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[PMID]:27779623
[Au] Autor:Rincón-Cortés M; Sullivan RM
[Ad] Endereço:Department of Child and Adolescent Psychiatry, Child Study Center, New York University Langone Medical Center, New York, NY, USA.
[Ti] Título:Emergence of social behavior deficit, blunted corticolimbic activity and adult depression-like behavior in a rodent model of maternal maltreatment.
[So] Source:Transl Psychiatry;6(10):e930, 2016 10 25.
[Is] ISSN:2158-3188
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Disrupted social behavior is a core symptom of multiple psychiatric and neurodevelopmental disorders. Many of these disorders are exacerbated by adverse infant experiences, including maltreatment and abuse, which negatively affect amygdala development. Although a link between impaired social behavior, abnormal amygdala function and depressive-like behavior following early adversity has been demonstrated in humans and animal models, the developmental emergence of maltreatment-related social deficits and associated amygdala neural activity are unknown. We used a naturalistic rodent model of maternal maltreatment during a sensitive period, postnatal days 8-12 (PN8-12), which produces social behavior deficits that precede adolescent depressive-like behavior and amygdala dysfunction, to examine social behavior in infancy, periweaning and adolescence. Neural activity in response to the social behavior test was assessed via c-Fos immunohistochemistry at these ages. A separate group of animals was tested for adult depressive-like behavior in the forced swim test. Maltreatment spared infant (PN16-18) social behavior but disrupted periweaning (PN20-22) and adolescent (PN42-48) social behavior. Maltreated rats exhibited blunted neural activation in the amygdala and other areas implicated in social functioning, including the medial prefrontal cortex and nucleus accumbens, at these ages and increased adult depressive-like behavior. These findings may suggest corticolimbic involvement in the emergence of maltreatment-induced social deficits that are linked to adult depressive-like behavior, thereby highlighting potential targets for therapeutic intervention. Understanding how infant experiences influence social behavior and age-specific expression across development may provide insights into basic neural mechanisms of social behaviors and disease-relevant social dysfunction exacerbated by early-life stress.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/fisiopatologia
Córtex Cerebral/fisiopatologia
Transtorno Depressivo/fisiopatologia
Modelos Animais de Doenças
Acontecimentos que Mudam a Vida
Transtornos do Comportamento Social/fisiopatologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Feminino
Expressão Gênica/genética
Masculino
Proteínas Proto-Oncogênicas c-fos/genética
Ratos
Ratos Long-Evans
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-fos)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1038/tp.2016.205


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[PMID]:28747197
[Au] Autor:Lim YH; Bae S; Kim BN; Shin CH; Lee YA; Kim JI; Hong YC
[Ad] Endereço:Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
[Ti] Título:Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children.
[So] Source:Environ Health;16(1):79, 2017 07 26.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring. We investigated the association between prenatal and postnatal exposure to BPA and social impairments in a sample of 4-year-old children. METHODS: We recruited second-trimester pregnant women between 2008 and 2011, and measured their creatinine-adjusted prenatal urine BPA levels. In 2014-2015, a subset of 4-year-old children born to these women underwent neurobehavioral assessment and physical examination. We collected urine and blood from the children and assessed social impairments, including deficits in social interaction, social communication, and other behavior patterns using the Korean version of the Social Communication Questionnaire (K-SCQ) (n = 304). We examined social impairments associated with prenatal exposure at mid-term pregnancy and postnatal exposure to BPA at 4 years of age, using linear and piecewise linear regression models. RESULTS: The relationship between prenatal BPA exposure and social communication was non-linear and statistically significant at or above the flexion point for BPA levels of 3.0 µg/g creatinine in girls (58.4%, 95% confidence interval [CI], 6.5% to 135.8%). Each 2-fold increase in postnatal BPA exposure was significantly associated with an 11.8% (95% CI, 0.6% to 24.3%) increase in impairment in social communication in 4-year old girls, as indicated by the linear regression model. CONCLUSION: Prenatal and postnatal BPA exposure is associated with social impairment at 4 years of age, particularly in girls.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/metabolismo
Disruptores Endócrinos/metabolismo
Exposição Ambiental
Poluentes Ambientais/metabolismo
Fenóis/metabolismo
Efeitos Tardios da Exposição Pré-Natal/epidemiologia
Transtornos do Comportamento Social/epidemiologia
[Mh] Termos MeSH secundário: Compostos Benzidrílicos/sangue
Compostos Benzidrílicos/urina
Pré-Escolar
Disruptores Endócrinos/sangue
Disruptores Endócrinos/urina
Poluentes Ambientais/sangue
Poluentes Ambientais/urina
Feminino
Seres Humanos
Masculino
Fenóis/sangue
Fenóis/urina
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Estudos Prospectivos
República da Coreia/epidemiologia
Transtornos do Comportamento Social/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Environmental Pollutants); 0 (Phenols); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-017-0289-2


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[PMID]:28658605
[Au] Autor:Henbid MT; Marks WN; Collins MJ; Cain SM; Snutch TP; Howland JG
[Ad] Endereço:Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
[Ti] Título:Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: Reversal by the T-type calcium channel antagonist Z944.
[So] Source:Exp Neurol;296:16-22, 2017 Oct.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Childhood absence epilepsy (CAE) is associated with interictal co-morbid symptoms including abnormalities in social behaviour. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a model of CAE that exhibits physiological and behavioural alterations characteristic of the human disorder. However, it is unknown if GAERS display the social deficits often observed in CAE. Sociability in rodents is thought to be mediated by neural circuits densely populated with T-type calcium channels and GAERS contain a missense mutation in the Cav3.2 T-type calcium channel gene. Thus, the objective of this study was to examine the effects of the clinical stage pan-T-type calcium channel blocker, Z944, on sociability behaviour in male and female GAERS and non-epileptic control (NEC) animals. Female GAERS showed reduced sociability in a three-chamber sociability task whereas male GAERS, male NECs, and female NECs all showed a preference for the chamber containing a stranger rat. In drug trials, pre-treatment with 5mg/kg of Z944 normalized sociability in female GAERS. In contrast, female NECs showed impaired sociability following Z944 treatment. Dose-dependent decreases in locomotor activity were noted following Z944 treatment in both strains. Treatment with 10mg/kg of Z944 altered exploration such that only 8 of the 16 rats tested explored both sides of the testing chamber. In those that explored the chamber, significant preference for the stranger rat was observed in GAERS but not NECs. Overall, the data suggest that T-type calcium channels are critical in regulating sociability in both GAERS and NEC animals. Future research should focus on T-type calcium channels in the treatment of sociability deficits observed in disorders such as CAE.
[Mh] Termos MeSH primário: Acetamidas/uso terapêutico
Benzamidas/uso terapêutico
Bloqueadores dos Canais de Cálcio/uso terapêutico
Epilepsia Tipo Ausência/complicações
Transtornos do Comportamento Social/tratamento farmacológico
Transtornos do Comportamento Social/etiologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Canais de Cálcio Tipo T/metabolismo
Modelos Animais de Doenças
Epilepsia Tipo Ausência/genética
Comportamento Exploratório/efeitos dos fármacos
Feminino
Locomoção/efeitos dos fármacos
Locomoção/genética
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetamides); 0 (Benzamides); 0 (Calcium Channel Blockers); 0 (Calcium Channels, T-Type); 0 (Z944 compound)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28596248
[Au] Autor:Saxon JA; Thompson JC; Jones M; Harris JM; Richardson AM; Langheinrich T; Neary D; Mann DM; Snowden JS
[Ad] Endereço:Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.
[Ti] Título:Examining the language and behavioural profile in FTD and ALS-FTD.
[So] Source:J Neurol Neurosurg Psychiatry;88(8):675-680, 2017 Aug.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently unknown whether the behavioural and cognitive syndrome in bvFTD with ALS (ALS-FTD) is indistinguishable from that of bvFTD alone. METHODS: A retrospective cohort of 241 patients with clinical diagnoses of bvFTD (n=185) or ALS-FTD (n=56) was examined with respect to behavioural, cognitive and neuropsychiatric symptoms. Features were rated as present or absent based on information recorded from clinical interviews and detailed neuropsychological assessment. RESULTS: A number of behavioural and affective changes were reported more frequently in bvFTD than ALS-FTD: social disinhibition (p<0.001), inertia (p<0.001), loss of sympathy and empathy (p 0.008), repetitive behaviours (p<0.001) and dietary changes (p<0.001). Warmth of affect demonstrated in the clinic setting was reported more often in ALS-FTD than bvFTD (p<0.001). Executive impairments occurred equally in both groups. Language impairments were more common in ALS-FTD than bvFTD: agrammatism (p<0.017) and impaired sentence comprehension (p<0.036). Psychotic features were relatively rare and did not distinguish the groups. CONCLUSIONS: Our findings suggest differences between bvFTD and ALS-FTD. In particular, while changes in social behaviour are prominent in bvFTD alone, there may be a comparatively greater degree of language impairment in ALS-FTD. Prospective exploration of the pattern of differences between these groups will be essential. Identification of a distinct neuropsychological phenotype in ALS-FTD may have clinical implications for early diagnosis, disease management and care planning and theoretical implications for our understanding of the relationship between ALS and FTD.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/diagnóstico
Demência Frontotemporal/diagnóstico
Transtornos da Linguagem/diagnóstico
Transtornos do Comportamento Social/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Afasia de Broca/diagnóstico
Transtornos da Percepção Auditiva/diagnóstico
Estudos de Coortes
Diagnóstico Diferencial
Progressão da Doença
Diagnóstico Precoce
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos do Humor/diagnóstico
Testes Neuropsicológicos
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2017-315667


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[PMID]:28411125
[Au] Autor:Stoppel DC; Anderson MP
[Ad] Endereço:Departments of Neurology and Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
[Ti] Título:Hypersociability in the Angelman syndrome mouse model.
[So] Source:Exp Neurol;293:137-143, 2017 Jul.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deletions and reciprocal triplications of the human chromosomal 15q11-13 region cause two distinct neurodevelopmental disorders. Maternally-derived deletions or inactivating mutations of UBE3A, a 15q11-13 gene expressed exclusively from the maternal allele in neurons, cause Angelman syndrome, characterized by intellectual disability, motor deficits, seizures, and a characteristic increased social smiling, laughing, and eye contact. Conversely, maternally-derived triplications of 15q11-13 cause a behavioral disorder on the autism spectrum with clinical features that include decreased sociability that we recently reconstituted in mice with Ube3a alone. Based on the unique sociability features reported in Angelman syndrome and the repressed sociability observed when Ube3a gene dosage is increased, we hypothesized that mice with neuronal UBE3A loss that models Angelman syndrome would display evidence of hypersocial behavior. We report that mice with maternally-inherited Ube3a gene deletion (Ube3a ) have a prolonged preference for, and interaction with, social stimuli in the three chamber social approach task. By contrast, interactions with a novel object are reduced. Further, ultrasonic vocalizations and physical contacts are increased in male and female Ube3a mice paired with an unfamiliar genotype-matched female. Single housing wild type mice increased these same social behavior parameters to levels observed in Ube3a mice where this effect was partially occluded. These results indicate sociability is repressed by social experience and the endogenous levels of UBE3A protein and suggest some social behavioral features observed in Angelman syndrome may reflect an increased social motivation.
[Mh] Termos MeSH primário: Síndrome de Angelman/complicações
Transtornos do Comportamento Social/etiologia
Ubiquitina-Proteína Ligases/deficiência
[Mh] Termos MeSH secundário: Análise de Variância
Síndrome de Angelman/genética
Animais
Modelos Animais de Doenças
Comportamento Exploratório/fisiologia
Feminino
Masculino
Camundongos
Camundongos Knockout
Atividade Motora/genética
Fatores de Tempo
Ubiquitina-Proteína Ligases/genética
Vocalização Animal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.3.2.26 (Ube3a protein, mouse); EC 2.3.2.27 (Ubiquitin-Protein Ligases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


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[PMID]:28401833
[Au] Autor:Kobak R; Zajac K; Abbott C; Zisk A; Bounoua N
[Ad] Endereço:University of Delaware.
[Ti] Título:Atypical dimensions of caregiver-adolescent interaction in an economically disadvantaged sample.
[So] Source:Dev Psychopathol;29(2):405-416, 2017 May.
[Is] ISSN:1469-2198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Goal-Corrected Partnership Adolescent Coding System (GPACS) has shown promise in assessing a secure as well as three atypical patterns of parent-adolescent interaction during a conflict discussion. The current study of 186 economically disadvantaged families examines the degree to which four GPACS patterns: secure/collaborative, hostile/punitive, role confused, and disoriented, prospectively predict adolescents' social competence and maladaptive behavior (internalizing, externalizing, and risk behaviors) at age 15 years after controlling for these social behaviors at age 13 years and contemporaneous GPACS scores. Adolescents from secure/collaborative dyads at age 13 were more likely to have a secure state of mind in the Adult Attachment Interview at age 15 and showed higher levels of teachers' ratings of empathy and lower levels of teachers' ratings of externalizing behaviors at age 15 years. Adolescents in disoriented dyads showed higher levels of teacher-rated internalizing problems, while male adolescents in role confused dyads reported higher levels of involvement in risk behaviors, including unprotected sexual activity and substance use problems.
[Mh] Termos MeSH primário: Relações Pais-Filho
Pobreza/psicologia
Transtorno Reativo de Vinculação na Infância/diagnóstico
Transtorno Reativo de Vinculação na Infância/psicologia
Transtornos do Comportamento Social/diagnóstico
Transtornos do Comportamento Social/psicologia
Populações Vulneráveis/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Empatia
Feminino
Seres Humanos
Controle Interno-Externo
Entrevista Psicológica
Estudos Longitudinais
Masculino
Determinação da Personalidade/estatística & dados numéricos
Psicometria
Assunção de Riscos
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1017/S0954579417000074


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[PMID]:28396361
[Au] Autor:Esopenko C; Chow TW; Tartaglia MC; Bacopulos A; Kumar P; Binns MA; Kennedy JL; Müller DJ; Levine B
[Ad] Endereço:Baycrest Health Sciences, Rotman Research Institute, Toronto, Canada.
[Ti] Título:Cognitive and psychosocial function in retired professional hockey players.
[So] Source:J Neurol Neurosurg Psychiatry;88(6):512-519, 2017 Jun.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: The relationship between repeated concussions and neurodegenerative disease has received significant attention, particularly research in postmortem samples. Our objective was to characterise retired professional ice hockey players' cognitive and psychosocial functioning in relation to concussion exposure and apolipoprotein ε4 status. METHODS: Alumni athletes (N=33, aged 34-71 years) and an age-matched sample of comparison participants (N=18) were administered measures of cognitive function and questionnaires concerning psychosocial and psychiatric functioning. RESULTS: No significant group differences were found on neuropsychological measures of speeded attention, verbal memory or visuospatial functions, nor were significant differences observed on computerised measures of response speed, inhibitory control and visuospatial problem solving. Reliable group differences in cognitive performance were observed on tests of executive and intellectual function; performance on these measures was associated with concussion exposure. Group differences were observed for cognitive, affective and behavioural impairment on psychosocial questionnaires and psychiatric diagnoses. There was no evidence of differential effects associated with age in the alumni athletes. Possession of an apolipoprotein ε4 allele was associated with increased endorsement of psychiatric complaints, but not with objective cognitive performance. CONCLUSIONS: We found only subtle objective cognitive impairment in alumni athletes in the context of high subjective complaints and psychiatric impairment. Apolipoprotein ε4 status related to psychiatric, but not cognitive status. These findings provide benchmarks for the degree of cognitive and behavioural impairment in retired professional athletes and a point of comparison for future neuroimaging and longitudinal studies.
[Mh] Termos MeSH primário: Traumatismos em Atletas/diagnóstico
Traumatismos em Atletas/psicologia
Concussão Encefálica/diagnóstico
Concussão Encefálica/psicologia
Transtornos Cognitivos/diagnóstico
Transtornos Cognitivos/psicologia
Hóquei/lesões
Transtornos Mentais/diagnóstico
Transtornos Mentais/psicologia
Aposentadoria
Transtornos do Comportamento Social/diagnóstico
Transtornos do Comportamento Social/psicologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Apolipoproteína E4/análise
Traumatismos em Atletas/epidemiologia
Concussão Encefálica/epidemiologia
Transtornos Cognitivos/epidemiologia
Estudos Transversais
Seres Humanos
Masculino
Transtornos Mentais/epidemiologia
Meia-Idade
Testes Neuropsicológicos/estatística & dados numéricos
Psicometria/estatística & dados numéricos
Valores de Referência
Transtornos do Comportamento Social/epidemiologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoprotein E4)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2016-315260


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[PMID]:28320339
[Au] Autor:Kashyap GC; Singh SK
[Ad] Endereço:Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Govandi Station Road, Deonar Mumbai, 400088, India. statskashyap@gmail.com.
[Ti] Título:Reliability and validity of general health questionnaire (GHQ-12) for male tannery workers: a study carried out in Kanpur, India.
[So] Source:BMC Psychiatry;17(1):102, 2017 Mar 21.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study was to test the reliability, validity and factor structure of GHQ-12 questionnaire on male tannery workers of India. We have tested three different factor models of the GHQ-12. METHODS: This paper used primary data obtained from a cross-sectional household study of tannery workers from Jajmau area of the city of Kanpur in northern India, which was conducted during January-June, 2015, as part of a doctoral program. The study covered 286 tannery workers from the study area. An interview schedule containing GHQ-12 was used for tannery workers who had completed at least 1 year at their present occupation preceding the survey. To test reliability, Cronbach's alpha test was used. The convergent test was used for validity. Confirmatory factor analysis was used to compare three factor structures for the GHQ-12. RESULTS: A total of 286 samples were analyzed in this study. The mean age of the tannery workers in this study was 38 years (SD = 1.42). We found the alpha coefficient to be 0.93 for the complete sample. The value of alpha represents the acceptable internal consistency for all the groups. Each item of scale showed almost the same internal consistency of 0.93 for the male tannery workers. The correlation between factor 1 (Anxiety and Depression) and factor 2 (Social Dysfunction) was 0.92. The correlation between factor 1 (Anxiety and Depression) and factor 3 (Loss of confidence) was the highest 0.98. Comparative fit index (CFI) estimate best-fitted for model-III that gave the CFI value 0.97. The SRMR indicator gave the lowest value 0.031 for the model-III. CONCLUSIONS: The findings suggest that the Hindi version of GHQ-12 is a reliable and valid tool for measuring psychological distress in male tannery workers of Kanpur city, India. Study found that the model proposed by the Graetz was the best fitted model for the data.
[Mh] Termos MeSH primário: Transtornos de Ansiedade/diagnóstico
Transtornos de Ansiedade/psicologia
Transtorno Depressivo/diagnóstico
Transtorno Depressivo/psicologia
Países em Desenvolvimento
Doenças Profissionais/diagnóstico
Doenças Profissionais/psicologia
Psicometria/estatística & dados numéricos
Transtornos do Comportamento Social/diagnóstico
Transtornos do Comportamento Social/psicologia
Inquéritos e Questionários
Curtume
[Mh] Termos MeSH secundário: Adulto
Comparação Transcultural
Estudos Transversais
Inquéritos Epidemiológicos
Seres Humanos
Índia
Masculino
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-017-1253-y


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[PMID]:28270464
[Au] Autor:Coffey CA; Brodsky SL; Sams DM
[Ad] Endereço:Mr. Coffey is a Student and Dr. Brodsky is Professor Emeritus and Scholar in Residence, Department of Psychology, The University of Alabama, Tuscaloosa, AL, Mr. Sams is an attorney with the Community Tax Law Project in Richmond, VA. cacoffey1@crimson.ua.edu.
[Ti] Título:I'll See You in Court…Again: Psychopathology and Hyperlitigious Litigants.
[So] Source:J Am Acad Psychiatry Law;45(1):62-71, 2017 Mar.
[Is] ISSN:1943-3662
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Persistent litigation is a problem in many legal jurisdictions and is costly at individual and systemic levels. This phenomenon is referred to as "querulous" behavior in psychiatric literature, whereas legal discourse refers to it as "vexatious litigation." We refer to this phenomenon as "hyperlitigious behavior" and those who engage in these actions as "hyperlitigious litigants." Hyperlitigious litigants and hyperlitigious behavior were once the focus of a considerable amount of psychiatric literature, but research devoted to these topics has declined over the past half century. A review of the published literature on hyperlitigious behavior in European and English-speaking countries highlights geographic differences in the conceptualization and management of this behavior. We provide an alternative framework to consider the motivation to engage in hyperlitigious behavior and suggest three strategies for mental health professionals who interact with these individuals. Finally, we call for a revival of discussions and research within the English-speaking psychiatric community to facilitate more informed decisions regarding the management and treatment of hyperlitigious behavior.
[Mh] Termos MeSH primário: Delusões/psicologia
Jurisprudência
Transtornos Paranoides/psicologia
Transtornos do Comportamento Social/psicologia
[Mh] Termos MeSH secundário: Vítimas de Crime/legislação & jurisprudência
Vítimas de Crime/psicologia
Delusões/diagnóstico
Transtornos Paranoides/diagnóstico
Psicopatologia
Transtornos do Comportamento Social/diagnóstico
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:28258510
[Au] Autor:Zhou B; Zhou H; Wu L; Zou X; Luo X; Fombonne E; Wang Y; Yan W; Xu X
[Ad] Endereço:Department of Child Healthcare, Children's Hospital of Fudan University, Shanghai, 201102, China.
[Ti] Título:Assessing the Accuracy of the Modified Chinese Autism Spectrum Rating Scale and Social Responsiveness Scale for Screening Autism Spectrum Disorder in Chinese Children.
[So] Source:Neurosci Bull;33(2):168-174, 2017 Apr.
[Is] ISSN:1995-8218
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:The reported prevalence of autism spectrum disorder (ASD) has been increasing rapidly in many parts of the world. However, data on its prevalence in China are largely missing. Here, we assessed the suitability of the modified Chinese version of a newly-developed ASD screening tool, the Modified Chinese Autism Spectrum Rating Scales (MC-ASRS) in screening for ASD in Chinese children aged 6-12 years, through comparison with the Social Responsiveness Scale (SRS) that has been widely used for ASD screening. We recruited the parents/caregivers of 1588 typically-developing children and 190 children with ASD aged 6-12 years to complete the MC-ASRS and SRS, and evaluated the validity of both scales in discriminating children with ASD from those developing typically. The results showed that MC-ASRS performed as well as SRS in sensitivity, specificity, and area-under-the-curve (both >0.95) in receiver operating characteristic analysis, with a fair false-negative rate. These results suggest that MC-ASRS is a promising tool for screening for children with ASD in the general Chinese population.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista
Programas de Rastreamento/métodos
Escalas de Graduação Psiquiátrica
Transtornos do Comportamento Social/diagnóstico
Transtornos do Comportamento Social/etiologia
[Mh] Termos MeSH secundário: Fatores Etários
Transtorno do Espectro Autista/complicações
Transtorno do Espectro Autista/diagnóstico
Transtorno do Espectro Autista/psicologia
Criança
China
Feminino
Seres Humanos
Masculino
Programas de Rastreamento/normas
Pais/psicologia
Curva ROC
Estudos Retrospectivos
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1007/s12264-017-0114-5



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