Base de dados : MEDLINE
Pesquisa : H01.181.529 [Categoria DeCS]
Referências encontradas : 31275 [refinar]
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[PMID]:29411802
[Au] Autor:Patel K; Singh N; Yadav J; Nayak JM; Sahoo SK; Lata J; Chand D; Kumar S; Kumar R
[Ad] Endereço:Department of Applied Chemistry, S.V. National Institute of Technology, Surat-395007, Gujarat, India. rajenderkumar@chem.svnit.ac.in.
[Ti] Título:Polydopamine films change their physicochemical and antimicrobial properties with a change in reaction conditions.
[So] Source:Phys Chem Chem Phys;20(8):5744-5755, 2018 Feb 21.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The morphology and physicochemical properties of polydopamine are not totally inherent and undergo changes with differing reaction conditions like the choice of solvent used for polymerization. The polymerisation of dopamine to polydopamine carried out in different solvents like sodium hydroxide, sodium bicarbonate, PBS and Tris leads to polydopamine with exceptionally different morphological and physicochemical features with each solvent. Additionally, the different physicochemical characteristics and morphologies bestow the polymer films with different extents of antimicrobial activity. Moreover, the findings supported by chemical evidence from X-ray photoelectron spectroscopy reveal that higher antibacterial activities were obtained against E. coli and S. aureus with polydopamine films prepared by Tris and NaOH solvent induced polymerization. The antibacterial activity observed in saline was found to be higher than that in PBS medium for both E. coli and S. aureus. The higher antibacterial activity of polydopamine films prepared in Tris and NaOH solvents was attributed to the covalent incorporation of -OH groups on the surface provided by nucleophilic Tris and NaOH solvents during the polymerisation process. The distinct physicochemical and morphological changes were supported by the results from contact angle measurements, FE-SEM, EDAX, AFM, and XPS analysis. The present finding provides insight into the different chemistry, morphologies and properties of the designed polydopamine films with controlled antibacterial/antifouling properties. Additionally, new insights into the mechanism of formation, physicochemical changes in morphology and properties of polydopamine coatings were revealed.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Escherichia coli/efeitos dos fármacos
Indóis/farmacologia
Polímeros/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Química Física
Escherichia coli/citologia
Indóis/síntese química
Indóis/química
Testes de Sensibilidade Microbiana
Estrutura Molecular
Tamanho da Partícula
Polímeros/síntese química
Polímeros/química
Staphylococcus aureus/citologia
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Indoles); 0 (Polymers); 0 (polydopamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp08406d


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[PMID]:29275233
[Au] Autor:Mostarda S; Passeri D; Carotti A; Cerra B; Colliva C; Benicchi T; Macchiarulo A; Pellicciari R; Gioiello A
[Ad] Endereço:Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy.
[Ti] Título:Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification.
[So] Source:Eur J Med Chem;144:349-358, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Glucuronidation is considered an important detoxification pathway of bile acids especially in cholestatic conditions. Glucuronides are less toxic than the parent free forms and are more easily excreted in urine. However, the pathophysiological significance of bile acid glucuronidation is still controversial and debated among the scientific community. Progress in this field has been strongly limited by the lack of appropriate methods for the preparation of pure glucuronides in the amount needed for biological and pharmacological studies. In this work, we have developed a new synthesis of bile acid C3-glucuronides enabling the convenient preparation of gram-scale quantities. The synthesized compounds have been characterized in terms of physicochemical properties and abilities to modulate key nuclear receptors including the farnesoid X receptor (FXR). In particular, we found that C3-glucuronides of chenodeoxycholic acid and lithocholic acid, respectively the most abundant and potentially cytotoxic species formed in patients affected by cholestasis, behave as FXR agonists and positively regulate the gene expression of transporter proteins, the function of which is critical in human conditions related to imbalances of bile acid homeostasis.
[Mh] Termos MeSH primário: Ácidos e Sais Biliares/farmacologia
Glucuronídeos/farmacologia
Receptores Citoplasmáticos e Nucleares/agonistas
[Mh] Termos MeSH secundário: Ácidos e Sais Biliares/química
Química Física
Relação Dose-Resposta a Droga
Glucuronídeos/química
Células HEK293
Células Hep G2
Seres Humanos
Simulação de Dinâmica Molecular
Estrutura Molecular
Receptores Citoplasmáticos e Nucleares/genética
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Glucuronides); 0 (Receptors, Cytoplasmic and Nuclear); 0 (farnesoid X-activated receptor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


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[PMID]:29148294
[Au] Autor:Xie X; Cong W; Zhao F; Li H; Xin W; Hou G; Wang C
[Ad] Endereço:a School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China , Binzhou Medical University , Yantai , P. R. China.
[Ti] Título:Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts.
[So] Source:J Enzyme Inhib Med Chem;33(1):98-105, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Twenty-four novel 5-phenyl-1,3,4-oxadiazole-2-thiol (POT) analogues, benzo[d]oxazole-2-thiol, benzo[d]thiazole-2-thiol and 5-methyl-1,3,4-thiadiazole-2-thiol-substituted N,N-bis(2-hydroxyethyl) quaternary ammonium salts (QAS) (5a-d, 6a-d, 7a-d, 10a-d, 13a-d, 16a-d) were prepared and characterised by FTIR, NMR and elemental analysis. Part of target compounds (5d, 6d, 7d, 10d, 13d, 16d) displayed potent antimicrobial effect against ten common pathogens (S. aureus, α-H-tococcus, ß-H-tococcus, E. coli, P. aeruginosa, Proteus vulgaris, Canidia Albicans, Cytospora mandshurica, Physalospora piricola, Aspergillus niger) and had relatively low cytotoxity against two human cell lines (HaCat and LO2). TEM and SEM images of E. coli and S. aureus morphologies treated with 7d showed that the antibacterial mechanism might be the QAS fixing on cell wall surfaces and puncturing to result in the release of bacterial cytoplasm. This study provides new information of QAS, which could be used to design novel antimicrobial agents applied in clinic or agriculture.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Fungos/efeitos dos fármacos
Compostos de Amônio Quaternário/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antifúngicos/química
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Parede Celular/efeitos dos fármacos
Química Física
Relação Dose-Resposta a Droga
Seres Humanos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Compostos de Amônio Quaternário/química
Sais/química
Sais/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Quaternary Ammonium Compounds); 0 (Salts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171118
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1396456


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[PMID]:28658226
[Au] Autor:Vallance C
[Ad] Endereço:Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
[Ti] Título:Physical chemistry: The fingerprints of reaction mechanisms.
[So] Source:Nature;546(7660):608-609, 2017 06 28.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Química Física
[Pt] Tipo de publicação:NEWS; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1038/546608a


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[PMID]:28388050
[Au] Autor:Rankovic Z
[Ad] Endereço:Eli Lilly and Company , 893 South Delaware Street, Indianapolis, Indiana 46285, United States.
[Ti] Título:CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain.
[So] Source:J Med Chem;60(14):5943-5954, 2017 Jul 27.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the "limits and boundaries" of the central nervous system (CNS) property space is a critical aspect of modern CNS drug design. Medicinal chemists are often guided by the physicochemical properties of marketed CNS drugs, which are heavily biased toward "traditional" aminergic targets and commonly described as small lipophilic amines. This miniperspective describes the statistical analysis of the calculated physicochemical properties for a diverse set of ligands for mostly "nontraditional" CNS targets and classified as either "brain penetrant" or "peripherally restricted" on the basis of the experimental mouse brain exposure. The results suggested that (a) the physicochemical property space conducive to brain exposure is larger than the one defined by the marketed CNS drugs and (b) the most critical brain exposure determinants are descriptors of the molecular size and hydrogen bond capacity. These findings led to a modified version of the CNS MPO scoring algorithm, termed CNS MPO.v2.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Fármacos do Sistema Nervoso Central/química
Fármacos do Sistema Nervoso Central/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Barreira Hematoencefálica/metabolismo
Química Física
Bases de Dados de Compostos Químicos
Camundongos
Permeabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.6b01469


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[PMID]:28347782
[Au] Autor:Matencio A; García-Carmona F; López-Nicolás JM
[Ad] Endereço:Department of Biochemistry and Molecular Biology-A, Faculty of Biology, University of Murcia, Campus de Espinardo, 30071, Murcia, Spain.
[Ti] Título:Aggregation of t10,c12 conjugated linoleic Acid in presence of natural and modified cyclodextrins. A physicochemical, thermal and computational analysis.
[So] Source:Chem Phys Lipids;204:57-64, 2017 Apr.
[Is] ISSN:1873-2941
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In this work the aggregation behavior of t10,c12 Conjugated linoleic acid (t10,c12-CLA) is presented for first time. The results show a c.m.c. of 25µM at pH 8 and 25°C. The encapsulation process with cyclodextrins (CDs) presented a 1:1 stoichiometry in all cases studied but the complexation constants were strongly dependent on the type of CDs used, the pH and temperature. Hydroxypropyl-beta-Cyclodextrin (HPßCD) was the best CD studied for encapsulating t10,c12-CLA. The resulting t10,c12-CLA-HPßCD complex showed a very high dependency on pH, which explains why a pK of 4.08 was found for first time, which was very close to the simulated value. Furthermore, the effect of temperature on the t10,c12-CLA-HPßCD was studied. The complexation constant (K ) showed an increase behavior with the temperature. In addition, molecular docking calculations provided further insights into how the different interactions influence the complexation constant. Finally, a comparative study with rumenic acid, an isomer, was carried out.
[Mh] Termos MeSH primário: Ciclodextrinas/química
Ácidos Linoleicos Conjugados/química
Simulação de Acoplamento Molecular
Temperatura Ambiente
[Mh] Termos MeSH secundário: Química Física
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclodextrins); 0 (Linoleic Acids, Conjugated)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE


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[PMID]:28092802
[Au] Autor:Bujalowski W; Jezewska MJ; Bujalowski PJ
[Ad] Endereço:Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555-1053, USA; Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555-1053, USA; The Sealy Center for Structural Biology, Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555-1053, USA. Electronic address: wbujalow@utmb.edu.
[Ti] Título:Signal and binding. I. Physico-chemical response to macromolecule-ligand interactions.
[So] Source:Biophys Chem;222:7-24, 2017 Mar.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Obtaining a detailed knowledge about energetics of ligand-macromolecule interactions is a prerequisite for elucidation of the nature, behavior, and activities of the formed complexes. The most commonly used methods in characterizing molecular interactions are physico-chemical techniques based mainly on spectroscopic, calorimetric, hydrodynamic, etc., measurements. The major advantage of the physico-chemical methods is that they do not require large quantities of material and, if performed carefully, do not perturb examined reactions. Applications of several different physico-chemical approaches, commonly encountered in analyses of biochemical interactions, are here reviewed and discussed, using examples of simple binding reactions. It is stressed that without determination of the relationship between the measured signal and the total average degree of binding, the performed analysis of a single physico-chemical titration curve may provide only fitting parameters, instead of meaningful interaction parameters, already for the binding systems with only two ligand molecules. Some possible pitfalls in the analyses of single titration curves are discussed.
[Mh] Termos MeSH primário: Química Física/métodos
Ligantes
Substâncias Macromoleculares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ligands); 0 (Macromolecular Substances)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:28011399
[Au] Autor:Platero E; Fernandez ME; Bonelli PR; Cukierman AL
[Ad] Endereço:Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Industrias, Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía-PINMATE, Intendente Güiraldes 2620, Ciudad Universitaria, (C1428BGA) Buenos Aires, Argentina.
[Ti] Título:Graphene oxide/alginate beads as adsorbents: Influence of the load and the drying method on their physicochemical-mechanical properties and adsorptive performance.
[So] Source:J Colloid Interface Sci;491:1-12, 2017 Apr 01.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Graphene oxide/alginate beads were prepared from lab-synthesized graphene oxide, varying its content within the beads (0.05, 0.125, and 0.25wt.%). Ethanol-drying and lyophilization were compared as drying methods to obtain suitable adsorbents which were later tested to the removal of a model organic molecule (methylene blue). The morphological and textural properties of all the beads were characterized by scanning electron microscopy and N adsorption/desorption isotherms at -196°C, respectively. Limited porosity was obtained for all cases (S <60m /g). Uniaxial compression tests were performed to assess the mechanical properties of the beads. Ethanol-dried ones exhibited higher Young's elasticity modulus (E=192kPa) than the lyophilized samples (twice at 0.25wt.% graphene oxide loading), which disclosed breakage points at lower deformation percentages. Adsorption experiments were conducted and dye adsorption isotherms were obtained for the beads with the best removal performance. The experimental data were better fitted by the Langmuir model. The highest maximum adsorption capacity (4.25mmol/g) was obtained for the lyophilized beads with the highest graphene oxide content. Mechanical properties were found to be affected also by the dye adsorption.
[Mh] Termos MeSH primário: Alginatos/química
Grafite/química
Óxidos/química
[Mh] Termos MeSH secundário: Adsorção
Química Física
Etanol/química
Liofilização
Ácido Glucurônico/química
Ácidos Hexurônicos/química
Tamanho da Partícula
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Hexuronic Acids); 0 (Oxides); 3K9958V90M (Ethanol); 7782-42-5 (Graphite); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


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[PMID]:27908412
[Au] Autor:Dos Reis Antunes Junior O; Antônio E; Mainardes RM; Khalil NM
[Ad] Endereço:Laboratory of Pharmaceutical Nanotechnology, Department of Pharmacy, Universidade Estadual do Centro-Oeste/UNICENTRO, Guarapuava/PR, Brazil.
[Ti] Título:Preparation, physicochemical characterization and antioxidant activity of diphenyl diselenide-loaded poly(lactic acid) nanoparticles.
[So] Source:J Trace Elem Med Biol;39:176-185, 2017 Jan.
[Is] ISSN:1878-3252
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, we developed, characterized and evaluated the antioxidant activity of poly (lactic acid) nanoparticles containing diphenyl diselenide (PhSe) . Nanoparticles were characterized in terms of mean particle size, polydispersity index, zeta potential, encapsulation efficiency, in vitro release profile, physical stability, polymer-drug interactions and thermal properties. Also, the antioxidant activity of nanoparticles on hypochlorous acid (HOCl) was assessed. Nanoparticles presented a mean size of 210nm, had low polydispersity, zeta potential of -24mV, and an encapsulation efficiency over 90%. Differential scanning calorimetry and X-ray diffraction results showed (PhSe) is dispersed in PLA matrix in an amorphous state. Lyophilized nanoparticles maintained physical stability over three months, while nanoparticles dispersed in water did not present stability over 7days. In vitro release assay was characterized by a biphasic release pattern with burst effect in 8h followed by a sustained release diffusion governed over 192h. Nanoencapsulation did not alter the antioxidant activity of (PhSe) on HOCl. The study concludes these properties of (PhSe) -loaded nanoparticles can be useful to extend the biological effects of (PhSe) .
[Mh] Termos MeSH primário: Antioxidantes/química
Derivados de Benzeno/química
Nanopartículas/química
Compostos Organosselênicos/química
Poliésteres/química
[Mh] Termos MeSH secundário: Química Física
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzene Derivatives); 0 (Organoselenium Compounds); 0 (Polyesters); 1666-13-3 (diphenyldiselenide); 459TN2L5F5 (poly(lactide))
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170812
[Lr] Data última revisão:
170812
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:27338298
[Au] Autor:Corina D; Bojin F; Ambrus R; Muntean D; Soica C; Paunescu V; Cristea M; Pinzaru I; Dehelean C
[Ad] Endereço:Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
[Ti] Título:Physico-chemical and Biological Evaluation of Flavonols: Fisetin, Quercetin and Kaempferol Alone and Incorporated in beta Cyclodextrins.
[So] Source:Anticancer Agents Med Chem;17(4):615-626, 2017.
[Is] ISSN:1875-5992
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fisetin,quercetin and kaempferol are among the important representatives of flavonols, biological active phytocomounds, with low water solubility. OBJECTIVE: To evaluate the antimicrobial effect, respectively the antiproliferative and pro apoptotic activity on the B164A5 murine melanoma cell line of pure flavonols and their beta cyclodextrins complexes. METHOD: Incorporation of fisetin, quercetin and kaempferol in beta cyclodextrins was proved by scanning electron microscopy (SEM), differencial scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). Pure compounds and their complexes were tested for antiproliferative (MTT) and pro-apoptotic activity (Annexin V-PI) on the B164A5 murine melanoma cell line and for the antimicrobial properties (Disk Diffusion Method) on the selected strains. RESULTS: The phytocompounds presented in a different manner in vitro chemopreventive activity against B164A5 murine melanoma cell line and weak antimicrobial effect. CONCLUSION: The three flavonols: fisetin, quercetin and kaempferol were successfully incorporated in beta-cyclodextrin (BCD) and hydroxylpropyl-beta-cyclodextrin (HPBCD). Incorporation in beta cyclodextrins had a mix effect on the biological activity conducing to decrease, increase or consistent effect compared to pure phytocompound, depending on the screened process and on the chosen combination.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antineoplásicos/farmacologia
Flavonoides/farmacologia
Quempferóis/farmacologia
Quercetina/farmacologia
beta-Ciclodextrinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/isolamento & purificação
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Bactérias/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Química Física
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Flavonoides/química
Flavonoides/isolamento & purificação
Quempferóis/química
Quempferóis/isolamento & purificação
Camundongos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Quercetina/química
Quercetina/isolamento & purificação
Relação Estrutura-Atividade
Células Tumorais Cultivadas
beta-Ciclodextrinas/química
beta-Ciclodextrinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Flavonoids); 0 (Kaempferols); 0 (beta-Cyclodextrins); 731P2LE49E (kaempferol); 9IKM0I5T1E (Quercetin); OO2ABO9578 (fisetin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE
[do] DOI:10.2174/1871520616666160621105306



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde