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[PMID]:28459618
[Au] Autor:Celedón JC; Burchard EG; Schraufnagel D; Castillo-Salgado C; Schenker M; Balmes J; Neptune E; Cummings KJ; Holguin F; Riekert KA; Wisnivesky JP; Garcia JGN; Roman J; Kittles R; Ortega VE; Redline S; Mathias R; Thomas A; Samet J; Ford JG; American Thoracic Society and the National Heart, Lung, and Blood Institute
[Ti] Título:An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States.
[So] Source:Ann Am Thorac Soc;14(5):814-826, 2017 May.
[Is] ISSN:2325-6621
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Health disparities related to race, ethnicity, and socioeconomic status persist and are commonly encountered by practitioners of pediatric and adult pulmonary, critical care, and sleep medicine in the United States. To address such disparities and thus progress toward equality in respiratory health, the American Thoracic Society and the National Heart, Lung, and Blood Institute convened a workshop in May of 2015. The workshop participants addressed health disparities by focusing on six topics, each of which concluded with a panel discussion that proposed recommendations for research on racial, ethnic, and socioeconomic disparities in pulmonary, critical care, and sleep medicine. Such recommendations address best practices to advance research on respiratory health disparities (e.g., characterize broad ethnic groups into subgroups known to differ with regard to a disease of interest), risk factors for respiratory health disparities (e.g., study the impact of new tobacco or nicotine products on respiratory diseases in minority populations), addressing equity in access to healthcare and quality of care (e.g., conduct longitudinal studies of the impact of the Affordable Care Act on respiratory and sleep disorders), the impact of personalized medicine on disparities research (e.g., implement large studies of pharmacogenetics in minority populations), improving design and methodology for research studies in respiratory health disparities (e.g., use study designs that reduce participants' burden and foster trust by engaging participants as decision-makers), and achieving equity in the pulmonary, critical care, and sleep medicine workforce (e.g., develop and maintain robust mentoring programs for junior faculty, including local and external mentors). Addressing these research needs should advance efforts to reduce, and potentially eliminate, respiratory, sleep, and critical care disparities in the United States.
[Mh] Termos MeSH primário: Grupos Étnicos/estatística & dados numéricos
Acesso aos Serviços de Saúde/estatística & dados numéricos
Disparidades nos Níveis de Saúde
Disparidades em Assistência à Saúde
Grupos Minoritários/estatística & dados numéricos
Doenças Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Política de Saúde
Seres Humanos
National Heart, Lung, and Blood Institute (U.S.)
Pneumologia
Classe Social
Sociedades Médicas
Estados Unidos
[Pt] Tipo de publicação:CONSENSUS DEVELOPMENT CONFERENCE, NIH; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1513/AnnalsATS.201702-167WS


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[PMID]:28636425
[Au] Autor:Woodruff PG; van den Berge M; Boucher RC; Brightling C; Burchard EG; Christenson SA; Han MK; Holtzman MJ; Kraft M; Lynch DA; Martinez FD; Reddel HK; Sin DD; Washko GR; Wenzel SE; Punturieri A; Freemer MM; Wise RA
[Ad] Endereço:1 Division of Pulmonary and Critical Care, University of California, San Francisco, California.
[Ti] Título:American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.
[So] Source:Am J Respir Crit Care Med;196(3):375-381, 2017 Aug 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent) including dyspnea and a productive cough. On the basis of age and smoking history, it is often easy to distinguish between asthma and COPD. However, some patients have features compatible with both diseases. Because clinical studies typically exclude these patients, their underlying disease mechanisms and appropriate treatment remain largely uncertain. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the American Thoracic Society, convened a workshop of investigators in San Francisco, California on May 14, 2016. At the workshop, current understanding of asthma-COPD overlap was discussed among clinicians, pathologists, radiologists, epidemiologists, and investigators with expertise in asthma and COPD. They considered knowledge gaps in our understanding of asthma-COPD overlap and identified strategies and research priorities that will advance its understanding. This report summarizes those discussions.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Asma/terapia
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/terapia
[Mh] Termos MeSH secundário: Asma/diagnóstico
Diagnóstico por Imagem
Pulmão/fisiopatologia
National Heart, Lung, and Blood Institute (U.S.)
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Sociedades Médicas
Estados Unidos
[Pt] Tipo de publicação:CONSENSUS DEVELOPMENT CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201705-0973WS


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[PMID]:28614402
[Au] Autor:Giffen CA; Wagner EL; Adams JT; Hitchcock DM; Welniak LA; Brennan SP; Carroll LE
[Ad] Endereço:Information Management Services, Inc., Calverton, Maryland, United States of America.
[Ti] Título:Providing researchers with online access to NHLBI biospecimen collections: The results of the first six years of the NHLBI BioLINCC program.
[So] Source:PLoS One;12(6):e0178141, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The National Heart, Lung, and Blood Institute (NHLBI), within the United States' National Institutes of Health (NIH), established the Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) in 2008 to develop the infrastructure needed to link the contents of the NHLBI Biorepository and the NHLBI Data Repository, and to promote the utilization of these scientific resources by the broader research community. Program utilization metrics were developed to measure the impact of BioLINCC on Biorepository access by researchers, including visibility, program efficiency, user characteristics, scientific impact, and research types. Input data elements were defined and are continually populated as requests move through the process of initiation through fulfillment and publication. This paper reviews the elements of the tracking metrics which were developed for BioLINCC and reports the results for the first six on-line years of the program.
[Mh] Termos MeSH primário: Bancos de Espécimes Biológicos/organização & administração
Manejo de Espécimes/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Internet
National Heart, Lung, and Blood Institute (U.S.)
National Institutes of Health (U.S.)
Desenvolvimento de Programas
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178141


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[PMID]:28542263
[Au] Autor:AlBadri A; Lai K; Wei J; Landes S; Mehta PK; Li Q; Johnson D; Reis SE; Kelsey SF; Bittner V; Sopko G; Shaw LJ; Pepine CJ; Bairey Merz CN
[Ad] Endereço:Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California, United States of America.
[Ti] Título:Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease: A report from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE).
[So] Source:PLoS One;12(5):e0177684, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Women with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD) and preserved left ventricular ejection fraction (EF) often have diastolic dysfunction and experience elevated rates of major adverse cardiac events (MACE), including heart failure (HF) hospitalization with preserved ejection fraction (HFpEF). We evaluated the predictive value of inflammatory biomarkers for long-term HF hospitalization and all-cause mortality in these women. METHODS: We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF. Multivariable Cox regression analysis tested associations between biomarker levels and adverse outcomes. RESULTS: Among 390 women, mean age 56 ± 11 years, median follow up of 6 years, we observed that there is continuous association between IL-6 level and HF hospitalization (adjusted hazard ratio [AHR] 2.5 [1.2-5.0], p = 0.02). In addition, we found significant association between IL-6, SAA levels and all-cause mortality AHR (1.8 [1.1-3.0], p = 0.01) (1.5 [1.0-2.1], p = 0.04), respectively. CONCLUSION: In women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF, elevated IL-6 predicted HF hospitalization and all-cause mortality, while SAA level was only associated with all-cause mortality. These results suggest that inflammation plays a role in the pathogenesis of development of HFpEF, as well all-cause mortality.
[Mh] Termos MeSH primário: Insuficiência Cardíaca/diagnóstico
Insuficiência Cardíaca/metabolismo
Isquemia Miocárdica/epidemiologia
National Heart, Lung, and Blood Institute (U.S.)
[Mh] Termos MeSH secundário: Biomarcadores/metabolismo
Estudos Transversais
Feminino
Insuficiência Cardíaca/complicações
Seres Humanos
Inflamação/complicações
Inflamação/metabolismo
Meia-Idade
Isquemia Miocárdica/complicações
Prognóstico
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177684


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[PMID]:28502823
[Au] Autor:Gold DR; Adamkiewicz G; Arshad SH; Celedón JC; Chapman MD; Chew GL; Cook DN; Custovic A; Gehring U; Gern JE; Johnson CC; Kennedy S; Koutrakis P; Leaderer B; Mitchell H; Litonjua AA; Mueller GA; O'Connor GT; Ownby D; Phipatanakul W; Persky V; Perzanowski MS; Ramsey CD; Salo PM; Schwaninger JM; Sordillo JE; Spira A; Suglia SF; Togias A; Zeldin DC; Matsui EC
[Ad] Endereço:Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass. Electronic address: diane.gold@channing.harvard.edu.
[Ti] Título:NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.
[So] Source:J Allergy Clin Immunol;140(4):933-949, 2017 Oct.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
[Mh] Termos MeSH primário: Poluição do Ar em Ambientes Fechados/efeitos adversos
Asma/prevenção & controle
Indústria Farmacêutica
National Heart, Lung, and Blood Institute (U.S.)
National Institute of Allergy and Infectious Diseases (U.S.)
National Institute of Environmental Health Sciences (U.S.)
Organizações sem Fins Lucrativos
[Mh] Termos MeSH secundário: Animais
Asma/diagnóstico
Asma/epidemiologia
Pesquisa Biomédica
Criança
Consensus Development Conferences, NIH as Topic
Saúde Ambiental
Obtenção de Fundos
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


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[PMID]:28498894
[Au] Autor:Budinger GRS; Kohanski RA; Gan W; Kobor MS; Amaral LA; Armanios M; Kelsey KT; Pardo A; Tuder R; Macian F; Chandel N; Vaughan D; Rojas M; Mora AL; Kovacs E; Duncan SR; Finkel T; Choi A; Eickelberg O; Chen D; Agusti A; Selman M; Balch WE; Busse P; Lin A; Morimoto R; Sznajder JI; Thannickal VJ
[Ad] Endereço:Feinberg School of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.
[Ti] Título:The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.
[So] Source:J Gerontol A Biol Sci Med Sci;72(11):1492-1500, 2017 Oct 12.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization, and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems-based platforms that can dynamically incorporate data sets that describe the genomics, transcriptomics, epigenomics, metabolomics, and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Pneumopatias/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Pneumopatias/fisiopatologia
Metabolômica/métodos
National Heart, Lung, and Blood Institute (U.S.)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1093/gerona/glx090


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[PMID]:28430547
[Au] Autor:Newman JH; Rich S; Abman SH; Alexander JH; Barnard J; Beck GJ; Benza RL; Bull TM; Chan SY; Chun HJ; Doogan D; Dupuis J; Erzurum SC; Frantz RP; Geraci M; Gillies H; Gladwin M; Gray MP; Hemnes AR; Herbst RS; Hernandez AF; Hill NS; Horn EM; Hunter K; Jing ZC; Johns R; Kaul S; Kawut SM; Lahm T; Leopold JA; Lewis GD; Mathai SC; McLaughlin VV; Michelakis ED; Nathan SD; Nichols W; Page G; Rabinovitch M; Rich J; Rischard F; Rounds S; Shah SJ; Tapson VF; Lowy N; Stockbridge N; Weinmann G; Xiao L
[Ad] Endereço:1 Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Medical Center, Nashville, Tennessee.
[Ti] Título:Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.
[So] Source:Am J Respir Crit Care Med;195(12):1661-1670, 2017 Jun 15.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Division of Lung Diseases of the NHLBI and the Cardiovascular Medical Education and Research Fund held a workshop to discuss how to leverage the anticipated scientific output from the recently launched "Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics" (PVDOMICS) program to develop newer approaches to pulmonary vascular disease. PVDOMICS is a collaborative, protocol-driven network to analyze all patient populations with pulmonary hypertension to define novel pulmonary vascular disease (PVD) phenotypes. Stakeholders, including basic, translational, and clinical investigators; clinicians; patient advocacy organizations; regulatory agencies; and pharmaceutical industry experts, joined to discuss the application of precision medicine to PVD clinical trials. Recommendations were generated for discussion of research priorities in line with NHLBI Strategic Vision Goals that include: (1) A national effort, involving all the stakeholders, should seek to coordinate biosamples and biodata from all funded programs to a web-based repository so that information can be shared and correlated with other research projects. Example programs sponsored by NHLBI include PVDOMICS, Pulmonary Hypertension Breakthrough Initiative, the National Biological Sample and Data Repository for PAH, and the National Precision Medicine Initiative. (2) A task force to develop a master clinical trials protocol for PVD to apply precision medicine principles to future clinical trials. Specific features include: (a) adoption of smaller clinical trials that incorporate biomarker-guided enrichment strategies, using adaptive and innovative statistical designs; and (b) development of newer endpoints that reflect well-defined and clinically meaningful changes. (3) Development of updated and systematic variables in imaging, hemodynamic, cellular, genomic, and metabolic tests that will help precisely identify individual and shared features of PVD and serve as the basis of novel phenotypes for therapeutic interventions.
[Mh] Termos MeSH primário: Hipertensão Pulmonar/terapia
Medicina de Precisão/métodos
[Mh] Termos MeSH secundário: Educação
Seres Humanos
National Heart, Lung, and Blood Institute (U.S.)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201701-0150WS


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[PMID]:28402243
[Au] Autor:Coady SA; Mensah GA; Wagner EL; Goldfarb ME; Hitchcock DM; Giffen CA
[Ad] Endereço:From the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.
[Ti] Título:Use of the National Heart, Lung, and Blood Institute Data Repository.
[So] Source:N Engl J Med;376(19):1849-1858, 2017 05 11.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Research on data sharing from clinical trials has focused on elucidating perceptions, barriers, and attitudes among trialists and study participants with respect to sharing data. However, little information exists regarding utilization or associated publication of articles once clinical trial data have been widely shared. METHODS: We analyzed administrative records of investigator requests for data access, linked publications, and bibliometrics to describe the use of the National Heart, Lung, and Blood Institute data repository. RESULTS: From January 2000 through May 2016, a total of 370 investigators requested data from 1 or more clinical trials. Requests for trial data have been increasing, with 195 investigators (53%) initiating requests during the last 4.4 years of the study period. The predominant reason for requesting data was post hoc secondary analysis of new questions (72%), followed by analytic or statistical approaches to clinical trials (9%) and meta-analyses or pooled study research (7%). Of 172 requests with online project descriptions, only 2 requests were initiated for reanalysis of primary-outcome findings. Data from 88 of 100 available clinical trials were requested at least once, and the median time from repository availability to first request was 235 days. A total of 277 articles were published on the basis of data from 47 trials. Citation metrics from 224 articles indicated that half of the publications have cumulative citations that rank in the top 34% normalized for subject category and year of publication. CONCLUSIONS: Demand for trial data for secondary analysis has been increasing. Requesting data for the a priori purpose of reanalysis or verification of original findings was rare.
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto
Conjuntos de Dados como Assunto/estatística & dados numéricos
Disseminação de Informação
National Heart, Lung, and Blood Institute (U.S.)
[Mh] Termos MeSH secundário: Bibliometria
Conjuntos de Dados como Assunto/utilização
Seres Humanos
Estimativa de Kaplan-Meier
Estudos Observacionais como Assunto
Publicações Periódicas como Assunto/estatística & dados numéricos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMsa1603542


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[PMID]:28193717
[Au] Autor:Rusconi P; Wilkinson JD; Sleeper LA; Lu M; Cox GF; Towbin JA; Colan SD; Webber SA; Canter CE; Ware SM; Hsu DT; Chung WK; Jefferies JL; Cordero C; Lipshultz SE; Pediatric Cardiomyopathy Registry Investigators
[Ad] Endereço:From the Department of Pediatrics, Miller School of Medicine, University of Miami, FL (P.R., S.E.L.); Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit (J.D.W., S.E.L.); Sanofi Genzyme Corporation, Boston, MA (G.F.C.); The Heart Institute,
[Ti] Título:Differences in Presentation and Outcomes Between Children With Familial Dilated Cardiomyopathy and Children With Idiopathic Dilated Cardiomyopathy: A Report From the Pediatric Cardiomyopathy Registry Study Group.
[So] Source:Circ Heart Fail;10(2), 2017 Feb.
[Is] ISSN:1941-3297
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Research comparing the survival of children with familial dilated cardiomyopathy (FDCM) to that of children with idiopathic dilated cardiomyopathy (IDCM) has produced conflicting results. METHODS AND RESULTS: We analyzed data from children with FDCM or IDCM using the National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry. Compared to children with IDCM (n=647), children with FDCM (n=223) were older (mean 6.2 versus 4.5 years, <0.001), less often had heart failure (64% versus 78%, <0.001), had less-depressed mean left ventricular fractional shortening scores (-7.85±3.98 versus -9.06±3.89, <0.001) and lower end-diastolic dimension scores (4.12±2.61 versus 4.91±2.57, <0.001) at diagnosis. The cumulative incidence of death was lower for patients with FDCM compared with IDCM ( =0.04; hazard ratio 0.64, =0.06), but no difference in risk of transplant or the combined death or transplant outcome. There was no difference in the proportion of children with echocardiographic normalization at 3 years of follow-up (FDCM, 30% versus IDCM, 26%; =0.33). Multivariable analysis showed no difference in outcomes between FDCM and IDCM but for both groups older age, congestive heart failure, and increased left ventricular end-systolic dimension score at diagnosis were independently associated with an increased risk of death or heart transplantation (all s<0.001). CONCLUSIONS: There was no survival difference between FDCM and IDCM after adjustment for other factors. Older age, congestive heart failure, and greater left ventricular dilation at diagnosis were independently associated with increased risk of the combined end point of death or transplantation. CLINICAL TRIAL REGISTRATION: URL: https://clinicaltrials.gov. Unique identifier: NCT00005391.
[Mh] Termos MeSH primário: Cardiomiopatia Dilatada/mortalidade
Cardiomiopatia Dilatada/terapia
[Mh] Termos MeSH secundário: Fatores Etários
Canadá/epidemiologia
Cardiomiopatia Dilatada/diagnóstico por imagem
Criança
Pré-Escolar
Intervalo Livre de Doença
Ecocardiografia
Feminino
Insuficiência Cardíaca/diagnóstico por imagem
Insuficiência Cardíaca/mortalidade
Insuficiência Cardíaca/terapia
Transplante de Coração
Seres Humanos
Hipertrofia Ventricular Esquerda/diagnóstico por imagem
Hipertrofia Ventricular Esquerda/mortalidade
Hipertrofia Ventricular Esquerda/terapia
Incidência
Lactente
Estimativa de Kaplan-Meier
Estudos Longitudinais
Masculino
Análise Multivariada
Contração Miocárdica
National Heart, Lung, and Blood Institute (U.S.)
Modelos de Riscos Proporcionais
Sistema de Registros
Fatores de Risco
Volume Sistólico
Fatores de Tempo
Resultado do Tratamento
Estados Unidos/epidemiologia
Função Ventricular Esquerda
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


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[PMID]:28186851
[Au] Autor:Shea KE; Wagner EL; Marchesani L; Meagher K; Giffen C
[Ad] Endereço:1 Precision For Medicine, Frederick, Maryland.
[Ti] Título:Efficiently Maintaining a National Resource of Historical and Contemporary Biological Collections: The NHLBI Biorepository Model.
[So] Source:Biopreserv Biobank;15(1):17-19, 2017 Feb.
[Is] ISSN:1947-5543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Reducing costs by improving storage efficiency has been a focus of the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen Repository (Biorepository) and Biologic Specimen and Data Repositories Information Coordinating Center (BioLINCC) programs for several years. METHODS: Study specimen profiles were compiled using the BioLINCC collection catalog. Cost assessments and calculations on the return on investments to consolidate or reduce a collection, were developed and implemented. RESULTS: Over the course of 8 months, the NHLBI Biorepository evaluated 35 collections that consisted of 1.8 million biospecimens. A total of 23 collections were selected for consolidation, with a total of 1.2 million specimens located in 21,355 storage boxes. The consolidation resulted in a savings of 4055 boxes of various sizes and 10.2 mechanical freezers (∼275 cubic feet) worth of space. CONCLUSION: As storage costs in a biorepository increase over time, the development and use of information technology tools to assess the potential advantage and feasiblity of vial consolidation can reduce maintenance expenses.
[Mh] Termos MeSH primário: Bancos de Espécimes Biológicos
Modelos Teóricos
[Mh] Termos MeSH secundário: Bancos de Espécimes Biológicos/economia
Seres Humanos
Investimentos em Saúde
National Heart, Lung, and Blood Institute (U.S.)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1089/bio.2016.0112



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