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[PMID]:28634266
[Au] Autor:Joëls M; de Kloet ER
[Ad] Endereço:Department of Translational NeuroscienceBrain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands.
[Ti] Título:30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The brain mineralocorticoid receptor: a saga in three episodes.
[So] Source:J Endocrinol;234(1):T49-T66, 2017 Jul.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In 1968, Bruce McEwen discovered that H-corticosterone administered to adrenalectomised rats is retained in neurons of hippocampus rather than those of hypothalamus. This discovery signalled the expansion of endocrinology into the science of higher brain regions. With this in mind, our contribution highlights the saga of the brain mineralocorticoid receptor (MR) in three episodes. First, the precloning era dominated by the conundrum of two types of corticosterone-binding receptors in the brain, which led to the identification of the high-affinity corticosterone receptor as the 'promiscuous' MR cloned in 1987 by Jeff Arriza and Ron Evans in addition to the classical glucocorticoid receptor (GR). Then, the post-cloning period aimed to disentangle the function of the brain MR from that of the closely related GR on different levels of biological complexity. Finally, the synthesis section that highlights the two faces of brain MR: Salt and Stress. 'Salt' refers to the regulation of salt appetite, and reciprocal arousal, motivation and reward, by a network of aldosterone-selective MR-expressing neurons projecting from nucleus tractus solitarii (NTS) and circumventricular organs. 'Stress' is about the limbic-forebrain nuclear and membrane MRs, which act as a switch in the selection of the best response to cope with a stressor. For this purpose, activation of the limbic MR promotes selective attention, memory retrieval and the appraisal process, while driving emotional expressions of fear and aggression. Subsequently, rising glucocorticoid concentrations activate GRs in limbic-forebrain circuitry underlying executive functions and memory storage, which contribute in balance with MR-mediated actions to homeostasis, excitability and behavioural adaptation.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Receptores de Mineralocorticoides/metabolismo
[Mh] Termos MeSH secundário: Animais
Clonagem Molecular
Regulação da Expressão Gênica/fisiologia
Rede Nervosa/fisiologia
Neuroendocrinologia
Receptores de Mineralocorticoides/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Receptors, Mineralocorticoid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-16-0660


  2 / 332 MEDLINE  
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[PMID]:28074555
[Au] Autor:Stavrou S; Nicolaides NC; Critselis E; Darviri C; Charmandari E; Chrousos GP
[Ad] Endereço:Postgraduate Course on the Science of Stress and Health Promotion, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
[Ti] Título:Paediatric stress: from neuroendocrinology to contemporary disorders.
[So] Source:Eur J Clin Invest;47(3):262-269, 2017 Mar.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stress is defined as a state of threatened or perceived as threatened homeostasis. A broad spectrum of extrinsic or intrinsic, real or perceived stressful stimuli, called 'stressors', activates a highly conserved system, the 'stress system', which adjusts homeostasis through central and peripheral neuroendocrine responses. Inadequate, excessive or prolonged adaptive responses to stress may underlie the pathogenesis of several disease states prevalent in modern societies. The development and severity of these conditions primarily depend on the genetic vulnerability of the individual, the exposure to adverse environmental factors and the timing of the stressful event(s), given that prenatal life, infancy, childhood and adolescence are critical periods characterized by increased vulnerability to stressors. MATERIALS AND METHODS: We conducted a systematic review of original articles and reviews published in MEDLINE from 1975 through June 2016. The search terms were 'childhood stress', 'pediatric stress', 'stress and disorders' and 'stress management'. RESULTS: In this review, we discuss the historical and neuroendocrine aspects of stress, and we present representative examples of paediatric stress system disorders, such as early-life adversity, obesity and bullying. We also discuss the adverse impact of a socio-economic crisis on childhood health. The tremendous progress of epigenetics has enabled us to have a deeper understanding of the molecular mechanisms underlying paediatric stress-related disorders. CONCLUSIONS: The need for early successful stress management techniques to decrease the incidence of paediatric stress-related diseases, as well as to prevent the development of several pathologic conditions in adolescence and adulthood, is imperative.
[Mh] Termos MeSH primário: Neuroendocrinologia
Sistemas Neurossecretores/fisiopatologia
Obesidade/fisiopatologia
Estresse Fisiológico
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Criança
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12724


  3 / 332 MEDLINE  
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[PMID]:27611700
[Au] Autor:Van den Berghe G
[Ad] Endereço:Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven University and Hospitals, Leuven, Belgium.
[Ti] Título:On the Neuroendocrinopathy of Critical Illness. Perspectives for Feeding and Novel Treatments.
[So] Source:Am J Respir Crit Care Med;194(11):1337-1348, 2016 Dec 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Typical for critical illnesses are substantial alterations within the hypothalamic-anterior pituitary-peripheral hormonal axes that are proportionate to the risk of poor outcome. These neuroendocrine responses to critical illness follow a biphasic pattern. The acute phase (first hours to days) is characterized by an increased release of anterior pituitary hormones, whereas altered target-organ sensitivity and hormone metabolism result in low levels of the anabolic peripheral effector hormones and contribute to the substantially elevated levels of the catabolic hormone cortisol. The prolonged phase of critical illness is hallmarked by a uniform suppression of the neuroendocrine axes, predominantly of central/hypothalamic origin, which contributes to the low (or insufficiently high in the case of cortisol) circulating levels of the target-organ hormones. Several of the acute-phase adaptations to critical illness are due to or accentuated by the concomitant fasting. Accepting the lack of macronutrients as well as the neuroendocrine responses to such fasting in the acute phase of critical illness has shown to beneficially affect outcome. In contrast, the neuroendocrine alterations that occur in the chronic phase of illness while patients are fully fed contribute to bone and skeletal muscle wasting and impose risk of adrenocortical atrophy. The combined administration of those hypothalamic releasing factors, which have been identified as suppressed or deficient during prolonged critical illness, may be a promising strategy to enhance recovery. The potential impact of treatment with such hypothalamic releasing factors on recovery from critical illness as well as on long-term rehabilitation should be investigated in future randomized controlled clinical trials.
[Mh] Termos MeSH primário: Estado Terminal/terapia
Comportamento Alimentar
Neuroendocrinologia/métodos
Sistemas Neurossecretores/patologia
Hormônios Liberadores de Hormônios Hipofisários/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Sistemas Neurossecretores/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pituitary Hormone-Releasing Hormones)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


  4 / 332 MEDLINE  
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Texto completo SciELO Brasil
Boguszewski, Cesar L
[PMID]:27533614
[Au] Autor:Vieira L; Boguszewski CL; Araújo LA; Bronstein MD; Miranda PA; Musolino NR; Naves LA; Vilar L; Ribeiro-Oliveira A; Gadelha MR
[Ad] Endereço:Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF-UFRJ), Rio de Janeiro, RJ, Brasil.
[Ti] Título:A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism.
[So] Source:Arch Endocrinol Metab;60(4):374-90, 2016 Aug.
[Is] ISSN:2359-4292
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentations include pituitary apoplexy or an incidental finding on imaging studies. Mass effect and hypopituitarism impose high morbidity and mortality. However, early diagnosis and effective treatment minimizes morbidity and mortality. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism is to provide a review of the diagnosis and treatment of patients with NFPA, emphasizing that the treatment should be performed in reference centers. This review is based on data published in the literature and the authors' experience. Arch Endocrinol Metab. 2016;60(4):374-90.
[Mh] Termos MeSH primário: Adenoma/diagnóstico
Adenoma/terapia
Neuroendocrinologia
Neoplasias Hipofisárias/diagnóstico
Neoplasias Hipofisárias/terapia
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Brasil
Diagnóstico Precoce
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Fatores de Risco
Sociedades Médicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160818
[St] Status:MEDLINE


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[PMID]:27422254
[Au] Autor:Selvaraj V; Tu LN
[Ad] Endereço:Department of Animal ScienceCornell University, Ithaca, New York, USA vs88@cornell.edu.
[Ti] Título:Current status and future perspectives: TSPO in steroid neuroendocrinology.
[So] Source:J Endocrinol;231(1):R1-R30, 2016 Oct.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mitochondrial translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), has received significant attention both as a diagnostic biomarker and as a therapeutic target for different neuronal disease pathologies. Recently, its functional basis believed to be mediating mitochondrial cholesterol import for steroid hormone production has been refuted by studies examining both in vivo and in vitro genetic Tspo-deficient models. As a result, there now exists a fundamental gap in the understanding of TSPO function in the nervous system, and its putative pharmacology in neurosteroid production. In this review, we discuss several recent findings in steroidogenic cells that are in direct contradiction to previous studies, and necessitate a re-examination of the purported role for TSPO in de novo neurosteroid biosynthesis. We critically examine the pharmacological effects of different TSPO-binding drugs with particular focus on studies that measure neurosteroid levels. We highlight the basis of key misconceptions regarding TSPO that continue to pervade the literature, and the need for interpretation with caution to avoid negative impacts. We also summarize the emerging perspectives that point to new directions that need to be investigated for understanding the molecular function of TSPO, only after which the true potential of this therapeutic target in medicine may be realized.
[Mh] Termos MeSH primário: Neuroendocrinologia/tendências
Neurotransmissores/biossíntese
Receptores de GABA/fisiologia
[Mh] Termos MeSH secundário: GABAérgicos/farmacologia
Seres Humanos
Células Neuroendócrinas/efeitos dos fármacos
Receptores de GABA/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (GABA Agents); 0 (Neurotransmitter Agents); 0 (Receptors, GABA); 0 (TSPO protein, human)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-16-0241


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[PMID]:26812692
[Au] Autor:de Herder WW
[Ad] Endereço:Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
[Ti] Título:Pareidolia in Neuroendocrinology: A Pituitary Macroadenoma Resembling "Big Bird".
[So] Source:J Clin Endocrinol Metab;101(4):1348-9, 2016 Apr.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The MRI picture of a pituitary macroadenoma with supra- and perisellar expansion resembled a famous character from a children's television series demonstrating that pareidolia is also observed in neuro-endocrinology and -radiology.
[Mh] Termos MeSH primário: Adenoma/patologia
Ilusões
Neoplasias Hipofisárias/patologia
[Mh] Termos MeSH secundário: Adenoma/diagnóstico por imagem
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Meia-Idade
Neuroendocrinologia
Percepção
Neoplasias Hipofisárias/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-1001


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[PMID]:26759429
[Au] Autor:Albers HE; Bittman E; Demas GE; Goldman B; Zucker I
[Ti] Título:Timothy J. Bartness.
[So] Source:J Biol Rhythms;31(1):6-11, 2016 Feb.
[Is] ISSN:1552-4531
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Disciplina de Cronobiologia/história
Neuroendocrinologia/história
[Mh] Termos MeSH secundário: História do Século XXI
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Bartness TJ
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160114
[St] Status:MEDLINE
[do] DOI:10.1177/0748730415626807


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[PMID]:26740399
[Au] Autor:McEwen BS
[Ad] Endereço:Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States. Electronic address: mcewen@mail.rockefeller.edu.
[Ti] Título:Stress-induced remodeling of hippocampal CA3 pyramidal neurons.
[So] Source:Brain Res;1645:50-4, 2016 Aug 15.
[Is] ISSN:1872-6240
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The discovery of steroid hormone receptors in brain regions that mediate virtually every aspect of brain function has broadened the definition of 'neuroendocrinology' to include the reciprocal communication between the brain and the body via hormonal and neural pathways. The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as determining the behavioral and physiological responses to the stressor. The adult and developing brain possess remarkable structural and functional plasticity in response to stress, including neurogenesis leading to neuronal replacement, dendritic remodeling, and synapse turnover. Stress causes an imbalance of neural circuitry subserving cognition, decision-making, anxiety and mood that can alter expression of those behaviors and behavioral states. The two Brain Research papers noted in this review played an important role in triggering these advances. This article is part of a Special Issue entitled SI:50th Anniversary Issue.
[Mh] Termos MeSH primário: Região CA3 Hipocampal/fisiopatologia
Neuroendocrinologia/história
Plasticidade Neuronal
Células Piramidais/fisiologia
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Animais
História do Século XX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE


  9 / 332 MEDLINE  
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[PMID]:26145291
[Au] Autor:Tsutsui K
[Ad] Endereço:Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Tokyo 162-8480, Japan. Electronic address: k-tsutsui@waseda.jp.
[Ti] Título:How to contribute to the progress of neuroendocrinology: New insights from discovering novel neuropeptides and neurosteroids regulating pituitary and brain functions.
[So] Source:Gen Comp Endocrinol;227:3-15, 2016 Feb 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obtaining new insights by discovering novel neuropeptides and neurosteroids regulating pituitary and brain functions is essential for the progress of neuroendocrinology. At the beginning of 1970s, gonadotropin-releasing hormone (GnRH) was discovered in mammals. Since then, it was generally accepted that GnRH is the only hypothalamic neuropeptide regulating gonadotropin release in vertebrates. In 2000, however, gonadotropin-inhibitory hormone (GnIH), a novel hypothalamic neuropeptide that actively inhibits gonadotropin release, was discovered in quail. The follow-up studies demonstrated that GnIH acts as a new key player for regulation of reproduction across vertebrates. It now appears that GnIH acts on the pituitary and the brain to serve a number of behavioral and physiological functions. On the other hand, a new concept has been established that the brain synthesizes steroids, called neurosteroids. The formation of neurosteroids in the brain was originally demonstrated in mammals and subsequently in other vertebrates. Recently, 7α-hydroxypregnenolone was discovered as a novel bioactive neurosteroid inducing locomotor behavior of vertebrates, indicating that neurosteroidogenesis in the brain is still incompletely elucidated in vertebrates. At the beginning of 2010s, it was further found that the pineal gland actively produces neurosteroids. Pineal neurosteroids act on the brain to regulate locomotor rhythms and neuronal survival. Furthermore, the interaction of neuropeptides and neurosteroids is becoming clear. GnIH decreases aggressive behavior by regulating neuroestrogen synthesis in the brain. This review summarizes these new insights by discovering novel neuropeptides and neurosteroids in the field of neuroendocrinology.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Hormônios Hipotalâmicos/metabolismo
Neuroendocrinologia
Neuropeptídeos/metabolismo
Neurotransmissores/metabolismo
Hipófise/metabolismo
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Hypothalamic Hormones); 0 (Neuropeptides); 0 (Neurotransmitter Agents)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE


  10 / 332 MEDLINE  
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[PMID]:26325008
[Au] Autor:Schonbrunn A
[Ad] Endereço:Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77225.
[Ti] Título:Editorial: Reproducibility in Research: A Cautionary Tale and Lessons Not Learned.
[So] Source:Mol Endocrinol;29(9):1219-21, 2015 Sep.
[Is] ISSN:1944-9917
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa Biomédica/normas
Neuroendocrinologia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:EDITORIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150902
[St] Status:MEDLINE
[do] DOI:10.1210/me.2015-1209



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