Base de dados : MEDLINE
Pesquisa : I01.880.735.950.500.340 [Categoria DeCS]
Referências encontradas : 939 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 94 ir para página                         

  1 / 939 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29286857
[Au] Autor:Svendsen ER
[Ad] Endereço:1 Medical University of South Carolina Charleston, South Carolina.
[Ti] Título:Chlorine Countermeasures: Supplemental Oxygen Equals Supplemental Lung Injury?
[So] Source:Am J Respir Cell Mol Biol;58(1):10-11, 2018 01.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/toxicidade
Guerra Química
Cloro/toxicidade
Lesão Pulmonar
Oxigênio/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Lesão Pulmonar/induzido quimicamente
Lesão Pulmonar/terapia
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 4R7X1O2820 (Chlorine); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0320ED


  2 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27836314
[Au] Autor:Madar R; Toledano R; Adini B
[Ad] Endereço:Soroka Medical Center, Beer Sheva, Israel; Department of Emergency Medicine, Recanati School of Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
[Ti] Título:Are chemical warfare exercises effective in knowledge retention of hospital personnel?
[So] Source:Am J Emerg Med;35(1):188-189, 2017 Jan.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Guerra Química
Competência Clínica
Recursos Humanos em Hospital
Treinamento por Simulação
Centros de Traumatologia
Lesões Relacionadas à Guerra/terapia
[Mh] Termos MeSH secundário: Pessoal de Saúde
Hospitais
Seres Humanos
Incidentes com Feridos em Massa
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


  3 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27636675
[Au] Autor:Kangas MJ; Burks RM; Atwater J; Lukowicz RM; Williams P; Holmes AE
[Ad] Endereço:a Department of Chemistry , Doane University , Crete , Nebraska , USA.
[Ti] Título:Colorimetric Sensor Arrays for the Detection and Identification of Chemical Weapons and Explosives.
[So] Source:Crit Rev Anal Chem;47(2):138-153, 2017 Mar 04.
[Is] ISSN:1547-6510
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a significant demand for devices that can rapidly detect chemical-biological-explosive (CBE) threats on-site and allow for immediate responders to mitigate spread, risk, and loss. The key to an effective reconnaissance mission is a unified detection technology that analyzes potential threats in real time. In addition to reviewing the current state of the art in the field, this review illustrates the practicality of colorimetric arrays composed of sensors that change colors in the presence of analytes. This review also describes an outlook toward future technologies, and describes how they could possibly be used in areas such as war zones to detect and identify hazardous substances.
[Mh] Termos MeSH primário: Guerra Química
Colorimetria/métodos
Substâncias Explosivas/análise
[Mh] Termos MeSH secundário: Colorimetria/instrumentação
Substâncias Perigosas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Explosive Agents); 0 (Hazardous Substances)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.1080/10408347.2016.1233805


  4 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28140437
[Au] Autor:Cornell M; Kelbaugh J; Todd B; Christianson K; Grayson K; O'Sullivan J; Johnson D; Loughren M
[Ad] Endereço:US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas.
[Ti] Título:Pharmacokinetics of sternal intraossesous atropine administration in normovolemic and hypovolemic swine.
[So] Source:Am J Disaster Med;11(4):233-236, 2016.
[Is] ISSN:1932-149X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Characterize and compare the pharmacokinetics of atropine administered via the sternal intraosseous (IO) route in a normovolemic and hypovolemic swine model. DESIGN: Prospective, experimental study. SETTING: Vivarium. SUBJECTS: Yorkshire-cross swine (N = 12). INTERVENTION: Atropine was administered via the sternal IO route to normovolemic and hypovolemic swine. Blood samples were drawn at regular intervals after atropine administration and analyzed for plasma atropine concentration. Pharmacokinetic parameters were obtained from modeling the plasma concentrations. MAIN OUTCOME MEASUREMENTS: Pharmacokinetic parameters, maximum concentration (Cmax), and time to maximum concentration (Tmax). RESULTS: The normovolemic and hypovolemic models reached peak plasma concentration immediately and had a very rapid distribution phase with no apparent absorption phase for the IO groups. The hypovolemic group had slower clearance and longer half-life compared to the normovolemic group. CONCLUSION: The sternal IO route is an effective method of administering atropine and is comparable to the previously reported tibial IO and intravenous data even under conditions of significant hemorrhage.
[Mh] Termos MeSH primário: Antídotos/administração & dosagem
Antídotos/farmacocinética
Atropina/administração & dosagem
Atropina/farmacocinética
Hipovolemia/tratamento farmacológico
Hipovolemia/fisiopatologia
Infusões Intraósseas
Antagonistas Muscarínicos/administração & dosagem
Antagonistas Muscarínicos/farmacocinética
Esterno
[Mh] Termos MeSH secundário: Animais
Guerra Química
Estudos Prospectivos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Muscarinic Antagonists); 7C0697DR9I (Atropine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


  5 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27908921
[Au] Autor:Khan K; Wozniak SE; Coleman J; Didolkar MS
[Ad] Endereço:Department of General Surgery, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
[Ti] Título:Wartime toxin exposure: recognising the silent killer.
[So] Source:BMJ Case Rep;2016, 2016 Dec 01.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Wartime toxin exposures have been implicated in the genesis of malignancy in war veterans. Agent Orange, one toxin among many, has been linked to malignancy and the subcomponent phenoxyacetic acid has been associated with soft tissue sarcomas (STSs). This case demonstrates the association between a wartime toxin exposure (Agent Orange) and subsequent cancer development. Ultimately, we aim to highlight the importance of simple, specific questions in the patient history to account for previous wartime toxin exposures.
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/envenenamento
Ácido 2,4-Diclorofenoxiacético/envenenamento
Guerra Química
Desfolhantes Químicos/envenenamento
Exposição Ambiental/efeitos adversos
Anamnese
Dibenzodioxinas Policloradas/envenenamento
Sarcoma/induzido quimicamente
Veteranos
Guerra do Vietnã
[Mh] Termos MeSH secundário: Administração Cutânea
Agente Laranja
Seres Humanos
Masculino
Meia-Idade
Medição de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Defoliants, Chemical); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


  6 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27830420
[Au] Autor:Iyengar AR; Pande AH
[Ad] Endereço:Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), 160062, Punjab, India.
[Ti] Título:Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.
[So] Source:Protein J;35(6):424-439, 2016 Dec.
[Is] ISSN:1875-8355
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nerve agents (NAs) are extremely neurotoxic synthetic organophosphate (OP) compounds exploited as weapons of mass destruction in terrorist attacks and chemical warfare. Considering the current world scenario, there is a persistent threat of NA-exposure to military personals and civilians. Various prophylactic and post-exposure treatments (such as atropine and oximes) available currently for NA-poisoning are inadequate and unsatisfactory and suffer from severe limitations. Hence, developing safe and effective treatment(s) against NA-poisoning is a critical necessity. With regards to counteracting NA-toxicity, the OP-hydrolyzing enzymes (OPHEs), which can hydrolyze and inactivate a variety of NAs, have emerged as promising candidates for the development of prophylactic therapy against NA-poisoning. However, there are many hurdles to be crossed before these enzymes can be brought to therapeutic use in humans. In this article, we have reviewed the various advancements in the field of development of OPHEs as prophylactic against NA-poisoning. The article majorly focuses on the toxic effects of NAs, various available therapies to counteract NA poisoning, the current status of OPHEs and attempts made to improve the various properties of these enzymes. Further, we have also briefly discussed about the prospective work that is needed to be undertaken for developing these OPHEs into those suitable for use in humans.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Guerra Química
Hidrolases/farmacologia
Agentes Neurotóxicos/metabolismo
Organofosfatos/metabolismo
[Mh] Termos MeSH secundário: Atropina/farmacologia
Clonidina/farmacologia
Diazepam/farmacologia
Antagonistas de Aminoácidos Excitatórios/farmacologia
Seres Humanos
Hidrólise
Agentes Neurotóxicos/farmacocinética
Agentes Neurotóxicos/toxicidade
Organofosfatos/farmacocinética
Organofosfatos/toxicidade
Oximas/farmacologia
Agonistas de Receptores Purinérgico P1/farmacologia
Brometo de Piridostigmina/farmacologia
Diálise Renal
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidotes); 0 (Excitatory Amino Acid Antagonists); 0 (Nerve Agents); 0 (Organophosphates); 0 (Oximes); 0 (Purinergic P1 Receptor Agonists); 7C0697DR9I (Atropine); EC 3.- (Hydrolases); KVI301NA53 (Pyridostigmine Bromide); MN3L5RMN02 (Clonidine); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


  7 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27737494
[Au] Autor:Gordon MK; DeSantis-Rodrigues A; Hahn R; Zhou P; Chang Y; Svoboda KK; Gerecke DR
[Ad] Endereço:Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey. magordon@eohsi.rutgers.edu.
[Ti] Título:The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies.
[So] Source:Ann N Y Acad Sci;1378(1):158-165, 2016 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mustard exposures result in epithelial-stromal separations in the cornea and epidermal-dermal separations in the skin. Large blisters often manifest in skin, while the cornea develops microblisters, and, when enough form, the epithelium sloughs. If the exposure is severe, healing can be imperfect and can result in long-term adverse consequences. For the cornea, this could manifest as recurrent corneal erosions. Since the corneal epithelial-stromal separations are in the region identified by electron microscopy as the lamina lucida, the same region affected by the blistering disease junctional epidermolysis bullosa (JEB), we postulated that the molecules that are defective in JEB would be the same ones cleaved by mustard compounds. These molecules are α6ß4 integrin and collagen XVII, which can be cleaved by matrix metalloproteinase-9 (MMP-9) and ADAM17, respectively. Therefore, our laboratory has tested MMP-9 and ADAM17 inhibitors as potential therapies to attenuate corneal mustard injury. Our results demonstrated that inhibiting MMP-9 and ADAM17 resulted in less epithelial-stromal separation in the corneas at 24 h postexposure, as compared with using only medium as a therapy.
[Mh] Termos MeSH primário: Membrana Basal/efeitos dos fármacos
Membrana Basal/patologia
Córnea/efeitos dos fármacos
Córnea/patologia
Inibidores de Metaloproteinases de Matriz/farmacologia
[Mh] Termos MeSH secundário: Proteína ADAM17/antagonistas & inibidores
Proteína ADAM17/metabolismo
Administração Cutânea
Animais
Membrana Basal/metabolismo
Guerra Química/tendências
Córnea/metabolismo
Seres Humanos
Metaloproteinase 9 da Matriz/metabolismo
Inibidores de Metaloproteinases de Matriz/uso terapêutico
Técnicas de Cultura de Órgãos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Matrix Metalloproteinase Inhibitors); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.86 (ADAM17 Protein); EC 3.4.24.86 (ADAM17 protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13226


  8 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27636894
[Au] Autor:Li C; Srivastava RK; Athar M
[Ad] Endereço:Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, Alabama.
[Ti] Título:Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicals.
[So] Source:Ann N Y Acad Sci;1378(1):143-157, 2016 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Arsenicals are highly reactive inorganic and organic derivatives of arsenic. These chemicals are very toxic and produce both acute and chronic tissue damage. On the basis of these observations, and considering the low cost and simple methods of their bulk syntheses, these agents were thought to be appropriate for chemical warfare. Among these, the best-known agent that was synthesized and weaponized during World War I (WWI) is Lewisite. Exposure to Lewisite causes painful inflammatory and blistering responses in the skin, lung, and eye. These chemicals also manifest systemic tissue injury following their cutaneous exposure. Although largely discontinued after WWI, stockpiles are still known to exist in the former Soviet Union, Germany, Italy, the United States, and Asia. Thus, access by terrorists or accidental exposure could be highly dangerous for humans and the environment. This review summarizes studies that describe the biological, pathophysiological, toxicological, and environmental effects of exposure to arsenicals, with a major focus on cutaneous injury. Studies related to the development of novel molecular pathobiology-based antidotes against these agents are also described.
[Mh] Termos MeSH primário: Intoxicação por Arsênico/metabolismo
Arsenicais/administração & dosagem
Substâncias para a Guerra Química/envenenamento
Exposição Ambiental/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Intoxicação por Arsênico/tratamento farmacológico
Intoxicação por Arsênico/epidemiologia
Guerra Química/tendências
Dimercaprol/uso terapêutico
Seres Humanos
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Arsenicals); 0 (Chemical Warfare Agents); 0 (Reactive Oxygen Species); 0CPP32S55X (Dimercaprol); 0N54LGU5WS (lewisite)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13214


  9 / 939 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27575382
[Au] Autor:Boddie C; Watson M; Sell TK
[Ti] Título:Federal Funding for Health Security in FY2017.
[So] Source:Health Secur;14(5):284-304, 2016 Sep-Oct.
[Is] ISSN:2326-5108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This latest article in the Federal Funding for Health Security series assesses FY2017 US government funding in 5 domains critical to strengthening health security: biosecurity, radiological and nuclear security, chemical security, pandemic influenza and emerging infectious disease, and multiple-hazard and general preparedness.
[Mh] Termos MeSH primário: Defesa Civil/economia
Planejamento em Desastres/economia
Governo Federal
Financiamento Governamental
Medidas de Segurança/economia
[Mh] Termos MeSH secundário: Guerra Biológica/economia
Guerra Biológica/prevenção & controle
Guerra Química/economia
Guerra Química/prevenção & controle
Controle de Doenças Transmissíveis/economia
Seres Humanos
Guerra Nuclear/economia
Guerra Nuclear/prevenção & controle
Terrorismo/economia
Terrorismo/prevenção & controle
Estados Unidos
United States Government Agencies/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE
[do] DOI:10.1089/hs.2016.0063


  10 / 939 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:27263214
[Au] Autor:Budko AA; Ivanovskii YV
[Ti] Título:[Use of chemical war gases at the Russian-German front during the First World War].
[So] Source:Voen Med Zh;337(2):75-81, 2016 Feb.
[Is] ISSN:0026-9050
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The First World War was notable for the widespread use of machine military hardware and absolutely new type of weapon--chemical weapon. As a result of the first gas attack by chlorine undertaken by the German army against the Russian armies on May, 31st, 1915, heavy poisonings have received 9100 people, 6000 of them died. Chemical attack of Germany against Russia was limited by the use chemical gases of suffocating action: chlorine, bromine,phosgene and diphosgene. It is not known exactly, how many times Germany attacked Russian positions with use of chemical gases. On available data, in the First World War from application by German of the chemical weapon Russia has suffered more, than any other of the at war countries: from five hundred thousand poisoned have died nearby 66,000 people. In turn, having received in the order the chemical weapon of own manufacture, Russian army itself tried to attack in the German armies. It is authentically known only about several cases of application dy Russian of fighting poison gases, and in all cases of loss of germen were insignificant.
[Mh] Termos MeSH primário: Guerra Química/história
I Guerra Mundial
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
Rússia (pré-1917)
[Pt] Tipo de publicação:ENGLISH ABSTRACT; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160606
[Lr] Data última revisão:
160606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160607
[St] Status:MEDLINE



página 1 de 94 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde