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Pesquisa : H02.403.044 [Categoria DeCS]
Referências encontradas : 5116 [refinar]
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  1 / 5116 MEDLINE  
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[PMID]:29255087
[Au] Autor:Bennett JC; Hood LE; Dreyer WJ; Potter M
[Ti] Título:Pillars Article: Evidence for Amino Acid Sequence Differences among Proteins Resembling the L-chain Subunits of Immunoglobulins. . 1965. 12: 81-87.
[So] Source:J Immunol;200(1):27-37, 2018 01 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alergia e Imunologia/história
Sítios de Ligação/genética
Neoplasias Hematológicas/imunologia
Cadeias Leves de Imunoglobulina/genética
Plasmócitos/fisiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
História do Século XX
Cadeias Leves de Imunoglobulina/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:CLASSICAL ARTICLE; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin Light Chains)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  2 / 5116 MEDLINE  
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[PMID]:29193348
[Ti] Título:Heading for centennial anniversary and beyond.
[So] Source:APMIS;125(12):1133, 2017 12.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Mh] Termos MeSH primário: Publicações Periódicas como Assunto
Editoração
[Mh] Termos MeSH secundário: Alergia e Imunologia
Aniversários e Eventos Especiais
Pesquisa Biomédica
História do Século XX
Microbiologia
Patologia
Publicações Periódicas como Assunto/história
[Pt] Tipo de publicação:EDITORIAL; HISTORICAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12797


  3 / 5116 MEDLINE  
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[PMID]:29236381
[Au] Autor:Ezepchuk YV; Kolybo DV
[Ti] Título:Nobel laureate Ilya I. Metchnikoff (1845-1916). Life story and scientific heritage.
[So] Source:Ukr Biochem J;88(6):98-109, 2016 Nov-Dec.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:A century of science after I. Metchnikoff's death demonstrated the truth in many of his views and judgments in the field of immunology, pathology, bacteriology, zoology and comparative embryology. Today Metchnikoff is deservedly called the father of the theory of cellular immunity, and also a harbinger of the theo­ry of natural immunity. His work in the field of lactic acid bacteria formed the basis for an entire industry of probiotics. Metchnikoff's doctrine of the possibility of extending human life is still relevant. This publication is one more attempt to tie the biography of the scientist with his creative legacy and his contribution in the world treasury of biological science.
[Mh] Termos MeSH primário: Alergia e Imunologia/história
Imunidade Inata
Prêmio Nobel
Fagocitose
[Mh] Termos MeSH secundário: Alergia e Imunologia/recursos humanos
História do Século XIX
História do Século XX
Seres Humanos
Federação Russa
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Metchnikoff iI
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.06.098


  4 / 5116 MEDLINE  
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[PMID]:29235825
[Au] Autor:Danilova VM; Vynogradova RP; Torkhova SG
[Ti] Título:[Inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine].
[So] Source:Ukr Biochem J;88(5):116-35, 2016 Sep-Oct.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:rus; ukr
[Ab] Resumo:The article is devoted to the inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and in the context of scholarly and organizational activities of Sergii Vasyl'ovych Komisarenko. This autumn marks 50th anniversary since young Sergii Komisarenko (now ­ Academician of NAS and NAMS of Ukraine, Dr. Biol. Sci., Professor) has joined the Palladin Institute of Biochemistry, has completed all stages of the academic carrier from PhD student to Head of the Institute. He is the first in Ukraine who started the new branch of research ­ molecular immunology, created a strong scientific school, which earned worldwide acclaim and made significant contribution to finding solutions to current problems in human health sciences. S.V. Komisarenko was among those, who were first in the USSR to use immunoenzyme and flow cytofluometric assays, hybridoma technology for producing monoclonal antibodies and immunochemical assay of proteins, which became the basis for development of highly sensitive and highly specific immunodiagnostic systems, which are of high necessity in medicine, veterinary, development of immunotechnologies, environment monitoring, etc. Under his leadership the Department has made a series of important discoveries and developments including relating to antitumour immunotoxins, effects of low dose radiation on the immune system of Chernobyl liquidators, immunochemical structure of neurotoxin apamine, cytochrom c, fibrinogen and fibrin molecules at different stages of polymerization, diphtheria toxin and its receptor, tuberculosis causing micobacterium, roles of protease-activated receptors (PARs) and nicotinic acetylcholine receptors of lymphocytes, nature of polyreactive immunoglobulins (PRIGs), among other important scientific contributions. S.V. Komisarenko and his colleagues also hold numerous (more than 80) author's certificates and patents in Ukraine and USSR.
[Mh] Termos MeSH primário: Academias e Institutos/história
Alergia e Imunologia/história
Bioquímica/história
Invenções/história
[Mh] Termos MeSH secundário: Alergia e Imunologia/recursos humanos
Bioquímica/recursos humanos
História do Século XX
História do Século XXI
Seres Humanos
Imunoglobulinas/análise
Ucrânia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Nm] Nome de substância:
0 (Immunoglobulins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.05.116


  5 / 5116 MEDLINE  
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[PMID]:29235336
[Au] Autor:Lugovska NE
[Ti] Título:[Inventive activity of the Departments of Protein Structure and Function, and Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine. Part II. National breakthrough in the study and diagnostics of human hemostasis system].
[So] Source:Ukr Biochem J;88(3):106-18, 2016 May-Jun.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:rus; ukr
[Ab] Resumo:The scientists of Protein Structure and Function, and Molecular Immunology Departments of the Palladin Institute of Biochemistry (NAS of Ukraine) under the supervision of member of NASU and NAMSU, prof. S. V. Komisarenko and corresponding member of NASU prof. E. V. Lugovskoy have made the real breakthrough in the field of research of the mechanisms of fibrin polymerization and formation of fibrin framework of thrombi. The immunodiagnostic test-systems for the evaluation of the risk of thrombus formation were developed for the first time. Researches have obtained the monoclonal antibodies to fibrinogen, fibrin, D-dimer and their fragments. These monoclonal antibodies were used as molecular probes for the localization of newly detected fibrin polymerization sites. Obtained antibodies with high affinity interact with fibrinogen, D-dimer and soluble fibrin ­ main markers of the risk of thrombus formation. They were used for the development of the immunodiagnostic test-systems to quantify these markers in human blood plasma for the evaluation of the state of haemostasis system, detection of prethrombotic states, disseminated intravascular coagulation, detection of thrombosis and monitoring of antithrombotic and fibrinolytic therapy. The successful trial of developed test-systems was carried out in clinics of Ukraine, and the State registration was obtained for the implementation of them into the clinical practice. Presented works were awarded State prize of Ukraine in Science and technology.
[Mh] Termos MeSH primário: Academias e Institutos/história
Alergia e Imunologia/história
Bioquímica/história
Transtornos da Coagulação Sanguínea/diagnóstico
Invenções/história
[Mh] Termos MeSH secundário: Alergia e Imunologia/recursos humanos
Bioquímica/recursos humanos
Transtornos da Coagulação Sanguínea/história
História do Século XX
História do Século XXI
Seres Humanos
Ucrânia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.03.106


  6 / 5116 MEDLINE  
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[PMID]:29242334
[Au] Autor:Nowotny H
[Ad] Endereço:Helga Nowotny is the former president of the European Research Council. helga.nowotny@wwtf.at.
[Ti] Título:Fotis Kafatos (1940-2017).
[So] Source:Science;358(6369):1387, 2017 Dec 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alergia e Imunologia/história
Doenças Transmissíveis/história
[Mh] Termos MeSH secundário: Grécia
História do Século XX
História do Século XXI
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Kafatos F
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aar6095


  7 / 5116 MEDLINE  
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[PMID]:28450288
[Au] Autor:Kermode-Scott B
[Ad] Endereço:Comox, Canada.
[Ti] Título:Mark Arnold Wainberg.
[So] Source:BMJ;357:j2026, 2017 04 27.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por HIV/terapia
Pesquisadores
[Mh] Termos MeSH secundário: Alergia e Imunologia
Fármacos Anti-HIV/farmacologia
Pesquisa Biomédica
Canadá
História do Século XX
História do Século XXI
Seres Humanos
Lamivudina/farmacologia
Masculino
Microbiologia
Pediatria
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Wainberg MA
[Nm] Nome de substância:
0 (Anti-HIV Agents); 2T8Q726O95 (Lamivudine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j2026


  8 / 5116 MEDLINE  
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[PMID]:28987220
[Au] Autor:Edwards MR; Strong K; Cameron A; Walton RP; Jackson DJ; Johnston SL
[Ad] Endereço:COPD & Asthma Section, National Heart Lung Institute, Imperial College London, London, United Kingdom; MRC & Asthma UK Centre for Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address: michael.edwards@imperial.ac.uk.
[Ti] Título:Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness.
[So] Source:J Allergy Clin Immunol;140(4):909-920, 2017 Oct.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viral respiratory tract infections are associated with asthma inception in early life and asthma exacerbations in older children and adults. Although how viruses influence asthma inception is poorly understood, much research has focused on the host response to respiratory viruses and how viruses can promote; or how the host response is affected by subsequent allergen sensitization and exposure. This review focuses on the innate interferon-mediated host response to respiratory viruses and discusses and summarizes the available evidence that this response is impaired or suboptimal. In addition, the ability of respiratory viruses to act in a synergistic or additive manner with T 2 pathways will be discussed. In this review we argue that these 2 outcomes are likely linked and discuss the available evidence that shows reciprocal negative regulation between innate interferons and T 2 mediators. With the renewed interest in anti-T 2 biologics, we propose a rationale for why they are particularly successful in controlling asthma exacerbations and suggest ways in which future clinical studies could be used to find direct evidence for this hypothesis.
[Mh] Termos MeSH primário: Hipersensibilidade/imunologia
Inflamação/imunologia
Infecções Respiratórias/imunologia
Células Th2/imunologia
Viroses/imunologia
[Mh] Termos MeSH secundário: Alergia e Imunologia/tendências
Animais
Progressão da Doença
Seres Humanos
Interferons/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
9008-11-1 (Interferons)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  9 / 5116 MEDLINE  
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[PMID]:28826774
[Au] Autor:Chinen J; Badran YR; Geha RS; Chou JS; Fried AJ
[Ad] Endereço:Immunology, Allergy and Rheumatology Section, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex. Electronic address: jxchinen@texaschildrens.org.
[Ti] Título:Advances in basic and clinical immunology in 2016.
[So] Source:J Allergy Clin Immunol;140(4):959-973, 2017 Oct.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Advances in basic immunology in 2016 included studies that further characterized the role of different proteins in the differentiation of effector T and B cells, including cytokines and proteins involved in the actin cytoskeleton. Regulation of granule formation and secretion in cytotoxic cells was also further described by examining patients with familial hemophagocytic lymphohistiocytosis. The role of prenylation in patients with mevalonate kinase deficiency leading to inflammation has been established. We reviewed advances in clinical immunology, as well as new approaches of whole-genome sequencing and genes newly reported to be associated with immunodeficiency, such as linker of activation of T cells (LAT); B-cell CLL/lymphoma 11B (BCL11B); RGD, leucine-rich repeat, tropomodulin domain, and proline-rich domain-containing protein (RLTPR); moesin; and Janus kinase 1 (JAK1). Trials of hematopoietic stem cell transplantation and gene therapy for primary immunodeficiency have had relative success; the use of autologous virus-specific cytotoxic T cells has proved effective as well. New medications are being explored, such as pioglitazone, which is under study for its role in enhancing the oxidative burst in patients with chronic granulomatous disease. Development of vaccines for HIV infection continues to provide insight into the immune response against a virus with an extraordinary mutation rate.
[Mh] Termos MeSH primário: Alergia e Imunologia/tendências
Transplante de Células-Tronco Hematopoéticas
Síndromes de Imunodeficiência/terapia
Imunoterapia/métodos
Tiazolidinedionas/uso terapêutico
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/genética
Animais
Ensaios Clínicos como Assunto
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Síndromes de Imunodeficiência/genética
Proteínas de Membrana/genética
Proteínas dos Microfilamentos/genética
Proteínas Repressoras/genética
Proteínas Supressoras de Tumor/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (BCL11B protein, human); 0 (LAT protein, human); 0 (LRRC16A protein, human); 0 (Membrane Proteins); 0 (Microfilament Proteins); 0 (Repressor Proteins); 0 (Thiazolidinediones); 0 (Tumor Suppressor Proteins); X4OV71U42S (pioglitazone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


  10 / 5116 MEDLINE  
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[PMID]:28814613
[Au] Autor:Okamoto K; Nakashima T; Shinohara M; Negishi-Koga T; Komatsu N; Terashima A; Sawa S; Nitta T; Takayanagi H
[Ad] Endereço:Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan; Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Japan Science and Technology Agency (JST), Precu
[Ti] Título:Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
[So] Source:Physiol Rev;97(4):1295-1349, 2017 Oct 01.
[Is] ISSN:1522-1210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The immune and skeletal systems share a variety of molecules, including cytokines, chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune cells under physiological and pathological conditions. Osteoimmunology was created as a new interdisciplinary field in large part to highlight the shared molecules and reciprocal interactions between the two systems in both heath and disease. Receptor activator of NF-κB ligand (RANKL) plays an essential role not only in the development of immune organs and bones, but also in autoimmune diseases affecting bone, thus effectively comprising the molecule that links the two systems. Here we review the function, gene regulation, and signal transduction of osteoimmune molecules, including RANKL, in the context of osteoclastogenesis as well as multiple other regulatory functions. Osteoimmunology has become indispensable for understanding the pathogenesis of a number of diseases such as rheumatoid arthritis (RA). We review the various osteoimmune pathologies, including the bone destruction in RA, in which pathogenic helper T cell subsets [such as IL-17-expressing helper T (Th17) cells] induce bone erosion through aberrant RANKL expression. We also focus on cellular interactions and the identification of the communication factors in the bone marrow, discussing the contribution of bone cells to the maintenance and regulation of hematopoietic stem and progenitors cells. Thus the time has come for a basic reappraisal of the framework for understanding both the immune and bone systems. The concept of a unified osteoimmune system will be absolutely indispensable for basic and translational approaches to diseases related to bone and/or the immune system.
[Mh] Termos MeSH primário: Imunidade
Esqueleto/imunologia
[Mh] Termos MeSH secundário: Alergia e Imunologia
Animais
Artrite Reumatoide/imunologia
Comunicação Celular
Células-Tronco Hematopoéticas/fisiologia
Seres Humanos
Osteoclastos/metabolismo
Osteologia
Osteoprotegerina/metabolismo
Ligante RANK/imunologia
Ligante RANK/metabolismo
Receptor Ativador de Fator Nuclear kappa-B/imunologia
Receptor Ativador de Fator Nuclear kappa-B/metabolismo
Transdução de Sinais
Esqueleto/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Osteoprotegerin); 0 (RANK Ligand); 0 (Receptor Activator of Nuclear Factor-kappa B); 0 (TNFRSF11A protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1152/physrev.00036.2016



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