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[PMID]:28576567
[Au] Autor:Callahan A; Anderson KD; Beattie MS; Bixby JL; Ferguson AR; Fouad K; Jakeman LB; Nielson JL; Popovich PG; Schwab JM; Lemmon VP; FAIR Share Workshop Participants
[Ad] Endereço:Stanford Center for Biomedical Informatics Research, Stanford University, Stanford 94305, CA, USA. Electronic address: acallaha@stanford.edu.
[Ti] Título:Developing a data sharing community for spinal cord injury research.
[So] Source:Exp Neurol;295:135-143, 2017 Sep.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The rapid growth in data sharing presents new opportunities across the spectrum of biomedical research. Global efforts are underway to develop practical guidance for implementation of data sharing and open data resources. These include the recent recommendation of 'FAIR Data Principles', which assert that if data is to have broad scientific value, then digital representations of that data should be Findable, Accessible, Interoperable and Reusable (FAIR). The spinal cord injury (SCI) research field has a long history of collaborative initiatives that include sharing of preclinical research models and outcome measures. In addition, new tools and resources are being developed by the SCI research community to enhance opportunities for data sharing and access. With this in mind, the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH) hosted a workshop on October 5-6, 2016 in Bethesda, MD, in collaboration with the Open Data Commons for Spinal Cord Injury (ODC-SCI) titled "Preclinical SCI Data: Creating a FAIR Share Community". Workshop invitees were nominated by the workshop steering committee (co-chairs: ARF and VPL; members: AC, KDA, MSB, KF, LBJ, PGP, JMS), to bring together junior and senior level experts including preclinical and basic SCI researchers from academia and industry, data science and bioinformatics experts, investigators with expertise in other neurological disease fields, clinical researchers, members of the SCI community, and program staff representing federal and private funding agencies. The workshop and ODC-SCI efforts were sponsored by the International Spinal Research Trust (ISRT), the Rick Hansen Institute, Wings for Life, the Craig H. Neilsen Foundation and NINDS. The number of attendees was limited to ensure active participation and feedback in small groups. The goals were to examine the current landscape for data sharing in SCI research and provide a path to its future. Below are highlights from the workshop, including perspectives on the value of data sharing in SCI research, workshop participant perspectives and concerns, descriptions of existing resources and actionable directions for further engaging the SCI research community in a model that may be applicable to many other areas of neuroscience. This manuscript is intended to share these initial findings with the broader research community, and to provide talking points for continued feedback from the SCI field, as it continues to move forward in the age of data sharing.
[Mh] Termos MeSH primário: Disseminação de Informação
Pesquisa
Traumatismos da Medula Espinal/terapia
[Mh] Termos MeSH secundário: Seres Humanos
National Institute of Neurological Disorders and Stroke (USA)
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28303425
[Au] Autor:Karaa A; Rahman S; Lombès A; Yu-Wai-Man P; Sheikh MK; Alai-Hansen S; Cohen BH; Dimmock D; Emrick L; Falk MJ; McCormack S; Mirsky D; Moore T; Parikh S; Shoffner J; Taivassalo T; Tarnopolsky M; Tein I; Odenkirchen JC; Goldstein A; Mito Working Group Member Participants:
[Ad] Endereço:Massachusetts General Hospital, Boston, MA, USA.
[Ti] Título:Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project.
[So] Source:J Inherit Metab Dis;40(3):403-414, 2017 May.
[Is] ISSN:1573-2665
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The common data elements (CDE) project was developed by the National Institute of Neurological Disorders and Stroke (NINDS) to provide clinical researchers with tools to improve data quality and allow for harmonization of data collected in different research studies. CDEs have been created for several neurological diseases; the aim of this project was to develop CDEs specifically curated for mitochondrial disease (Mito) to enhance clinical research. METHODS: Nine working groups (WGs), composed of international mitochondrial disease experts, provided recommendations for Mito clinical research. They initially reviewed existing NINDS CDEs and instruments, and developed new data elements or instruments when needed. Recommendations were organized, internally reviewed by the Mito WGs, and posted online for external public comment for a period of eight weeks. The final version was again reviewed by all WGs and the NINDS CDE team prior to posting for public use. RESULTS: The NINDS Mito CDEs and supporting documents are publicly available on the NINDS CDE website ( https://commondataelements.ninds.nih.gov/ ), organized into domain categories such as Participant/Subject Characteristics, Assessments, and Examinations. CONCLUSION: We developed a comprehensive set of CDE recommendations, data definitions, case report forms (CRFs), and guidelines for use in Mito clinical research. The widespread use of CDEs is intended to enhance Mito clinical research endeavors, including natural history studies, clinical trial design, and data sharing. Ongoing international collaboration will facilitate regular review, updates and online publication of Mito CDEs, and support improved consistency of data collection and reporting.
[Mh] Termos MeSH primário: Elementos de Dados Comuns/normas
Doenças Mitocondriais/patologia
Doenças do Sistema Nervoso/patologia
Acidente Vascular Cerebral/patologia
[Mh] Termos MeSH secundário: Pesquisa Biomédica/normas
Coleta de Dados/normas
Seres Humanos
National Institute of Neurological Disorders and Stroke (USA)
Projetos de Pesquisa/normas
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1007/s10545-017-0035-5


  3 / 112 MEDLINE  
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[PMID]:27845358
[Au] Autor:Mulcahey MJ; Vogel LC; Sheikh M; Arango-Lasprilla JC; Augutis M; Garner E; Hagen EM; Jakeman LB; Kelly E; Martin R; Odenkirchen J; Scheel-Sailer A; Schottler J; Taylor H; Thielen CC; Zebracki K
[Ad] Endereço:Department of Occupational Therapy, Jefferson College of Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.
[Ti] Título:Recommendations for the National Institute for Neurologic Disorders and Stroke spinal cord injury common data elements for children and youth with SCI.
[So] Source:Spinal Cord;55(4):331-340, 2017 Apr.
[Is] ISSN:1476-5624
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:STUDY DESIGN: In 2014, the adult spinal cord injury (SCI) common data element (CDE) recommendations were made available. This project was a review of the adult SCI CDE for relevance to children and youth with SCI. OBJECTIVES: The objective of this study was to review the National Institute of Neurologic Disorders and Stroke (NINDS) adult SCI CDEs for relevance to children and youth with SCI. SETTING: International. METHODS: The pediatric working group consisted of international members with varied fields of expertise related to pediatric SCI. The group convened biweekly meetings for 6 months in 2015. All of the adult SCI CDEs were reviewed, evaluated and modified/created for four age groups: 0-5 years, 6-12 years, 13-15 years and 16-18 years. Whenever possible, results of published research studies were used to guide recommendations. In the absence of empirical support, grey literature and international content expert consensus were garnered. Existing pediatric NINDS CDEs and new CDEs were developed in areas where adult recommendations were not appropriate. After internal working group review of domain recommendations, these pediatric CDEs were vetted during a public review from November through December 2015. RESULTS: Version 1.0 of the pediatric SCI CDEs was posted in February 2016. CONCLUSION: The pediatric SCI CDEs are incorporated directly into the NINDS SCI CDE sets and can be found at https://commondataelements.ninds.nih.gov.
[Mh] Termos MeSH primário: Elementos de Dados Comuns
Traumatismos da Medula Espinal
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Seres Humanos
Lactente
Recém-Nascido
National Institute of Neurological Disorders and Stroke (USA)
Traumatismos da Medula Espinal/diagnóstico
Traumatismos da Medula Espinal/epidemiologia
Traumatismos da Medula Espinal/terapia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE
[do] DOI:10.1038/sc.2016.139


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[PMID]:28269839
[Au] Autor:Cui L; Huang Y; Tao S; Lhatoo SD; Zhang GQ
[Ad] Endereço:Institute of Biomedical Informatics, University of Kentucky, Lexington, KY; Department of Computer Science, University of Kentucky, Lexington, KY; Center for SUDEP Research (NINDS-funded Center Without Walls for Collaborative Research in the Epilepsies), Cleveland, OH.
[Ti] Título:ODaCCI: Ontology-guided Data Curation for Multisite Clinical Research Data Integration in the NINDS Center for SUDEP Research.
[So] Source:AMIA Annu Symp Proc;2016:441-450, 2016.
[Is] ISSN:1942-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sudden Unexpected Death in Epilepsy (SUDEP) is the leading mode of epilepsy-related death. The Center for SUDEP Research (CSR) is an NINDS-funded Center Without Wall's initiative aimed at prospectively creating a comprehensive clinical research resource for SUDEP. This resource consists of a growing set of data and biological samples of a statistically significant cohort of patients at an elevated risk, best represented by the Epilepsy Monitoring Unit (EMU) patient population. The Informatics and Data Analytics Core (IDAC) of CSR has developed a state-of-the- art informatics infrastructure, to integrate patient data captured in multiple EMU's at a greatly accelerated pace. Data quality assurance is a priority of IDAC. This paper reports our approach, Ontology-guided Data Curation for Multisite Clinical Research Data Integration (ODaCCI), to address the challenging task of centralized data curation while new data is continuously generated and integrated from distributed sites. ODaCCI leverages the Epilepsy and Seizure Ontology not only for upstream data capture, but also for supporting a range of quality assurance tasks such as data quality monitoring, data update, and data reports. Between October 2014 and February 2016, ODaCCI has integrated phenotypic and electroencephalogram signal data of 629 patients from 7 clinical sites, while supporting continuous and asynchronous data quality enhancement overtime.
[Mh] Termos MeSH primário: Pesquisa Biomédica
Curadoria de Dados
Morte Súbita
Epilepsia
[Mh] Termos MeSH secundário: Ontologias Biológicas
Morte Súbita/epidemiologia
Morte Súbita/etiologia
Eletroencefalografia
Epilepsia/mortalidade
Seres Humanos
Monitorização Fisiológica
National Institute of Neurological Disorders and Stroke (USA)
Garantia da Qualidade dos Cuidados de Saúde
Fatores de Risco
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


  5 / 112 MEDLINE  
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[PMID]:26825352
[Au] Autor:Balucani C; Levine SR; Khoury JC; Khatri P; Saver JL; Broderick JP
[Ad] Endereço:Downstate Medical Center, The State University of New York, Brooklyn, New York. Electronic address: clotilde.balucani@downstate.edu.
[Ti] Título:Acute Ischemic Stroke with Very Early Clinical Improvement: A National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trials Exploratory Analysis.
[So] Source:J Stroke Cerebrovasc Dis;25(4):894-901, 2016 Apr.
[Is] ISSN:1532-8511
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A high proportion of patients excluded from recombinant tissue plasminogen activator (rt-PA) treatment because of rapid improvement occurring before treatment decision had incomplete recovery. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Trials dataset allows for systematic analyses of very early postrandomization improvement (VEPRIM) in stroke severity as a National Institutes of Health Stroke Scale (NIHSS) score was available for all subjects enrolled in the study at baseline (NIHSSB) and at 2 hours after randomization (NIHSS2H). We explored various definitions of VEPRIM to characterize predictive values for clinical outcomes. METHODS: Post hoc analyses of the NINDS rt-PA Stroke Trials were conducted. VEPRIM was defined as the difference between the NIHSSB and the NIHSS2H scores using 3 approaches: raw, percent, and normalized change. We assessed the association between VEPRIM and 3-month favorable outcome (mRS score of 0-1), symptomatic intracerebral hemorrhage (sICH), and death. RESULTS: In the 624 subjects, every VEPRIM definition was independently associated with an increased probability of favorable outcome: for each unit of change within the VEPRIM definitions, there were 2%-24% (all P < .05) relative increased probability of favorable outcome, 2%-15% (all P < .05) decreased likelihood of death, and 2%-13% (all P < .05) decreased likelihood of sICH. Adjusting for NIHSSB and prestroke mRS scores, there was a significant rt-PA treatment effect for improvement seen for all 3 VEPRIM definitions. CONCLUSIONS: VEPRIM predicted favorable outcomes independent of definition and treatment arm. Patients with VEPRIM by any definition, while doing better than patients without VEPRIM, also derived increased clinical benefit when treated with rt-PA compared to placebo. Even with VEPRIM, a substantial percentage of patients had unfavorable outcomes.
[Mh] Termos MeSH primário: Fibrinolíticos/uso terapêutico
Avaliação de Resultados (Cuidados de Saúde)/métodos
Avaliação de Resultados (Cuidados de Saúde)/normas
Acidente Vascular Cerebral/tratamento farmacológico
Ativador de Plasminogênio Tecidual/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Área Sob a Curva
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
National Institute of Neurological Disorders and Stroke (USA)/normas
Índice de Gravidade de Doença
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Fibrinolytic Agents); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160131
[St] Status:MEDLINE


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[PMID]:26814236
[Au] Autor:Mott M; Janis S; Koroshetz WJ
[Ad] Endereço:From the National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
[Ti] Título:StrokeNet Takes Off: National Institute of Neurological Disorders and Stroke Organizational Update.
[So] Source:Stroke;47(3):e51-2, 2016 Mar.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto
Serviços de Informação/organização & administração
National Institute of Neurological Disorders and Stroke (USA)/organização & administração
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto/métodos
Seres Humanos
Serviços de Informação/tendências
National Institute of Neurological Disorders and Stroke (USA)/tendências
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/terapia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160128
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.115.012063


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[PMID]:26810152
[Au] Autor:Carandang RA
[Ad] Endereço:Departments of Neurology, Anesthesiology, and Surgery, University of Massachusetts Medical School, Worcester2Departments of Neurology, Anesthesiology, and Surgery, UMass Memorial Medical Center, Worcester, Massachusetts.
[Ti] Título:Thirty Years After the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Trial: A New Era for Stroke Therapy.
[So] Source:JAMA Neurol;73(3):265-7, 2016 Mar.
[Is] ISSN:2168-6157
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: National Institute of Neurological Disorders and Stroke (USA)
Ativador de Plasminogênio Tecidual/uso terapêutico
[Mh] Termos MeSH secundário: Isquemia Encefálica/tratamento farmacológico
Fibrinolíticos/uso terapêutico
Seres Humanos
Proteínas Recombinantes
Acidente Vascular Cerebral/tratamento farmacológico
Terapia Trombolítica
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Fibrinolytic Agents); 0 (Recombinant Proteins); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE
[do] DOI:10.1001/jamaneurol.2015.4453


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Registro de Ensaios Clínicos
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[PMID]:26751506
[Au] Autor:Wills AM; Pérez A; Wang J; Su X; Morgan J; Rajan SS; Leehey MA; Pontone GM; Chou KL; Umeh C; Mari Z; Boyd J; NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators
[Ad] Endereço:Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.
[Ti] Título:Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.
[So] Source:JAMA Neurol;73(3):321-8, 2016 Mar.
[Is] ISSN:2168-6157
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: Greater body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) is associated with improved survival among persons with Huntington disease or amyotrophic lateral sclerosis. Weight loss is common among persons with Parkinson disease (PD) and is associated with worse quality of life. OBJECTIVE: To explore the association between change in BMI, Unified Parkinson's Disease Rating Scale (UPDRS) motor and total scores, and survival among persons with PD and to test whether there is a positive association between BMI at randomization and survival. DESIGN, SETTING, AND PARTICIPANTS: Secondary analysis (from May 27, 2014, to October 13, 2015) of longitudinal data (3-6 years) from 1673 participants who started the National Institute of Neurological Disorders and Stroke Exploratory Trials in PD Long-term Study-1 (NET-PD LS-1). This was a double-blind randomized placebo-controlled clinical trial of creatine monohydrate (10 g/d) that was performed at 45 sites throughout the United States and Canada. Participants with early (within 5 years of diagnosis) and treated (receiving dopaminergic therapy) PD were enrolled from March 2007 to May 2010 and followed up until September 2013. MAIN OUTCOMES AND MEASURES: Change across time in motor UPDRS score, change across time in total UPDRS score, and time to death. Generalized linear mixed models were used to estimate the effect of BMI on the change in motor and total UPDRS scores after controlling for covariates. Survival was analyzed using Cox proportional hazards models of time to death. A participant's BMI was measured at randomization, and BMI trajectory groups were classified according to whether participants experienced weight loss ("decreasing BMI"), weight stability ("stable BMI"), or weight gain ("increasing BMI") during the study. RESULTS: Of the 1673 participants (mean [SD] age, 61.7 [9.6] years; 1074 [64.2%] were male), 158 (9.4%) experienced weight loss (decreasing BMI), whereas 233 (13.9%) experienced weight gain (increasing BMI). After adjusting for covariates, we found that the weight-loss group's mean (SE) motor UPDRS score increased by 1.48 (0.28) (P < .001) more points per visit than the weight-stable group's mean (SE) motor UPDRS score. The weight-gain group's mean (SE) motor UPDRS score decreased by -0.51 (0.24) (P = .03) points per visit, relative to the weight-stable group. While there was an unadjusted difference in survival between the 3 BMI trajectory groups (log-rank P < .001), this was not significant after adjusting for covariates. CONCLUSIONS AND RELEVANCE: Change in BMI was inversely associated with change in motor and total UPDRS scores in the NET-PD LS-1. Change in BMI was not associated with survival; however, these results were limited by the low number of deaths in the NET-PD LS-1. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00449865.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Progressão da Doença
Doença de Parkinson/mortalidade
Doença de Parkinson/fisiopatologia
Índice de Gravidade de Doença
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
National Institute of Neurological Disorders and Stroke (USA)
Ensaios Clínicos Controlados Aleatórios como Assunto
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160112
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jamaneurol.2015.4265


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[PMID]:26715457
[Au] Autor:Broderick JP; Palesch YY; Janis LS; National Institutes of Health StrokeNet Investigators
[Ad] Endereço:From the Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, OH (J.P.B.); Department of Public Health Sciences, Medical University of South Carolina, Charleston (Y.Y.P); and the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (L.S.J.). joseph.broderick@uc.edu.
[Ti] Título:The National Institutes of Health StrokeNet: A User's Guide.
[So] Source:Stroke;47(2):301-3, 2016 Feb.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa Biomédica/organização & administração
Comportamento Cooperativo
Acidente Vascular Cerebral/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Sistemas de Informação
National Institute of Neurological Disorders and Stroke (USA)
National Institutes of Health (U.S.)
Projetos de Pesquisa
Estados Unidos
[Pt] Tipo de publicação:EDITORIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151231
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.115.011743


  10 / 112 MEDLINE  
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PubMed Central Texto completo
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[PMID]:26667418
[Au] Autor:McKee AC; Cairns NJ; Dickson DW; Folkerth RD; Keene CD; Litvan I; Perl DP; Stein TD; Vonsattel JP; Stewart W; Tripodis Y; Crary JF; Bieniek KF; Dams-O'Connor K; Alvarez VE; Gordon WA; TBI/CTE group
[Ad] Endereço:Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA. amckee@bu.edu.
[Ti] Título:The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
[So] Source:Acta Neuropathol;131(1):75-86, 2016 Jan.
[Is] ISSN:1432-0533
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed by post-mortem examination of brain tissue. As the first part of a series of consensus panels funded by the NINDS/NIBIB to define the neuropathological criteria for CTE, preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer's disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam. The results demonstrated that there was good agreement among the neuropathologists who reviewed the cases (Cohen's kappa, 0.67) and even better agreement between reviewers and the diagnosis of CTE (Cohen's kappa, 0.78). Based on these results, the panel defined the pathognomonic lesion of CTE as an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern. The group also defined supportive but non-specific p-tau-immunoreactive features of CTE as: pretangles and NFTs affecting superficial layers (layers II-III) of cerebral cortex; pretangles, NFTs or extracellular tangles in CA2 and pretangles and proximal dendritic swellings in CA4 of the hippocampus; neuronal and astrocytic aggregates in subcortical nuclei; thorn-shaped astrocytes at the glial limitans of the subpial and periventricular regions; and large grain-like and dot-like structures. Supportive non-p-tau pathologies include TDP-43 immunoreactive neuronal cytoplasmic inclusions and dot-like structures in the hippocampus, anteromedial temporal cortex and amygdala. The panel also recommended a minimum blocking and staining scheme for pathological evaluation and made recommendations for future study. This study provides the first step towards the development of validated neuropathological criteria for CTE and will pave the way towards future clinical and mechanistic studies.
[Mh] Termos MeSH primário: Lesão Encefálica Crônica/diagnóstico
Emaranhados Neurofibrilares/patologia
[Mh] Termos MeSH secundário: Doença de Alzheimer/patologia
Autopsia
Lesão Encefálica Crônica/fisiopatologia
Seres Humanos
National Institute of Biomedical Imaging and Bioengineering (U.S.)
National Institute of Neurological Disorders and Stroke (USA)
Neurônios/patologia
Tauopatias/patologia
Estados Unidos
Proteínas tau/metabolismo
[Pt] Tipo de publicação:CONSENSUS DEVELOPMENT CONFERENCE, NIH; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (tau Proteins)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151216
[St] Status:MEDLINE
[do] DOI:10.1007/s00401-015-1515-z



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