Base de dados : MEDLINE
Pesquisa : I01.320.500 [Categoria DeCS]
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  1 / 13 MEDLINE  
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[PMID]:28704433
[Au] Autor:Romero-Alvarez D; Escobar LE; Varela S; Larkin DJ; Phelps NBD
[Ad] Endereço:Hospital General Enrique Garcés, Unidad de Epidemiología, Quito, Ecuador.
[Ti] Título:Forecasting distributions of an aquatic invasive species (Nitellopsis obtusa) under future climate scenarios.
[So] Source:PLoS One;12(7):e0180930, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Starry stonewort (Nitellopsis obtusa) is an alga that has emerged as an aquatic invasive species of concern in the United States. Where established, starry stonewort can interfere with recreational uses of water bodies and potentially have ecological impacts. Incipient invasion of starry stonewort in Minnesota provides an opportunity to predict future expansion in order to target early detection and strategic management. We used ecological niche models to identify suitable areas for starry stonewort in Minnesota based on global occurrence records and present-day and future climate conditions. We assessed sensitivity of forecasts to different parameters, using four emission scenarios (i.e., RCP 2.6, RCP 4.5, RCP 6, and RCP 8.5) from five future climate models (i.e., CCSM, GISS, IPSL, MIROC, and MRI). From our niche model analyses, we found that (i) occurrences from the entire range, instead of occurrences restricted to the invaded range, provide more informed models; (ii) default settings in Maxent did not provide the best model; (iii) the model calibration area and its background samples impact model performance; (iv) model projections to future climate conditions should be restricted to analogous environments; and (v) forecasts in future climate conditions should include different future climate models and model calibration areas to better capture uncertainty in forecasts. Under present climate, the most suitable areas for starry stonewort are predicted to be found in central and southeastern Minnesota. In the future, suitable areas for starry stonewort are predicted to shift in geographic range under some future climate models and to shrink under others, with most permutations indicating a net decrease of the species' suitable range. Our suitability maps can serve to design short-term plans for surveillance and education, while future climate models suggest a plausible reduction of starry stonewort spread in the long-term if the trends in climate warming remain.
[Mh] Termos MeSH primário: Caráceas/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Mudança Climática
Ecossistema
Espécies Introduzidas
Minnesota
Modelos Biológicos
Previsões Demográficas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180930


  2 / 13 MEDLINE  
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[PMID]:27854420
[Au] Autor:Weir HK; Anderson RN; Coleman King SM; Soman A; Thompson TD; Hong Y; Moller B; Leadbetter S
[Ad] Endereço:Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F76, Atlanta, GA 30341. E-mail: hbw4@cdc.gov.
[Ti] Título:Heart Disease and Cancer Deaths - Trends and Projections in the United States, 1969-2020.
[So] Source:Prev Chronic Dis;13:E157, 2016 11 17.
[Is] ISSN:1545-1151
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Heart disease and cancer are the first and second leading causes of death in the United States. Age-standardized death rates (risk) have declined since the 1960s for heart disease and for cancer since the 1990s, whereas the overall number of heart disease deaths declined and cancer deaths increased. We analyzed mortality data to evaluate and project the effect of risk reduction, population growth, and aging on the number of heart disease and cancer deaths to the year 2020. METHODS: We used mortality data, population estimates, and population projections to estimate and predict heart disease and cancer deaths from 1969 through 2020 and to apportion changes in deaths resulting from population risk, growth, and aging. RESULTS: We predicted that from 1969 through 2020, the number of heart disease deaths would decrease 21.3% among men (-73.9% risk, 17.9% growth, 34.7% aging) and 13.4% among women (-73.3% risk, 17.1% growth, 42.8% aging) while the number of cancer deaths would increase 91.1% among men (-33.5% risk, 45.6% growth, 79.0% aging) and 101.1% among women (-23.8% risk, 48.8% growth, 76.0% aging). We predicted that cancer would become the leading cause of death around 2016, although sex-specific crossover years varied. CONCLUSION: Risk of death declined more steeply for heart disease than cancer, offset the increase in heart disease deaths, and partially offset the increase in cancer deaths resulting from demographic changes over the past 4 decades. If current trends continue, cancer will become the leading cause of death by 2020.
[Mh] Termos MeSH primário: Cardiopatias/mortalidade
Expectativa de Vida/tendências
Neoplasias/mortalidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Causas de Morte
Feminino
Previsões
Seres Humanos
Masculino
Meia-Idade
Previsões Demográficas
Análise de Regressão
Distribuição por Sexo
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.5888/pcd13.160211


  3 / 13 MEDLINE  
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Texto completo SciELO Saúde Pública
[PMID]:27598014
[Au] Autor:Bortoletto DV; Utsunomiya YT; Perri SH; Ferreira F; Nunes CM
[Ad] Endereço:Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, Brasil.
[Ti] Título:Age structure of owned dogs under compulsory culling in a visceral leishmaniasis endemic area.
[So] Source:Cad Saude Publica;32(8):e00026115, 2016 Sep 05.
[Is] ISSN:1678-4464
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The age structure of the dog population is essential for planning and evaluating control programs for zoonotic diseases. We analyzed data of an owned-dog census in order to characterize, for the first time, the structure of a dog population under compulsory culling in a visceral leishmaniasis endemic area (Panorama, São Paulo State, Brazil) that recorded a dog-culling rate of 28% in the year of the study. Data on 1,329 households and 1,671 owned dogs revealed an owned dog:human ratio of 1:7. The mean age of dogs was estimated at 1.73 years; the age pyramid indicated high birth and mortality rates at the first year of age with an estimated cumulative mortality of 78% at the third year of age and expected life span of 2.75 years. In spite of the high mortality, a growth projection simulation suggested that the population has potential to grow in a logarithmic scale over the years. The estimated parameters can be further applied in models to maximize the impact and minimize financial inputs of visceral leishmaniasis control measures.
[Mh] Termos MeSH primário: Distribuição por Idade
Abate de Animais
Censos
Doenças do Cão/epidemiologia
Leishmaniose Visceral/veterinária
[Mh] Termos MeSH secundário: Abate de Animais/estatística & dados numéricos
Animais
Brasil/epidemiologia
Doenças do Cão/mortalidade
Cães
Leishmaniose Visceral/epidemiologia
Leishmaniose Visceral/mortalidade
Propriedade/estatística & dados numéricos
Previsões Demográficas/métodos
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


  4 / 13 MEDLINE  
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[PMID]:27272215
[Au] Autor:Porch CE; Lauretta MV
[Ad] Endereço:Southeast Fisheries Science Center, National Marine Fisheries Service, Miami, Florida, United States of America.
[Ti] Título:On Making Statistical Inferences Regarding the Relationship between Spawners and Recruits and the Irresolute Case of Western Atlantic Bluefin Tuna (Thunnus thynnus).
[So] Source:PLoS One;11(6):e0156767, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Forecasts of the future abundance of western Atlantic bluefin tuna (Thunnus thynnus) have, for nearly two decades, been based on two competing views of future recruitment potential: (1) a "low" recruitment scenario based on hockey-stick (two-line) curve where the expected level of recruitment is set equal to the geometric mean of the recruitment estimates for the years after a supposed regime-shift in 1975, and (2) a "high" recruitment scenario based on a Beverton-Holt curve fit to the time series of spawner-recruit pairs beginning in 1970. Several investigators inferred the relative plausibility of these two scenarios based on measures of their ability to fit estimates of spawning biomass and recruitment derived from stock assessment outputs. Typically, these comparisons have assumed the assessment estimates of spawning biomass are known without error. It is shown here that ignoring error in the spawning biomass estimates can predispose model-choice approaches to favor the regime-shift hypothesis over the Beverton-Holt curve with higher recruitment potential. When the variance of the observation error approaches that which is typically estimated for assessment outputs, the same model-choice approaches tend to favor the single Beverton-Holt curve. For this and other reasons, it is argued that standard model-choice approaches are insufficient to make the case for a regime shift in the recruitment dynamics of western Atlantic bluefin tuna. A more fruitful course of action may be to move away from the current high/low recruitment dichotomy and focus instead on adopting biological reference points and management procedures that are robust to these and other sources of uncertainty.
[Mh] Termos MeSH primário: Reprodução
Atum/fisiologia
[Mh] Termos MeSH secundário: Animais
Pesqueiros
Modelos Teóricos
Dinâmica Populacional
Previsões Demográficas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0156767


  5 / 13 MEDLINE  
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[PMID]:27257850
[Au] Autor:Schilling C; Dalziel K; Nunn R; Du Plessis K; Shi WY; Celermajer D; Winlaw D; Weintraub RG; Grigg LE; Radford DJ; Bullock A; Gentles TL; Wheaton GR; Hornung T; Justo RN; d'Udekem Y
[Ad] Endereço:Centre for Health Policy, The University of Melbourne, 207 Bouverie St Carlton, Victoria 3051, Australia.
[Ti] Título:The Fontan epidemic: Population projections from the Australia and New Zealand Fontan Registry.
[So] Source:Int J Cardiol;219:14-9, 2016 Sep 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The number and age demographic of the future Fontan population is unknown. METHODS: Population projections were calculated probabilistically using microsimulation. Mortality hazard rates for each Fontan recipient were calculated from survivorship of 1353 Fontan recipients in the Australia and New Zealand Fontan Registry, based on Fontan type, age at Fontan, gender and morphology. Projected rates of new Fontan procedures were generated from historical rates of Fontan procedures per population births. RESULTS: At the end of 2014, the living Fontan population of Australia and New Zealand was 1265 people from an Australian and New Zealand regional population of 28 million (4.5 per 100,000 population). Of those, 165 (13%) received an atrio-pulmonary (AP) procedure, 262 (21%) a lateral tunnel (LT) procedure and 838 (66%) an extra-cardiac conduit (ECC) procedure. This population is expected to grow to 1917 (95% CI: 1846: 1986) by 2025 (5.8 per 100,000 population), with 149 (8%) AP procedures, 254 (13%) LT procedures, and 1514 (79%) ECC procedures. By 2045, the living Fontan population is expected to reach 2986 (95% CI: 2877: 3085; 7.2 per 100,000 population). The average age of the Fontan population is expected to increase from 18years in 2014 to 23years (95% CI: 22-23) by 2025, and 31years (95% CI: 30-31) by 2045. CONCLUSION: The Australian and New Zealand population of patients alive after a Fontan procedure will double over the next 20years increasing the demand for heart-failure services and cardiac transplantation. Greater consideration for the needs of this mostly adult Fontan population will be necessary.
[Mh] Termos MeSH primário: Técnica de Fontan/mortalidade
Técnica de Fontan/tendências
Previsões Demográficas/métodos
Sistema de Registros
[Mh] Termos MeSH secundário: Adolescente
Adulto
Austrália/epidemiologia
Criança
Feminino
Seres Humanos
Masculino
Nova Zelândia/epidemiologia
Taxa de Sobrevida/tendências
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE


  6 / 13 MEDLINE  
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[PMID]:27174974
[Au] Autor:Dunn EC
[Ad] Endereço:Department of Geography, Indiana University, Bloomington, IN, USA. elcdunn@indiana.edu.
[Ti] Título:ESSAY. Refugee protection and resettlement problems.
[So] Source:Science;352(6287):772-3, 2016 May 13.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Emigração e Imigração
Refugiados
[Mh] Termos MeSH secundário: Assistência à Saúde
União Europeia
Abastecimento de Alimentos
República da Geórgia
Seres Humanos
Jordânia
Líbano
Previsões Demográficas
Turquia
Incerteza
Abastecimento de Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160513
[Lr] Data última revisão:
160513
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.1126/science.aaf8962


  7 / 13 MEDLINE  
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[PMID]:26771471
[Au] Autor:Søreide K; Wijnhoven BP
[Ad] Endereço:Department of Gastrointestinal Surgery, PO Box 8100, Stavanger University Hospital, N-4068 Stavanger, Norway. ksoreide@mac.com.
[Ti] Título:Surgery for an ageing population.
[So] Source:Br J Surg;103(2):e7-9, 2016 Jan.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Serviços de Saúde para Idosos/organização & administração
Procedimentos Cirúrgicos Operatórios/métodos
[Mh] Termos MeSH secundário: Idoso
Saúde Global
Serviços de Saúde para Idosos/tendências
Seres Humanos
Relações Interprofissionais
Equipe de Assistência ao Paciente
Previsões Demográficas
Procedimentos Cirúrgicos Operatórios/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160116
[Lr] Data última revisão:
160116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160116
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10071


  8 / 13 MEDLINE  
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[PMID]:26712770
[Au] Autor:Peltzer K; Pengpid S
[Ad] Endereço:ASEAN Institute for Health Development, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom 73170, Thailand. karl.pel@mahidol.ac.th.
[Ti] Título:Health Risk Behaviour among In-School Adolescents in the Philippines: Trends between 2003, 2007 and 2011, A Cross-Sectional Study.
[So] Source:Int J Environ Res Public Health;13(1):73, 2015 Dec 24.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Intermittent monitoring of health risk behaviours at the population level is important for the planning and evaluation of national health promotion intervention programmes. The study aimed to provide trend estimates on the prevalence of various health risk behaviours assessed in the Global School-based Health Survey in 2003, 2007 and 2011 in the Philippines. Three waves of cross-sectional data included 18,285 school-going adolescents, 47.4% male and 52.6% female, aged between 11 years or younger and 16 years or older, with a mean age of about 14.7 years (SD = 1.2), and mainly in second to fourth year study Grade. Significant improvements in health risk and risk behaviours (overweight or obese and smokeless tobacco use among boys, being in a physical fight, troubles from alcohol drinking, mental health, oral and hand hygiene among both boys and girls) but also increases in health risk behaviour (bullying victimization, injury and loneliness) among both boys and girls were found in this large study over a period of eight years in the Philippines. High prevalences of health risk behaviours and increases in some of them should call for intensified school health promotion programmes to reduce such risk behaviours.
[Mh] Termos MeSH primário: Comportamento do Adolescente/psicologia
Atitude Frente à Saúde
Comportamentos Relacionados com a Saúde
Inquéritos Epidemiológicos/tendências
Assunção de Riscos
Estudantes/psicologia
Estudantes/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Criança
Estudos Transversais
Feminino
Seres Humanos
Masculino
Filipinas
Previsões Demográficas
Serviços de Saúde Escolar/tendências
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151230
[St] Status:MEDLINE


  9 / 13 MEDLINE  
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[PMID]:26421722
[Au] Autor:Gutfraind A; Boodram B; Prachand N; Hailegiorgis A; Dahari H; Major ME
[Ad] Endereço:Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America; The Program for Experimental & Theoretical Modeling, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of
[Ti] Título:Agent-Based Model Forecasts Aging of the Population of People Who Inject Drugs in Metropolitan Chicago and Changing Prevalence of Hepatitis C Infections.
[So] Source:PLoS One;10(9):e0137993, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:People who inject drugs (PWID) are at high risk for blood-borne pathogens transmitted during the sharing of contaminated injection equipment, particularly hepatitis C virus (HCV). HCV prevalence is influenced by a complex interplay of drug-use behaviors, social networks, and geography, as well as the availability of interventions, such as needle exchange programs. To adequately address this complexity in HCV epidemic forecasting, we have developed a computational model, the Agent-based Pathogen Kinetics model (APK). APK simulates the PWID population in metropolitan Chicago, including the social interactions that result in HCV infection. We used multiple empirical data sources on Chicago PWID to build a spatial distribution of an in silico PWID population and modeled networks among the PWID by considering the geography of the city and its suburbs. APK was validated against 2012 empirical data (the latest available) and shown to agree with network and epidemiological surveys to within 1%. For the period 2010-2020, APK forecasts a decline in HCV prevalence of 0.8% per year from 44(± 2)% to 36(± 5)%, although some sub-populations would continue to have relatively high prevalence, including Non-Hispanic Blacks, 48(± 5)%. The rate of decline will be lowest in Non-Hispanic Whites and we find, in a reversal of historical trends, that incidence among non-Hispanic Whites would exceed incidence among Non-Hispanic Blacks (0.66 per 100 per years vs 0.17 per 100 person years). APK also forecasts an increase in PWID mean age from 35(± 1) to 40(± 2) with a corresponding increase from 59(± 2)% to 80(± 6)% in the proportion of the population >30 years old. Our studies highlight the importance of analyzing subpopulations in disease predictions, the utility of computer simulation for analyzing demographic and health trends among PWID and serve as a tool for guiding intervention and prevention strategies in Chicago, and other major cities.
[Mh] Termos MeSH primário: Simulação por Computador
Hepatite C/epidemiologia
Dinâmica Populacional/tendências
Abuso de Substâncias por Via Intravenosa/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Patógenos Transmitidos pelo Sangue
Chicago/epidemiologia
Conjuntos de Dados como Assunto
Feminino
Seres Humanos
Masculino
Programas de Troca de Agulhas/estatística & dados numéricos
Previsões Demográficas
Vigilância da População
Prevalência
Abuso de Substâncias por Via Intravenosa/complicações
Abuso de Substâncias por Via Intravenosa/virologia
Transtornos Relacionados ao Uso de Substâncias/complicações
Transtornos Relacionados ao Uso de Substâncias/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151001
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0137993


  10 / 13 MEDLINE  
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[PMID]:26296933
[Au] Autor:Castillo-Quan JI; Kinghorn KJ; Bjedov I
[Ad] Endereço:Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK.
[Ti] Título:Genetics and pharmacology of longevity: the road to therapeutics for healthy aging.
[So] Source:Adv Genet;90:1-101, 2015.
[Is] ISSN:0065-2660
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aging can be defined as the progressive decline in tissue and organismal function and the ability to respond to stress that occurs in association with homeostatic failure and the accumulation of molecular damage. Aging is the biggest risk factor for human disease and results in a wide range of aging pathologies. Although we do not completely understand the underlying molecular basis that drives the aging process, we have gained exceptional insights into the plasticity of life span and healthspan from the use of model organisms such as the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Single-gene mutations in key cellular pathways that regulate environmental sensing, and the response to stress, have been identified that prolong life span across evolution from yeast to mammals. These genetic manipulations also correlate with a delay in the onset of tissue and organismal dysfunction. While the molecular genetics of aging will remain a prosperous and attractive area of research in biogerontology, we are moving towards an era defined by the search for therapeutic drugs that promote healthy aging. Translational biogerontology will require incorporation of both therapeutic and pharmacological concepts. The use of model organisms will remain central to the quest for drug discovery, but as we uncover molecular processes regulated by repurposed drugs and polypharmacy, studies of pharmacodynamics and pharmacokinetics, drug-drug interactions, drug toxicity, and therapeutic index will slowly become more prevalent in aging research. As we move from genetics to pharmacology and therapeutics, studies will not only require demonstration of life span extension and an underlying molecular mechanism, but also the translational relevance for human health and disease prevention.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Longevidade/efeitos dos fármacos
[Mh] Termos MeSH secundário: Envelhecimento/genética
Animais
Antioxidantes/administração & dosagem
Seres Humanos
Modelos Animais
Previsões Demográficas
Qualidade de Vida
Nações Unidas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150822
[Lr] Data última revisão:
150822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150823
[St] Status:MEDLINE



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