Base de dados : MEDLINE
Pesquisa : I01.409.418.750.600.650.496 [Categoria DeCS]
Referências encontradas : 16190 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1619 ir para página                         

  1 / 16190 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29406656
[Au] Autor:Gentille J
[Ti] Título:How Heroes Saved My Life.
[So] Source:Pediatr Nurs;42(6):310-1, 2016 Nov-Dec.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por HIV/etiologia
Infecções por HIV/psicologia
Cardiopatias Congênitas/complicações
Cardiopatias Congênitas/enfermagem
Relações Enfermeiro-Paciente
Enfermeiras Pediátricas/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Infecções por HIV/enfermagem
Seres Humanos
Lactente
National Institutes of Health (U.S.)
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; PERSONAL NARRATIVES
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  2 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460639
[Au] Autor:Furuya H; Brenner D; Rosser CJ
[Ad] Endereço:Clinical and Translational Research Program, University of Hawaii Cancer Center, 701 Ilalo St, Rm 327, Honolulu, HI, 96813, USA.
[Ti] Título:On the brink of extinction: the future of translational physician-scientists in the United States.
[So] Source:J Transl Med;15(1):88, 2017 May 01.
[Is] ISSN:1479-5876
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over the past decade, we have seen an unparalleled growth in our knowledge of cancer biology and the translation of this biology into a new generation of therapeutic tools that are changing cancer treatment outcomes. With the continued explosion of new biologic discoveries, we find ourselves with a limited number of trained and engaged translational physician-scientists capable of bridging the chasm between basic science and clinical science. Here, we discuss the current state translational physician-scientists find themselves in and offer solutions to navigate during this difficult time.
[Mh] Termos MeSH primário: Médicos
Pesquisadores
Pesquisa Médica Translacional
[Mh] Termos MeSH secundário: Seres Humanos
National Institutes of Health (U.S.)
Apoio à Pesquisa como Assunto
Estados Unidos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s12967-017-1188-6


  3 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29300998
[Au] Autor:Reusch JEB; Kumar TR; Regensteiner JG; Zeitler PS; Conference Participants
[Ad] Endereço:Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
[Ti] Título:Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span.
[So] Source:Endocrinology;159(1):9-19, 2018 01 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The National Institutes of Health (NIH) Office of Research in Women's Health now functions under a mandate calling for the systematic inclusion of both female and male cells, animals, and human subjects in all types of research, so that sex as a biological variable is understood in health and disease. Sex-specific data can improve disease prevention, diagnosis, and treatment as well as reduce inequities. Inclusion of women in research studies has modestly improved over the last 20 years, yet preclinical research is still primarily done using male animal models and male-derived cells, with the result that many conclusions are made based on incomplete and sex-biased data. There are important, yet poorly studied, sex differences in cardiometabolic disease. To begin to address these sex differences, the Center for Women's Health Research at the University of Colorado held its inaugural National Conference, "Sex Differences Across the Lifespan: A Focus on Metabolism," in September 2016 (cwhr@ucdenver.edu). Research to address the important goal of understanding key sex differences in cardiometabolic disease across the life span is lacking. The goal of this article is to discuss the current state of research addressing sex differences in cardiometabolic health across the life span, to outline critical research gaps that must be addressed in response to NIH mandates, and, importantly, to develop strategies to address sex as a biological variable to understand disease mechanisms as well as develop diagnostic and therapeutic modalities.
[Mh] Termos MeSH primário: Envelhecimento
Pesquisa Biomédica/métodos
Metabolômica/métodos
Determinação de Necessidades de Cuidados de Saúde
Saúde da Mulher
[Mh] Termos MeSH secundário: Animais
Pesquisa Biomédica/tendências
Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/fisiopatologia
Doenças Cardiovasculares/prevenção & controle
Doenças Cardiovasculares/terapia
Congressos como Assunto
Efeitos Psicossociais da Doença
Feminino
Seres Humanos
Masculino
Metabolômica/tendências
National Institutes of Health (U.S.)
Gravidez
Caracteres Sexuais
Fatores Sexuais
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-03019


  4 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28457227
[Au] Autor:Ochocinska MJ; Zlokovic BV; Searson PC; Crowder AT; Kraig RP; Ljubimova JY; Mainprize TG; Banks WA; Warren RQ; Kindzelski A; Timmer W; Liu CH
[Ad] Endereço:National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Dr., Room 9149, Bethesda, MD, 20892-7950, USA. Margaret.Ochocinska@nih.gov.
[Ti] Título:NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.
[So] Source:Fluids Barriers CNS;14(1):12, 2017 May 01.
[Is] ISSN:2045-8118
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood-brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics. The second day of the workshop focused on technical advances in in vitro models, BBB manipulations and nanoparticle-based drug carrier designs, with the goal of improving drug delivery to the central nervous system. The presentations and discussions underscored the role of the BBI in brain injury, as well as the role of the BBB as both a limiting factor and a potential conduit for drug delivery to the brain. At the conclusion of the meeting, the participants discussed challenges and opportunities confronting BBI translational researchers. In particular, the participants recommended using BBI translational research to stimulate advances in diagnostics, as well as targeted delivery approaches for detection and therapy of both brain injury and disease.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/fisiopatologia
Encefalopatias/patologia
National Institutes of Health (U.S.)
Pesquisa Médica Translacional
[Mh] Termos MeSH secundário: Animais
Transporte Biológico
Barreira Hematoencefálica/diagnóstico por imagem
Barreira Hematoencefálica/patologia
Encefalopatias/diagnóstico por imagem
Encefalopatias/fisiopatologia
Seres Humanos
Imagem por Ressonância Magnética
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180203
[Lr] Data última revisão:
180203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1186/s12987-017-0061-6


  5 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29285540
[Au] Autor:Spong CY; Bianchi DW
[Ad] Endereço:Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
[Ti] Título:Improving Public Health Requires Inclusion of Underrepresented Populations in Research.
[So] Source:JAMA;319(4):337-338, 2018 Jan 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto
Grupos Minoritários
Seleção de Pacientes
Saúde Pública
[Mh] Termos MeSH secundário: Idoso
Criança
Pessoas com Deficiência
Feminino
Seres Humanos
Masculino
National Institutes of Health (U.S.)
Medicina de Precisão
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19138


  6 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29204602
[Au] Autor:Sachs RE; Ginsburg PB; Goldman DP
[Ad] Endereço:Washington University in St Louis School of Law, St Louis, Missouri.
[Ti] Título:Encouraging New Uses for Old Drugs.
[So] Source:JAMA;318(24):2421-2422, 2017 Dec 26.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aprovação de Drogas
Reposicionamento de Medicamentos
Medicamentos Genéricos
Financiamento Governamental
[Mh] Termos MeSH secundário: Distinções e Prêmios
Aprovação de Drogas/economia
Reposicionamento de Medicamentos/economia
Medicamentos Genéricos/economia
Política de Saúde
Seres Humanos
National Institutes of Health (U.S.)
Patentes como Assunto
Estados Unidos
United States Food and Drug Administration
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Generic)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.17535


  7 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28929489
[Au] Autor:Inoue-Choi M; Hartge P; Liao LM; Caporaso N; Freedman ND
[Ad] Endereço:Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
[Ti] Título:Association between long-term low-intensity cigarette smoking and incidence of smoking-related cancer in the national institutes of health-AARP cohort.
[So] Source:Int J Cancer;142(2):271-280, 2018 Jan 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An increasing proportion of US smokers smoke ≤10 cigarettes per day (CPD) or do not smoke every day, yet the health effects of low-intensity smoking are poorly understood. We identified lifelong smokers of <1 or 1-10 CPD and evaluated risk of incident cancer among 238,525 cancer-free adults, aged 59-82, in the NIH-AARP Diet and Health Study. A questionnaire administered in 2004-2005 assessed CPD during nine age-periods (<15 to ≥70). We estimated hazard ratios (HR) and 95% confidence intervals (CI) using multivariable-adjusted Cox proportional hazards regression with age as the underlying time metric. Of the 18,233 current smokers, (7.6%), 137 and 1,243 reported consistently smoking <1 CPD and 1-10 CPD, respectively. Relative to never smokers, current smokers who reported consistently smoking 1-10 CPD over their lifetime were 2.34 (95% CI = 1.86-2.93) times more likely to develop smoking-related cancer. Current lifetime smokers of <1 CPD were 1.89 (95% CI = 0.90-3.96) times more likely to develop tobacco-related cancer, although the association did not reach statistical significance. Associations were observed for lifelong smoking of ≤10 CPD with lung cancer (HR = 9.65, 95% CI = 6.93-13.43); bladder cancer (HR = 2.22, 95% CI = 1.22-4.05); and pancreatic cancer (HR = 2.03, 95%CI: 1.05-3.95). Among lifelong ≤10 CPD smokers, former smokers had lower risks of smoking-related cancer with longer time since cessation and longer smoking duration. Lifelong <1 and 1-10 CPD smokers are at increased risk of incident cancer relative to never smokers and would benefit from cessation, providing further evidence that even low-levels of cigarette smoking cause cancer.
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Neoplasias Pulmonares/epidemiologia
Neoplasias Pancreáticas/epidemiologia
Neoplasias da Bexiga Urinária/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Incidência
Neoplasias Pulmonares/etiologia
Masculino
Meia-Idade
National Institutes of Health (U.S.)
Estadiamento de Neoplasias
Neoplasias Pancreáticas/etiologia
Prognóstico
Medição de Risco
Fatores de Tempo
Estados Unidos/epidemiologia
Neoplasias da Bexiga Urinária/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.31059


  8 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29176420
[Au] Autor:Silvestre J; Abbatematteo JM; Chang B; Serletti JM
[Ad] Endereço:Philadelphia, Pa. From the Perelman School of Medicine at the University of Pennsylvania.
[Ti] Título:Trends and Predictors of National Institutes of Health Funding to Plastic Surgery Residency Programs.
[So] Source:Plast Reconstr Surg;140(6):1301-1311, 2017 Dec.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recent studies have demonstrated low levels of National Institutes of Health funding for surgical research. The authors compared the funding in plastic surgery with the funding for other surgical specialties. METHODS: A query of National Institutes of Health grants awarded to departments of surgical specialties was performed using the National Institutes of Health RePORTER database (2008 to 2016). Trends in funding were compared by specialty and adjusted for the number of active physicians in each specialty. Plastic surgery residency program characteristics were correlated with funding procurement. RESULTS: Eight hundred eighty-nine faculty at 94 plastic surgery residency programs were queried. Forty-eight investigators (5.4 percent) at 23 programs (24.4 percent) had National Institutes of Health funding. From 2008 to 2016, a total of $84,142,138 was awarded through 81 grants. Funding supported translational (44.6 percent), clinical (26.4 percent), basic science (27.2 percent), and educational (1.7 percent) research. In 2016, plastic surgery received the least amount of National Institutes of Health funding per active physician ($1,530) relative to orthopedic surgery ($3124), obstetrics and gynecology ($3885), urology ($5943), otolaryngology ($9999), general surgery ($11,649), ophthalmology ($11,933), and neurologic surgery ($20,874). Plastic surgery residency program characteristics associated with National Institutes of Health funding were high ranking and had more than 10 clinical faculty (p < 0.05). CONCLUSIONS: Plastic surgery receives the least National Institutes of Health funding among the surgical specialties. Departments and divisions of plastic surgery should support investigators applying for research grants to increase future National Institutes of Health funding.
[Mh] Termos MeSH primário: Internato e Residência/economia
Cirurgia Plástica/educação
[Mh] Termos MeSH secundário: Administração Financeira/tendências
Apoio Financeiro
Seres Humanos
National Institutes of Health (U.S.)
Cirurgia Plástica/economia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003866


  9 / 16190 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28953883
[Au] Autor:Lloyd-Price J; Mahurkar A; Rahnavard G; Crabtree J; Orvis J; Hall AB; Brady A; Creasy HH; McCracken C; Giglio MG; McDonald D; Franzosa EA; Knight R; White O; Huttenhower C
[Ad] Endereço:Biostatistics Department, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
[Ti] Título:Strains, functions and dynamics in the expanded Human Microbiome Project.
[So] Source:Nature;550(7674):61-66, 2017 10 05.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The characterization of baseline microbial and functional diversity in the human microbiome has enabled studies of microbiome-related disease, diversity, biogeography, and molecular function. The National Institutes of Health Human Microbiome Project has provided one of the broadest such characterizations so far. Here we introduce a second wave of data from the study, comprising 1,631 new metagenomes (2,355 total) targeting diverse body sites with multiple time points in 265 individuals. We applied updated profiling and assembly methods to provide new characterizations of microbiome personalization. Strain identification revealed subspecies clades specific to body sites; it also quantified species with phylogenetic diversity under-represented in isolate genomes. Body-wide functional profiling classified pathways into universal, human-enriched, and body site-enriched subsets. Finally, temporal analysis decomposed microbial variation into rapidly variable, moderately variable, and stable subsets. This study furthers our knowledge of baseline human microbial diversity and enables an understanding of personalized microbiome function and dynamics.
[Mh] Termos MeSH primário: Microbiota/fisiologia
Filogenia
[Mh] Termos MeSH secundário: Conjuntos de Dados como Assunto
Seres Humanos
Metagenoma/genética
Metagenoma/fisiologia
Microbiota/genética
Anotação de Sequência Molecular
National Institutes of Health (U.S.)
Especificidade de Órgãos
Análise Espaço-Temporal
Fatores de Tempo
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1038/nature23889


  10 / 16190 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28919174
[Au] Autor:Roskies AL
[Ad] Endereço:Department of Philosophy, Dartmouth College, Hanover, NH 03755, USA. Electronic address: adina.roskies@dartmouth.edu.
[Ti] Título:New NIH Regulations Say Most Basic Human Brain Research Is a Clinical Trial.
[So] Source:Neuron;96(1):14-16, 2017 Sep 27.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:New NIH definitions classify virtually all human brain and behavioral research as clinical trials. The new definitions will change regulatory, reporting, and funding schemes for noninvasive studies such as neuroimaging. Resulting burdens threaten the viability of basic biobehavioral science research.
[Mh] Termos MeSH primário: Pesquisa Comportamental/classificação
Ensaios Clínicos como Assunto/classificação
National Institutes of Health (U.S.)
Neurociências/classificação
Controle Social Formal
[Mh] Termos MeSH secundário: Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE



página 1 de 1619 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde