[PMID]: | 28453970 |
[Au] Autor: | Yamamoto R; Koyama D; Matsukawa M |
[Ad] Endereço: | Faculty of Life and Medical Sciences, Doshisha University, 1-3 Tataramiyakodani, Kyotanabe, Kyoto 610-0321, Japan; Wave Electronics Research Center, Doshisha University, 1-3 Tataramiyakodani, Kyotanabe, Kyoto 610-0321, Japan. |
[Ti] Título: | On-chip ultrasonic manipulation of microparticles by using the flexural vibration of a glass substrate. |
[So] Source: | Ultrasonics;79:81-86, 2017 08. |
[Is] ISSN: | 1874-9968 |
[Cp] País de publicação: | Netherlands |
[La] Idioma: | eng |
[Ab] Resumo: | As biotechnology develops, techniques for manipulating and separating small particles such as cells and DNA are required in the life sciences. This paper investigates on-chip manipulation of microparticles in small channels by using ultrasonic vibration. The chip consists of a rectangular glass substrate with a cross-shaped channel (cross-section: 2.0×2.0mm ) and four lead zirconate titanate transducers attached to the substrate's four corners. To efficiently generate the flexural vibration mode on the chip, we used finite element analysis to optimize the configurations of the glass substrate and transducers. Silicon carbide microparticles with an average diameter of 50µm were immersed in the channels, which were filled with ethanol. By applying an in-phase input voltage of 75V at 225kHz to the four transducers, a flexural vibration mode with a wavelength of 13mm was excited on the glass substrate, and this flexural vibration generated an acoustic standing wave in the channel. The particles could be trapped at the nodal lines of the standing wave. By controlling the driving phase difference between the two pairs of transducers, the vibrational distribution of the substrate could be moved along the channels so that the acoustic standing wave moved in the same direction. The trapped particles could be manipulated by the two-phase drive, and the transport direction could be switched at the junction of the channels orthogonally by changing the combination of the driving condition to four transducers. |
[Mh] Termos MeSH primário: |
Vidro/química Chumbo/química Titânio/química Ultrassom/métodos Zircônio/química
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[Mh] Termos MeSH secundário: |
Análise de Elementos Finitos Tamanho da Partícula Som Vibração
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 12626-81-2 (lead titanate zirconate); 2P299V784P (Lead); C6V6S92N3C (Zirconium); D1JT611TNE (Titanium) |
[Em] Mês de entrada: | 1801 |
[Cu] Atualização por classe: | 180118 |
[Lr] Data última revisão:
| 180118 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170429 |
[St] Status: | MEDLINE |
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