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| [PMID]: | 27774695 |
| [Au] Autor: | Bellana B; Liu ZX; Diamond NB; Grady CL; Moscovitch M |
| [Ad] Endereço: | Department of Psychology, University of Toronto, Toronto, Ontario, Canada. |
| [Ti] Título: | Similarities and differences in the default mode network across rest, retrieval, and future imagining. |
| [So] Source: | Hum Brain Mapp;38(3):1155-1171, 2017 Mar. | | [Is] ISSN: | 1097-0193 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | The default mode network (DMN) has been identified reliably during rest, as well as during the performance of tasks such as episodic retrieval and future imagining. It remains unclear why this network is engaged across these seemingly distinct conditions, though many hypotheses have been proposed to account for these effects. Prior to generating hypotheses explaining common DMN involvement, the degree of commonality in the DMN across these conditions, within individuals, must be statistically determined to test whether or not the DMN is truly a unitary network, equally engaged across rest, retrieval and future imagining. To provide such a test, we used comparable paradigms (self-directed, uninterrupted thought of equal duration) across the three conditions (rest, retrieval, and future imagining) in a within-participant design. We found lower than expected pattern similarity in DMN functional connectivity across the three conditions. Similarity in connectivity accounted for only 40-50% of the total variance. Partial Least Squares (PLS) analyses revealed the medial temporal regions of the DMN were preferentially coupled with one another during episodic retrieval and future imagining, whereas the non-medial temporal regions of the DMN (e.g., medial prefrontal cortex, lateral temporal cortex, and temporal pole) were preferentially coupled during rest. These results suggest that DMN connectivity may be more flexible than previously considered. Our findings are in line with emerging evidence that the DMN is not a static network engaged commonly across distinct cognitive processes, but is instead a dynamic system, topographically changing in relation to ongoing cognitive demands. Hum Brain Mapp 38:1155-1171, 2017. © 2016 Wiley Periodicals, Inc. |
| [Mh] Termos MeSH primário: |
Encéfalo/diagnóstico por imagem
Processamento de Imagem Assistida por Computador
Imagem por Ressonância Magnética/métodos
Modelos Neurológicos
Vias Neurais/diagnóstico por imagem
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| [Mh] Termos MeSH secundário: |
Adolescente
Análise de Variância
Mapeamento Encefálico
Feminino
Seres Humanos
Masculino
Vias Neurais/fisiologia
Descanso
Pensamento/fisiologia
Adulto Jovem
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE |
| [Em] Mês de entrada: | 1802 |
| [Cu] Atualização por classe: | 180213 |
[Lr] Data última revisão:
| 180213 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 161025 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1002/hbm.23445 |
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