.
[Mh] Termos MeSH primário: Acesso à Informação
Neurociências/métodos
Software
[Mh] Termos MeSH secundário: Disseminação de Informação
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  4 / 6199 MEDLINE  
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[PMID]:28155423
[Au] Autor:Loewenau A; Weindling PJ
[Ad] Endereço:Department of Community Health Sciences and Calgary Institute for the Humanities, University of Calgary.
[Ti] Título:Nazi Medical Research in Neuroscience: Medical Procedures, Victims, and Perpetrators.
[So] Source:Can Bull Med Hist;33(2):418-446, 2016.
[Is] ISSN:0823-2105
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Issues relating to the euthanasia killings of the mentally ill, the medical research conducted on collected body parts, and the clinical investigations on living victims under National Socialism are among the best-known abuses in medical history. But to date, there have been no statistics compiled regarding the extent and number of the victims and perpetrators, or regarding their identities in terms of age, nationality, and gender. "Victims of Unethical Human Experiments and Coerced Research under National Socialism," a research project based at Oxford Brookes University, has established an evidence-based documentation of the overall numbers of victims and perpetrators through specific record linkages of the evidence from the period of National Socialism, as well as from post-WWII trials and other records. This article examines the level and extent of these unethical medical procedures as they relate to the field of neuroscience. It presents statistical information regarding the victims, as well as detailing the involvement of the perpetrators and Nazi physicians with respect to their post-war activities and subsequent court trials.
[Mh] Termos MeSH primário: Holocausto
Experimentação Humana
Neurociências/história
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Eutanásia
Feminino
História do Século XX
Holocausto/história
Holocausto/estatística & dados numéricos
Experimentação Humana/ética
Experimentação Humana/história
Experimentação Humana/legislação & jurisprudência
Experimentação Humana/estatística & dados numéricos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Nacional-Socialismo
Pesquisadores/história
Pesquisadores/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.3138/cbmh.33.2.152-27012015


  5 / 6199 MEDLINE  
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[PMID]:28155421
[Au] Autor:Lanzoni S
[Ad] Endereço:Department of Continuing Education, Harvard University.
[Ti] Título:Imagining and Imaging the Social Brain: The Case of Mirror Neurons.
[So] Source:Can Bull Med Hist;33(2):447-464, 2016.
[Is] ISSN:0823-2105
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:In a contemporary setting in which all things "neuro" have great cultural sway, an analysis of the ways in which neuroscience is indebted to the methods and findings of the social sciences has received less attention. Indeed, in the new specialization of social neuroscience, neuroscientists now collaborate with contemporary psychologists and invoke historical psychological theories to help theorize empathy and social understanding. This article examines the overlap between psychological frameworks of social emotion and neuroscience in the case of mirror neurons, discovered in the 1990s. Some neuroscientists purport that mirror neurons underlie the social behaviours of imitation and empathy, and have found support for this view of theories of simulation and embodied cognition. They have also invoked pragmatic and phenomenological approaches to mind and behaviour dating back to the early 20 century. Neuroscientists have thus imported, adapted, and interpreted psychological models to help define social understanding, empathy, and imitation in many imaging studies.
[Mh] Termos MeSH primário: Neurônios-Espelho
Modelos Psicológicos
Neurociências
[Mh] Termos MeSH secundário: Emoções
Empatia
Seres Humanos
Comportamento Imitativo
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.3138/cbmh.33.2.151-27012015


  6 / 6199 MEDLINE  
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[PMID]:29096079
[Au] Autor:Terenzio M; Schiavo G; Fainzilber M
[Ad] Endereço:Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
[Ti] Título:Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience.
[So] Source:Neuron;96(3):667-679, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells.
[Mh] Termos MeSH primário: Biologia Celular/tendências
Citoesqueleto/fisiologia
Neurônios/fisiologia
Neurociências/tendências
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Neurociências/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


  7 / 6199 MEDLINE  
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[PMID]:29096074
[Au] Autor:Rost BR; Schneider-Warme F; Schmitz D; Hegemann P
[Ad] Endereço:German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Optogenetic Tools for Subcellular Applications in Neuroscience.
[So] Source:Neuron;96(3):572-603, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability to study cellular physiology using photosensitive, genetically encoded molecules has profoundly transformed neuroscience. The modern optogenetic toolbox includes fluorescent sensors to visualize signaling events in living cells and optogenetic actuators enabling manipulation of numerous cellular activities. Most optogenetic tools are not targeted to specific subcellular compartments but are localized with limited discrimination throughout the cell. Therefore, optogenetic activation often does not reflect context-dependent effects of highly localized intracellular signaling events. Subcellular targeting is required to achieve more specific optogenetic readouts and photomanipulation. Here we first provide a detailed overview of the available optogenetic tools with a focus on optogenetic actuators. Second, we review established strategies for targeting these tools to specific subcellular compartments. Finally, we discuss useful tools and targeting strategies that are currently missing from the optogenetics repertoire and provide suggestions for novel subcellular optogenetic applications.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Celulares/fisiologia
Espaço Intracelular/genética
Neurônios/fisiologia
Neurociências/métodos
Optogenética/métodos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Espaço Intracelular/química
Espaço Intracelular/metabolismo
Neurônios/química
Neurociências/tendências
Optogenética/tendências
Rodopsina/análise
Rodopsina/genética
Sistemas do Segundo Mensageiro/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
9009-81-8 (Rhodopsin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


  8 / 6199 MEDLINE  
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[PMID]:29096073
[Au] Autor:Hosp F; Mann M
[Ad] Endereço:Max-Planck-Institute of Biochemistry, Department of Proteomics and Signal Transduction, 82152 Martinsried, Germany.
[Ti] Título:A Primer on Concepts and Applications of Proteomics in Neuroscience.
[So] Source:Neuron;96(3):558-571, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic" technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Neurônios/fisiologia
Neurociências/métodos
Proteômica/métodos
[Mh] Termos MeSH secundário: Animais
Encéfalo/citologia
Cromatografia Líquida/métodos
Seres Humanos
Espectrometria de Massas/métodos
Neurociências/tendências
Proteômica/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


  9 / 6199 MEDLINE  
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[PMID]:29096071
[Au] Autor:Südhof TC
[Ad] Endereço:Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, 265 Campus Drive, CA 94305-5453, USA. Electronic address: tcs1@stanford.edu.
[Ti] Título:Molecular Neuroscience in the 21 Century: A Personal Perspective.
[So] Source:Neuron;96(3):536-541, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Neurobiologia/tendências
Plasticidade Neuronal/fisiologia
Neurociências/tendências
[Mh] Termos MeSH secundário: Animais
Encéfalo/citologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


  10 / 6199 MEDLINE  
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[PMID]:28957676
[Au] Autor:Farah MJ
[Ad] Endereço:Center for Neuroscience & Society, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA 19104, USA. Electronic address: mfarah@upenn.edu.
[Ti] Título:The Neuroscience of Socioeconomic Status: Correlates, Causes, and Consequences.
[So] Source:Neuron;96(1):56-71, 2017 Sep 27.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human beings differ in their socioeconomic status (SES), with accompanying differences in physical and mental health as well as cognitive ability. Although SES has long been used as a covariate in human brain research, in recognition of its potential to account for behavioral and neural differences among people, only recently have neuroscientists made SES a topic of research in its own right. How does SES manifest in the brain, and how do its neural correlates relate to the causes and consequences of SES? This review summarizes the current state of knowledge regarding these questions. Particular challenges of research on the neuroscience of SES are discussed, and the relevance of this topic to neuroscience more generally is considered.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Cognição/fisiologia
Neurociências
Classe Social
[Mh] Termos MeSH secundário: Animais
Encéfalo/crescimento & desenvolvimento
Seres Humanos
Individualidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE



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