Base de dados : MEDLINE
Pesquisa : H02.004 [Categoria DeCS]
Referências encontradas : 1328 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 133 ir para página                         

  1 / 1328 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29211741
[Au] Autor:Essex H; Parrott S; Atkin K; Ballard K; Bland M; Eldred J; Hewitt C; Hopton A; Keding A; Lansdown H; Richmond S; Tilbrook H; Torgerson D; Watt I; Wenham A; Woodman J; MacPherson H
[Ad] Endereço:Department of Health Sciences, University of York, York, United Kingdom.
[Ti] Título:An economic evaluation of Alexander Technique lessons or acupuncture sessions for patients with chronic neck pain: A randomized trial (ATLAS).
[So] Source:PLoS One;12(12):e0178918, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To assess the cost-effectiveness of acupuncture and usual care, and Alexander Technique lessons and usual care, compared with usual GP care alone for chronic neck pain patients. METHODS: An economic evaluation was undertaken alongside the ATLAS trial, taking both NHS and wider societal viewpoints. Participants were offered up to twelve acupuncture sessions or twenty Alexander lessons (equivalent overall contact time). Costs were in pounds sterling. Effectiveness was measured using the generic EQ-5D to calculate quality adjusted life years (QALYs), as well as using a specific neck pain measure-the Northwick Park Neck Pain Questionnaire (NPQ). RESULTS: In the base case analysis, incremental QALY gains were 0.032 and 0.025 in the acupuncture and Alexander groups, respectively, in comparison to usual GP care, indicating moderate health benefits for both interventions. Incremental costs were £451 for acupuncture and £667 for Alexander, mainly driven by intervention costs. Acupuncture was likely to be cost-effective (ICER = £18,767/QALY bootstrapped 95% CI £4,426 to £74,562) and was robust to most sensitivity analyses. Alexander lessons were not cost-effective at the lower NICE threshold of £20,000/QALY (£25,101/QALY bootstrapped 95% CI -£150,208 to £248,697) but may be at £30,000/QALY, however, there was considerable statistical uncertainty in all tested scenarios. CONCLUSIONS: In comparison with usual care, acupuncture is likely to be cost-effective for chronic neck pain, whereas, largely due to higher intervention costs, Alexander lessons are unlikely to be cost-effective. However, there were high levels of missing data and further research is needed to assess the long-term cost-effectiveness of these interventions.
[Mh] Termos MeSH primário: Acupuntura/métodos
Dor Crônica/terapia
Análise Custo-Benefício
Movimento
Manipulações Musculoesqueléticas/métodos
Cervicalgia/terapia
[Mh] Termos MeSH secundário: Acupuntura/economia
Fatores Etários
Feminino
Seres Humanos
Masculino
Manipulações Musculoesqueléticas/economia
Atenção Primária à Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178918


  2 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28712482
[Au] Autor:Leow MQH; Cui SL; Mohamed Shah MTB; Cao T; Tay SC; Tay PKC; Ooi CC
[Ad] Endereço:Biomechanics Laboratory, Singapore General Hospital, Singapore. Electronic address: mabelleowqihe@yahoo.com.
[Ti] Título:Ultrasonography in Acupuncture-Uses in Education and Research.
[So] Source:J Acupunct Meridian Stud;10(3):216-219, 2017 Jun.
[Is] ISSN:2093-8152
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:This study aims to explore the potential use of ultrasound in locating the second posterior sacral foramen acupuncture point, quantifying depth of insertion and describing surrounding anatomical structures. We performed acupuncture needle insertion on a study team member. There were four steps in our experiment. First, the acupuncturist located the acupuncture point by palpation. Second, we used an ultrasound machine to visualize the structures surrounding the location of the acupuncture point and measure the depth required for needle insertion. Third, the acupuncturist inserted the acupuncture needle into the acupuncture point at an angle of 30°. Fourth, we performed another ultrasound scan to ensure that the needle was in the desired location. Results suggested that ultrasound could be used to locate the acupuncture point and estimate the depth of needle insertion. The needle was inserted to a depth of 4.0 cm to reach the surface of the sacral foramen. Based on Pythagoras theorem, taking a needle insertion angle of 30° and a needle insertion depth of 4.0 cm, the estimated perpendicular depth is 1.8 cm. An ultrasound scan corroborated the depth of 1.85 cm. The use of an ultrasound-guided technique for needle insertion in acupuncture practice could help standardize the treatment. Clinicians and students would be able to visualize and measure the depth of the sacral foramen acupuncture point, to guide the depth of needle insertion. This methodological guide could also be used to create a standard treatment protocol for research. A similar mathematical guide could also be created for other acupuncture points in future.
[Mh] Termos MeSH primário: Pontos de Acupuntura
Terapia por Acupuntura/métodos
Acupuntura/educação
Acupuntura/métodos
Sacro/diagnóstico por imagem
Medula Espinal/diagnóstico por imagem
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Sacro/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE


  3 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28712476
[Au] Autor:Muzhikov V; Vershinina E; Belenky V; Muzhikov R
[Ad] Endereço:Med Byte Limited, Saint Petersburg, Russia. Electronic address: mujikov_v@mail.ru.
[Ti] Título:Comparative Assessment of the Heart's Functioning by Using the Akabane Test and Classical Methods of Instrumental Examination.
[So] Source:J Acupunct Meridian Stud;10(3):171-179, 2017 Jun.
[Is] ISSN:2093-8152
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Acupuncture physicians have studied the application of reflexotherapy to cardiology. However, no one has investigated the connection of ancient Chinese diagnostic methods with modern tools. A total of 102 patients (54 men and 48 women) with heart pathology, namely, sick-sinus syndrome, Wolff-Parkinson-White syndrome, and atrioventricular blockade, were studied using the usual instrumental methods (transesophageal electrophysiological study of the heart, echocardiography), after which they underwent Akabane thermopuncture testing as in traditional Chinese medicine. The results of cardio examination from one side of the Akabane test with that from the other side were compared by means of a multiple stepwise regression analysis. We revealed the effects on the characteristic pattern of acupuncture channel lesions inherent in a definite heart pathology, i.e., the most vulnerable acupuncture channel (AC), of such factors as disturbances of the contractile, conductive, or automatic heart functions, and changes in the chambers' size or circulation volume. Сhanges in the indices of the left and the right branches of these channels usually reflect the opposing natures of the changes in these indicators, which should be considered in reflexotherapy. The main value of the Akabane test along with the use of mathematical analysis lies in early, quick, and inexpensive detection of the above-mentioned heart disturbances.
[Mh] Termos MeSH primário: Bloqueio Atrioventricular/diagnóstico
Coração/fisiopatologia
Síndrome do Nó Sinusal/diagnóstico
Síndrome de Wolff-Parkinson-White/diagnóstico
[Mh] Termos MeSH secundário: Acupuntura/métodos
Ecocardiografia/métodos
Feminino
Coração/diagnóstico por imagem
Sistema de Condução Cardíaco/fisiopatologia
Seres Humanos
Hipertermia Induzida/métodos
Masculino
Meridianos
Reflexoterapia/métodos
Síndrome do Nó Sinusal/diagnóstico por imagem
Síndrome do Nó Sinusal/fisiopatologia
Nó Sinoatrial/fisiopatologia
Síndrome de Wolff-Parkinson-White/diagnóstico por imagem
Síndrome de Wolff-Parkinson-White/fisiopatologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE


  4 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28495839
[Au] Autor:Nakada Y; Takashi M; Arai K; Arai M
[Ad] Endereço:Department of Kampo Medicine, Tokai University School of Medicine, Isehara, Japan.
[Ti] Título:Medical residents' interest in and current status of Japanese postgraduate education in acupuncture and moxibustion: a follow-up survey.
[So] Source:Acupunct Med;35(4):297-302, 2017 Aug.
[Is] ISSN:1759-9873
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Japanese traditional medicine (Kampo medicine) is an important subject in Japanese medical schools. Acupuncture and moxibustion (AM), essential categories of Kampo medicine, are taught in a few medical schools today. However, the current state of postgraduate AM education is unknown. OBJECTIVE: To compare medical residents' awareness of AM before their AM education in the 4th year of medical school with that after completion of their 2-year postgraduate medical residency. METHODS: We conducted a postal questionnaire survey of medical residents at the end of their 2-year residency. We required a signature on this questionnaire so that we could examine for changes in their awareness of AM with those determined by similar, signed, former questionnaire surveys conducted before and at the end of their 4th-year AM lectures in medical school (reported previously). The completed questionnaires were returned by mail or facsimile. RESULTS: Among 93 residents, there were 72 (77.4%) effective responses. Only three residents (4%) had opportunities to learn AM during residency. Among the 68 residents who were not afforded the opportunity to do so, after completing their two-year residency, 32(47%) stated that they would like to study AM. Interest in AM was significantly less than that of the proportion of medical students (81%) who were initially interested in AM when surveyed just before their fourth year lectures on AM. CONCLUSIONS: Postgraduate AM education for medical residents appears to be relatively scarce in Japan. Moreover, medical residents' levels of interest in AM were lower than those demonstrated before their 4th-year AM lectures in medical school.
[Mh] Termos MeSH primário: Acupuntura/educação
Internato e Residência/recursos humanos
Moxibustão
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Japão
Masculino
Médicos/psicologia
Estudantes de Medicina/psicologia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1136/acupmed-2016-011204


  5 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28480437
[Au] Autor:Fu JY; Zhang X; Zhao YH; Tong HF; Chen DZ; Huang MH
[Ad] Endereço:Technical Reports Service and Information Research Center, Institute of Scientific and Technical Information of China, Beijing, P.R. China.
[Ti] Título:BIBLIOMETRIC ANALYSIS OF ACUPUNCTURE RESEARCH FRONTS AND THEIR WORLDWIDE DISTRIBUTION OVER THREE DECADES.
[So] Source:Afr J Tradit Complement Altern Med;14(3):257-273, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Considerable research has been conducted on acupuncture worldwide. This study chronologically examined the changing features and research fronts of acupuncture and elucidated the differences among the six most productive countries. METHODS: Bibliographic coupling is a powerful tool for identifying the research fronts of a field. Acupuncture-related publications worldwide and from the six most productive countries during 1983-2012 were retrieved from the Science Citation Index Expanded and Social Science Citation Index. To form the research fronts, the 100 most highly cited papers (HCPs) were clustered in terms of references shared. RESULTS: The United States had the highest proportion of HCPs. The effectiveness of acupuncture in areas such as relieving neck and back pain, migraines and headaches, and knee osteoarthritis symptoms was a predominant topic. Initially, the endogenous opioid peptide system was the primary research focus in the acupuncture mechanism research; however, during 1993-2012, researchers focused more on the functional magnetic resonance imaging of brain activity. In addition, acupuncture use and prevalence, the attitudes of health practitioners, and the effects of expectancy and belief were also major topics. Researches from Western countries, including the United States, England, and Germany, showed more interest in clinical trials and economic- and ethics-related studies, whereas those from East Asian countries including China, Japan, and South Korea focused more on mechanism research. CONCLUSION: Western countries dominated the research fronts of acupuncture. The patterns of the research fronts varied worldwide, indicating continuity and innovation in research in each country.
[Mh] Termos MeSH primário: Terapia por Acupuntura
Acupuntura/estatística & dados numéricos
Bibliometria
Pesquisa Biomédica/estatística & dados numéricos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i3.27


  6 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28274213
[Au] Autor:Jocham A; Kriston L; Berberat PO; Schneider A; Linde K
[Ad] Endereço:Institute of General Practice, Klinikum rechts der Isar, Technical University of Munich, Orleansstrasse 47, 81667, Munich, Germany.
[Ti] Título:How do medical students engaging in elective courses on acupuncture and homeopathy differ from unselected students? A survey.
[So] Source:BMC Complement Altern Med;17(1):148, 2017 Mar 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We aimed to investigate whether students at German medical schools participating in elective courses on acupuncture and homeopathy differ from an unselected group of students regarding attitudes and personality traits. METHODS: Elective courses on acupuncture and homeopathy in the academic half-year 2013/14 all over Germany were identified and participants invited to fill in a questionnaire including nineteen questions on attitudes towards Complementary and Alternative Medicine (CAM), orientation towards science, care and status orientation, and a short validated instrument (Big-Five-Inventory-10) to measure personality traits (extraversion, neuroticism, openness, conscientiousness, and agreeableness). Participants of a mandatory family medicine course at one university served as unselected control group. RESULTS: Two hundred twenty and 113 students from elective courses on acupuncture and homeopathy, respectively, and 315 control students participated (response rate 93%). Students participating in elective courses had much more positive attitudes towards CAM, somewhat lower science and status orientation, and somewhat higher care orientation than control group students (all p-values for three-group comparisons < 0.001). There were no differences between the three groups regarding personality traits with the exception of lower values for agreeableness in controls (p = 0.009). CONCLUSIONS: The findings of this study show that attitudes of students participating in elective courses on acupuncture or homeopathy at German medical schools differ to a considerable degree from the attitudes of unselected students.
[Mh] Termos MeSH primário: Acupuntura/educação
Atitude do Pessoal de Saúde
Homeopatia/educação
Estudantes de Medicina/psicologia
Estudantes de Medicina/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Alemanha
Seres Humanos
Masculino
Personalidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1653-z


  7 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28240210
[Au] Autor:Monnais L
[Ad] Endereço:Département d'histoire, Centre d'études de l'Asie de l'est (CETASE) ; Chaire de recherche du Canada sur le pluralisme en santé, Université de Montréal, CP 6128, Succursale Centre-ville, Montréal, QC, H3C 3J7, Canada.
[Ti] Título:[Alternative medicine, from North America to East Asia: between persistent exclusion and embodied pluralism].
[Ti] Título:Médecines alternatives, du continent nord-américain à l'Asie orientale - Entre exclusion réitérée et pluralisme incorporé..
[So] Source:Med Sci (Paris);33(2):183-187, 2017 Feb.
[Is] ISSN:1958-5381
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:At a time of growing interest in integrative approaches to health and care, this article examines, from a historical perspective, the factors underlying the global popularity of so-called complementary and alternative medicines (CAM). Focusing on the multiple and changing meanings of the concepts used with reference to CAM since the nineteenth century, it emphasizes the agency of CAM practitioners' and calls into question a linear progression from outright exclusion to gradual inclusion into mainstream health care systems. This analysis concludes that biomedicine and "other" medical systems have mutually defined each other in a process of co-production that has had a significant impact on the medicalization of contemporary societies from North America to East Asia.
[Mh] Termos MeSH primário: Terapias Complementares
[Mh] Termos MeSH secundário: Acupuntura
Terapias Complementares/história
Terapias Complementares/psicologia
Terapias Complementares/utilização
Diversidade Cultural
Extremo Oriente
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
América do Norte
Segurança do Paciente
Fatores de Risco
Distância Social
Marginalização Social
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1051/medsci/20173302014


  8 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28202010
[Au] Autor:Fontaine C; Daurès JP; Landais P
[Ad] Endereço:UPRES EA2415-Institut Universitaire de Recherche Clinique, Université de Montpellier, 641, Av. du doyen G.-Giraud, Montpellier, France. charles.fontaine@usherbrooke.ca.
[Ti] Título:On the censored cost-effectiveness analysis using copula information.
[So] Source:BMC Med Res Methodol;17(1):27, 2017 Feb 15.
[Is] ISSN:1471-2288
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Information and theory beyond copula concepts are essential to understand the dependence relationship between several marginal covariates distributions. In a therapeutic trial data scheme, most of the time, censoring occurs. That could lead to a biased interpretation of the dependence relationship between marginal distributions. Furthermore, it could result in a biased inference of the joint probability distribution function. A particular case is the cost-effectiveness analysis (CEA), which has shown its utility in many medico-economic studies and where censoring often occurs. METHODS: This paper discusses a copula-based modeling of the joint density and an estimation method of the costs, and quality adjusted life years (QALY) in a cost-effectiveness analysis in case of censoring. This method is not based on any linearity assumption on the inferred variables, but on a punctual estimation obtained from the marginal distributions together with their dependence link. RESULTS: Our results show that the proposed methodology keeps only the bias resulting statistical inference and don't have anymore a bias based on a unverified linearity assumption. An acupuncture study for chronic headache in primary care was used to show the applicability of the method and the obtained ICER keeps in the confidence interval of the standard regression methodology. CONCLUSION: For the cost-effectiveness literature, such a technique without any linearity assumption is a progress since it does not need the specification of a global linear regression model. Hence, the estimation of the a marginal distributions for each therapeutic arm, the concordance measures between these populations and the right copulas families is now sufficient to process to the whole CEA.
[Mh] Termos MeSH primário: Acupuntura
Análise Custo-Benefício/estatística & dados numéricos
Transtornos da Cefaleia/terapia
Modelos Estatísticos
Anos de Vida Ajustados por Qualidade de Vida
[Mh] Termos MeSH secundário: Seres Humanos
Funções Verossimilhança
Atenção Primária à Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1186/s12874-017-0305-9


  9 / 1328 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28082267
[Au] Autor:Leow MQH; Cao T; Loke AMK; Tay SC
[Ad] Endereço:Biomechanics Laboratory, Singapore General Hospital, Singapore, Singapore.
[Ti] Título:Use of X-rays to study acupuncture points of the hand: implications for education.
[So] Source:Acupunct Med;35(3):233-235, 2017 06.
[Is] ISSN:1759-9873
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Pontos de Acupuntura
Acupuntura/educação
Mãos/anatomia & histologia
[Mh] Termos MeSH secundário: Acupuntura/instrumentação
Terapia por Acupuntura
Mãos/efeitos da radiação
Seres Humanos
Radiografia
Raios X
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1136/acupmed-2016-011307


  10 / 1328 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27966183
[Au] Autor:Wang Z; Chen T; Long M; Chen L; Wang L; Yin N; Chen Z
[Ad] Endereço:Department of Pathogen Biology, College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
[Ti] Título:Electro-acupuncture at Acupoint ST36 Ameliorates Inflammation and Regulates Th1/Th2 Balance in Delayed-Type Hypersensitivity.
[So] Source:Inflammation;40(2):422-434, 2017 Apr.
[Is] ISSN:1573-2576
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increasing evidence indicates anti-allergic and anti-inflammatory effects of electro-acupuncture (EA) therapy. However, its underlying mechanism on delayed-type hypersensitivity (DTH), a classic allergic inflammatory disease, still remains unclear. In this study, we aimed to explore the immunomodulatory mechanism of EA intervention in a mouse model of ovalbumin (OVA)-induced DTH. Mice were randomly divided into four groups: Control, OVA-DTH, DTH + EA, DTH + Sham. "Zusanli" acupoint (ST36) was used for DTH + EA, whereas a non-acupoint (localized 5 mm below the "Zusanli" acupoint) was selected for DTH + Sham. Footpad thickness was checked, and the infiltration of inflammatory cells was estimated by hematoxylin and eosin staining. Levels of IgG and IgE in serum of different groups and inflammatory cytokines in the supernatants from homogenized footpads, including IFN-γ, TNF-α, IL-4, and IL-5, were determined by ELISA. Cell proliferation of spleen lymphocytes was assayed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The frequency of CD4 IFN-γ and CD4 IL-4 T cells was analyzed with flow cytometry. In addition, the mRNA and protein expression of T-bet and GATA-3 were evaluated by real-time PCR and Western blotting, respectively. Our data showed EA treatment at acupoint ST36 relieved the pathological progression of DTH responses via reduction in footpad swelling, infiltration of inflammatory cells, levels of IgG and IgE as well as decreased production of IFN-γ and TNF-α in homogenized footpad tissue. Moreover, detailed studies were performed revealing that EA attenuated the percentage of CD4 IFN-γ T cells and prevented Th cells differentiation into Th1 cells, and this results from inhibiting secretion of IFN-γ and suppressing expression of T-bet, an IFN-γ transcription factor. The results indicated that EA treatment improved Th1-mediated allergic skin inflammation via restoring Th1/Th2 balance by curbing Th1 differentiation. These findings suggested that EA at acupoint ST36 might be a useful and promising therapeutic for allergic inflammatory as well as Th1-mediated inflammation response.
[Mh] Termos MeSH primário: Pontos de Acupuntura
Acupuntura/métodos
Hipersensibilidade Tardia/terapia
Inflamação/terapia
Equilíbrio Th1-Th2
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Movimento Celular
Proliferação Celular
Imunoglobulina E/análise
Imunoglobulina G/análise
Inflamação/patologia
Camundongos
Ovalbumina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 37341-29-0 (Immunoglobulin E); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE
[do] DOI:10.1007/s10753-016-0487-z



página 1 de 133 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde