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[PMID]:28949918
[Au] Autor:Packenham JP; Rosselli RT; Ramsey SK; Taylor HA; Fothergill A; Slutsman J; Miller A
[Ad] Endereço:Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) , Research Triangle Park, North Carolina, USA.
[Ti] Título:Conducting Science in Disasters: Recommendations from the NIEHS Working Group for Special IRB Considerations in the Review of Disaster Related Research.
[So] Source:Environ Health Perspect;125(9):094503, 2017 Sep 25.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:SUMMARY: Research involving human subjects after public health emergencies and disasters may pose ethical challenges. These challenges may include concerns about the vulnerability of prospective disaster research participants, increased research burden among disaster survivors approached by multiple research teams, and potentially reduced standards in the ethical review of research by institutional review boards (IRBs) due to the rush to enter the disaster field. The NIEHS Best Practices Working Group for Special IRB Considerations in the Review of Disaster Related Research was formed to identify and address ethical and regulatory challenges associated with the review of disaster research. The working group consists of a diverse collection of disaster research stakeholders across a broad spectrum of disciplines. The working group convened in July 2016 to identify recommendations that are instrumental in preparing IRBs to review protocols related to public health emergencies and disasters. The meeting included formative didactic presentations and facilitated breakout discussions using disaster-related case studies. Major thematic elements from these discussions were collected and documented into 15 working group recommendations, summarized in this article, that address topics such as IRB disaster preparedness activities, informed consent, vulnerable populations, confidentiality, participant burden, disaster research response integration and training, IRB roles/responsibilities, community engagement, and dissemination of disaster research results. https://doi.org/10.1289/EHP2378.
[Mh] Termos MeSH primário: Desastres
National Institute of Environmental Health Sciences (U.S.)
[Mh] Termos MeSH secundário: Emergências
Comitês de Ética em Pesquisa
Seres Humanos
Estudos Prospectivos
Saúde Pública
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1289/EHP2378


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[PMID]:28927536
[Au] Autor:Zeiger E
[Ad] Endereço:Errol Zeiger Consulting, 800 Indian Springs Road., Chapel Hill, NC 27514, USA. Electronic address: zeiger@nc.rr.com.
[Ti] Título:Reflections on a career and on the history of genetic toxicity testing in the National Toxicology Program.
[So] Source:Mutat Res;773:282-292, 2017 Jul.
[Is] ISSN:1873-135X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:One of the highly visible aspects of the U.S. National Toxicology Program (NTP) has been its genetic toxicity testing program, which has been responsible for testing, and making publicly available, in vitro and in vivo test data on thousands of chemicals since 1979. What is less well known, however, is that this NTP program had its origin in two separate testing programs that were initiated independently at the National Cancer Institute (NCI) and the National Institute of Environmental Health Sciences (NIEHS) before the NTP was established. The NCI program was in response to the 1971 National Cancer Act which dramatically increased the NCI budget. In contrast, the NIEHS testing program can be traced back to a publication by Bruce Ames, not the one describing the mutagenicity assay he developed that became known as the Ames test, but because in 1975 he published an article showing that hair dyes were mutagenic. The protocols developed for these NCI contracts became the basis for the NTP Salmonella testing contracts that were awarded a few years later. These protocols, with their supporting NTP data, strongly influenced the initial in vitro OECD Test Guidelines. The background and evolution of the NTP genetic toxicity testing program is described, along with some of the more significant milestone discoveries and accomplishments from this program.
[Mh] Termos MeSH primário: Testes de Mutagenicidade
United States Government Agencies/história
[Mh] Termos MeSH secundário: Animais
Bioensaio
Linhagem Celular
Bases de Dados Factuais
História do Século XX
História do Século XXI
Seres Humanos
Camundongos
Mutagênicos/toxicidade
National Cancer Institute (U.S.)
National Institute of Environmental Health Sciences (U.S.)
Salmonella typhimurium/efeitos dos fármacos
Estados Unidos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


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[PMID]:28502823
[Au] Autor:Gold DR; Adamkiewicz G; Arshad SH; Celedón JC; Chapman MD; Chew GL; Cook DN; Custovic A; Gehring U; Gern JE; Johnson CC; Kennedy S; Koutrakis P; Leaderer B; Mitchell H; Litonjua AA; Mueller GA; O'Connor GT; Ownby D; Phipatanakul W; Persky V; Perzanowski MS; Ramsey CD; Salo PM; Schwaninger JM; Sordillo JE; Spira A; Suglia SF; Togias A; Zeldin DC; Matsui EC
[Ad] Endereço:Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass. Electronic address: diane.gold@channing.harvard.edu.
[Ti] Título:NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.
[So] Source:J Allergy Clin Immunol;140(4):933-949, 2017 Oct.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
[Mh] Termos MeSH primário: Poluição do Ar em Ambientes Fechados/efeitos adversos
Asma/prevenção & controle
Indústria Farmacêutica
National Heart, Lung, and Blood Institute (U.S.)
National Institute of Allergy and Infectious Diseases (U.S.)
National Institute of Environmental Health Sciences (U.S.)
Organizações sem Fins Lucrativos
[Mh] Termos MeSH secundário: Animais
Asma/diagnóstico
Asma/epidemiologia
Pesquisa Biomédica
Criança
Consensus Development Conferences, NIH as Topic
Saúde Ambiental
Obtenção de Fundos
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


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[PMID]:28212109
[Au] Autor:Henry HF; Suk WA
[Ti] Título:Sustainable exposure prevention through innovative detection and remediation technologies from the NIEHS Superfund Research Program.
[So] Source:Rev Environ Health;32(1-2):35-44, 2017 Mar 01.
[Is] ISSN:2191-0308
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Innovative devices and tools for exposure assessment and remediation play an integral role in preventing exposure to hazardous substances. New solutions for detecting and remediating organic, inorganic, and mixtures of contaminants can improve public health as a means of primary prevention. Using a public health prevention model, detection and remediation technologies contribute to primary prevention as tools to identify areas of high risk (e.g. contamination hotspots), to recognize hazards (bioassay tests), and to prevent exposure through contaminant cleanups. Primary prevention success is ultimately governed by the widespread acceptance of the prevention tool. And, in like fashion, detection and remediation technologies must convey technical and sustainability advantages to be adopted for use. Hence, sustainability - economic, environmental, and societal - drives innovation in detection and remediation technology. The National Institute of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP) is mandated to advance innovative detection, remediation, and toxicity screening technology development through grants to universities and small businesses. SRP recognizes the importance of fast, accurate, robust, and advanced detection technologies that allow for portable real-time, on-site characterization, monitoring, and assessment of contaminant concentration and/or toxicity. Advances in non-targeted screening, biological-based assays, passive sampling devices (PSDs), sophisticated modeling approaches, and precision-based analytical tools are making it easier to quickly identify hazardous "hotspots" and, therefore, prevent exposures. Innovation in sustainable remediation uses a variety of approaches: in situ remediation; harnessing the natural catalytic properties of biological processes (such as bioremediation and phytotechnologies); and application of novel materials science (such as nanotechnology, advanced membranes, new carbon materials, and materials reuse). Collectively, the investment in new technologies shows promise to reduce the amount and toxicity of hazardous substances in the environment. This manuscript highlights SRP funded innovative devices and tools for exposure assessment and remediation of organic, inorganic, and mixtures of contaminants with a particular focus on sustainable technologies.
[Mh] Termos MeSH primário: Exposição Ambiental/prevenção & controle
Monitoramento Ambiental/métodos
Recuperação e Remediação Ambiental/métodos
Substâncias Perigosas/toxicidade
Saúde Pública
[Mh] Termos MeSH secundário: Seres Humanos
National Institute of Environmental Health Sciences (U.S.)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hazardous Substances)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28183924
[Au] Autor:Cornwall W
[Ti] Título:Rules of evidence.
[So] Source:Science;355(6325):564-567, 2017 Feb 10.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/toxicidade
Compostos Benzidrílicos/toxicidade
Segurança Química
Estrogênios não Esteroides/toxicidade
Mimetismo Molecular
Fenóis/toxicidade
Testes de Toxicidade Crônica/normas
[Mh] Termos MeSH secundário: Animais
Guias como Assunto
Seres Humanos
National Institute of Environmental Health Sciences (U.S.)
Ratos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Benzhydryl Compounds); 0 (Estrogens, Non-Steroidal); 0 (Phenols); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1126/science.355.6325.564


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[PMID]:27837599
[Au] Autor:Suk WA
[Ti] Título:The CEECHE: a practical approach for reducing exposures and disease outcomes in Central and Eastern Europe.
[So] Source:Rev Environ Health;32(1-2):3-8, 2017 Mar 01.
[Is] ISSN:2191-0308
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:While each region of the world faces unique challenges, environmental threats to vulnerable populations throughout Central and Eastern Europe (CEE) present a significant public health challenge. Environmental pollution is widespread, resulting from the consequences of rapid industrialization during the Soviet Union era. To help address these concerns, a meeting, sponsored in part by the National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP), was convened in 1994. The meeting, "Hazardous Wastes - Exposure, Remediation, and Policy," brought together representatives of the governments of seven countries in the region, scientists from the United States and Western Europe, and representatives from international organizations to explore hazardous waste problems in the region. Since 1994, the SRP and partners have been holding meetings throughout CEE to share important information regarding environmental health. The general sessions have shifted from a focus on describing the problems in each country related to hazardous waste, exposure assessment, risk reduction, and risk communication, to an exchange of information to better define links between health and the environment and strategies to improve regional problems. The 1994 meeting and subsequent meetings raised issues such as heavy metal contamination, exposures from hazardous waste, and pollution caused by deficiencies in disposal of waste overall. Research priorities that were identified included development of reliable biomarkers, better understanding of the relationship between nutrition and chemical toxicity, more epidemiological studies in CEE, better methods of environmental data analysis, and development of remediation tools. Here, we review examples of research from current SRP grantees that address many of these issues. In 2004, the first official Central and Eastern European Conference on Health and the Environment (CEECHE) was held, and has been held biannually at venues across CEE. The CEECHE provides a forum for researchers and engineers, and organizations with diverse professional expertise and backgrounds, to jointly examine pressing environment and health issues, engage in cooperative research, and develop and disseminate innovative prevention strategies for addressing these issues. The CEECHE facilitates more intentional integration of disciplines to achieve a fundamental understanding of biological, environmental, and engineering processes and exploit this knowledge to contribute to solving environmental exposure-related issues. Critical to the CEECHE mission is the participation of trainees and junior scientists who will share their data and engage broadly with the scientific community. Scientific inquiry that supports a paradigm whereby knowledge gained through understanding disease processes resulting from environmental exposures would further our understanding of potential human health effects, and provide a creative, holistic approach to integrate seemingly discrete biological systems and geological, ecological and human health risk assessments into more comprehensive models. Such models will be discussed which advance the mission of reducing the public health burden of hazardous substances through interdisciplinary research and training.
[Mh] Termos MeSH primário: Exposição Ambiental/prevenção & controle
Saúde Ambiental
Substâncias Perigosas/toxicidade
Medição de Risco
[Mh] Termos MeSH secundário: Europa (Continente)
Europa Oriental
Seres Humanos
National Institute of Environmental Health Sciences (U.S.)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


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[PMID]:27899110
[Au] Autor:Lichtveld M; Goldstein B; Grattan L; Mundorf C
[Ad] Endereço:Department of Global Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
[Ti] Título:Then and now: lessons learned from community- academic partnerships in environmental health research.
[So] Source:Environ Health;15(1):117, 2016 Nov 29.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:On the occasion of the 50 anniversary of the National Institutes of Environmental Health Sciences we reflect on how environmental research incorporating community members as active partners has evolved, benefited communities and advanced environmental health research. We highlight the commitment to community partnerships in the aftermath of the 2010 Deep Water Horizon Oil Spill, and how that commitment helped improve science. We provide examples of community-academic partnerships across the engagement spectrum. Finally, we offer suggestions to improve the community engagement in order to cultivate more long partnerships and better scientific research.
[Mh] Termos MeSH primário: Pesquisa Participativa Baseada na Comunidade
Saúde Ambiental
[Mh] Termos MeSH secundário: Desastres
Seres Humanos
National Institute of Environmental Health Sciences (U.S.)
Estados Unidos
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE


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[PMID]:27668911
[Au] Autor:Antony VB; Redlich CA; Pinkerton KE; Balmes J; Harkema JR
[Ad] Endereço:1 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
[Ti] Título:National Institute of Environmental Health Sciences: 50 Years of Advancing Science and Improving Lung Health.
[So] Source:Am J Respir Crit Care Med;194(10):1190-1195, 2016 Nov 15.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The American Thoracic Society celebrates the 50th anniversary of the National Institute of Environmental Health Sciences (NIEHS). The NIEHS has had enormous impact through its focus on research, training, and translational science on lung health. It has been an advocate for clean air both in the United States and across the world. The cutting-edge science funded by the NIEHS has led to major discoveries that have broadened our understanding of the pathogenesis and treatment for lung disease. Importantly, the NIEHS has developed and fostered mechanisms that require cross-cutting science across the spectrum of areas of inquiry, bringing together environmental and social scientists with clinicians to bring their expertise on specific areas of investigation. The intramural program of the NIEHS nurtures cutting-edge science, and the extramural program encourages investigator-initiated research while at the same time providing broader direction through important initiatives. Under the umbrella of the NIEHS and guided by Dr. Linda Birnbaum, the director of the NIEHS, important collaborative programs, such as the Superfund Program and the National Toxicology Program, work to discover mechanisms to protect from environmental toxins. The American Thoracic Society has overlapping goals with the NIEHS, and the strategic plans of both august bodies converge to synergize on population lung health. These bonds must be tightened and highlighted as we work toward our common goals.
[Mh] Termos MeSH primário: Saúde Ambiental/métodos
Pneumopatias/prevenção & controle
Pulmão/fisiologia
National Institute of Environmental Health Sciences (U.S.)
[Mh] Termos MeSH secundário: Seres Humanos
Pesquisa Médica Translacional
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


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[PMID]:27384574
[Au] Autor:Miller A; Yeskey K; Garantziotis S; Arnesen S; Bennett A; O'Fallon L; Thompson C; Reinlib L; Masten S; Remington J; Love C; Ramsey S; Rosselli R; Galluzzo B; Lee J; Kwok R; Hughes J
[Ad] Endereço:National Institute of Environmental Health Sciences, Bethesda, MD 20892, USA. miller.aubrey@nih.gov.
[Ti] Título:Integrating Health Research into Disaster Response: The New NIH Disaster Research Response Program.
[So] Source:Int J Environ Res Public Health;13(7), 2016 Jul 04.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The need for high quality and timely disaster research has been a topic of great discussion over the past several years. Recent high profile incidents have exposed gaps in knowledge about the health impacts of disasters or the benefits of specific interventions-such was the case with the 2010 Gulf Oil Spill and recent events associated with lead-contaminated drinking water in Flint, Michigan, and the evolving health crisis related to Zika virus disease. Our inability to perform timely research to inform the community about health and safety risks or address specific concerns further heightens anxiety and distrust. Since nearly all disasters, whether natural or man-made, have an environmental health component, it is critical that specialized research tools and trained researchers be readily available to evaluate complex exposures and health effects, especially for vulnerable sub-populations such as the elderly, children, pregnant women, and those with socioeconomic and environmental disparities. In response, the National Institute of Environmental Health Science has initiated a Disaster Research Response Program to create new tools, protocols, networks of researchers, training exercises, and outreach involving diverse groups of stakeholders to help overcome the challenges of disaster research and to improve our ability to collect vital information to reduce the adverse health impacts and improve future preparedness.
[Mh] Termos MeSH primário: Pesquisa Biomédica
Planejamento em Desastres/métodos
[Mh] Termos MeSH secundário: Desastres
National Institute of Environmental Health Sciences (U.S.)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE


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[PMID]:27035154
[Au] Autor:Birnbaum LS; Burke TA; Jones JJ
[Ad] Endereço:Office of the Director, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
[Ti] Título:Informing 21st-Century Risk Assessments with 21st-Century Science.
[So] Source:Environ Health Perspect;124(4):A60-3, 2016 Apr.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding and preventing adverse impacts from chemicals in the environment is fundamental to protecting public health, and chemical risk assessments are used to inform public health decisions in the United States and around the world. Traditional chemical risk assessments focus on health effects of environmental contaminants on a chemical-by-chemical basis, largely based on data from animal models using exposures that are typically higher than those experienced by humans. Results from environmental epidemiology studies sometimes show effects that are not observed in animal studies at human exposure levels that are lower than those used in animal studies. In addition, new approaches such as Toxicology in the 21st Century (Tox21) and exposure forecasting (ExpoCast) are generating mechanistic data that provide broad coverage of chemical space, chemical mixtures, and potential associated health outcomes, along with improved exposure estimates. It is becoming clear that risk assessments in the future will need to use the full range of available mechanistic, animal, and human data to integrate multiple types of data and to consider nontraditional health outcomes and end points. This perspective was developed at the "Strengthening the Scientific Basis of Chemical Safety Assessments" workshop, which was cosponsored by the U.S. Environmental Protection Agency and the National Institute of Environmental Health Sciences, where gaps between the emerging science and traditional chemical risk assessments were explored, and approaches for bridging the gaps were considered.
[Mh] Termos MeSH primário: Poluentes Ambientais/toxicidade
Medição de Risco/métodos
Toxicologia/métodos
[Mh] Termos MeSH secundário: Animais
Biologia Computacional/métodos
Exposição Ambiental/efeitos adversos
Saúde Ambiental
Previsões
Seres Humanos
National Institute of Environmental Health Sciences (U.S.)
Estados Unidos
United States Environmental Protection Agency
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE
[do] DOI:10.1289/ehp.1511135



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