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[PMID]:29183075
[Au] Autor:Van Wagoner RM; Eichner A; Bhasin S; Deuster PA; Eichner D
[Ad] Endereço:Sports Medicine Research and Testing Laboratory, Salt Lake City, Utah.
[Ti] Título:Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet.
[So] Source:JAMA;318(20):2004-2010, 2017 11 28.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Recent reports have described the increasing use of nonsteroidal selective androgen receptor modulators, which have not been approved by the US Food and Drug Administration (FDA), to enhance appearance and performance. The composition and purity of such products is not known. Objective: To determine the chemical identity and the amounts of ingredients in dietary supplements and products marketed and sold through the internet as selective androgen receptor modulators and compare the analyzed contents with product labels. Design and Setting: Web-based searches were performed from February 18, 2016, to March 25, 2016, using the Google search engine on the Chrome and Internet Explorer web browsers to identify suppliers selling selective androgen receptor modulators. The products were purchased and the identities of the compounds and their amounts were determined from April to August 2016 using chain-of-custody and World Anti-Doping Association-approved analytical procedures. Analytical findings were compared against the label information. Exposures: Products marketed and sold as selective androgen receptor modulators. Main Outcomes and Measures: Chemical identities and the amount of ingredients in each product marketed and sold as selective androgen receptor modulators. Results: Among 44 products marketed and sold as selective androgen receptor modulators, only 23 (52%) contained 1 or more selective androgen receptor modulators (Ostarine, LGD-4033, or Andarine). An additional 17 products (39%) contained another unapproved drug, including the growth hormone secretagogue ibutamoren, the peroxisome proliferator-activated receptor-δ agonist GW501516, and the Rev-ErbA agonist SR9009. Of the 44 tested products, no active compound was detected in 4 (9%) and substances not listed on the label were contained in 11 (25%). In only 18 of the 44 products (41%), the amount of active compound in the product matched that listed on the label. The amount of the compounds listed on the label differed substantially from that found by analysis in 26 of 44 products (59%). Conclusions and Relevance: In this limited investigation involving chemical analyses of 44 products marketed as selective androgen receptor modulators and sold via the internet, most products contained unapproved drugs and substances. Only 52% contained selective androgen receptor modulators and many were inaccurately labeled.
[Mh] Termos MeSH primário: Anabolizantes/química
Comércio
Rotulagem de Medicamentos
Internet
Substâncias para Melhoria do Desempenho/química
Receptores Androgênicos
[Mh] Termos MeSH secundário: Acetamidas/análise
Aminofenóis/análise
Anilidas/análise
Aprovação de Drogas
Tráfico de Drogas
Nitrilos/análise
Pirrolidinas/análise
Estados Unidos
United States Food and Drug Administration
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (4-(2-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile); 0 (Acetamides); 0 (Aminophenols); 0 (Anabolic Agents); 0 (Anilides); 0 (Nitriles); 0 (Performance-Enhancing Substances); 0 (Pyrrolidines); 0 (Receptors, Androgen); 7UT2HAH49H (andarine); O3571H3R8N (ostarine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.17069


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[PMID]:27770695
[Au] Autor:Carrieri P; Vilotitch A; Nordmann S; Lions C; Michel L; Mora M; Morel A; Maradan G; Spire B; Roux P; Methaville Study Group
[Ad] Endereço:INSERM U912 (SESSTIM), Marseille, France; Université Aix Marseille, IRD, UMR-S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.
[Ti] Título:Decrease in self-reported offences and incarceration rates during methadone treatment: A comparison between patients switching from buprenorphine to methadone and maintenance treatment incident users (ANRS-Methaville trial).
[So] Source:Int J Drug Policy;39:86-91, 2017 01.
[Is] ISSN:1873-4758
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients receiving buprenorphine who are poor responders can continue to commit drug-related offences. Switching them from buprenorphine to methadone may result in reduced criminal behaviour. We compared self-reported offences and incarceration before and after starting methadone treatment of patients switching from buprenorphine (PSB) and maintenance treatment incident users (MIU). METHODS: Data on offences, incarceration and other information, were obtained via a telephone interview. Mixed models were used to assess the impact of methadone initiation and being PSB or MIU on (1) the number of days when offences were committed (drug sale, drug purchase, other offences) and (2) experiencing incarceration during the previous 6 months. RESULTS: Among the 176 patients with at least one assessment for self-reported offences, 51.7% were PSB. Receiving methadone was significantly associated with a reduction in the number of days when drug sale or drug purchase offences were committed, but not other offences. PSB and MIU groups were different only for drug purchase, as PSB were more likely to have a higher number of days of drug purchase from month 3 onwards. A reduction of 77% in the likelihood of experiencing incarceration was observed and this was comparable in PSB and MIU. CONCLUSION: Switching non-responding buprenorphine patients to methadone can result in a major reduction in offences and incarceration rates. Increasing access to methadone, using more flexible models of care is urgent for clinical and public health reasons.
[Mh] Termos MeSH primário: Buprenorfina/efeitos adversos
Crime/estatística & dados numéricos
Metadona/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Tráfico de Drogas/estatística & dados numéricos
Feminino
França
Seres Humanos
Masculino
Tratamento de Substituição de Opiáceos/estatística & dados numéricos
Ensaios Clínicos Controlados Aleatórios como Assunto/estatística & dados numéricos
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
40D3SCR4GZ (Buprenorphine); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:28414530
[Au] Autor:Syvertsen JL; Bazzi AR; Mittal ML
[Ad] Endereço:a Department of Anthropology , The Ohio State University , Columbus , Ohio , USA.
[Ti] Título:Hope Amidst Horror: Documenting the Effects of the "War On Drugs" Among Female Sex Workers and Their Intimate Partners in Tijuana, Mexico.
[So] Source:Med Anthropol;36(6):566-583, 2017 Aug-Sep.
[Is] ISSN:1545-5882
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sensationalistic media coverage has fueled stereotypes of the Mexican border city of Tijuana as a violent battleground of the global drug war. While the drug war shapes health and social harms in profoundly public ways, less visible are the experiences and practices of hope that forge communities of care and represent more private responses to this crisis. In this article, we draw on ethnographic fieldwork and photo elicitation with female sex workers who inject drugs and their intimate, non-commercial partners in Tijuana to examine the personal effects of the drug war. Drawing on a critical phenomenology framework, which links political economy with phenomenological concern for subjective experience, we explore the ways in which couples try to find hope amidst the horrors of the drug war. Critical visual scholarship may provide a powerful alternative to dominant media depictions of violence, and ultimately clarify why this drug war must end.
[Mh] Termos MeSH primário: Crime/etnologia
Tráfico de Drogas/etnologia
Profissionais do Sexo/psicologia
Parceiros Sexuais/psicologia
Abuso de Substâncias por Via Intravenosa/etnologia
[Mh] Termos MeSH secundário: Adulto
Antropologia Médica
Criança
Feminino
Pessoas em Situação de Rua
Seres Humanos
Masculino
México/etnologia
Fotografia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1080/01459740.2017.1317770


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[PMID]:28265799
[Au] Autor:Aissa J; Boos J; Rubbert C; Caspers J; Schleich C; Thomas C; Kröpil P; Antoch G; Miese F
[Ad] Endereço:Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, Moorenstr 5, D-40225, Dusseldorf, Germany. Joel.Aissa@med.uni-duesseldorf.de.
[Ti] Título:Optimizing radiation exposure in screening of body packing: image quality and diagnostic acceptability of an 80 kVp protocol with automated tube current modulation.
[So] Source:Forensic Sci Med Pathol;13(2):145-150, 2017 Jun.
[Is] ISSN:1556-2891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the objective and subjective image quality of a novel computed tomography (CT) protocol with reduced radiation dose for body packing with 80 kVp and automated tube current modulation (ATCM) compared to a standard body packing CT protocol. 80 individuals who were examined between March 2012 and July 2015 in suspicion of ingested drug packets were retrospectively included in this study. Thirty-one CT examinations were performed using ATCM and a fixed tube voltage of 80 kVp (group A). Forty-nine CT examinations were performed using a standard protocol with a tube voltage of 120 kVp and a fixed tube current time product of 40 mAs (group B). Subjective and objective image quality and visibility of drug packets were assessed. Radiation exposure of both protocols was compared. Contrast-to-noise ratio (group A: 0.56 ± 0.36; group B: 1.13 ± 0.91) and Signal-to-noise ratio (group A: 3.69 ± 0.98; group B: 7.08 ± 2.67) were significantly lower for group A compared to group B (p < 0.001). Subjectively, image quality was decreased for group A compared to group B (2.5 ± 0.8 vs. 1.2 ± 0.4; p < 0.001). Attenuation of body packets was higher with the new protocol (group A: 362.2 ± 70.3 Hounsfield Units (HU); group B: 210.6 ± 60.2 HU; p = 0.005). Volumetric Computed Tomography Dose Index (CTDIvol) and Dose Length Product (DLP) were significantly lower in group A (CTDIvol 2.2 ± 0.9 mGy, DLP 105.7 ± 52.3 mGycm) as compared to group B (CTDIvol 2.7 ± 0.1 mGy, DLP 126.0 ± 9.7 mGycm, p = 0.002 and p = 0.01). The novel 80 kVp CT protocol with ATCM leads to a significant dose reduction compared to a standard CT body packing protocol. The novel protocol led to a diagnostic image quality and cocaine body packets were reliably detected due to the high attenuation.
[Mh] Termos MeSH primário: Tráfico de Drogas
Dose de Radiação
Radiografia Abdominal
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1007/s12024-017-9848-7


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[PMID]:28259089
[Au] Autor:Van Buskirk J; Bruno R; Dobbins T; Breen C; Burns L; Naicker S; Roxburgh A
[Ad] Endereço:National Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, New South Wales, 2052, Australia. Electronic address: j.vanbuskirk@unsw.edu.au.
[Ti] Título:The recovery of online drug markets following law enforcement and other disruptions.
[So] Source:Drug Alcohol Depend;173:159-162, 2017 Apr 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Online drug markets operating on the 'darknet' ('cryptomarkets') facilitate the trade of illicit substances at an international level. The present study assessed the longitudinal impact on cryptomarket trading of two major disruptions: a large international law enforcement operation, 'Operation Onymous'; and the closure of the largest cryptomarket, Evolution. METHODS: Almost 1150 weekly snapshots of a total of 39 cryptomarkets were collected between October 2013 and November 2015. Data were collapsed by month and the number of unique vendor aliases operating across markets was assessed using interrupted time series regression. RESULTS: Following both Operation Onymous and the closure of Evolution, significant drops of 627 (p=0.014) and 910 vendors (p<0.001) were observed, respectively. However, neither disruption significantly affected the rate at which vendor numbers increased overall. CONCLUSIONS: Operation Onymous and the closure of Evolution were associated with considerable, though temporary, reductions in the number of vendors operating across cryptomarkets. Vendor numbers, however, recovered at a constant rate. While these disruptions likely impacted cryptomarket trading at the time, these markets appear resilient to disruption long-term.
[Mh] Termos MeSH primário: Comércio/legislação & jurisprudência
Publicidade Direta ao Consumidor/legislação & jurisprudência
Tráfico de Drogas/legislação & jurisprudência
Controle de Medicamentos e Entorpecentes/legislação & jurisprudência
Internet/legislação & jurisprudência
Aplicação da Lei
Disponibilidade de Medicamentos Via Internet/legislação & jurisprudência
[Mh] Termos MeSH secundário: Comércio/tendências
Publicidade Direta ao Consumidor/tendências
Tráfico de Drogas/tendências
Controle de Medicamentos e Entorpecentes/tendências
Seres Humanos
Internacionalidade/legislação & jurisprudência
Internet/tendências
Disponibilidade de Medicamentos Via Internet/tendências
Análise de Regressão
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


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[PMID]:28107530
[Au] Autor:Dufresnes C; Jan C; Bienert F; Goudet J; Fumagalli L
[Ad] Endereço:Laboratory for Conservation Biology, Department of Ecology and Evolution, Biophore Building, University of Lausanne, Lausanne, Switzerland.
[Ti] Título:Broad-Scale Genetic Diversity of Cannabis for Forensic Applications.
[So] Source:PLoS One;12(1):e0170522, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cannabis (hemp and marijuana) is an iconic yet controversial crop. On the one hand, it represents a growing market for pharmaceutical and agricultural sectors. On the other hand, plants synthesizing the psychoactive THC produce the most widespread illicit drug in the world. Yet, the difficulty to reliably distinguish between Cannabis varieties based on morphological or biochemical criteria impedes the development of promising industrial programs and hinders the fight against narcotrafficking. Genetics offers an appropriate alternative to characterize drug vs. non-drug Cannabis. However, forensic applications require rapid and affordable genotyping of informative and reliable molecular markers for which a broad-scale reference database, representing both intra- and inter-variety variation, is available. Here we provide such a resource for Cannabis, by genotyping 13 microsatellite loci (STRs) in 1 324 samples selected specifically for fibre (24 hemp varieties) and drug (15 marijuana varieties) production. We showed that these loci are sufficient to capture most of the genome-wide diversity patterns recently revealed by NGS data. We recovered strong genetic structure between marijuana and hemp and demonstrated that anonymous samples can be confidently assigned to either plant types. Fibres appear genetically homogeneous whereas drugs show low (often clonal) diversity within varieties, but very high genetic differentiation between them, likely resulting from breeding practices. Based on an additional test dataset including samples from 41 local police seizures, we showed that the genetic signature of marijuana cultivars could be used to trace crime scene evidence. To date, our study provides the most comprehensive genetic resource for Cannabis forensics worldwide.
[Mh] Termos MeSH primário: Cannabis/genética
Tráfico de Drogas
[Mh] Termos MeSH secundário: Marcadores Genéticos/genética
Variação Genética/genética
Genótipo
Repetições de Microssatélites/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170522


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[PMID]:28084644
[Au] Autor:Huestis MA; Tyndale RF
[Ad] Endereço:Chemistry and Drug Metabolism, IRP, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
[Ti] Título:Designer Drugs 2.0.
[So] Source:Clin Pharmacol Ther;101(2):152-157, 2017 Feb.
[Is] ISSN:1532-6535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This "Designer Drugs 2.0" issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily cannabinoids and cathinones, and the repurposing of established psychoactive compounds (e.g., modafinil, psilocybin, lysergic acid diethylamide, and 3,4-methylenedioxymethamphetamine) that simultaneously offer new pharmacotherapies and pose serious health problems. Novel psychoactive substances were initially used as potent tools to investigate endogenous neurotransmitter systems; for example, synthetic cannabinoids have much higher potency than Δ9-tetrahydrocannabinol at the cannabinoid receptors. However, they are now being used illicitly as well as being tested for their efficacy in numerous clinical indications. Likewise, previously established psychoactive drugs are being repurposed as treatments for a wide variety of indications where currently approved medications are ineffective. This set of papers examines the arising problems associated with designer drugs (e.g., adverse events, psychosis, rapid new synthesis, abuse liability testing, internet sales, scheduling) as well as the potential therapeutic promises in areas as diverse as cognition enhancement, exercise-mimetics, epilepsy, multiple sclerosis, and posttraumatic stress disorder.
[Mh] Termos MeSH primário: Canabinoides/efeitos adversos
Drogas Desenhadas/efeitos adversos
Psicotrópicos/efeitos adversos
[Mh] Termos MeSH secundário: Canabinoides/farmacologia
Canabinoides/uso terapêutico
Drogas Desenhadas/farmacologia
Drogas Desenhadas/uso terapêutico
Dronabinol/efeitos adversos
Dronabinol/metabolismo
Tráfico de Drogas
Seres Humanos
Abuso de Maconha/epidemiologia
Psicotrópicos/farmacologia
Psicotrópicos/uso terapêutico
Receptores de Canabinoides/metabolismo
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cannabinoids); 0 (Designer Drugs); 0 (Psychotropic Drugs); 0 (Receptors, Cannabinoid); 7J8897W37S (Dronabinol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1002/cpt.575


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[PMID]:28154682
[Au] Autor:Ngatchou W; Lemogoum D; Essola B; Ramadan A; Ngassa M; Guimfacq V; Mols P; Towo PY
[Ad] Endereço:Department of Cardiac Surgery, St Pierre Hospital, Brussels, Belgium; Department of Emergency Medicine, St Pierre Hospital, Brussels, Belgium.
[Ti] Título:Cannabis body packing: a case report.
[So] Source:Pan Afr Med J;24:327, 2016.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Drug traffic is a major concern worldwide. We report a case of a 27-year old male who presented with a diffuse abdominal plain to the emergency department. Abdominal X-ray demonstrated multiple foreign bodies along the intestinal tract, which were found to be cannabis packets. The patient was treated conservatively with a good result.
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Cannabis
Corpos Estranhos/diagnóstico por imagem
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico por imagem
Adulto
Tráfico de Drogas
Seres Humanos
Intestinos/diagnóstico por imagem
Masculino
Drogas Ilícitas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2016.24.327.9450


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[PMID]:27980168
[Au] Autor:Wade L
[Ti] Título:After the vanishing.
[So] Source:Science;354(6318):1369-1371, 2016 Dec 16.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vítimas de Crime
Tráfico de Drogas
Antropologia Forense/recursos humanos
[Mh] Termos MeSH secundário: Identificação Biométrica
Restos Mortais
Sepultamento
Família
Antropologia Forense/métodos
Antropologia Forense/tendências
Seres Humanos
México
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27895061
[Au] Autor:Cousins S
[Ad] Endereço:Liverpool.
[Ti] Título:Five thousand dead and counting: the Philippines' bloody war on drugs.
[So] Source:BMJ;355:i6177, 2016 Nov 28.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Tráfico de Drogas/legislação & jurisprudência
Tráfico de Drogas/prevenção & controle
Aplicação da Lei
Transtornos Relacionados ao Uso de Substâncias/prevenção & controle
[Mh] Termos MeSH secundário: Seres Humanos
Filipinas/epidemiologia
Centros de Tratamento de Abuso de Substâncias
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/reabilitação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.i6177



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