Base de dados : MEDLINE
Pesquisa : H01.770.808 [Categoria DeCS]
Referências encontradas : 2847 [refinar]
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[PMID]:29253905
[Au] Autor:Jäger G; Hofer C; Kapeller M; Füllsack M
[Ad] Endereço:Institute of Systems Sciences, Innovation and Sustainability Research, University of Graz, Graz, Austria.
[Ti] Título:Hidden early-warning signals in scale-free networks.
[So] Source:PLoS One;12(12):e0189853, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Critical transitions of complex systems can often be predicted by so-called early-warning signals (EWS). In some cases, however, such signals cannot be detected although a critical transition is imminent. Observing a relation of EWS-detectability and the network topology in which the system is implemented, we simulate and investigate scale-free networks and identify which networks show, and which do not show EWS in the framework of a two state system that exhibits critical transitions. Additionally, we adapt our approach by examining the effective state of the system, rather than its natural state, and conclude that this transformation can reveal hidden EWS in networks where those signals are otherwise obscured by a complex topology.
[Mh] Termos MeSH primário: Modelos Teóricos
Teoria de Sistemas
[Mh] Termos MeSH secundário: Algoritmos
Simulação por Computador
Probabilidade
Ciência
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189853


  2 / 2847 MEDLINE  
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[PMID]:29252988
[Au] Autor:Zhou D; Elmokashfi A
[Ad] Endereço:Simula Research Laboratory, 1325 Lysaker, Norway.
[Ti] Título:Overload-based cascades on multiplex networks and effects of inter-similarity.
[So] Source:PLoS One;12(12):e0189624, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although cascading failures caused by overload on interdependent/interconnected networks have been studied in the recent years, the effect of overlapping links (inter-similarity) on robustness to such cascades in coupled networks is not well understood. This is an important issue since shared links exist in many real-world coupled networks. In this paper, we propose a new model for load-based cascading failures in multiplex networks. We leverage it to compare different network structures, coupling schemes, and overload rules. More importantly, we systematically investigate the impact of inter-similarity on the robustness of the whole system under an initial intentional attack. Surprisingly, we find that inter-similarity can have a negative impact on robustness to overload cascades. To the best of our knowledge, we are the first to report the competition between the positive and the negative impacts of overlapping links on the robustness of coupled networks. These results provide useful suggestions for designing robust coupled traffic systems.
[Mh] Termos MeSH primário: Teoria de Sistemas
[Mh] Termos MeSH secundário: Algoritmos
Simulação por Computador
Conhecimento
Modelos Teóricos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189624


  3 / 2847 MEDLINE  
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[PMID]:28877267
[Au] Autor:Xie T; Liu W; Anderson BD; Liu X; Gray GC
[Ad] Endereço:Faculty of Health Service, Second Military Medical University, Shanghai, China.
[Ti] Título:A system dynamics approach to understanding the One Health concept.
[So] Source:PLoS One;12(9):e0184430, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There have been many terms used to describe the One Health concept, including movement, strategy, framework, agenda, approach, among others. However, the inter-relationships of the disciplines engaged in the One Health concept have not been well described. To identify and better elucidate the internal feedback mechanisms of One Health, we employed a system dynamics approach. First, a systematic literature review was conducted via searches in PubMed, Web of Knowledge, and ProQuest with the search terms: 'One Health' and (concept* or approach*). In addition, we used the HistCite® tool to add significant articles on One Health to the library. Then, of the 2368 articles identified, 19 were selected for evaluating the inter-relationships of disciplines engaged in One Health. Herein, we report a visually rich, theoretical model regarding interactions of various disciplines and complex problem descriptors engaged in One Health problem solving. This report provides a conceptual framework for future descriptions of the interdisciplinary engagements involved in One Health.
[Mh] Termos MeSH primário: Saúde Global
Promoção da Saúde/métodos
Teoria de Sistemas
[Mh] Termos MeSH secundário: Comportamentos Relacionados com a Saúde
Seres Humanos
Modelos Teóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184430


  4 / 2847 MEDLINE  
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[PMID]:28706024
[Au] Autor:Sales-Pardo M
[Ad] Endereço:Department of Chemical Engineering, Universitat Rovira i Virgili, 43007 Tarragona, Spain. marta.sales@urv.cat.
[Ti] Título:The importance of being modular.
[So] Source:Science;357(6347):128-129, 2017 07 14.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Modelos Teóricos
Teoria de Sistemas
[Mh] Termos MeSH secundário: Animais
Dinâmica Populacional
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1126/science.aan8075


  5 / 2847 MEDLINE  
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[PMID]:28411668
[Au] Autor:Dupin CM
[Ad] Endereço:Haute école de santé (HES-SO), 47, avenue de Champel, 1206 Genève, Suisse. Electronic address: cecile.dupin@hesge.ch.
[Ti] Título:[Realist evaluation for implementation research].
[Ti] Título:Évaluation réaliste pour la recherche en implémentation..
[So] Source:Soins;62(814):52-55, 2017 Apr.
[Is] ISSN:0038-0814
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The realist approach to evaluation can be useful faced with the complexity of health interventions in populations. Implementation is the process by which these interventions are put into practice. Scientific realism can provide an important contribution to the development of programme theories through implementation research, and help to reveal the distal and proximal mechanisms of programmes aimed at combatting social inequalities in healthcare.
[Mh] Termos MeSH primário: Implementação de Plano de Saúde
Pesquisa sobre Serviços de Saúde
Disparidades em Assistência à Saúde
[Mh] Termos MeSH secundário: Pesquisa em Enfermagem Clínica/métodos
Pesquisa em Enfermagem Clínica/organização & administração
Pesquisa em Enfermagem Clínica/normas
Assistência à Saúde
Implementação de Plano de Saúde/organização & administração
Implementação de Plano de Saúde/normas
Pesquisa sobre Serviços de Saúde/métodos
Pesquisa sobre Serviços de Saúde/organização & administração
Disparidades em Assistência à Saúde/organização & administração
Seres Humanos
Cuidados de Enfermagem
Avaliação de Programas e Projetos de Saúde/métodos
Teoria de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


  6 / 2847 MEDLINE  
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[PMID]:28401834
[Au] Autor:Martin MJ; Sturge-Apple ML; Davies PT; Romero CV; Buckholz A
[Ad] Endereço:University of Rochester.
[Ti] Título:A process model of the implications of spillover from coparenting conflicts into the parent-child attachment relationship in adolescence.
[So] Source:Dev Psychopathol;29(2):417-431, 2017 May.
[Is] ISSN:1469-2198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drawing on a two-wave, multimethod, multi-informant design, this study provides the first test of a process model of spillover specifying why and how disruptions in the coparenting relationship influence the parent-adolescent attachment relationship. One hundred ninety-four families with an adolescent aged 12-14 (M age = 12.4) were followed for 1 year. Mothers and adolescents participated in two experimental tasks designed to elicit behavioral expressions of parent and adolescent functioning within the attachment relationship. Using a novel observational approach, maternal safe haven, secure base, and harshness (i.e., hostility and control) were compared as potential unique mediators of the association between conflict in the coparenting relationship and adolescent problems. Path models indicated that, although coparenting conflicts were broadly associated with maternal parenting difficulties, only secure base explained the link to adolescent adjustment. Adding further specificity to the process model, maternal secure base support was uniquely associated with adolescent adjustment through deficits in adolescents' secure exploration. Results support the hypothesis that coparenting disagreements undermine adolescent adjustment in multiple domains specifically by disrupting mothers' ability to provide a caregiving environment that supports adolescent exploration during a developmental period in which developing autonomy is a crucial stage-salient task.
[Mh] Termos MeSH primário: Conflito Familiar/psicologia
Modelos Psicológicos
Relações Pais-Filho
Poder Familiar/psicologia
Transtorno Reativo de Vinculação na Infância/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Hostilidade
Seres Humanos
Masculino
Relações Mãe-Filho
Transtorno Reativo de Vinculação na Infância/diagnóstico
Fatores de Risco
Ajustamento Social
Teoria de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1017/S0954579417000086


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[PMID]:28322442
[Au] Autor:Decker JT; Hobson EC; Zhang Y; Shin S; Thomas AL; Jeruss JS; Arnold KB; Shea LD
[Ad] Endereço:Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel, 1119 Gerstacker, Ann Arbor 48109, Michigan.
[Ti] Título:Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells.
[So] Source:Biotechnol Bioeng;114(9):2085-2095, 2017 Sep.
[Is] ISSN:1097-0290
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The development of resistance to targeted therapeutics is a challenging issue for the treatment of cancer. Cancers that have mutations in BRCA, a DNA repair protein, have been treated with poly(ADP-ribose) polymerase (PARP) inhibitors, which target a second DNA repair mechanism with the aim of inducing synthetic lethality. While these inhibitors have shown promise clinically, the development of resistance can limit their effectiveness as a therapy. This study investigated mechanisms of resistance in BRCA-mutated cancer cells (HCC1937) to Olaparib (AZD2281) using TRACER, a technique for measuring dynamics of transcription factor (TF) activity in living cells. TF activity was monitored in the parental HCC1937 cell line and two distinct resistant cell lines, one with restored wild-type BRCA1 and one with acquired resistance independent of BRCA1 for 48 h during treatment with Olaparib. Partial least squares discriminant analysis (PLSDA) was used to categorize the three cell types based on TF activity, and network analysis was used to investigate the mechanism of early response to Olaparib in the study cells. NOTCH signaling was identified as a common pathway linked to resistance in both Olaparib-resistant cell types. Western blotting confirmed upregulation of NOTCH protein, and sensitivity to Olaparib was restored through co-treatment with a gamma secretase inhibitor. The identification of NOTCH signaling as a common pathway contributing to PARP inhibitor resistance by TRACER indicates the efficacy of transcription factor dynamics in identifying targets for intervention in treatment-resistant cancer and provides a new method for determining effective strategies for directed chemotherapy. Biotechnol. Bioeng. 2017;114: 2085-2095. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/metabolismo
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais/métodos
Ftalazinas/administração & dosagem
Piperazinas/administração & dosagem
Análise Serial de Tecidos/métodos
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Neoplasias da Mama/patologia
Linhagem Celular Tumoral
Seres Humanos
Terapia de Alvo Molecular/métodos
Teoria de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Phthalazines); 0 (Piperazines); 0 (Transcription Factors); WOH1JD9AR8 (olaparib)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1002/bit.26293


  8 / 2847 MEDLINE  
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[PMID]:28248751
[Au] Autor:Clancy TR
[Ad] Endereço:Author Affiliation: Clinical Professor and Associate Dean, School of Nursing, The University of Minnesota, Minneapolis.
[Ti] Título:Technological Complexity: Have We Reached a Tipping Point?
[So] Source:J Nurs Adm;47(4):195-197, 2017 Apr.
[Is] ISSN:1539-0721
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As systems evolve over time, their natural tendency is to become increasingly more complex. Studies in the field of complex systems have generated new perspectives on the application of management strategies in health systems. Much of this research appears as a natural extension of the cross-disciplinary field of systems theory. This article focuses on why technological complexity is increasing and strategies nurse administrators can use to successfully implement change in the face of it.
[Mh] Termos MeSH primário: Assistência à Saúde/história
Assistência à Saúde/organização & administração
Invenções/história
Cuidados de Enfermagem/organização & administração
Transferência de Tecnologia
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
Teoria de Sistemas
Estados Unidos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1097/NNA.0000000000000454


  9 / 2847 MEDLINE  
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[PMID]:28215288
[Au] Autor:Perone S; Simmering VR
[Ad] Endereço:Washington State University, Pullman, WA, United States. Electronic address: sammy.perone@wsu.edu.
[Ti] Título:Applications of Dynamic Systems Theory to Cognition and Development: New Frontiers.
[So] Source:Adv Child Dev Behav;52:43-80, 2017.
[Is] ISSN:0065-2407
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A central goal in developmental science is to explain the emergence of new behavioral forms. Researchers consider potential sources of behavioral change depending partly on their theoretical perspective. This chapter reviews one perspective, dynamic systems theory, which emphasizes the interactions among multiple components to drive behavior and developmental change. To illustrate the central concepts of dynamic systems theory, we describe empirical and computational studies from a range of domains, including motor development, the Piagetian A-not-B task, infant visual recognition, visual working memory capacity, and language learning. We conclude by advocating for a broader application of dynamic systems approaches to understanding cognitive and behavioral development, laying out the remaining barriers we see and suggested ways to overcome them.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Desenvolvimento Infantil/fisiologia
Cognição/fisiologia
Teoria de Sistemas
[Mh] Termos MeSH secundário: Atenção/fisiologia
Mapeamento Encefálico
Criança
Pré-Escolar
Seres Humanos
Lactente
Aprendizagem/fisiologia
Memória de Curto Prazo/fisiologia
Vias Neurais/fisiologia
Reconhecimento Visual de Modelos/fisiologia
Teoria Psicológica
Desempenho Psicomotor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


  10 / 2847 MEDLINE  
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[PMID]:27924411
[Au] Autor:Li J; Lindberg DV; Smith RA; Reluga TC
[Ad] Endereço:Department of Mathematics, California State University, Northridge, Northridge, CA, 91330, USA. jing.li@csun.edu.
[Ti] Título:Provisioning of Public Health Can Be Designed to Anticipate Public Policy Responses.
[So] Source:Bull Math Biol;79(1):163-190, 2017 Jan.
[Is] ISSN:1522-9602
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Public health policies can elicit strong responses from individuals. These responses can promote, reduce, and even reverse the expected benefits of the policies. Therefore, projections of individual responses to policy can be important ingredients in policy design. Yet our foresight of individual responses to public health investment remains limited. This paper formulates a population game describing the prevention of infectious disease transmission when community health depends on the interactions of individual and public investments. We compare three common relationships between public and individual investments and explain how each relationship alters policy responses and health outcomes. Our methods illustrate how identifying system interactions between nature and society can help us anticipate policy responses.
[Mh] Termos MeSH primário: Saúde Pública
Política Pública
[Mh] Termos MeSH secundário: Controle de Doenças Transmissíveis/métodos
Controle de Doenças Transmissíveis/estatística & dados numéricos
Teoria do Jogo
Seres Humanos
Conceitos Matemáticos
Modelos Biológicos
Teoria de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1007/s11538-016-0231-8



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