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[PMID]: 28365209 [Au] Autor: Levin LA; Miller JW; Zack DJ; Friedlander M; Smith LEH [Ad] Endereço: Department of Ophthalmology, McGill University, Montreal, Canada; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: leonard.levin@mcgill.ca. [Ti] Título: Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative. [So] Source: Ophthalmology;124(7):926-934, 2017 Jul. [Is] ISSN: 1549-4713 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The National Eye Institute launched the Audacious Goals Initiative (AGI) in 2013 with the aim "to restore vision through the regeneration of neurons and neural connections in the eye and visual system." An AGI Town Hall held at the Association for Research in Vision and Ophthalmology Annual Meeting in 2016 brought together basic, translational, and clinical scientists to address the clinical implications of the AGI, with a particular emphasis on diseases amenable to regenerative medicine and strategies to deal with barriers to progess. An example of such a barrier is that replacement of lost neurons may be insufficient because damage to other neurons and non-neuronal cells is common in retinal and optic nerve disease. Reparative processes such as gliosis and fibrosis also can make it difficult to replenish and regenerate neurons. Other issues include choice of animal models, selecting appropriate endpoints, ethics of informed consent, and regulatory issues. Another area critical to next steps in the AGI is the choice of target diseases and the stage at which early development studies should be focused. For example, an advantage of doing clinical trials in patients with early disease is that supporting cellular and structural constituents are still likely to be present. However, regenerative studies in patients with late disease make it easier to detect the effects of replacement therapy against the background of severe visual loss, whereas it may be harder to detect incremental improvement in visual function in those with early disease and considerable remaining visual function. Achieving the goals of the AGI also requires preclinical advances, new imaging techniques, and optimizing translational issues. The work of the AGI is expected to take at least 10 years but should eventually result in therapies to restore some degree of vision to the blind. [Mh] Termos MeSH primário: Terapia Baseada em Transplante de Células e Tecidos/tendências Metas Oftalmologia/métodos Doenças do Nervo Óptico/terapia [Mh] Termos MeSH secundário: Animais Seres Humanos National Eye Institute (U.S.) Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170721 [Lr] Data última revisão: 170721 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170403 [St] Status: MEDLINE

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[PMID]: 27626145 [Au] Autor: Briceño CA; Fuller ML; Bradley EA; Nelson CC [Ad] Endereço: Department of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA. [Ti] Título: Assessment of the Abbreviated National Eye Institute Visual Function Questionnaire (NEI VFQ 9) in blepharoptosis and dermatochalasis. [So] Source: Arq Bras Oftalmol;79(4):226-8, 2016 Jul-Aug. [Is] ISSN: 1678-2925 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: PURPOSE: To evaluate the Abbreviated National Eye Institute Visual Function Questionnaire (NEI VFQ 9), which is shorter than those previously published, as a tool for assessing vision-related quality of life in patients with ptosis and dermatochalasis. METHODS: This is a cohort study of 46 patients who underwent blepharoptosis and/or upper eyelid blepharoplasty surgery by a single surgeon (CN) in 2013 in a public, academic, ambulatory care referral center. Patients included 29 who underwent blepharoplasty, 11 who underwent ptosis surgery, and 6 who underwent combined surgery. The NEI-VFQ 9 was administered pre- and postoperatively, and the composite scores were compared using Student's t-test. Survey duration was timed in a subset of patients. The hypothesis was that the NEI VFQ 9 could detect a statistically significant improvement in composite score after surgical intervention. RESULTS: The mean pre- and postoperative NEI VFQ 9 composite scores were 74.9 and 86.8, respectively, in the blepharoplasty-only group (P<0.0001), 72.07 and 86.41, respectively, in the ptosis-only group (P=0.004), and 75.8 and 87.2, respectively, in the combined group (P=0.022). There was no correlation between the gain in composite score and the change in upper eyelid margin to reflex distance. Twenty-five patients were timed filling out the survey, and the mean was 2.3 min. CONCLUSIONS: The NEI VFQ 9 consistently demonstrates a significant increase in visual function for blepharoptosis and dermatochalasis patients. Thus, it may be a useful tool for assessing vision-related quality of life in patients with ptosis and dermatochalasis. [Mh] Termos MeSH primário: Blefaroptose/cirurgia Doenças Palpebrais/cirurgia Pálpebras/cirurgia Qualidade de Vida Inquéritos e Questionários/normas [Mh] Termos MeSH secundário: Idoso Blefaroplastia/métodos Estudos de Coortes Cútis Laxa/cirurgia Feminino Seres Humanos Masculino Meia-Idade National Eye Institute (U.S.) Satisfação do Paciente Reprodutibilidade dos Testes Fatores de Tempo Resultado do Tratamento Estados Unidos Acuidade Visual [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160915 [St] Status: MEDLINE

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[PMID]: 27483331 [Au] Autor: Alqudah A; Mansberger SL; Gardiner SK; Demirel S [Ad] Endereço: Devers Eye Institute, Legacy Health, Portland, OR. [Ti] Título: Vision-related Quality of Life in Glaucoma Suspect or Early Glaucoma Patients. [So] Source: J Glaucoma;25(8):629-33, 2016 Aug. [Is] ISSN: 1536-481X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To determine the association of vision-related quality of life (QoL) to demographic factors and visual function in glaucoma suspect or early glaucoma patients. MATERIALS AND METHODS: We administered the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) on the same day as a comprehensive ocular examination to participants either with glaucoma or at high risk for developing glaucoma. Regression models were used to determine the association between VFQ-25 composite and subscale scores, visual field status, logMAR equivalent visual acuity (VA), age, and sex. In all analyses we used data from the eye with the best mean deviation (MD), best pattern SD, and best VA. RESULTS: Data from 198 participants were analyzed. The mean best MD (±SD) was 0.02±1.52 dB (range, -5.11 to 2.63 dB) and the mean best pattern SD was 1.75±1.03 dB (range, 0.91 to 8.36 dB). The mean VFQ-25 composite score was 91.6±6.7 (range, 54.5 to 100.0). Composite score and the Distance Activities, Color Vision subscale scores were associated with best MD (P≤0.05). The General Vision and Driving subscale scores were associated with best VA (P≤0.03). The composite score and the Distance Activities, Driving, and Color Vision subscale scores were associated with age (P≤0.05). Finally, the Distance Activities, Driving, and Peripheral Vision subscale scores were associated with sex (P≤0.04). CONCLUSIONS: Vision-related QoL is associated with visual field status even in early and suspected glaucoma. It is also associated with VA, age, and sex. Particular decreases in QoL are related to distance activities, driving, and color vision. [Mh] Termos MeSH primário: Glaucoma Qualidade de Vida Transtornos da Visão [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Estudos Transversais Feminino Glaucoma/complicações Glaucoma/fisiopatologia Glaucoma/psicologia Seres Humanos Pressão Intraocular/fisiologia Masculino Meia-Idade National Eye Institute (U.S.) Perfil de Impacto da Doença Inquéritos e Questionários Estados Unidos Transtornos da Visão/etiologia Transtornos da Visão/fisiopatologia Transtornos da Visão/psicologia Acuidade Visual/fisiologia Campos Visuais/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160803 [St] Status: MEDLINE [do] DOI: 10.1097/IJG.0000000000000445

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[PMID]: 27408950 [Au] Autor: Snyder A [Ti] Título: Robert Nussenblatt. [So] Source: Lancet;388(10039):24, 2016 Jul 02. [Is] ISSN: 1474-547X [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Alergia e Imunologia/história National Eye Institute (U.S.)/história [Mh] Termos MeSH secundário: História do Século XX História do Século XXI Estados Unidos Uveíte [Pt] Tipo de publicação: BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS [Ps] Nome de pessoa como assunto: Nussenblatt R [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 170920 [Lr] Data última revisão: 170920 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 160714 [St] Status: MEDLINE

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[PMID]: 26990163 [Au] Autor: Goldberg JL; Guido W; Agi Workshop Participants [Ad] Endereço: Byers Eye Institute Stanford University, Palo Alto, California, United States. [Ti] Título: Report on the National Eye Institute Audacious Goals Initiative: Regenerating the Optic Nerve. [So] Source: Invest Ophthalmol Vis Sci;57(3):1271-5, 2016 Mar. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The National Eye Institute (NEI) hosted a workshop on November 19, 2014, as part of the Audacious Goals Initiative (AGI), an NEI-led effort to rapidly expand therapies for eye diseases through coordinated research funding. The central audacious goal aims to demonstrate by 2025 the restoration of usable vision in humans through the regeneration of neurons and neural connections in the eye and visual system. This workshop focused on identifying promising strategies for optic nerve regeneration. Its principal objective was to solicit input on future AGI-related funding announcements, and specifically to ask, where are we now in our scientific progress, and what progress should we reach for in the coming years? A full report was generated as a white paper posted on the NEI Web site; this report summarizes the discussion and outcomes from the meeting and serves as guidance for future funding of research that focuses on optic nerve regeneration. [Mh] Termos MeSH primário: Metas National Eye Institute (U.S.) Oftalmologia Nervo Óptico/fisiologia Vias Visuais/fisiologia [Mh] Termos MeSH secundário: Seres Humanos Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW [Em] Mês de entrada: 1607 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160319 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.15-18500

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[PMID]: 26948319 [Au] Autor: González Martín-Moro J; Hernández Verdejo JL; Azurza Rivas G [Ad] Endereço: Servicio de Oftalmología, Hospital Universitario del Henares, Coslada, Madrid, España; Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, España. Electronic address: juliogmm@yahoo.es. [Ti] Título: History and pre-history of optotypes: From Alcor and Mizar to the ETDRS optotype. [Ti] Título: Historia y prehistoria de los optotipos: de Alcor y Mizar al optotipo ETDRS.. [So] Source: Arch Soc Esp Oftalmol;91(11):e91-e92, 2016 Nov. [Is] ISSN: 1989-7286 [Cp] País de publicação: Spain [La] Idioma: eng; spa [Mh] Termos MeSH primário: Testes Visuais/história Acuidade Visual [Mh] Termos MeSH secundário: França História do Século XVIII História do Século XIX História do Século XX História Antiga Seres Humanos National Eye Institute (U.S.) Reprodutibilidade dos Testes Astros Celestes Estados Unidos Testes Visuais/instrumentação [Pt] Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170922 [Lr] Data última revisão: 170922 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160308 [St] Status: MEDLINE

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[PMID]: 25642814 [Au] Autor: Orta AÖ; Öztürker ZK; Erkul SÖ; Bayraktar S; Yilmaz OF [Ad] Endereço: *Orto Medica Hospital †Istanbul Training and Research Hospital ‡Istanbul Surgery Hospital §Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. [Ti] Título: The correlation between glaucomatous visual field loss and vision-related quality of life. [So] Source: J Glaucoma;24(5):e121-7, 2015 Jun-Jul. [Is] ISSN: 1536-481X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To evaluate the vision-related quality of life (QoL) of glaucoma patients in terms of the correlation between visual field (VF) loss and National Eye Institute Visual Functioning Questionnaire-39 (NEI VFQ-39) survey. MATERIALS AND METHODS: A total of 244 glaucoma patients were examined with monocular Humphrey 24-2 central full threshold and Esterman binocular VF tests. Patients were grouped according to their monocular VFs done by Advanced Glaucoma Intervention Study (AGIS) classification and Esterman binocular VF efficiency scores. NEI VFQ-39 was applied for the evaluation of vision-related QoL. RESULTS: NEI VFQ-39 subscales and total scores were evaluated and the highest mean average values were in "color vision" (92.00±16.59) and "social functioning" (90.74±15.98). The lowest mean average values were in "general health" (54.76±18.86) and "general vision" (66.03±17.59). All the subscales except "general health" and "ocular pain" showed positive correlations with the monocular and Esterman binocular VF groupings. Pearson correlation analysis between NEI VFQ-39 subscales and the AGIS VF classification-based groups indicated that the subscales had statistically significant negative correlations except the "general health" (r=-0.151, P=0.018) and "ocular pain" (r=-0.048, P=0.455). The highest correlation with AGIS VF classification was in "driving" (r=-0.477, P=0.001) and "general vision" (r=-0.446, P=0.000) subscales. There was statistically significant correlation between NEI VFQ-39 subscales and Esterman binocular VF groups except "general health" (r=-0.064, P=0.318) and "ocular pain" (r=-0.062, P=0.337). The highest negative correlation was in "distant activities" (r=-0.522, P=0.000) and the lowest negative correlation was in "color vision" (r=-0.416, P=0.000) subscales. The highest correlation between binocular distant and binocular near-visual acuities was in "distant activities" and the lowest correlation was in "role difficulties" subscales. CONCLUSIONS: There is statistically significant correlation between the glaucoma patients' VF loss and the vision-related QoL. The evaluation of self-reported vision status in glaucoma patients may be a guide for the rehabilitation of their disabilities in vision-related daily activities. [Mh] Termos MeSH primário: Glaucoma/fisiopatologia Glaucoma/psicologia Qualidade de Vida/psicologia Transtornos da Visão/fisiopatologia Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Atividades Cotidianas Adulto Idoso Feminino Seres Humanos Pressão Intraocular/fisiologia Masculino Meia-Idade National Eye Institute (U.S.) Estudos Prospectivos Perfil de Impacto da Doença Inquéritos e Questionários Estados Unidos Visão Binocular/fisiologia Testes de Campo Visual Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1508 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150203 [St] Status: MEDLINE [do] DOI: 10.1097/IJG.0000000000000225

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[PMID]: 25411934 [Au] Autor: Cortina MS; Hallak JA [Ad] Endereço: *Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL; and †Quantitative Scientific Solutions, LLC, Washington, DC. [Ti] Título: Vision-related quality-of-life assessment using NEI VFQ-25 in patients after Boston keratoprosthesis implantation. [So] Source: Cornea;34(2):160-4, 2015 Feb. [Is] ISSN: 1536-4798 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: The aim of this study was to determine the impact of Boston keratoprosthesis (KPro) implantation on patient-reported visual function using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25). METHODS: This is a prospective study of patients undergoing implantation of Boston KPro. The NEI VFQ-25 was used to assess vision-related quality of life preoperatively and postoperatively at 3 and 6 months and yearly thereafter. Baseline scores were compared with postoperative scores using paired t test. Stratified analysis was performed to compare results by visual acuity of the contralateral eye. RESULTS: Twenty-four patients were included. Mean baseline NEI VFQ-25 overall score was 44.6. At the first follow-up time point, mean overall score was 70.0, representing a statistically significant change from baseline (P < 0.001). Breakdown of subcategories within VFQ-25 showed significant improvement in general vision, near and distance activities, social functioning, mental health, role difficulties, dependency, color vision, and peripheral vision (P < 0.05). This improvement was also observed when comparing baseline scores with postoperative scores at average follow-up of 16 months. Although a greater change in scores was observed in patients who had poor vision in the contralateral eye, patients with vision better than 20/200 in the nonsurgical eye showed statistically significant improvement in overall scores and subscale scores compared with baseline. CONCLUSIONS: The quality of life of patients who underwent KPro significantly improved postoperatively compared with their preoperative status. These results did not change when stratifying by visual acuity of the contralateral eye. [Mh] Termos MeSH primário: Órgãos Artificiais Córnea Doenças da Córnea/psicologia Implante de Prótese Qualidade de Vida/psicologia Perfil de Impacto da Doença Visão Ocular/fisiologia [Mh] Termos MeSH secundário: Doenças da Córnea/cirurgia Feminino Seguimentos Seres Humanos Masculino Meia-Idade National Eye Institute (U.S.) Estudos Prospectivos Inquéritos e Questionários Estados Unidos Acuidade Visual/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1507 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141121 [St] Status: MEDLINE [do] DOI: 10.1097/ICO.0000000000000310

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[PMID]: 24767911 [Au] Autor: Mollazadegan K; Huang J; Khadka J; Wang Q; Yang F; Gao R; Pesudovs K [Ad] Endereço: From the School of Optometry and Ophthalmology and Eye Hospital (Mollazadegan, Huang, Khadka, Wang, Yang, Gao), Wenzhou Medical University Wenzhou, Zhejiang, China; the Department of Clinical Neuroscience, St. Erik Eye Hospital (Mollazadegan), Karolinska Institutet, Stockholm, Sweden; NH&MRC Cen [Ti] Título: Cross-cultural validation of the National Eye Institute Visual Function Questionnaire. [So] Source: J Cataract Refract Surg;40(5):774-84, 2014 May. [Is] ISSN: 1873-4502 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To assess the native and the previously Rasch-modified National Eye Institute Visual Function Questionnaire (NEI VFQ) scales in a Chinese population. SETTING: Eye Hospital of Wenzhou Medical University, Wenzhou, China. DESIGN: Questionnaire development. METHODS: Patients on the waiting list for cataract surgery completed the 39-item NEI VFQ (NEI VFQ-39). Rasch analysis was performed in 3 steps as follows: (1) Assess the psychometric properties of the original NEI VFQ. (2) Reassess the previously proposed Rasch-modified NEI VFQ scales by Pesudovs et al. (2010) in Chinese populations. (3) Compare the scores of previously recommended scales of the NEI VFQ with new Rasch-modified scales of the same questionnaire using Bland-Altman plots. RESULTS: Four hundred thirty-five patients (median age 70 years; range 35 to 90 years) completed the NEI VFQ-39. Response categories for 4 question types were dysfunctional and therefore repaired. The original NEI VFQ-39 and NEI VFQ-25 showed good measurement precision. However, both versions showed multidimensionality, misfitting items, suboptimum targeting, and nonfunctioning subscales. Using the previously proposed Rasch-modified scales of the NEI VFQ yielded valid measurement of each construct in the 39-item and 25-item questionnaire. Comparison between the earlier proposed NEI VFQ scales and the new versions developed in this population showed good agreement. CONCLUSIONS: The original NEI VFQ was once again found to be flawed. The previously proposed Rasch-analyzed versions of the NEI VFQ and the new Chinese versions showed good agreement. [Mh] Termos MeSH primário: Catarata/fisiopatologia National Eye Institute (U.S.) Perfil de Impacto da Doença Inquéritos e Questionários Transtornos da Visão/fisiopatologia Visão Ocular/fisiologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Grupo com Ancestrais do Continente Asiático Austrália China Comparação Transcultural Feminino Seres Humanos Masculino Meia-Idade Reprodutibilidade dos Testes Estados Unidos Acuidade Visual/fisiologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES [Em] Mês de entrada: 1509 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140429 [St] Status: MEDLINE

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[PMID]: 24621120 [Au] Autor: Kymes SM [Ad] Endereço: The Medwin Group , Saint Louis, MO , USA. [Ti] Título: Is it time to move beyond the QALY in vision research? [So] Source: Ophthalmic Epidemiol;21(2):63-5, 2014 Apr. [Is] ISSN: 1744-5086 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Pesquisa Biomédica Oftalmologia Anos de Vida Ajustados por Qualidade de Vida [Mh] Termos MeSH secundário: Análise Custo-Benefício Seres Humanos National Eye Institute (U.S.) Perfil de Impacto da Doença Estados Unidos [Pt] Tipo de publicação: EDITORIAL [Em] Mês de entrada: 1408 [Cu] Atualização por classe: 140313 [Lr] Data última revisão: 140313 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140314 [St] Status: MEDLINE [do] DOI: 10.3109/09286586.2014.895843

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