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[PMID]:28458998
[Au] Autor:Fan J; Zhong M; Zhu X; Gan J; Liu W; Niu C; Liao H; Zhang H; Yi J; Tan C
[Ad] Endereço:Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
[Ti] Título:Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder.
[So] Source:Neuroimage Clin;15:1-7, 2017.
[Is] ISSN:2213-1582
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Few studies have explored the neurobiological basis of insight level in obsessive-compulsive disorder (OCD), though the salience network (SN) has been implicated in insight deficits in schizophrenia. This study was then designed to investigate whether resting-state (rs) functional connectivity (FC) of SN was associated with insight level in OCD patients. We analyzed rs-functional magnetic resonance imaging (fMRI) data from 21 OCD patients with good insight (OCD-GI), 19 OCD patients with poor insight (OCD-PI), and 24 healthy controls (HCs). Seed-based whole-brain FC and ROI (region of interest)-wise connectivity analyses were performed with seeds/ROIs in the bilateral anterior insula (AI) and dorsal anterior cingulate cortex (dACC). The right AI-right medial orbital frontal cortex (mOFC) connectivity was found to be uniquely decreased in the OCD-PI group, and the value of this aberrant connectivity correlated with insight level in OCD patients. In addition, we found that the OCD-GI group had significantly increased right AI-left dACC connectivity within the SN, relative to HCs (overall trend for groups: OCD-GI > OCD-PI > HC). Our findings suggest that abnormal right AI-right mOFC FC may mediate insight deficits in OCD, perhaps due to impaired encoding and integration of self-evaluative information about OCD-related beliefs and behaviors. Our findings indicate a SN connectivity dissociation between OCD-GI and OCD-PI patients and support the notion of considering OCD-GI and OCD-PI as two distinct disorder subtypes.
[Mh] Termos MeSH primário: Lobo Frontal/diagnóstico por imagem
Imagem por Ressonância Magnética
Rede Nervosa/diagnóstico por imagem
Transtorno Obsessivo-Compulsivo/diagnóstico por imagem
Córtex Pré-Frontal/diagnóstico por imagem
Descanso
[Mh] Termos MeSH secundário: Adolescente
Adulto
Córtex Cerebral/diagnóstico por imagem
Córtex Cerebral/fisiopatologia
Feminino
Lobo Frontal/fisiopatologia
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Rede Nervosa/fisiopatologia
Transtorno Obsessivo-Compulsivo/fisiopatologia
Córtex Pré-Frontal/fisiopatologia
Descanso/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1016/j.nicl.2017.04.002


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[PMID]:29381744
[Au] Autor:Biniaminov N; Bandt S; Roth A; Haertel S; Neumann R; Bub A
[Ad] Endereço:Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany.
[Ti] Título:Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study.
[So] Source:PLoS One;13(1):e0189254, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Regular physical activity and physical fitness are closely related to a positive health status in humans. In this context, the muscle becomes more important due to its function as an endocrine organ. Muscle tissue secretes "myokines" in response to physical activity and it is speculated that these myokines are involved in physical activity induced positive health effects. Recently, the newly discovered myokine Irisin thought to be secreted by the muscle in response to physical activity and might be related to the health inducing effect by inducing browning of white adipose tissue. Speculating that myokines at least partly mediate exercise related health effects one would assume that regular physical activity and physical fitness are associated with resting Irisin concentrations in healthy humans. To investigate the association between resting Irisin concentration and either short-term physical activity, habitual physical activity, or physical fitness, data of 300 healthy participants from the cross-sectional KarMeN-study were analyzed. By applying different activity measurements we determined short-term and habitual physical activity, as well as physical fitness. Fasting serum samples were collected to determine resting Irisin concentrations by Enzyme-linked Immunosorbent Assay. Multivariate linear regression analysis served to investigate associations of the individual physical activity parameters with Irisin concentrations. Therefore, lean body mass and total fat mass (both determined by dual-energy X-ray absorptiometry) as well as age and parameters of glucose metabolism were included as confounders in multivariate linear regression analysis. Results showed that Irisin serum concentrations were not related to measures of physical activity and physical fitness in healthy humans under resting conditions, irrespective of the applied methods. Therefore we assume that if physical activity related effects are partly induced by myokines, permanently increased Irisin serum concentration may not be necessary to induce health-related exercise effects.
[Mh] Termos MeSH primário: Fibronectinas/metabolismo
Aptidão Física
Descanso
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Calorimetria
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Músculo Esquelético/secreção
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (FNDC5 protein, human); 0 (Fibronectins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189254


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[PMID]:29339868
[Au] Autor:Nevin A; Mayr H; Atresh S; Kemp I; Simmons J; Vivanti A; Hickman IJ
[Ad] Endereço:Department of Nutrition and Dietetics, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
[Ti] Título:Feasibility and Acceptability of Implementing Indirect Calorimetry Into Routine Clinical Care of Patients With Spinal Cord Injury.
[So] Source:Top Spinal Cord Inj Rehabil;22(4):269-276, 2016.
[Is] ISSN:1945-5763
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the absence of reliable predictive equations, indirect calorimetry (IC) remains the gold standard for assessing energy requirements after spinal cord injury (SCI), but it is typically confined to a research setting. The purpose of this study is to assess the feasibility and acceptability of implementing IC into routine clinical care in an Australian SCI rehabilitation facility. Bedside IC (canopy hood) was performed, and patients completed an IC acceptability questionnaire (open-ended; yes/no; 5-point Likert scale). Fasted resting energy expenditure (REE) steady-state criteria were applied to assess data quality, and adherence to a test ≥20 minutes was recorded. Staff were surveyed to assess impact of IC on usual care. Of 35 eligible patients, 9 declined (7 reported claustrophobia). One patient could not be tested before discharge and 25 underwent IC (84% male, injury level C2-L2, AIS A-D). Anxiety prevented one patient from completing IC, while another failed to fast. The remaining 23 patients achieved a steady-state REE (≥5 consecutive minutes with ≤10% coefficient of variation for VO and VCO ). Test-retest ( = 5) showed <10% variation in REE. Patients deemed the procedure acceptable, with 88% reporting a willingness to repeat IC. Eighty percent of patients and 90% of staff agreed it was acceptable for IC to be integrated into usual care. This study found that IC is a feasible and acceptable addition to the routine clinical care of patients recovering from SCI and may serve to improve accuracy of nutrition interventions for this patient population.
[Mh] Termos MeSH primário: Calorimetria Indireta
Metabolismo Energético
Necessidades Nutricionais
Traumatismos da Medula Espinal/reabilitação
[Mh] Termos MeSH secundário: Adulto
Idoso
Austrália
Feminino
Seres Humanos
Masculino
Meia-Idade
Descanso
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1310/sci2016-00001


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[PMID]:28744114
[Au] Autor:Coelho-Júnior HJ; Irigoyen MC; Aguiar SDS; Gonçalves IO; Câmara NOS; Cenedeze MA; Asano RY; Rodrigues B; Uchida MC
[Ad] Endereço:Applied Kinesiology Laboratory-LCA, School of Physical Education, University of Campinas, Barão Geraldo, Campinas, São Paulo.
[Ti] Título:Acute effects of power and resistance exercises on hemodynamic measurements of older women.
[So] Source:Clin Interv Aging;12:1103-1114, 2017.
[Is] ISSN:1178-1998
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to compare the acute effects of resistance training (RT) and power training (PT) on the hemodynamic parameters and nitric oxide (NO) bioavailability of older women. MATERIALS AND METHODS: A randomized experimental design was used in this study. Twenty-one older women (age: 67.1±4.6 years; body mass index: 28.03±4.9 kg/m ; systolic blood pressure: 135.1±21.1 mmHg) were recruited to participate in this study. Volunteers were randomly allocated into PT, RT, and control session (CS) groups. The PT and RT groups underwent a single session of physical exercise equalized by training volume, characterized by 3 sets of 8-10 repetitions in 8 different exercises. However, RT group performed exercise at a higher intensity (difficult) than PT (moderate) group. On the other hand, concentric contractions were faster in PT group than in RT group. Hemodynamic parameters and saliva samples (for NO quantification) were collected before and during an hour after exercise completion. RESULTS: Results demonstrated post-exercise hypotension during 35 minutes in the PT when compared to rest period ( =0.001). In turn, RT showed decreased heart rate and double product ( <0.001) during the whole evaluation period after exercise completion compared with the rest period. NO levels increased in the PT and RT during the whole evaluation period in relation to rest period. However, there were no differences between PT, RT, and CS regarding hemodynamic and NO evaluations. CONCLUSION: Data indicate that an acute session of power and resistance exercise can be effective to cause beneficial changes on hemodynamic parameters and NO levels in older women.
[Mh] Termos MeSH primário: Hemodinâmica/fisiologia
Treinamento de Resistência/métodos
[Mh] Termos MeSH secundário: Idoso
Pressão Sanguínea/fisiologia
Índice de Massa Corporal
Exercício/fisiologia
Feminino
Seres Humanos
Meia-Idade
Óxido Nítrico/análise
Hipotensão Pós-Exercício/epidemiologia
Descanso/fisiologia
Saliva/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.2147/CIA.S133838


  5 / 14474 MEDLINE  
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[PMID]:29184204
[Au] Autor:Winder AT; Echagarruga C; Zhang Q; Drew PJ
[Ad] Endereço:Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA.
[Ti] Título:Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.
[So] Source:Nat Neurosci;20(12):1761-1769, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.
[Mh] Termos MeSH primário: Hemodinâmica/fisiologia
Descanso/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Volume Sanguíneo
Circulação Cerebrovascular/fisiologia
Nervo Facial/fisiologia
Imagem por Ressonância Magnética
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Movimento/fisiologia
Fenômenos Fisiológicos do Sistema Nervoso
Estimulação Luminosa
Córtex Somatossensorial/irrigação sanguínea
Vibrissas/inervação
Vibrissas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0007-y


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[PMID]:28467922
[Au] Autor:Goodpaster BH; Sparks LM
[Ad] Endereço:Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford Burnham Prebys Medical Discovery Institute, 301 East Princeton Street, Orlando, FL 32804, USA. Electronic address: bret.goodpaster@flhosp.org.
[Ti] Título:Metabolic Flexibility in Health and Disease.
[So] Source:Cell Metab;25(5):1027-1036, 2017 May 02.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics" technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Redes e Vias Metabólicas
Músculo Esquelético/metabolismo
Obesidade/metabolismo
[Mh] Termos MeSH secundário: Animais
Restrição Calórica
Diabetes Mellitus Tipo 2/terapia
Metabolismo Energético
Exercício
Terapia por Exercício
Jejum
Ácidos Graxos/metabolismo
Glucose/metabolismo
Seres Humanos
Resistência à Insulina
Metaboloma
Metabolômica
Obesidade/terapia
Descanso
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Fatty Acids); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:27770478
[Au] Autor:Nugent AC; Luber B; Carver FW; Robinson SE; Coppola R; Zarate CA
[Ad] Endereço:Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
[Ti] Título:Deriving frequency-dependent spatial patterns in MEG-derived resting state sensorimotor network: A novel multiband ICA technique.
[So] Source:Hum Brain Mapp;38(2):779-791, 2017 02.
[Is] ISSN:1097-0193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recently, independent components analysis (ICA) of resting state magnetoencephalography (MEG) recordings has revealed resting state networks (RSNs) that exhibit fluctuations of band-limited power envelopes. Most of the work in this area has concentrated on networks derived from the power envelope of beta bandpass-filtered data. Although research has demonstrated that most networks show maximal correlation in the beta band, little is known about how spatial patterns of correlations may differ across frequencies. This study analyzed MEG data from 18 healthy subjects to determine if the spatial patterns of RSNs differed between delta, theta, alpha, beta, gamma, and high gamma frequency bands. To validate our method, we focused on the sensorimotor network, which is well-characterized and robust in both MEG and functional magnetic resonance imaging (fMRI) resting state data. Synthetic aperture magnetometry (SAM) was used to project signals into anatomical source space separately in each band before a group temporal ICA was performed over all subjects and bands. This method preserved the inherent correlation structure of the data and reflected connectivity derived from single-band ICA, but also allowed identification of spatial spectral modes that are consistent across subjects. The implications of these results on our understanding of sensorimotor function are discussed, as are the potential applications of this technique. Hum Brain Mapp 38:779-791, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Mapeamento Encefálico
Ondas Encefálicas/fisiologia
Encéfalo/fisiologia
Magnetoencefalografia
Rede Nervosa/fisiologia
Descanso
[Mh] Termos MeSH secundário: Adulto
Encéfalo/diagnóstico por imagem
Estudos de Coortes
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Rede Nervosa/diagnóstico por imagem
Oxigênio/sangue
Análise de Componente Principal
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1002/hbm.23417


  8 / 14474 MEDLINE  
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[PMID]:28460314
[Au] Autor:Ge R; Blumberger DM; Downar J; Daskalakis ZJ; Dipinto AA; Tham JCW; Lam R; Vila-Rodriguez F
[Ad] Endereço:Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
[Ti] Título:Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study.
[So] Source:J Affect Disord;218:75-81, 2017 Aug 15.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Treatment resistant depression (TRD) remains a clinical challenge, and finding biomarkers that predict treatment response are a long sought goal to precisely indicate treatments. This pilot study aims to characterize brain dysfunction in TRD patients who underwent rTMS to define neuroimaging biomarkers that discriminate non-responders (NR) from responders (R). METHODS: 20 TRD patients who underwent a course of rTMS to the left DLPFC were categorized into R and NR groups based on a >50% reduction in HRSD scores. Utilizing resting-state fMRI and ICA techniques, this study compared baseline RSNs of R vs. NR as well as TRD vs. healthy volunteer group. Regression analysis was conducted to link regions with clinical improvements. ROC analysis was further conducted to confirm the utility of the identified regions in classifying the patients. RESULTS: Prior to treatment, non-responders displayed hyper-connectivity in ACC/VMPFC, PCC/pC, dACC and insula within RSNs that have been associated with MDD pathology. Regression results showed that regions associated with clinical improvements overlapped largely with regions that showed aberrant connectivity. ACC/VMPFC, dACC and left insula, which are hub regions of DMN and SN, exhibited excellent performance (highest sensitivity=100% and highest specificity=82%) in discriminating the response status of the patients. LIMITATIONS: Relatively small sample size. CONCLUSIONS: Our findings provide insight into fMRI predictive measures of treatment response to rTMS treatment, and demonstrate the potential of RSNs-based biomarkers in predicting response to rTMS treatment. Future studies are needed to validate the application of these measures to inform individual treatment indications.
[Mh] Termos MeSH primário: Transtorno Depressivo Resistente a Tratamento/fisiopatologia
Rede Nervosa/fisiopatologia
Estimulação Magnética Transcraniana/métodos
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Transtorno Depressivo Resistente a Tratamento/diagnóstico por imagem
Transtorno Depressivo Resistente a Tratamento/terapia
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Rede Nervosa/diagnóstico por imagem
Projetos Piloto
Córtex Pré-Frontal/diagnóstico por imagem
Córtex Pré-Frontal/fisiopatologia
Análise de Componente Principal
Curva ROC
Análise de Regressão
Descanso
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:27774695
[Au] Autor:Bellana B; Liu ZX; Diamond NB; Grady CL; Moscovitch M
[Ad] Endereço:Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Similarities and differences in the default mode network across rest, retrieval, and future imagining.
[So] Source:Hum Brain Mapp;38(3):1155-1171, 2017 Mar.
[Is] ISSN:1097-0193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The default mode network (DMN) has been identified reliably during rest, as well as during the performance of tasks such as episodic retrieval and future imagining. It remains unclear why this network is engaged across these seemingly distinct conditions, though many hypotheses have been proposed to account for these effects. Prior to generating hypotheses explaining common DMN involvement, the degree of commonality in the DMN across these conditions, within individuals, must be statistically determined to test whether or not the DMN is truly a unitary network, equally engaged across rest, retrieval and future imagining. To provide such a test, we used comparable paradigms (self-directed, uninterrupted thought of equal duration) across the three conditions (rest, retrieval, and future imagining) in a within-participant design. We found lower than expected pattern similarity in DMN functional connectivity across the three conditions. Similarity in connectivity accounted for only 40-50% of the total variance. Partial Least Squares (PLS) analyses revealed the medial temporal regions of the DMN were preferentially coupled with one another during episodic retrieval and future imagining, whereas the non-medial temporal regions of the DMN (e.g., medial prefrontal cortex, lateral temporal cortex, and temporal pole) were preferentially coupled during rest. These results suggest that DMN connectivity may be more flexible than previously considered. Our findings are in line with emerging evidence that the DMN is not a static network engaged commonly across distinct cognitive processes, but is instead a dynamic system, topographically changing in relation to ongoing cognitive demands. Hum Brain Mapp 38:1155-1171, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Processamento de Imagem Assistida por Computador
Imagem por Ressonância Magnética/métodos
Modelos Neurológicos
Vias Neurais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Análise de Variância
Mapeamento Encefálico
Feminino
Seres Humanos
Masculino
Vias Neurais/fisiologia
Descanso
Pensamento/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/hbm.23445


  10 / 14474 MEDLINE  
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[PMID]:29184200
[Au] Autor:Stoodley CJ; D'Mello AM; Ellegood J; Jakkamsetti V; Liu P; Nebel MB; Gibson JM; Kelly E; Meng F; Cano CA; Pascual JM; Mostofsky SH; Lerch JP; Tsai PT
[Ad] Endereço:Department of Psychology and Center for Behavioral Neuroscience, American University, Washington, DC, USA. stoodley@american.edu.
[Ti] Título:Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.
[So] Source:Nat Neurosci;20(12):1744-1751, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans resulted in altered functional connectivity with the inferior parietal lobule, and children with ASD showed atypical functional connectivity in this circuit. Atypical RCrusI-inferior parietal lobule structural connectivity was also evident in the Purkinje neuron (PN) TscI ASD mouse model. Additionally, chemogenetically mediated inhibition of RCrusI PN activity in mice was sufficient to generate ASD-related social, repetitive, and restricted behaviors, while stimulation of RCrusI PNs rescued social impairment in the PN TscI ASD mouse model. Together, these studies reveal important roles for RCrusI in ASD-related behaviors. Further, the rescue of social behaviors in an ASD mouse model suggests that investigation of the therapeutic potential of cerebellar neuromodulation in ASD may be warranted.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/patologia
Transtorno do Espectro Autista/psicologia
Cerebelo/patologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Criança
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Aprendizagem em Labirinto
Camundongos
Camundongos Transgênicos
Vias Neurais/fisiopatologia
Células de Purkinje
Descanso
Olfato
Comportamento Social
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0004-1



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