Base de dados : MEDLINE
Pesquisa : HP1.007.091 [Categoria DeCS]
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  1 / 19153 MEDLINE  
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[PMID]:28462811
[Au] Autor:Iqbal J; Walsh MT; Hammad SM; Hussain MM
[Ad] Endereço:Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, NY 11203, USA; King Abdullah International Medical Research Center, MNGHA, Al Ahsa 31982, Saudi Arabia.
[Ti] Título:Sphingolipids and Lipoproteins in Health and Metabolic Disorders.
[So] Source:Trends Endocrinol Metab;28(7):506-518, 2017 07.
[Is] ISSN:1879-3061
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders.
[Mh] Termos MeSH primário: Saúde
Lipoproteínas/fisiologia
Doenças Metabólicas/etiologia
Esfingolipídeos/metabolismo
Esfingolipídeos/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Resistência à Insulina/fisiologia
Lipoproteínas/sangue
Lipoproteínas/metabolismo
Doenças Metabólicas/sangue
Doenças Metabólicas/metabolismo
Esfingolipídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Lipoproteins); 0 (Sphingolipids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  2 / 19153 MEDLINE  
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[PMID]:27347727
[Au] Autor:Duggan KA; McDevitt EA; Whitehurst LN; Mednick SC
[Ad] Endereço:a Department of Psychology , University of California , Riverside, Riverside , California , USA.
[Ti] Título:To Nap, Perchance to DREAM: A Factor Analysis of College Students' Self-Reported Reasons for Napping.
[So] Source:Behav Sleep Med;16(2):135-153, 2018 Mar-Apr.
[Is] ISSN:1540-2010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although napping has received attention because of its associations with health and use as a method to understand the function of sleep, to our knowledge no study has systematically and statistically assessed reasons for napping. Using factor analysis, we determined the underlying structure of reasons for napping in diverse undergraduates (N = 430, 59% female) and examined their relationships with self-reported sleep, psychological health, and physical health. The five reasons for napping can be summarized using the acronym DREAM (Dysregulative, Restorative, Emotional, Appetitive, and Mindful). Only Emotional reasons for napping were uniformly related to lower well-being. The use of factor analysis raises possibilities for future research, including examining the stability, structure, and psychological and physical health processes related to napping throughout the lifespan.
[Mh] Termos MeSH primário: Análise Fatorial
Autorrelato
Sono
Estudantes/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Saúde
Seres Humanos
Masculino
Sono/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160628
[St] Status:MEDLINE
[do] DOI:10.1080/15402002.2016.1178115


  3 / 19153 MEDLINE  
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[PMID]:29329347
[Au] Autor:Torres SMF; Furrow E; Souza CP; Granick JL; de Jong EP; Griffin TJ; Wang X
[Ad] Endereço:Veterinary Clinical Sciences Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, United States of America.
[Ti] Título:Salivary proteomics of healthy dogs: An in depth catalog.
[So] Source:PLoS One;13(1):e0191307, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To provide an in-depth catalog of the salivary proteome and endogenous peptidome of healthy dogs, evaluate proteins and peptides with antimicrobial properties, and compare the most common salivary proteins and peptides between different breed phylogeny groups. METHODS: 36 healthy dogs without evidence of periodontal disease representing four breed phylogeny groups, based upon single nucleotide polymorphism haplotypes (ancient, herding/sighthound, and two miscellaneous groups). Saliva collected from dogs was pooled by phylogeny group and analyzed using nanoscale liquid chromatography-tandem mass spectrometry. Resulting tandem mass spectra were compared to databases for identification of endogenous peptides and inferred proteins. RESULTS: 2,491 proteins and endogenous peptides were found in the saliva of healthy dogs with no periodontal disease. All dog phylogeny groups' saliva was rich in proteins and peptides with antimicrobial functions. The ancient breeds group was distinct in that it contained unique proteins and was missing many proteins and peptides present in the other groups. CONCLUSIONS AND CLINICAL RELEVANCE: Using a sophisticated nanoscale liquid chromatography-tandem mass spectrometry, we were able to identify 10-fold more salivary proteins than previously reported in dogs. Seven of the top 10 most abundant proteins or peptides serve immune functions and many more with various antimicrobial mechanisms were found. This is the most comprehensive analysis of healthy canine saliva to date, and will provide the groundwork for future studies analyzing salivary proteins and endogenous peptides in disease states.
[Mh] Termos MeSH primário: Saúde
Proteômica
Proteínas e Peptídeos Salivares/metabolismo
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Masculino
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Salivary Proteins and Peptides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191307


  4 / 19153 MEDLINE  
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[PMID]:28683448
[Au] Autor:Lopetuso LR; Petito V; Graziani C; Schiavoni E; Paroni Sterbini F; Poscia A; Gaetani E; Franceschi F; Cammarota G; Sanguinetti M; Masucci L; Scaldaferri F; Gasbarrini A
[Ad] Endereço:Department of Internal Medicine, Gastroenterology Division, Policlinico "A. Gemelli" Hospital, Rome, Italy.
[Ti] Título:Gut Microbiota in Health, Diverticular Disease, Irritable Bowel Syndrome, and Inflammatory Bowel Diseases: Time for Microbial Marker of Gastrointestinal Disorders.
[So] Source:Dig Dis;36(1):56-65, 2018.
[Is] ISSN:1421-9875
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) patients. DD, IBS, and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected. Microbiota composition was evaluated through a metagenomic gene-targeted approach. GI pathology represented a continuous spectrum of diseases where IBD displayed one extreme, while CT displayed the other. Among Phyla, Biplot PC2/PC3 and dendogram plot showed major differences in samples from IBS and IBD. DD resembled species CT composition, but not for Bacteroides fragilis. In IBS, Dialister spp. and then Faecalibacterium prausnitzii were the most representative species. Ulcerative colitis showed a reduced concentration of Clostridium difficile and an increase of Bacteroides fragilis. In Crohn's disease, Parabacteroides distasonis was the most represented, while Faecalibacterium prausnitzii and Bacteroides fragilis were significantly reduced. Each disorder has its definite overall microbial signature, which produces a clear differentiation from the others. On the other hand, shared alterations constitute the "core dysbiosis" of GI diseases. The assessment of these microbial markers represents a parameter that may complete the diagnostic assessment.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Doenças Diverticulares/microbiologia
Microbioma Gastrointestinal
Saúde
Doenças Inflamatórias Intestinais/microbiologia
Síndrome do Intestino Irritável/microbiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Filogenia
Análise de Componente Principal
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1159/000477205


  5 / 19153 MEDLINE  
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[PMID]:28743462
[Au] Autor:Bakhshinejad B; Ghiasvand S
[Ad] Endereço:Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Título:Bacteriophages in the human gut: Our fellow travelers throughout life and potential biomarkers of heath or disease.
[So] Source:Virus Res;240:47-55, 2017 08 15.
[Is] ISSN:1872-7492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The gastrointestinal (GI) tract is populated by a huge variety of viruses. Bacterial viruses (bacteriophages) constitute the largest and the most unrecognized part of virome. The total bacteriophage community of the human gut is called phageome. Phages colonize the gut from the earliest moments of life and become our fellow travelers throughout life. Phageome seems to be unique to each individual and shows a high degree of interpersonal variation. In the healthy gut, a vast majority of phages have a lysogenic lifestyle. These prophages serve as a major respository of mobile genetic elements in the gut and play key roles in the exchange of genetic material between bacterial species via horizontal gene transfer (HGT). But, imbalance in the gut microbial community during dysbiosis, caused by diseases or environmental stresses such as antibiotics, is accompanied by induction of prophages leading to a decreased ratio of symbionts to pathobionts. Based on this, a diseased gut is transformed from an environment predominantly occupied by prophages to an ecosystem mostly inhabited by lytic phages. A growing body of evidence has provided support for the notion that phageome structure and composition change dependent on the physiological or pathological status of the body. This has been demonstrated by pronounced quantitative and qualitative differences between the phageome of healthy individuals and patients. Although many aspects of the contribution made by phages to human biology remain to be understood, recent findings favor the suggestion that phageome might represent potential to serve as a biomarker of health or disease.
[Mh] Termos MeSH primário: Bacteriófagos/isolamento & purificação
Trato Gastrointestinal/virologia
[Mh] Termos MeSH secundário: Animais
Bacteriófagos/classificação
Bacteriófagos/genética
Bacteriófagos/fisiologia
Biomarcadores/análise
Biomarcadores/metabolismo
Saúde
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  6 / 19153 MEDLINE  
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[PMID]:29261752
[Au] Autor:Greenfield J; Hudson M; Vinet E; Fortin PR; Bykerk V; Pineau CA; Wang M; Bernatsky S; Baron M; Canadian Scleroderma Research Group and Canadian Inflammatory Myopathy Study Group
[Ad] Endereço:Department of Anatomy McGill University, Montréal, Quebec, Canada.
[Ti] Título:A comparison of health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARDs).
[So] Source:PLoS One;12(12):e0189840, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To compare physical and mental health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARD). METHODS: Incident subjects enrolled in four SARD cohorts, namely systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA) and idiopathic inflammatory myopathies (IIM) were studied. The outcomes of interest were baseline Short Form Health Survey physical (PCS) and mental (MCS) component summary scores. Multivariate analysis was conducted to determine whether PCS and MCS scores differed across SARD type. RESULTS: The study included 118 SLE (93% women, mean age 36 years), 108 SSc (79% women, mean age 55), 64 RA (63% women, mean age 58) and 25 IIM (68% women, mean age 49) subjects. Mean PCS scores were 38.9 ± 12.2 in SLE, 37.1 ± 13.3 in RA, 35.0 ± 13.6 in SSc and 28.0 ± 15.4 in IIM. Mean MCS scores were 45.0 ± 13.3 in RA, 44.4 ± 14.7 in SSc, 40.1 ± 14.3 in SLE and 33.6 ± 18.7 in IIM. SARD type was an independent predictor of HRQoL with, in some cases, the magnitude of the differences reaching one standard deviation (IIM worse PCS scores compared to SLE (ß -12.23 [95% CI -18.11, -6.36; p<0.001]); IIM worse MCS scores compared to SSc (ß -11.05 [95% CI -17.53, -4.58; p = 0.001]) and RA (ß -11.72 [95% CI -18.62, -4.81; p = 0.001]). CONCLUSIONS: Cross-SARD research provides a novel approach to gain greater understanding of commonalities and differences across rheumatic diseases. The differences observed warrant further research into correlates and trajectories over time.
[Mh] Termos MeSH primário: Doenças Autoimunes/patologia
Saúde
Qualidade de Vida
Doenças Reumáticas/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189840


  7 / 19153 MEDLINE  
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[PMID]:29252996
[Au] Autor:Fermont JM; Blazeby JM; Rogers CA; Wordsworth S; By-Band-Sleeve Study Management Group
[Ad] Endereço:Department of Medicine, Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom.
[Ti] Título:The EQ-5D-5L is a valid approach to measure health related quality of life in patients undergoing bariatric surgery.
[So] Source:PLoS One;12(12):e0189190, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bariatric surgery is considered an effective treatment for individuals with severe and complex obesity. Besides reducing weight and improving obesity related comorbidities such as diabetes, bariatric surgery could improve patients' health-related quality of life. However, the frequently used instrument to measure quality of life, the EQ-5D has not been validated for use in bariatric surgery, which is a major limitation to its use in this clinical context. Our study undertook a psychometric validation of the 5 level EQ-5D (EQ-5D-5L) using clinical trial data to measure health-related quality of life in patients with severe and complex obesity undergoing bariatric surgery. Health-related quality of life was assessed at baseline (before randomisation) and six months later in 189 patients in a randomised controlled trial of bariatric surgery. Patients completed two generic health-related quality of life instruments, the EQ-5D-5L and SF-12, which were used together for the validation using data from all patients in the trial as the trial is ongoing. Psychometric analyses included construct and criterion validity and responsiveness to change. Of the 189 validation patients, 141 (75%) were female, the median age was 49 years old (range 23-70 years) and body mass index ranged from 33-70 kg/m2. For construct validity, there were significant improvements in the distribution of responses in all EQ-5D dimensions between baseline and 6 months after randomisation. For criterion validity, the highest degree of correlation was between the EQ-5D pain/discomfort and SF-12 bodily pain domain. For responsiveness the EQ-5D and SF-12 showed statistically significant improvements in health-related quality of life between baseline and 6 months after randomisation. The EQ-5D-5L is a valid generic measure for measuring health-related quality of life in bariatric surgery patients.
[Mh] Termos MeSH primário: Cirurgia Bariátrica
Saúde
Qualidade de Vida
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adulto
Demografia
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189190


  8 / 19153 MEDLINE  
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[PMID]:27776013
[Au] Autor:Friedman EE; Duffus WA
[Ad] Endereço:Office of Health Equity, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
[Ti] Título:Chronic health conditions in Medicare beneficiaries 65 years and older with HIV infection.
[So] Source:AIDS;30(16):2529-2536, 2016 Oct 23.
[Is] ISSN:1473-5571
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine sociodemographic factors and chronic health conditions of people living with HIV (PLWHIV/HIV+) at least 65 years old and compare their chronic disease prevalence with beneficiaries without HIV. DESIGN: National fee-for-service Medicare claims data (parts A and B) from 2006 to 2009 were used to create a retrospective cohort of beneficiaries at least 65 years old. METHODS: Beneficiaries with an inpatient or skilled nursing facility claim, or outpatient claims with HIV diagnosis codes were considered HIV+. HIV+ beneficiaries were compared with uninfected beneficiaries on demographic factors and on the prevalence of hypertension, hyperlipidemia, ischemic heart disease, rheumatoid arthritis/osteoarthritis, and diabetes. Odds ratios (OR), 95% confidence intervals (CIs), and P values were calculated. Adjustment variables included age, sex, race/ethnicity, end stage renal disease (ESRD), and dual Medicare-Medicaid enrollment. Chronic conditions were examined individually and as an index from zero to all five conditions. RESULTS: Of 29 060 418 eligible beneficiaries, 24 735 (0.09%) were HIV+. HIV+ beneficiaries were more likely to be Hispanic, African-American, male, and younger (P > 0.0001) and were 1.5-2.1 times as likely to have a chronic disease [diabetes (adjusted OR) 1.51, 95% CI (1.47, 1.55): rheumatoid arthritis/osteoarthritis 2.14, 95% CI (2.08, 2.19)], and 2.4-7 times as likely to have 1-5 comorbid chronic conditions [1 condition (adjusted OR) 2.38, 95% CI (2.21, 2.57): 5 conditions 7.07, 95% CI (6.61, 7.56)]. CONCLUSION: Our results show that PLWHIV at least 65 years old are at higher risk of comorbidities than other fee-for-service Medicare beneficiaries. This finding has implications for the cost and health management of PLWHIV 65 years and older.
[Mh] Termos MeSH primário: Doença Crônica/epidemiologia
Comorbidade
Infecções por HIV/complicações
Benefícios do Seguro
Medicare
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Saúde
Seres Humanos
Masculino
Prevalência
Estudos Retrospectivos
Medição de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  9 / 19153 MEDLINE  
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[PMID]:29176879
[Au] Autor:Chan EYY; Wang SS; Ho JY; Huang Z; Liu S; Guo C
[Ad] Endereço:Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
[Ti] Título:Socio-demographic predictors of health and environmental co-benefit behaviours for climate change mitigation in urban China.
[So] Source:PLoS One;12(11):e0188661, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aims to examine the patterns and socio-demographic predictors of health and environmental co-benefit behaviours that support climate change mitigation in a densely populated Asian metropolis-Hong Kong. METHODS: A population-based, stratified and cross-sectional random digit dialling telephone survey study was conducted between January and February 2016, among the Cantonese-speaking population aged 15 and above in Hong Kong. Socio-demographic data and the self-reported practice of 10 different co-benefit behaviours were solicited. Ethics approval and participant's verbal consent were sought. FINDINGS: The study sample consisted of 1,017 respondents (response rate: 63.6%) were comparable to the age, gender and geographical distributions of the Hong Kong population found in the latest 2011 Hong Kong Population Census. Among the co-benefit behaviours, using less packaging and disposable shopping bags were practiced in the highest frequency (70.1%). However, four behaviours were found to have never been practiced by more than half of the respondents, including bringing personal eating utensils when dining in restaurants or small eateries, showering less than five minutes, having one vegetarian meal a week, and buying more organic food. Results of multivariable logistic regression showed that frequency of practicing co-benefit behaviours were consistently associated with gender and age. CONCLUSION: Urban residents in Hong Kong do not engage in the practice of co-benefit behaviours in a uniform way. In general, females and older people are more likely to adopt co-benefit behaviours in their daily lives. Further research to assess the knowledge and attitudes of the population towards these co-benefit behaviours will provide support to relevant climate change mitigation policies and education programmes.
[Mh] Termos MeSH primário: Cidades
Mudança Climática
Demografia
Meio Ambiente
Conhecimentos, Atitudes e Prática em Saúde
Saúde
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
China/epidemiologia
Feminino
Hong Kong/epidemiologia
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188661


  10 / 19153 MEDLINE  
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[PMID]:29176866
[Au] Autor:Tamura M; Hoshi C; Kobori M; Takahashi S; Tomita J; Nishimura M; Nishihira J
[Ad] Endereço:Food Research Institute of National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan.
[Ti] Título:Quercetin metabolism by fecal microbiota from healthy elderly human subjects.
[So] Source:PLoS One;12(11):e0188271, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quercetin is a polyphenol found in food that has numerous health benefits. This study investigated the relationship between quercetin metabolism, gut microbiota composition, and dietary intake in elderly Japanese subjects. A food frequency questionnaire was used to assess dietary intake during the week prior to stool sample collection. Fecal suspensions from 56 subjects were anaerobically incubated with quercetin and fecal microbiota composition was analyzed by next-generation sequencing. Inter-individual variations in quercetin concentration and fecal microbiota composition at family level suggested differences in microbial quercetin metabolism. The abundance of Sutterellaceae (r = -0.292) and Oscillospiraceae (r = -0.334) was negatively correlated whereas that of Fusobacteriaceae (r = 0.361) and Enterobacteriaceae (r = 0.321) was positively correlated with quercetin concentration. Niacin (r = -0.313), vitamin B6 (r = -0.297), vitamin B12 (r = -0.266), vitamin D (r = -0.301), and ratio of animal protein to total protein (r = -0.27) were also negatively correlated with quercetin concentration. Bacterial abundance was positively or negatively related to intake of food components. This is the first report describing the relationship between fecal quercetin metabolism, human microbiota, and dietary intake in the elderly.
[Mh] Termos MeSH primário: Fezes/microbiologia
Saúde
Microbiota
Quercetina/metabolismo
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Grupo com Ancestrais do Continente Asiático
Índice de Massa Corporal
Comportamento Alimentar
Seres Humanos
Masculino
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188271



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