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[PMID]:29220336
[Au] Autor:Blankenship C
[Ad] Endereço:International Academy of Compounding Pharmacists.
[Ti] Título:Join the Partnership for Personalized Prescriptions (P3) Advocacy Effort!
[So] Source:Int J Pharm Compd;21(6):468, 2017 Nov-Dec.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Defesa do Paciente
Medicina de Precisão
Prescrições
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29324808
[Au] Autor:Yu Y; Lv Y; Yao B; Duan L; Zhang X; Xie L; Chang C
[Ad] Endereço:Institute of Sports Medicine, Peking University Third Hospital, Beijing, China.
[Ti] Título:A novel prescription pedometer-assisted walking intervention and weight management for Chinese occupational population.
[So] Source:PLoS One;13(1):e0190848, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: Information technology has been previously used for the research and practice of health promotion. Appropriate and effective health promotion methods used by professional groups remain to be investigated. This study aimed to assess the feasibility and effectiveness of a weight management program among the Chinese occupational population using and a novel information technology exercise prescription. STUDY DESIGN AND PARTICIPANTS: A 3-month open, self-monitored intervention trial, involving individualized pedometer-assisted exercise prescription and a one-time targeted dietary guidance prior to exercise was conducted on the Chinese occupational population aged 18-65 years in China from 2015 to 2016. Data were collected from March 2015 to May 2016 and analyzed from June 2016 to August 2016. Participants were also asked to synchronize exercise data of the pedometer to the Internet-based Health System Center daily (at least weekly), by connecting to the personal computer (PC) using a USB cable or via Bluetooth. RESULTS: Eligible participants included 802 Chinese occupational persons, and 718 of them followed exercise interventions with 89.5% (718/802) adherence to the exercise programs. Of them, 688 participants completed the program with 85.8% (688/802) adherence to the exercise program and their data were analyzed. Weight decreased by 2.2% among all overweight/obese participants, with 1.8% reduction in waist circumference and 3.3% reduction in body fat percentage (p< 0.001). Weight and body fat percentage in normal-weight individuals decreased by 0.7% and 2.5%, respectively (p < 0.01). A weight gain of 1.0% was observed in all underweight participants (p< 0.05), and 68.2% (208/305) of overweight/obese participants experienced weight loss, with an average reduction of 3.5%, with 20.2% (42/208) of them achieving weight loss ≥5%. Blood pressure and fasting serum glucose decreased significantly in both the overweight/obese and the normal-weight individuals (p < 0.05). The incidence of hypertension was significantly lower and lifestyle behavior significantly improved (p < 0.05). CONCLUSION: The prescription pedometer-assisted walking intervention can effectively improve exercise adherence and manage weight. This approach was also effective in controlling the risk factors of weight-related chronic diseases. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR) ChiCTR-OOh-16010229.
[Mh] Termos MeSH primário: Actigrafia/instrumentação
Terapia por Exercício/instrumentação
Sobrepeso/terapia
Terapia Assistida por Computador/instrumentação
Caminhada
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
China
Estudos de Viabilidade
Feminino
Seres Humanos
Hiperglicemia/complicações
Hiperglicemia/fisiopatologia
Hiperglicemia/terapia
Hiperlipidemias/complicações
Hiperlipidemias/fisiopatologia
Hiperlipidemias/terapia
Hipertensão/complicações
Hipertensão/fisiopatologia
Hipertensão/terapia
Internet
Masculino
Meia-Idade
Sobrepeso/complicações
Sobrepeso/fisiopatologia
Cooperação do Paciente
Prescrições
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190848


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[PMID]:29049576
[Ti] Título:Medicolegal: Illegal Prescribing of Intoxicating Liquor.
[So] Source:JAMA;318(14):1398, 2017 10 10.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bebidas Alcoólicas/história
Jurisprudência/história
Prescrições/história
[Mh] Termos MeSH secundário: Regulamentação Governamental/história
História do Século XX
Seres Humanos
Legislação como Assunto/história
Masculino
Washington
[Pt] Tipo de publicação:CLASSICAL ARTICLE; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10490


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[PMID]:28931017
[Au] Autor:Randhawa AK; Parikh JS; Kuk JL
[Ad] Endereço:School of Kinesiology and Health Science at York University, Toronto, Canada.
[Ti] Título:Trends in medication use by body mass index and age between 1988 and 2012 in the United States.
[So] Source:PLoS One;12(9):e0184089, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Whether the increase in prescription medication use over time differs by age and obesity status is unclear. METHOD: National Health and Nutrition Examination Survey (NHANES) between 1988 and 2012 was analyzed (n = 57,543). FINDINGS: Increased medication use over time was seen in older individuals of all body mass index (BMI) classes, with the most prominent increase in those with obesity (p<0.001). For example, older men (≥65y) with obesity took 3.1 more medications between 1988 and 2012 versus 1.5 for normal weight older men. There were minimal differences in medication use over time in younger individuals. In men, the odds of taking antihypertensives, lipid-lowering medication, antidiabetics, and antidepressants increased with age, time and BMI wherein the association between age and medication use was magnified over time (age*time, p<0.05). In women, older women with overweight or obesity had a greater increase in the likelihood of antihypertensives and antidiabetics medication over time (BMI*time, p>0.05). CONCLUSION: Older individuals of all BMI classes may be driving the increase in medication use over time. However, the rise in the likelihood of taking cardiometabolic medications over time was generally not different between those with or without obesity in men with some increases seen in older women. Further research may be required to assess accessibility and barriers to medication use among certain demographics.
[Mh] Termos MeSH primário: Obesidade/patologia
Prescrições/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Índice de Massa Corporal
Peso Corporal
Feminino
Seres Humanos
Entrevistas como Assunto
Masculino
Meia-Idade
Inquéritos Nutricionais
Razão de Chances
Inquéritos e Questionários
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184089


  5 / 2330 MEDLINE  
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[PMID]:28768628
[Au] Autor:Huybrechts KF; Bateman BT; Desai RJ; Hernandez-Diaz S; Rough K; Mogun H; Kerzner LS; Davis JM; Stover M; Bartels D; Cottral J; Patorno E
[Ad] Endereço:Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA khuybrechts@bwh.harvard.edu.
[Ti] Título:Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study.
[So] Source:BMJ;358:j3326, 2017 Aug 02.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To assess the impact of in utero co-exposure to psychotropic medications and opioids on the incidence and severity of neonatal drug withdrawal. Observational cohort study. Nationwide sample of pregnancies in publicly insured women in the US, nested in the Medicaid Analytic eXtract (2000-10). 201 275 pregnant women with public insurance who were exposed to opioids around the time of delivery and their liveborn infants. In utero exposure to psychotropic medications, in particular antidepressants, atypical antipsychotics, benzodiazepines, gabapentin, and non-benzodiazepine hypnotics (Z drugs), with prescriptions filled within the same time window as prescriptions for opioids. Diagnosis of neonatal drug withdrawal in infants exposed in utero to opioids and psychotropic medications compared with opioids alone. The absolute risk for neonatal drug withdrawal ranged from 1.0% in infants exposed in utero to prescription opioids alone to 11.4% for those exposed to opioids co-prescribed with gabapentin. Among neonates exposed in utero to prescription opioids, the relative risk adjusted for propensity score was 1.34 (95% confidence interval 1.22 to 1.47) with concomitant exposure to antidepressants, 1.49 (1.35 to 1.63) with benzodiazepines, 1.61 (1.26 to 2.06) with gabapentin, 1.20 (0.95 to 1.51) with antipsychotics, and 1.01 (0.88 to 1.15) with Z drugs. In utero exposure to two or more psychotropic medications along with opioids was associated with a twofold increased risk of withdrawal (2.05, 1.77 to 2.37). The severity of the withdrawal seemed increased in neonates exposed to both opioids and psychotropic medications compared with opioids alone. During pregnancy, the use of psychotropic medications in addition to prescription opioids is common, despite a lack of safety data. The current findings suggest that these drugs could further increase the risk and severity of neonatal drug withdrawal.
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Antipsicóticos/efeitos adversos
Quimioterapia Combinada/efeitos adversos
Transtornos do Humor/tratamento farmacológico
Síndrome de Abstinência Neonatal
Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico
Complicações na Gravidez/tratamento farmacológico
Efeitos Tardios da Exposição Pré-Natal/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Recém-Nascido
Masculino
Medicaid/estatística & dados numéricos
Meia-Idade
Transtornos do Humor/epidemiologia
Síndrome de Abstinência Neonatal/epidemiologia
Síndrome de Abstinência Neonatal/prevenção & controle
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Padrões de Prática Médica
Gravidez
Complicações na Gravidez/epidemiologia
Gestantes/psicologia
Efeitos Tardios da Exposição Pré-Natal/prevenção & controle
Prescrições/estatística & dados numéricos
Estudos Prospectivos
Fatores de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Antipsychotic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j3326


  6 / 2330 MEDLINE  
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[PMID]:28700631
[Au] Autor:Horvat OJ; Tomas AD; Paut Kusturica MM; Savkov AV; Bukumiric DU; Tomic ZS; Sabo AJ
[Ad] Endereço:Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine Novi Sad, University of Novi Sad, Novi Sad, Serbia.
[Ti] Título:Is the level of knowledge a predictor of rational antibiotic use in Serbia?
[So] Source:PLoS One;12(7):e0180799, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The objective of this study was to investigate the knowledge, attitudes and behavior regarding antibiotics of the general population. METHODS: The study sample consisted of adult subjects who consulted general practitioners at health centers in Serbia and agreed to complete the questionnaire. A total of 668 questionnaires were distributed; 500 respondents completed the entire questionnaire (response rate 74.85%). RESULTS: The average age was 51.65 ± 16.56 years, 60.80% of the respondents were women. The median antibiotic knowledge score was 9. Predictors of adequate antibiotic knowledge were higher education level and a family member whose ocuppation was related to health-care. Overall, 58.4% of respondents believed that antibiotics could be used to treat common cold. Around a half of the respondents (47.2%) self-medicated with antibiotics at least once during their life-time, and around a quarter (24.2%) during the last treatment of infection. Patients with inadequate knowledge had 3 times higher chances of self-medicating with antibiotics compared to those with adequate knowledge. Although 98.20% of respondents claimed that antibiotic treatment should be started after a visit to a doctor and receiving a prescription, only 65.8% obtained antibiotics with prescription from a doctor during the last infection. CONCLUSIONS: Although these results demonstrate that respondents had a relatively adequate level of knowledge regarding antibiotics use, some areas of misconceptions and improper behavior were identified. Therefore, further rationalization should be focused on educational campaigns targeting the behavior of patients with regard to antibiotic use.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Prescrições/estatística & dados numéricos
Sérvia
Classe Social
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180799


  7 / 2330 MEDLINE  
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[PMID]:28674305
[Au] Autor:Hagiwara H; Nishikawa R; Fukuzawa K; Tohkin M
[Ad] Endereço:Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University.
[Ti] Título:The Survey of the Compliance Situation to the Antihypertensive Therapy Guideline by Analyzing Japanese National Claims Data.
[So] Source:Yakugaku Zasshi;137(7):893-901, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Kidney disease (KD) is a serious risk factor for cardiovascular event, and it is important to protect the heart and kidneys during treatment of the high blood pressure to prevent cardiovascular event. Japanese guideline (JSH2014) suggests using combination therapy to reduce the risk of comorbidities rather than high-dose monotherapy for the patients with cardiovascular disease and KD. Therefore, the present study assessed antihypertensive prescription patterns in Japanese patients with ischemic heart disease related diseases (IHDRD) and KD, and evaluated whether the prescription patterns match with the guideline-suggested therapies by analyzing the national insurance claims database (NDB). We extracted antihypertensive prescription patterns among Japanese IHDRD patients from the data of October 2011 of NDB, and examined the effect of KD on the prescription patterns. The number of prescribed antihypertensive was associated with KD among patients regardless of IHDRD. Patients with IHDRD and KD were more frequently prescribed combination therapy (calcium channel blockers/angiotensin II receptor blockers) than the calcium channel blocker monotherapy, based on the JSH2014. On the other hand, we did not observe the standard use of diuretics for patients with heart failure, which is suggested by the JSH2014. These findings suggested that patients with IHDRD and KD were frequently prescribed combination therapy to achieve its cardioprotective and renoprotective effects, according to the JSH2014, but the prescription profile to the patients with heart failure didn't match that of guideline-suggested therapies. This study provided a clinically important information and demonstrated the utility of NDB for compliance assessment for therapeutics guideline.
[Mh] Termos MeSH primário: Antagonistas de Receptores de Angiotensina/administração & dosagem
Anti-Hipertensivos/administração & dosagem
Bloqueadores dos Canais de Cálcio/administração & dosagem
Bases de Dados Factuais
Fidelidade a Diretrizes/estatística & dados numéricos
Hipertensão/tratamento farmacológico
Revisão da Utilização de Seguros
Guias de Prática Clínica como Assunto
Prescrições/estatística & dados numéricos
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Asiático
Comorbidade
Quimioterapia Combinada/estatística & dados numéricos
Seres Humanos
Hipertensão/epidemiologia
Nefropatias/epidemiologia
Nefropatias/prevenção & controle
Isquemia Miocárdica/epidemiologia
Isquemia Miocárdica/prevenção & controle
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin Receptor Antagonists); 0 (Antihypertensive Agents); 0 (Calcium Channel Blockers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00038


  8 / 2330 MEDLINE  
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[PMID]:28617688
[Au] Autor:Vagge A; Nelson LB
[Ad] Endereço:aPediatric Ophthalmology and Ocular Genetics, Wills Eye Hospital, Philadelphia, Pennsylvania, USA bEye Clinic, DiNOGMI, University of Genoa, Genoa, Italy.
[Ti] Título:Compliance with the prescribed occlusion treatment for amblyopia.
[So] Source:Curr Opin Ophthalmol;28(5):454-459, 2017 Sep.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The present review article is an update on the current evidence about compliance to the prescribed occlusion treatment for amblyopia. In particular, the authors focus on the predictors and causes of noncompliance and possible interventions to increase it. RECENT FINDINGS: Compliance with prescribed occlusion treatment is often challenging. Reported rates of compliance range widely from 49% to 87%. Objective monitoring of occlusion has opened up new research opportunities and allow the design of effective therapeutic regimens. Also, predictors and causes of noncompliance have been investigated and their knowledge may help the clinician to improved compliance with prescribed occlusion treatment for amblyopia. SUMMARY: Although many of the studies assessing the effectiveness of interventions to increase compliance to patching treatment for amblyopia have many limitations, evidences support that use of educational supports, parents, and patient understanding on the importance of patching and written information should be considered to increase compliance with patching.
[Mh] Termos MeSH primário: Ambliopia/terapia
Cooperação do Paciente
Prescrições
Privação Sensorial
[Mh] Termos MeSH secundário: Ambliopia/fisiopatologia
Seres Humanos
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000409


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[PMID]:28605172
[Au] Autor:Martin D; Luz PM; Lake JE; Clark JL; Campos DP; Veloso VG; Moreira RI; Cardoso SW; Klausner JD; Grinsztejn B
[Ad] Endereço:Department of Emergency Medicine, Highland Hospital, Oakland, CA, USA.
[Ti] Título:Pharmacy refill data can be used to predict virologic failure for patients on antiretroviral therapy in Brazil.
[So] Source:J Int AIDS Soc;20(1):21405, 2017 06 05.
[Is] ISSN:1758-2652
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Pharmacy adherence measures such as pharmacy dispensing ratios (PDRs) have previously been shown to be predictive of virologic outcomes. We aimed to determine the optimal interval of PDR assessment for predicting virologic failure for HIV-infected patients on antiretroviral therapy (ART). METHODS: Using national Brazilian ART pharmacy refill data, we examined PDRs for patients ≥18 years of age with at least one HIV RNA level ≥180 days after ART initiation on or after 1 January 2011. Patients with a documented ART change ≤270 days prior to viral load test date were excluded. Logistic regression models were used to describe associations between virologic failure, defined as an HIV RNA level ≥400 copies/mL and PDRs, defined as the number of days index drug dispensed (non-nucleoside reverse-transcriptase inhibitor or protease inhibitor) per 180- and 90-day, interval preceding viral load testing, adjusting for sex, age, race, time since ART initiation and index drug. Backward elimination of insignificant variables was performed after adjusting for PDR. A predictive probability of virologic failure was calculated using the corresponding odds ratios for the PDR and any other significant variables. The diagnostic performance of the PDR interval was assessed by calculating the area under the receiver operating characteristic curve (AUROC) for the predictive probability with respect to virologic failure. A total of 1,025 patients were included (68% were male, median age 40 years, median time on ART 3.4 years). The PDR was found to be significantly associated with virologic failure for all of the PDR intervals ( < 0.001). There was an increased risk of virologic failure for all PDRs <0.95. The 90-180 days interval had a AUROC of 0.842, compared to 0.841 and 0.829 for the 0-180 days and 0-90 days intervals, respectively. The PDR performed well as a predictive tool to identify patients in virologic failure with the 90-180-days interval prior to viral load testing being marginally more predictive. CONCLUSIONS: The validation and use of the pharmacy dispensing ratio using public pharmacy refill data could aid in early identification of patients with poor adherence and prevent development of treatment failure and drug resistance in Brazil.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Infecções por HIV/tratamento farmacológico
Prescrições
Falha de Tratamento
[Mh] Termos MeSH secundário: Adulto
Brasil
Feminino
Seres Humanos
Masculino
Meia-Idade
Prescrições/estatística & dados numéricos
Curva ROC
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.7448/IAS.20.1.21405


  10 / 2330 MEDLINE  
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[PMID]:28431507
[Au] Autor:Deelen JWT; Visser CE; Prins JM; van Hest RM
[Ad] Endereço:Academic Medical Center, Amsterdam, the Netherlands. j.w.t.deelen@umcutrecht.nl.
[Ti] Título:Antimicrobial prophylaxis outside the operating theatre, an audit in a university hospital.
[So] Source:BMC Infect Dis;17(1):296, 2017 Apr 21.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prophylactic use of antimicrobial agents to prevent infections in non-surgical situations has hardly been investigated. We investigate the extent, indications and appropriateness of antimicrobial prophylaxis given outside the operating room in a tertiary care hospital. METHODS: Four point-prevalence surveys were conducted in which all inpatients on that day were screened for the use of prophylactic antimicrobials: medical prophylaxis, prophylaxis around non-surgical interventions and surgical prophylaxis given on the ward. The primary endpoint was the extent of prophylaxis relative to the total number of antimicrobial prescriptions. We also investigated per prescription the presence of a (local) protocol and adherence to these protocols. RESULTS: We registered in total 1020 antimicrobial prescriptions, of which 317 (31.1%) were given as prophylaxis. 827/1020 were antibiotic prescriptions. Of these antibiotic prescriptions, 17.0% was medical prophylaxis, 2.7% prophylaxis around non-surgical interventions and 6.9% surgical prophylaxis administered on a ward. For medical antibiotic prophylaxis, a protocol was present in 125 of 141 prescriptions (88.7%); the protocol was followed in 118 cases (94.4%). For prophylaxis around non-surgical interventions and surgical prophylaxis on the wards, protocol presence and adherence rates were 59.1% and 92.3%, and 73.3% and 97.6% respectively. Of the 96 antiviral and 97 antifungal prescriptions, 42.7% and 57.8%, respectively, were medical prophylaxis, of which 95.1 and 96.3% were prescribed according to protocols respectively. CONCLUSIONS: Antimicrobial prophylaxis outside the operating theatre is responsible for a considerable part of total in-hospital antimicrobial use. For most prescriptions there was a protocol and adherence to the protocols was high. The main targets for improvement were prophylaxis around non-surgical interventions and surgical prophylaxis given on the ward.
[Mh] Termos MeSH primário: Antibioticoprofilaxia/métodos
Antibioticoprofilaxia/utilização
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Anti-Infecciosos/uso terapêutico
Feminino
Hospitais Universitários/estatística & dados numéricos
Seres Humanos
Pacientes Internados
Países Baixos
Salas Cirúrgicas
Prescrições/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2354-4



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