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[PMID]:29368461
[Au] Autor:Steigerwald J
[Ti] Título:The Subject as Instrument: Galvanic Experiments, Organic Apparatus and Problems of Calibration.
[So] Source:Clio Med;95:80-110, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Calibragem
Desenho de Equipamento/história
Resposta Galvânica da Pele
Experimentação Humana/história
Neurofisiologia/história
[Mh] Termos MeSH secundário: Fenômenos Eletromagnéticos
História do Século XVIII
História do Século XIX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 4924 MEDLINE  
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[PMID]:29368460
[Au] Autor:Iliffe R
[Ti] Título:Galvanic Humans.
[So] Source:Clio Med;95:52-79, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Resposta Galvânica da Pele
Experimentação Humana/história
Neurofisiologia/história
[Mh] Termos MeSH secundário: Estimulação Elétrica
Fenômenos Eletromagnéticos
História do Século XVIII
História do Século XIX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  3 / 4924 MEDLINE  
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[PMID]:29208226
[Au] Autor:Dyakova O; Nordström K
[Ad] Endereço:Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
[Ti] Título:Image statistics and their processing in insect vision.
[So] Source:Curr Opin Insect Sci;24:7-14, 2017 Dec.
[Is] ISSN:2214-5753
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Natural scenes may appear random, but are not only constrained in space and time, but also show strong spatial and temporal correlations. Spatial constraints and correlations can be described by quantifying image statistics, which include intuitive measures such as contrast, color and luminance, but also parameters that need some type of transformation of the image. In this review we will discuss some common tools used to quantify spatial and temporal parameters of naturalistic visual input, and how these tools have been used to inform us about visual processing in insects. In particular, we will review findings that would not have been possible using conventional, experimenter defined stimuli.
[Mh] Termos MeSH primário: Insetos/fisiologia
Neurofisiologia/métodos
Visão Ocular
Percepção Visual
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  4 / 4924 MEDLINE  
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[PMID]:28837905
[Au] Autor:Bagheri E; Dauwels J; Dean BC; Waters CG; Westover MB; Halford JJ
[Ad] Endereço:School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore. Electronic address: elham001@e.ntu.edu.sg.
[Ti] Título:Interictal epileptiform discharge characteristics underlying expert interrater agreement.
[So] Source:Clin Neurophysiol;128(10):1994-2005, 2017 Oct.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The presence of interictal epileptiform discharges (IED) in the electroencephalogram (EEG) is a key finding in the medical workup of a patient with suspected epilepsy. However, inter-rater agreement (IRA) regarding the presence of IED is imperfect, leading to incorrect and delayed diagnoses. An improved understanding of which IED attributes mediate expert IRA might help in developing automatic methods for IED detection able to emulate the abilities of experts. Therefore, using a set of IED scored by a large number of experts, we set out to determine which attributes of IED predict expert agreement regarding the presence of IED. METHODS: IED were annotated on a 5-point scale by 18 clinical neurophysiologists within 200 30-s EEG segments from recordings of 200 patients. 5538 signal analysis features were extracted from the waveforms, including wavelet coefficients, morphological features, signal energy, nonlinear energy operator response, electrode location, and spectrogram features. Feature selection was performed by applying elastic net regression and support vector regression (SVR) was applied to predict expert opinion, with and without the feature selection procedure and with and without several types of signal normalization. RESULTS: Multiple types of features were useful for predicting expert annotations, but particular types of wavelet features performed best. Local EEG normalization also enhanced best model performance. As the size of the group of EEGers used to train the models was increased, the performance of the models leveled off at a group size of around 11. CONCLUSIONS: The features that best predict inter-rater agreement among experts regarding the presence of IED are wavelet features, using locally standardized EEG. Our models for predicting expert opinion based on EEGer's scores perform best with a large group of EEGers (more than 10). SIGNIFICANCE: By examining a large group of EEG signal analysis features we found that wavelet features with certain wavelet basis functions performed best to identify IEDs. Local normalization also improves predictability, suggesting the importance of IED morphology over amplitude-based features. Although most IED detection studies in the past have used opinion from three or fewer experts, our study suggests a "wisdom of the crowd" effect, such that pooling over a larger number of expert opinions produces a better correlation between expert opinion and objectively quantifiable features of the EEG.
[Mh] Termos MeSH primário: Eletroencefalografia/normas
Epilepsia/diagnóstico
Epilepsia/fisiopatologia
Neurofisiologia/normas
[Mh] Termos MeSH secundário: Bases de Dados Factuais/normas
Eletroencefalografia/métodos
Feminino
Seres Humanos
Masculino
Neurofisiologia/métodos
Variações Dependentes do Observador
Estudos Retrospectivos
Software/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


  5 / 4924 MEDLINE  
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[PMID]:28771570
[Au] Autor:Friedrich J; Yang W; Soudry D; Mu Y; Ahrens MB; Yuste R; Peterka DS; Paninski L
[Ad] Endereço:Department of Statistics, Grossman Center for the Statistics of Mind, and Center for Theoretical Neuroscience, Columbia University, New York, New York, United States of America.
[Ti] Título:Multi-scale approaches for high-speed imaging and analysis of large neural populations.
[So] Source:PLoS Comput Biol;13(8):e1005685, 2017 Aug.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Progress in modern neuroscience critically depends on our ability to observe the activity of large neuronal populations with cellular spatial and high temporal resolution. However, two bottlenecks constrain efforts towards fast imaging of large populations. First, the resulting large video data is challenging to analyze. Second, there is an explicit tradeoff between imaging speed, signal-to-noise, and field of view: with current recording technology we cannot image very large neuronal populations with simultaneously high spatial and temporal resolution. Here we describe multi-scale approaches for alleviating both of these bottlenecks. First, we show that spatial and temporal decimation techniques based on simple local averaging provide order-of-magnitude speedups in spatiotemporally demixing calcium video data into estimates of single-cell neural activity. Second, once the shapes of individual neurons have been identified at fine scale (e.g., after an initial phase of conventional imaging with standard temporal and spatial resolution), we find that the spatial/temporal resolution tradeoff shifts dramatically: after demixing we can accurately recover denoised fluorescence traces and deconvolved neural activity of each individual neuron from coarse scale data that has been spatially decimated by an order of magnitude. This offers a cheap method for compressing this large video data, and also implies that it is possible to either speed up imaging significantly, or to "zoom out" by a corresponding factor to image order-of-magnitude larger neuronal populations with minimal loss in accuracy or temporal resolution.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Biologia Computacional/métodos
Processamento de Imagem Assistida por Computador/métodos
Neurônios/citologia
[Mh] Termos MeSH secundário: Algoritmos
Animais
Camundongos
Neurofisiologia
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005685


  6 / 4924 MEDLINE  
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[PMID]:28377435
[Au] Autor:Slominski TN; Momsen JL; Montplaisir LM
[Ad] Endereço:Department of Biological Science, North Dakota State University, Fargo, North Dakota tara.slominski@ndsu.edu.
[Ti] Título:Drawing on student knowledge of neuroanatomy and neurophysiology.
[So] Source:Adv Physiol Educ;41(2):212-221, 2017 Jun 01.
[Is] ISSN:1522-1229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drawings are an underutilized assessment format in Human Anatomy and Physiology (HA&P), despite their potential to reveal student content understanding and alternative conceptions. This study used student-generated drawings to explore student knowledge in a HA&P course. The drawing tasks in this study focused on chemical synapses between neurons, an abstract concept in HA&P. Using two preinstruction drawing tasks, students were asked to depict synaptic transmission and summation. In response to the first drawing task, 20% of students ( = 352) created accurate representations of neuron anatomy. The remaining students created drawings suggesting an inaccurate or incomplete understanding of synaptic transmission. Of the 208 inaccurate student-generated drawings, 21% depicted the neurons as touching. When asked to illustrate summation, only 10 students (roughly 4%) were able to produce an accurate drawing. Overall, students were more successful at drawing anatomy (synapse) than physiology (summation) before formal instruction. The common errors observed in student-generated drawings indicate students do not enter the classroom as blank slates. The error of "touching" neurons in a chemical synapse suggests that students may be using intuitive or experiential knowledge when reasoning about physiological concepts. These results ) support the utility of drawing tasks as a tool to reveal student content knowledge about neuroanatomy and neurophysiology; and ) suggest students enter the classroom with better knowledge of anatomy than physiology. Collectively, the findings from this study inform both practitioners and researchers about the prevalence and nature of student difficulties in HA&P, while also demonstrating the utility of drawing in revealing student knowledge.
[Mh] Termos MeSH primário: Avaliação Educacional/métodos
Conhecimento
Neuroanatomia/educação
Neurofisiologia/educação
Estudantes/estatística & dados numéricos
[Mh] Termos MeSH secundário: Compreensão
Avaliação Educacional/normas
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1152/advan.00129.2016


  7 / 4924 MEDLINE  
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[PMID]:28377433
[Au] Autor:Casagrand J; Semsar K
[Ad] Endereço:Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado Janet.Casagrand@colorado.edu.
[Ti] Título:Redesigning a course to help students achieve higher-order cognitive thinking skills: from goals and mechanics to student outcomes.
[So] Source:Adv Physiol Educ;41(2):194-202, 2017 Jun 01.
[Is] ISSN:1522-1229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here we describe a 4-yr course reform and its outcomes. The upper-division neurophysiology course gradually transformed from a traditional lecture in 2004 to a more student-centered course in 2008, through the addition of evidence-based active learning practices, such as deliberate problem-solving practice on homework and peer learning structures, both inside and outside of class. Due to the incremental nature of the reforms and absence of pre-reform learning assessments, we needed a way to retrospectively assess the effectiveness of our efforts. To do this, we first looked at performance on 12 conserved exam questions. Students performed significantly higher post-reform on questions requiring lower-level cognitive skills and those requiring higher-level cognitive skills. Furthermore, student performance on conserved questions was higher post-reform in both the top and bottom quartiles of students, although lower-quartile student performance did not improve until after the first exam. To examine student learning more broadly, we also used Bloom's taxonomy to quantify a significant increase in the Bloom's level of exams, with students performing equally well post-reform on exams that had over twice as many questions at higher cognitive skill levels. Finally, we believe that four factors provided critical contributions to the success of the course reform, including: transformation efforts across multiple course components, alignment between formative and evaluative course materials, student buy-in to course instruction, and instructional support. This reform demonstrates both the effectiveness of incorporating student-centered, active learning into our course, and the utility of using Bloom's level as a metric to assess course reform.
[Mh] Termos MeSH primário: Currículo/normas
Neurofisiologia/educação
[Mh] Termos MeSH secundário: Cognição
Currículo/tendências
Avaliação Educacional
Metas
Seres Humanos
Estudantes
Pensamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1152/advan.00102.2016


  8 / 4924 MEDLINE  
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[PMID]:28216125
[Au] Autor:Abrams DA; Nicol T; White-Schwoch T; Zecker S; Kraus N
[Ad] Endereço:Auditory Neuroscience Laboratory, The Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL, 60208, USA. Electronic address: daa@stanford.edu.
[Ti] Título:Population responses in primary auditory cortex simultaneously represent the temporal envelope and periodicity features in natural speech.
[So] Source:Hear Res;348:31-43, 2017 May.
[Is] ISSN:1878-5891
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Speech perception relies on a listener's ability to simultaneously resolve multiple temporal features in the speech signal. Little is known regarding neural mechanisms that enable the simultaneous coding of concurrent temporal features in speech. Here we show that two categories of temporal features in speech, the low-frequency speech envelope and periodicity cues, are processed by distinct neural mechanisms within the same population of cortical neurons. We measured population activity in primary auditory cortex of anesthetized guinea pig in response to three variants of a naturally produced sentence. Results show that the envelope of population responses closely tracks the speech envelope, and this cortical activity more closely reflects wider bandwidths of the speech envelope compared to narrow bands. Additionally, neuronal populations represent the fundamental frequency of speech robustly with phase-locked responses. Importantly, these two temporal features of speech are simultaneously observed within neuronal ensembles in auditory cortex in response to clear, conversation, and compressed speech exemplars. Results show that auditory cortical neurons are adept at simultaneously resolving multiple temporal features in extended speech sentences using discrete coding mechanisms.
[Mh] Termos MeSH primário: Córtex Auditivo/fisiologia
Fala
Osso Temporal/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Percepção Auditiva/fisiologia
Potenciais Evocados Auditivos/fisiologia
Feminino
Cobaias
Masculino
Neurofisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


  9 / 4924 MEDLINE  
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[PMID]:28202664
[Au] Autor:Volta M; Melrose H
[Ad] Endereço:Center for Biomedicine, EURAC Research, Via Galvani 31, Bolzano 39100, Italy mattia.volta@eurac.edu melrose.heather@mayo.edu.
[Ti] Título:LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.
[So] Source:Biochem Soc Trans;45(1):113-122, 2017 Feb 08.
[Is] ISSN:1470-8752
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of familial Parkinson's disease (PD), resembling the sporadic disorder. Intensive effort has been directed toward LRRK2 mouse modeling and investigation, aimed at reproducing the human disease to inform mechanistic studies of pathogenesis and design of neuroprotective therapies. The physiological function of LRRK2 is still under exploration, but a clear role in striatal neurophysiology and animal behavior has emerged. Alterations in LRRK2 impair dopamine (DA) transmission, regulation and signaling, in addition to corticostriatal synaptic plasticity. Consistently, several subtle abnormalities in motor and nonmotor abilities have been demonstrated in LRRK2 genetic mouse models, generally paralleling preclinical symptoms of early DA dysfunction. However, the variability in model design and phenotypes observed requires a critical approach in interpreting the results, adapting the model used to the specific research question. Etiologically appropriate knockin mice might represent the ultimate animal model in which to study early disease mechanisms and therapies as well as to investigate drug effectiveness and off-target consequences.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/metabolismo
Neuroquímica/métodos
Neurofisiologia/métodos
Doença de Parkinson/enzimologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/genética
Camundongos Transgênicos
Mutação
Doença de Parkinson/genética
Doença de Parkinson/fisiopatologia
Córtex Visual/química
Córtex Visual/patologia
Córtex Visual/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 2.7.11.1 (Leucine-Rich Repeat Serine-Threonine Protein Kinase-2); EC 2.7.11.1 (Lrrk2 protein, mouse)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1042/BST20160238


  10 / 4924 MEDLINE  
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[PMID]:28179051
[Au] Autor:Otte A
[Ti] Título:Music and Neurophysiology.
[So] Source:Dtsch Arztebl Int;114(3):43, 2017 01 20.
[Is] ISSN:1866-0452
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Música
Neurofisiologia
[Mh] Termos MeSH secundário: Encéfalo
Cognição
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE



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