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[PMID]:29183021
[Au] Autor:Chantziantoniou N; Mukherjee M; Donnelly AD; Pantanowitz L; Austin RM
[Ad] Endereço:Department of Pathology, Cytopathology Section, Sidra Medicine, Qatar Foundation, Doha, Qatar.
[Ti] Título:Digital Applications in Cytopathology: Problems, Rationalizations, and Alternative Approaches.
[So] Source:Acta Cytol;62(1):68-76, 2018.
[Is] ISSN:1938-2650
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this work was to raise awareness of problems using digital applications for examining, teaching, and applying telecytology at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia; University of Nebraska Medical Center (UNMC), Omaha, NE, USA; and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. The objective was to rationalize problems and propose alternative digital approaches. STUDY DESIGN: We sought to identify solutions to improve the following: (a) interpretive examination scores at KAMC for complex cytological templates (i.e., high-grade squamous intraepithelial lesions [HSIL]) when using static digital images (SDI) of cells in regions of interest (ROI); (b) visualization of cells in 3D clusters when teaching at UNMC using 2D and 3D whole-slide imaging (WSI); and (c) visualization of cells through streaming telecytology at UPMC. RESULTS: Composite SDI (CSDI) improved test scores for complex interpretations (i.e., HSIL) by converging diagnostic criteria from multiple ROI. Multiplane focusing through z-stacked WSI facilitated the teaching of cytological entities characterized by 3D cell clusters and consultative telecytology through robotic cell analysis. CONCLUSIONS: Adequately visualized cytomorphology and multiplane focusing are essential for virtual cytopathology examinations, teaching, or consultative telecytology. Visualization of diagnostic criteria through 2D or 3D imaging is critical. Panoptiq panoramic WSI with integrated z-stacked video clips enables optimal applied telecytology.
[Mh] Termos MeSH primário: Instrução por Computador
Educação Médica/métodos
Interpretação de Imagem Assistida por Computador/métodos
Microscopia/métodos
Patologia/educação
Lesões Intraepiteliais Escamosas Cervicais/patologia
Telepatologia/métodos
Neoplasias do Colo do Útero/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Nebraska
Teste de Papanicolaou
Pennsylvania
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Arábia Saudita
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1159/000484434


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[PMID]:29193348
[Ti] Título:Heading for centennial anniversary and beyond.
[So] Source:APMIS;125(12):1133, 2017 12.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Mh] Termos MeSH primário: Publicações Periódicas como Assunto
Editoração
[Mh] Termos MeSH secundário: Alergia e Imunologia
Aniversários e Eventos Especiais
Pesquisa Biomédica
História do Século XX
Microbiologia
Patologia
Publicações Periódicas como Assunto/história
[Pt] Tipo de publicação:EDITORIAL; HISTORICAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12797


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[PMID]:29193347
[Ti] Título:In Memoriam Ben Vainer 18.6.1969-21.6.2017.
[So] Source:APMIS;125(12):1041, 2017 12.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Mh] Termos MeSH primário: Gastroenterologia/história
Patologia/história
[Mh] Termos MeSH secundário: Dinamarca
História do Século XX
História do Século XXI
Seres Humanos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Vainer B
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12776


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[PMID]:29319946
[Au] Autor:Food and Drug Administration, HHS.
[Ti] Título:Medical Devices; Hematology and Pathology Devices; Classification of a Cervical Intraepithelial Neoplasia Test System. Final order.
[So] Source:Fed Regist;83(2):232-4, 2018 Jan 03.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA or we) is classifying the cervical intraepithelial neoplasia (CIN) test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the CIN test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/diagnóstico
Segurança de Equipamentos/classificação
Histologia/classificação
Histologia/instrumentação
Patologia/classificação
Patologia/instrumentação
[Mh] Termos MeSH secundário: Biomarcadores Tumorais
Neoplasia Intraepitelial Cervical/patologia
Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:29319944
[Au] Autor:Food and Drug Administration, HHS.
[Ti] Título:Medical Devices; Hematology and Pathology Devices; Classification of the Whole Slide Imaging System. Final order.
[So] Source:Fed Regist;83(1):20-2, 2018 Jan 02.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA or we) is classifying the whole slide imaging system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the whole slide imaging system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.
[Mh] Termos MeSH primário: Diagnóstico por Computador/classificação
Diagnóstico por Computador/instrumentação
Segurança de Equipamentos/classificação
Hematologia/classificação
Hematologia/instrumentação
Microscopia/classificação
Microscopia/instrumentação
Patologia/classificação
Patologia/instrumentação
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:28973239
[Ti] Título:The Changing Concepts in Pathology.
[So] Source:JAMA;318(13):1288, 2017 Oct 03.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Patologia/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10489


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[PMID]:28967948
[Au] Autor:Caron JE; March JK; Cohen MB; Schmidt RL
[Ad] Endereço:Department of Pathology and ARUP Laboratories, University of Utah Health Sciences Center, Salt Lake City.
[Ti] Título:A Survey of the Prevalence and Impact of Reporting Guideline Endorsement in Pathology Journals.
[So] Source:Am J Clin Pathol;148(4):314-322, 2017 Oct 01.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: To determine the prevalence of reporting guideline endorsement in pathology journals and to estimate the impact of guideline endorsement. Methods: We compared the quality of reporting in two sets of studies: (1) studies published in journals that explicitly mentioned a guideline vs studies published in journals that did not and (2) studies that cited a guideline vs studies that did not. The quality of reporting in prognostic biomarker studies was assessed using the REporting recommendations for tumor MARKer prognostic studies (REMARK) guideline. Results: We found that six (10%) of the 59 leading pathology journals explicitly mention reporting guidelines in the instructions to authors. Only one journal required authors to submit a checklist. There was significant variation in the rate at which various REMARK items were reported (P < .001). Journal endorsement was associated with more complete reporting (P = .04). Studies that cited REMARK had greater adherence to the REMARK reporting guidelines than studies that did not (P = .02). Conclusions: The prevalence of guideline endorsement is relatively low in pathology journals, but guideline endorsement may improve the quality of reporting.
[Mh] Termos MeSH primário: Patologia/normas
Publicações Periódicas como Assunto/normas
Relatório de Pesquisa/normas
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Fidelidade a Diretrizes/normas
Fidelidade a Diretrizes/estatística & dados numéricos
Guias como Assunto
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqx080


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[PMID]:28701127
[Au] Autor:Magin PJ; Tapley A; Morgan S; Henderson K; Holliday EG; Davey AR; Ball J; Catzikiris NF; Mulquiney KJ; van Driel ML
[Ad] Endereço:University of Newcastle, Newcastle, NSW parker.magin@newcastle.edu.au.
[Ti] Título:Changes in pathology test ordering by early career general practitioners: a longitudinal study.
[So] Source:Med J Aust;207(2):70-74, 2017 Jul 17.
[Is] ISSN:1326-5377
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the number of pathology tests ordered by general practice registrars during their first 18-24 months of clinical general practice. DESIGN: Longitudinal analysis of ten rounds of data collection (2010-2014) for the Registrar Clinical Encounters in Training (ReCEnT) study, an ongoing, multicentre, cohort study of general practice registrars in Australia. The principal analysis employed negative binomial regression in a generalised estimating equations framework (to account for repeated measures on registrars).Setting, participants: General practice registrars in training posts with five of 17 general practice regional training providers in five Australian states. The registrar participation rate was 96.4%. MAIN OUTCOME MEASURE: Number of pathology tests requested per consultation. The time unit for analysis was the registrar training term (the 6-month full-time equivalent component of clinical training); registrars contributed data for up to four training terms. RESULTS: 876 registrars contributed data for 114 584 consultations. The number of pathology tests requested increased by 11% (95% CI, 8-15%; P < 0.001) per training term. CONCLUSIONS: Contrary to expectations, pathology test ordering by general practice registrars increased significantly during their first 2 years of clinical practice. This causes concerns about overtesting. As established general practitioners order fewer tests than registrars, test ordering may peak during late vocational training and early career practice. Registrars need support during this difficult period in the development of their clinical practice patterns.
[Mh] Termos MeSH primário: Clínicos Gerais/educação
Patologia/estatística & dados numéricos
Padrões de Prática Médica/estatística & dados numéricos
Encaminhamento e Consulta/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Austrália
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Análise Multivariada
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE


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[PMID]:28686498
[Au] Autor:Brissette MD; Johnson KA; Raciti PM; McCloskey CB; Gratzinger DA; Conran RM; Domen RE; Hoffman RD; Post MD; Roberts CA; Rojiani AM; Powell SZ
[Ti] Título:Perceptions of Unprofessional Attitudes and Behaviors: Implications for Faculty Role Modeling and Teaching Professionalism During Pathology Residency.
[So] Source:Arch Pathol Lab Med;141(10):1394-1401, 2017 Oct.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Changes occurring in medicine have raised issues about medical professionalism. Professionalism is included in the Core Competencies and Milestones for all pathology residents. Previous studies have looked at resident professionalism attitudes and behaviors in primary care but none have looked specifically at pathology. OBJECTIVE: - To examine behavior and attitudes toward professionalism within pathology and to determine how professionalism is taught in residency programs. DESIGN: - Surveys were sent to all College of American Pathologists junior members and all pathology residency program directors, and responses were compared. RESULTS: - Although no single behavior received the same professionalism rating among residents and program directors, both groups identified the same behaviors as being the most unprofessional: posting identifiable patient information or case images to social media, making a disparaging comment about a physician colleague or member of the support staff on social media or in a public hospital space, and missing work without reporting the time off. Faculty were observed displaying most of these behaviors as often or more often than residents by both groups. The most common means to teach professionalism in pathology residencies is providing feedback as situations arise and teaching by example. Age differences were found within each group and between groups for observed behaviors and attitudes. CONCLUSIONS: - As teaching by example was identified as a common educational method, faculty must be aware of the role their behavior and attitudes have in shaping resident behavior and attitudes. These results suggest a need for additional resources to teach professionalism during pathology residency.
[Mh] Termos MeSH primário: Atitude do Pessoal de Saúde
Internato e Residência
Patologia/educação
Profissionalismo/educação
[Mh] Termos MeSH secundário: Adulto
Educação de Pós-Graduação em Medicina
Docentes
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0477-CP


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[PMID]:28521328
[Au] Autor:Queiroz Filho J; de Oliveira Crispim Freitas JC; Caldas Pessoa D; Eleutério Júnior J; Giraldo PC; Gonçalves AK
[Ad] Endereço:Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
[Ti] Título:Assessment of 100% Rapid Review as an Effective Tool for Internal Quality Control in Cytopathological Services.
[So] Source:Acta Cytol;61(3):207-213, 2017.
[Is] ISSN:1938-2650
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate the 100% rapid review (100%-RR) as an effective tool for internal quality control (IQC) in gynecological cytopathology services. STUDY DESIGN: A total of 8,677 swabs were analyzed; the negative results were submitted to 100%-RR. Divergent cases were discussed in a consensus meeting to reach a conclusion on the final diagnosis. The data were entered into SAS statistical software, and the agreement of the 100%-RR results with the final diagnosis was tested with the weighted kappa statistic. RESULTS: Of the 8,155 smears characterized as negative, 255 (3.13%) were abnormal smears, and 552 (6.77%) unsatisfactory smears were deemed negative. Regarding the results on the 8,155 smears subjected to 100%-RR when compared with the final diagnosis, there was agreement in 7,063 (86.60%) of them, and there were 1,092 (13.40%) discordant results (65.6%, unsatisfactory; 5.47%, atypical squamous cells of undetermined significance [ASC-US]). The κ index had an agreement of 0.867, with κ = 0.734 (p < 0.0001). Compared with the final diagnosis, the sensitivity of 100%-RR was 99.91% and its specificity was 99.4% for severe abnormalities. The sensitivity for high-grade squamous intraepithelial lesions was 88.2%, with a specificity of 100.00%. For abnormalities considered borderline, such as ASC-US, the sensitivity was 94.50% and the specificity was 99.5%. CONCLUSION: The 100%-RR was considered efficient when used as an IQC method.
[Mh] Termos MeSH primário: Citodiagnóstico/métodos
Citodiagnóstico/normas
Patologia/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Controle de Qualidade
Estatística como Assunto
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1159/000475833



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