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[PMID]:28456536
[Au] Autor:More Bayona JA; Karuppannan AK; Barreda DR
[Ad] Endereço:Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2P5, Canada.
[Ti] Título:Contribution of leukocytes to the induction and resolution of the acute inflammatory response in chickens.
[So] Source:Dev Comp Immunol;74:167-177, 2017 Sep.
[Is] ISSN:1879-0089
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A successful immune response against invading pathogens relies on the efficient activation of host defense mechanisms and a timely return to immune homeostasis. Despite their importance, these mechanisms remain ill-defined in most animal groups. This study focuses on the acute inflammatory response of chickens, important both as an avian model with a unique position in evolution as well as an increasingly notable target of infectious zoonotic diseases. We took advantage of an in vivo self-resolving intra-abdominal challenge model to provide an integrative view of leukocyte responses during the induction and resolution phases of acute inflammation. Our results showed rapid leukocyte infiltration into the abdominal cavity post zymosan challenge (significant increase as early as 4 h), which was dominated by heterophils. Peak leukocyte infiltration and ROS production reached maximum levels at 12 h post challenge, which was significantly earlier than comparative studies in teleost fish and mice. Both heterophils and monocyte/macrophages contributed to ROS production. Local leukocyte infiltration was preceded by an increase in peripheral leukocytes and a drop in the number of bone marrow leukocytes. The proportion of apoptotic leukocytes increased following peak of acute inflammation, rising to significant levels within the abdominal cavity by 48 h, consistent with other indicators for the resolution of inflammation. Importantly, comparison of chicken phagocytic responses with those previously shown in agnathan, teleost and murine models suggested a progressive evolutionary shift towards an increased sensitivity to pro-inflammatory pathogen-derived particles and decreased sensitivity towards homeostatic stimuli. Thus, while significant conservation can be noted across the immune systems of endotherms, this study highlights additional unique features that govern the induction and resolution of acute inflammation in the avian system, which may be relevant to disease susceptibility and performance.
[Mh] Termos MeSH primário: Doenças das Aves/imunologia
Galinhas/imunologia
Inflamação/imunologia
Leucócitos/imunologia
Peritônio/fisiologia
Zoonoses/imunologia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Apoptose
Evolução Biológica
Movimento Celular
Proliferação Celular
Peixes
Seres Humanos
Imunidade Inata
Camundongos
Fagocitose
Fisiologia Comparada
Espécies Reativas de Oxigênio/metabolismo
Zimosan/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 9010-72-4 (Zymosan)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  2 / 1244 MEDLINE  
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[PMID]:28092374
[Au] Autor:Engelhardt B; Vajkoczy P; Weller RO
[Ad] Endereço:Theodor Kocher Institute, University of Bern, Bern, Switzerland.
[Ti] Título:The movers and shapers in immune privilege of the CNS.
[So] Source:Nat Immunol;18(2):123-131, 2017 Feb.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS. Recent rediscoveries of lymphatic vessels within the dura mater surrounding the brain, made possible by modern live-cell imaging technologies, have revived this discussion. This review emphasizes the fact that understanding immune privilege of the CNS requires intimate knowledge of its unique anatomy. Endothelial, epithelial and glial brain barriers establish compartments in the CNS that differ strikingly with regard to their accessibility to immune-cell subsets. There is a unique system of lymphatic drainage from the CNS to the peripheral lymph nodes. We summarize current knowledge on the cellular and molecular mechanisms involved in immune-cell trafficking and lymphatic drainage from the CNS, and we take into account differences in rodent and human CNS anatomy.
[Mh] Termos MeSH primário: Sistema Nervoso Central/imunologia
Dura-Máter/imunologia
Tolerância Imunológica
Microglia/imunologia
Fisiologia Comparada
[Mh] Termos MeSH secundário: Animais
Autoimunidade
Movimento Celular/imunologia
Sistema Nervoso Central/anatomia & histologia
Seres Humanos
Vigilância Imunológica
Camundongos
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1038/ni.3666


  3 / 1244 MEDLINE  
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[PMID]:27395034
[Au] Autor:Shiina T; Blancher A; Inoko H; Kulski JK
[Ad] Endereço:Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
[Ti] Título:Comparative genomics of the human, macaque and mouse major histocompatibility complex.
[So] Source:Immunology;150(2):127-138, 2017 Feb.
[Is] ISSN:1365-2567
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The MHC is a highly polymorphic genomic region that encodes the transplantation and immune regulatory molecules. It receives special attention for genetic investigation because of its important role in the regulation of innate and adaptive immune responses and its strong association with numerous infectious and/or autoimmune diseases. The MHC locus was first discovered in the mouse and for the past 50 years it has been studied most intensively in both mice and humans. However, in recent years the macaque species have emerged as some of the more important and advanced experimental animal models for biomedical research into MHC with important human immunodeficiency virus/simian immunodeficiency virus and transplantation studies undertaken in association with precise MHC genotyping and haplotyping methods using Sanger sequencing and next-generation sequencing. Here, in this special issue on 'Macaque Immunology' we provide a short review of the genomic similarities and differences among the human, macaque and mouse MHC class I and class II regions, with an emphasis on the association of the macaque class I region with MHC polymorphism, haplotype structure and function.
[Mh] Termos MeSH primário: Doenças Autoimunes/genética
Genômica
Imunidade
Infecção/genética
Macaca
Complexo Principal de Histocompatibilidade/genética
Camundongos
[Mh] Termos MeSH secundário: Animais
Evolução Molecular
Genótipo
Histocompatibilidade/genética
Seres Humanos
Imunidade/genética
Fisiologia Comparada
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160711
[St] Status:MEDLINE
[do] DOI:10.1111/imm.12624


  4 / 1244 MEDLINE  
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[PMID]:27852759
[Au] Autor:Kohl KD; Carey HV
[Ad] Endereço:Department of Biological Sciences, Vanderbilt University, Nashville, TN 53705, USA kevin.d.kohl@gmail.com hannah.carey@wisc.edu.
[Ti] Título:A place for host-microbe symbiosis in the comparative physiologist's toolbox.
[So] Source:J Exp Biol;219(Pt 22):3496-3504, 2016 Nov 15.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although scientists have long appreciated that metazoans evolved in a microbial world, we are just beginning to appreciate the profound impact that host-associated microbes have on diverse aspects of animal biology. The enormous growth in our understanding of host-microbe symbioses is rapidly expanding the study of animal physiology, both technically and conceptually. Microbes associate functionally with various body surfaces of their hosts, although most reside in the gastrointestinal tract. Gut microbes convert dietary and host-derived substrates to metabolites such as short-chain fatty acids, thereby providing energy and nutrients to the host. Bacterial metabolites incorporated into the host metabolome can activate receptors on a variety of cell types and, in doing so, alter host physiology (including metabolism, organ function, biological rhythms, neural activity and behavior). Given that host-microbe interactions affect diverse aspects of host physiology, it is likely that they influence animal ecology and, if they confer fitness benefits, the evolutionary trajectory of a species. Multiple variables - including sampling regime, environmental parameters, host metadata and analytical methods - can influence experimental outcomes in host-microbiome studies, making careful experimental design and execution crucial to ensure reproducible and informative studies in the laboratory and field. Integration of microbiomes into comparative physiology and ecophysiological investigations can reveal the potential impacts of the microbiota on physiological responses to changing environments, and is likely to bring valuable insights to the study of host-microbiome interactions among a broad range of metazoans, including humans.
[Mh] Termos MeSH primário: Microbiota
Fisiologia Comparada/métodos
Simbiose/fisiologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Ecossistema
Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


  5 / 1244 MEDLINE  
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[PMID]:27708045
[Au] Autor:Rühli F; van Schaik K; Henneberg M
[Ad] Endereço:Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland; frank.ruehli@iem.uzh.ch.
[Ti] Título:Evolutionary Medicine: The Ongoing Evolution of Human Physiology and Metabolism.
[So] Source:Physiology (Bethesda);31(6):392-397, 2016 Nov 01.
[Is] ISSN:1548-9221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The field of evolutionary medicine uses evolutionary principles to understand changes in human anatomy and physiology that have occurred over time in response to environmental changes. Through this evolutionary-based approach, we can understand disease as a consequence of anatomical and physiological "trade-offs" that develop to facilitate survival and reproduction. We demonstrate how diachronic study of human anatomy and physiology is fundamental for an increased understanding of human health and disease.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Evolução Biológica
Meio Ambiente
Medicina
Reprodução/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Medicina/tendências
Fisiologia Comparada/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE


  6 / 1244 MEDLINE  
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[PMID]:27062879
[Au] Autor:Polejaeva IA; Rutigliano HM; Wells KD
[Ad] Endereço:Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.
[Ti] Título:Livestock in biomedical research: history, current status and future prospective.
[So] Source:Reprod Fertil Dev;28(1-2):112-24, 2016.
[Is] ISSN:1031-3613
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Livestock models have contributed significantly to biomedical and surgical advances. Their contribution is particularly prominent in the areas of physiology and assisted reproductive technologies, including understanding developmental processes and disorders, from ancient to modern times. Over the past 25 years, biomedical research that traditionally embraced a diverse species approach shifted to a small number of model species (e.g. mice and rats). The initial reasons for focusing the main efforts on the mouse were the availability of murine embryonic stem cells (ESCs) and genome sequence data. This powerful combination allowed for precise manipulation of the mouse genome (knockouts, knockins, transcriptional switches etc.) leading to ground-breaking discoveries on gene functions and regulation, and their role in health and disease. Despite the enormous contribution to biomedical research, mouse models have some major limitations. Their substantial differences compared with humans in body and organ size, lifespan and inbreeding result in pronounced metabolic, physiological and behavioural differences. Comparative studies of strategically chosen domestic species can complement mouse research and yield more rigorous findings. Because genome sequence and gene manipulation tools are now available for farm animals (cattle, pigs, sheep and goats), a larger number of livestock genetically engineered (GE) models will be accessible for biomedical research. This paper discusses the use of cattle, goats, sheep and pigs in biomedical research, provides an overview of transgenic technology in farm animals and highlights some of the beneficial characteristics of large animal models of human disease compared with the mouse. In addition, status and origin of current regulation of GE biomedical models is also reviewed.
[Mh] Termos MeSH primário: Animais de Laboratório/fisiologia
Pesquisa Biomédica/história
Modelos Animais de Doenças
Gado/fisiologia
Fisiologia Comparada/história
Técnicas de Reprodução Assistida/história
[Mh] Termos MeSH secundário: Experimentação Animal/história
Experimentação Animal/legislação & jurisprudência
Animais
Animais Geneticamente Modificados
Animais de Laboratório/genética
Pesquisa Biomédica/legislação & jurisprudência
Pesquisa Biomédica/tendências
Bovinos
Engenharia Genética/história
Engenharia Genética/legislação & jurisprudência
Engenharia Genética/tendências
Cabras
História do Século XX
História do Século XXI
Gado/genética
Técnicas de Reprodução Assistida/veterinária
Carneiro Doméstico
Sus scrofa
Pesquisa Médica Translacional/história
Pesquisa Médica Translacional/legislação & jurisprudência
Pesquisa Médica Translacional/tendências
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE
[do] DOI:10.1071/RD15343


  7 / 1244 MEDLINE  
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[PMID]:26902932
[Au] Autor:Brugman S
[Ad] Endereço:Animal Sciences Group, Cell Biology and Immunology, Wageningen University, De Elst 1, room Ee1253, 6708 WD Wageningen, Netherlands. Electronic address: Sylvia.brugman@wur.nl.
[Ti] Título:The zebrafish as a model to study intestinal inflammation.
[So] Source:Dev Comp Immunol;64:82-92, 2016 11.
[Is] ISSN:1879-0089
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Starting out as a model for developmental biology, during the last decade, zebrafish have also gained the attention of the immunologists and oncologists. Due to its small size, high fecundity and full annotation of its genome, the zebrafish is an attractive model system. The fact that fish are transparent early in life combined with the growing list of immune cell reporter fish, enables in vivo tracking of immune responses in a complete organism. Since zebrafish develop ex utero from a fertilized egg, immune development can be monitored from the start of life. Given that several gut functions and immune genes are conserved between zebrafish and mammals, the zebrafish is an interesting model organism to investigate fundamental processes underlying intestinal inflammation and injury. This review will first provide some background on zebrafish intestinal development, bacterial colonization and immunity, showing the similarities and differences compared to mammals. This will be followed by an overview of the existing models for intestinal disease, and concluded by future perspectives in light of the newest technologies and insights.
[Mh] Termos MeSH primário: Infecções Bacterianas/imunologia
Modelos Animais de Doenças
Imunidade nas Mucosas
Inflamação/imunologia
Doenças Inflamatórias Intestinais/genética
Intestinos/fisiologia
Peixe-Zebra/imunologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Edição de Genes/métodos
Genes Reporter/genética
Seres Humanos
Inflamação/genética
Mamíferos
Microbiota
Fisiologia Comparada
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160224
[St] Status:MEDLINE


  8 / 1244 MEDLINE  
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[PMID]:26493017
[Au] Autor:Söderhäll K
[Ad] Endereço:Uppsala University, Department of Comparative Physiology, Norbyvagen 18A, 752 36 Uppsala, Sweden. Electronic address: kenneth.soderhall@ebc.uu.se.
[Ti] Título:Announcing the appointment of Mike Belosevic as Coeditor-in-Chief.
[So] Source:Dev Comp Immunol;55:A1, 2016 Feb.
[Is] ISSN:1879-0089
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alergia e Imunologia
Biologia do Desenvolvimento
Revisão da Pesquisa por Pares
Fisiologia Comparada
[Mh] Termos MeSH secundário: Animais
Políticas Editoriais
Seres Humanos
Invertebrados
Vertebrados
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151219
[Lr] Data última revisão:
151219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151024
[St] Status:MEDLINE


  9 / 1244 MEDLINE  
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[PMID]:26455465
[Au] Autor:Smith LC; Hudgell MA; Deiss T; Golconda P; Krasnec K; Lun CM; Neely H; Pereiro P; Priyam M; Semple SL; Skokal U; Tacchi L; Takizawa F; Xu Z; Yadav S
[Ad] Endereço:Department of Biological Sciences, George Washington University, Washington DC, USA. Electronic address: csmith@gwu.edu.
[Ti] Título:Conference Report: The 13th Congress of the International Society of Developmental and Comparative Immunology.
[So] Source:Dev Comp Immunol;55:56-64, 2016 Feb.
[Is] ISSN:1879-0089
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alergia e Imunologia
Biologia do Desenvolvimento
Fisiologia Comparada
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Cooperação Internacional
Sociedades Científicas
Espanha
[Pt] Tipo de publicação:CONGRESSES; LETTER; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151219
[Lr] Data última revisão:
151219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151013
[St] Status:MEDLINE


  10 / 1244 MEDLINE  
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[PMID]:26538171
[Au] Autor:Hoppeler HH; Handel MJ; Moulton OC
[Ad] Endereço:Editor in Chief, Journal of Experimental Biology hoppeler@ana.unibe.ch.
[Ti] Título:Supporting biologists, inspiring biology.
[So] Source:J Exp Biol;218(Pt 21):3351-2, 2015 Nov.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Biologia
Publicações Periódicas como Assunto
Fisiologia Comparada
[Mh] Termos MeSH secundário: Biologia/economia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151106
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.132845



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