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[PMID]:29496866
[Au] Autor:Mackall CL
[Ad] Endereço:Department of Pediatrics and Medicine, and Stanford Cancer Institute, 265 Campus Way, G3141A, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.
[Ti] Título:Engineering a designer immunotherapy.
[So] Source:Science;359(6379):990-991, 2018 03 02.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Engenharia
Imunoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180303
[St] Status:MEDLINE
[do] DOI:10.1126/science.aas9434


  2 / 3186 MEDLINE  
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[PMID]:28749810
[Au] Autor:Waterman G; Kase K; Orion I; Broisman A; Milstein O
[Ad] Endereço:*Department of Research & Development, StemRad, Ltd., 6 Raoul Wallenberg St. 1st Floor Tel Aviv 6971905, Israel; †Department of Nuclear Engineering, Ben-Gurion University of the Negev. P.O.B. 653, Beer-Sheva 84105, Israel.
[Ti] Título:Selective Shielding of Bone Marrow: An Approach to Protecting Humans from External Gamma Radiation.
[So] Source:Health Phys;113(3):195-208, 2017 09.
[Is] ISSN:1538-5159
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The current feasibility of protecting emergency responders through bone marrow selective shielding is highlighted in the recent OECD/NEA report on severe accident management. Until recently, there was no effective personal protection from externally penetrating gamma radiation. In Chernobyl, first-responders wore makeshift lead sheeting, whereas in Fukushima protective equipment from gamma radiation was not available. Older protective solutions that use thin layers of shielding over large body surfaces are ineffective for energetic gamma radiation. Acute exposures may result in Acute Radiation Syndrome where the survival-limiting factor up to 10 Gy uniform, homogeneous exposure is irreversible bone marrow damage. Protracted, lower exposures may result in malignancies of which bone marrow is especially susceptible, being compounded by leukemia's short latency time. This highlights the importance of shielding bone marrow for preventing both deterministic and stochastic effects. Due to the extraordinary regenerative potential of hematopoietic stem cells, to effectively prevent the deterministic effects of bone marrow exposure, it is sufficient to protect only a small fraction of this tissue. This biological principle allows for a new class of equipment providing unprecedented attenuation of radiation to select marrow-rich regions, deferring the hematopoietic sub-syndrome of Acute Radiation Syndrome to much higher doses. As approximately half of the body's active bone marrow resides within the pelvis region, shielding this area holds great promise for preventing the deterministic effects of bone marrow exposure and concomitantly reducing stochastic effects. The efficacy of a device that selectively shields this region and other radiosensitive organs in the abdominal area is shown here.
[Mh] Termos MeSH primário: Medula Óssea/efeitos da radiação
Raios gama/efeitos adversos
Proteção Radiológica/instrumentação
[Mh] Termos MeSH secundário: Síndrome Aguda da Radiação/prevenção & controle
Socorristas
Engenharia
Seres Humanos
Método de Monte Carlo
Imagens de Fantasmas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1097/HP.0000000000000688


  3 / 3186 MEDLINE  
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[PMID]:27562960
[Au] Autor:DiBartolo PM; Gregg-Jolly L; Gross D; Manduca CA; Iverson E; Cooke DB; Davis GK; Davidson C; Hertz PE; Hibbard L; Ireland SK; Mader C; Pai A; Raps S; Siwicki K; Swartz JE
[Ad] Endereço:Clark Science Center, Smith College, Northampton, MA 01063 pdibarto@smith.edu.
[Ti] Título:Principles and Practices Fostering Inclusive Excellence: Lessons from the Howard Hughes Medical Institute's Capstone Institutions.
[So] Source:CBE Life Sci Educ;15(3), 2016.
[Is] ISSN:1931-7913
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Best-practices pedagogy in science, technology, engineering, and mathematics (STEM) aims for inclusive excellence that fosters student persistence. This paper describes principles of inclusivity across 11 primarily undergraduate institutions designated as Capstone Awardees in Howard Hughes Medical Institute's (HHMI) 2012 competition. The Capstones represent a range of institutional missions, student profiles, and geographical locations. Each successfully directed activities toward persistence of STEM students, especially those from traditionally underrepresented groups, through a set of common elements: mentoring programs to build community; research experiences to strengthen scientific skill/identity; attention to quantitative skills; and outreach/bridge programs to broaden the student pool. This paper grounds these program elements in learning theory, emphasizing their essential principles with examples of how they were implemented within institutional contexts. We also describe common assessment approaches that in many cases informed programming and created traction for stakeholder buy-in. The lessons learned from our shared experiences in pursuit of inclusive excellence, including the resources housed on our companion website, can inform others' efforts to increase access to and persistence in STEM in higher education.
[Mh] Termos MeSH primário: Academias e Institutos
Educação de Pós-Graduação
[Mh] Termos MeSH secundário: Relações Comunidade-Instituição
Avaliação Educacional
Engenharia/educação
Seres Humanos
Matemática/educação
Desenvolvimento de Programas
Ciência/educação
Estudantes
Tecnologia/educação
Pensamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:180127
[Lr] Data última revisão:
180127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE


  4 / 3186 MEDLINE  
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[PMID]:28453182
[Au] Autor:Thangavel R; Kaliyappan K; Ramasamy HV; Sun X; Lee YS
[Ad] Endereço:Faculty of Applied Chemical Engineering, Chonnam National University, Gwang-ju, 500-757, Korea.
[Ti] Título:Engineering the Pores of Biomass-Derived Carbon: Insights for Achieving Ultrahigh Stability at High Power in High-Energy Supercapacitors.
[So] Source:ChemSusChem;10(13):2805-2815, 2017 07 10.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Electrochemical supercapacitors with high energy density are promising devices due to their simple construction and long-term cycling performance. The development of a supercapacitor based on electrical double-layer charge storage with high energy density that can preserve its cyclability at higher power presents an ongoing challenge. Herein, we provide insights to achieve a high energy density at high power with an ultrahigh stability in an electrical double-layer capacitor (EDLC) system by using carbon from a biomass precursor (cinnamon sticks) in a sodium ion-based organic electrolyte. Herein, we investigated the dependence of EDLC performance on structural, textural, and functional properties of porous carbon engineered by using various activation agents. The results demonstrate that the performance of EDLCs is not only dependent on their textural properties but also on their structural features and surface functionalities, as is evident from the electrochemical studies. The electrochemical results are highly promising and revealed that the porous carbon with poor textural properties has great potential to deliver high capacitance and outstanding stability over 300 000 cycles compared with porous carbon with good textural properties. A very low capacitance degradation of around 0.066 % per 1000 cycles, along with high energy density (≈71 Wh kg ) and high power density, have been achieved. These results offer a new platform for the application of low-surface-area biomass-derived carbons in the design of highly stable high-energy supercapacitors.
[Mh] Termos MeSH primário: Biomassa
Carbono/química
Capacitância Elétrica
Engenharia
[Mh] Termos MeSH secundário: Adsorção
Animais
Condutividade Elétrica
Eletroquímica
Química Verde
Porosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
7440-44-0 (Carbon)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700492


  5 / 3186 MEDLINE  
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[PMID]:28470502
[Au] Autor:Shi B; Jiang J; Liu R; Khan AU; Wang P
[Ad] Endereço:School of Municipal and Environment Engineering, Harbin Institute of Technology, Harbin, 150090, China.
[Ti] Título:Engineering risk assessment for emergency disposal projects of sudden water pollution incidents.
[So] Source:Environ Sci Pollut Res Int;24(17):14819-14833, 2017 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Without an engineering risk assessment for emergency disposal in response to sudden water pollution incidents, responders are prone to be challenged during emergency decision making. To address this gap, the concept and framework of emergency disposal engineering risks are reported in this paper. The proposed risk index system covers three stages consistent with the progress of an emergency disposal project. Fuzzy fault tree analysis (FFTA), a logical and diagrammatic method, was developed to evaluate the potential failure during the process of emergency disposal. The probability of basic events and their combination, which caused the failure of an emergency disposal project, were calculated based on the case of an emergency disposal project of an aniline pollution incident in the Zhuozhang River, Changzhi, China, in 2014. The critical events that can cause the occurrence of a top event (TE) were identified according to their contribution. Finally, advices on how to take measures using limited resources to prevent the failure of a TE are given according to the quantified results of risk magnitude. The proposed approach could be a potential useful safeguard for the implementation of an emergency disposal project during the process of emergency response.
[Mh] Termos MeSH primário: Medição de Risco
Poluição da Água
[Mh] Termos MeSH secundário: China
Engenharia
Rios
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-9078-2


  6 / 3186 MEDLINE  
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[PMID]:28982147
[Au] Autor:Nash M; Davies A; Moore R
[Ad] Endereço:School of Social Sciences, University of Tasmania, Hobart, Tasmania, Australia.
[Ti] Título:What style of leadership do women in STEMM fields perform? Findings from an international survey.
[So] Source:PLoS One;12(10):e0185727, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is widely acknowledged that women in science, technology, engineering, mathematics, and medicine (STEMM) fields are underrepresented in leadership globally. However, little is known about how leadership styles of women in STEMM relate to this underrepresentation. This article discusses findings from a survey examining how 61 women in STEMM define leadership and describe their own leadership styles. Using content analysis and drawing on Full Range Leadership Model factors, findings suggest that women define leadership and describe their own leadership styles using transformational factors. However, there was no consistency in how participants defined ideal leadership or how they defined their own leadership styles. This finding unsettles ideas of distinctly gendered leadership styles. We argue that expectations that leadership will be performed in distinctly gendered styles may be contributing to the underrepresentation of women in leadership roles in STEMM.
[Mh] Termos MeSH primário: Engenharia
Liderança
Matemática
Ciência
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185727


  7 / 3186 MEDLINE  
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[PMID]:28834366
[Au] Autor:Chen TH; Yang CH; Su CY; Lee TC; Dong QF; Chang JK
[Ad] Endereço:Institute of Materials Science and Engineering, National Central University, 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan.
[Ti] Título:Electrolyte Engineering: Optimizing High-Rate Double-Layer Capacitances of Micropore- and Mesopore-Rich Activated Carbon.
[So] Source:ChemSusChem;10(18):3534-3539, 2017 Sep 22.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Various types of electrolyte cations as well as binary cations are used to optimize the capacitive performance of activated carbon (AC) with different pore structures. The high-rate capability of micropore-rich AC, governed by the mobility of desolvated cations, can outperform that of mesopore-rich AC, which essentially depends on the electrolyte conductivity.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Capacitância Elétrica
Eletrólitos/química
Engenharia
[Mh] Termos MeSH secundário: Porosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Electrolytes); 16291-96-6 (Charcoal)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701476


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[PMID]:28812890
[Au] Autor:Chomenidis C; Drakakis G; Tsiliki G; Anagnostopoulou E; Valsamis A; Doganis P; Sopasakis P; Sarimveis H
[Ad] Endereço:School of Chemical Engineering, National Technical University of Athens , Heroon Polytechneiou 9, Zografou, Athens, Greece.
[Ti] Título:Jaqpot Quattro: A Novel Computational Web Platform for Modeling and Analysis in Nanoinformatics.
[So] Source:J Chem Inf Model;57(9):2161-2172, 2017 Sep 25.
[Is] ISSN:1549-960X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Engineered nanomaterials (ENMs) are increasingly infiltrating our lives as a result of their applications across multiple fields. However, ENM formulations may result in the modulation of pathways and mechanisms of toxic action that endanger human health and the environment. Alternative testing methods such as in silico approaches are becoming increasingly popular for assessing the safety of ENMs, as they are cost- and time-effective. Additionally, computational approaches support the industrial safer-by-design challenge and the REACH legislation objective of reducing animal testing. Because of the novelty of the field, there is also an evident need for harmonization in terms of databases, ontology, and modeling infrastructures. To this end, we present Jaqpot Quattro, a comprehensive open-source web application for ENM modeling with emphasis on predicting adverse effects of ENMs. We describe the system architecture and outline the functionalities, which include nanoQSAR modeling, validation services, read-across predictions, optimal experimental design, and interlaboratory testing.
[Mh] Termos MeSH primário: Informática/métodos
Internet
Nanoestruturas/efeitos adversos
[Mh] Termos MeSH secundário: Engenharia
Nanoestruturas/química
Relação Estrutura-Atividade
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jcim.7b00223


  9 / 3186 MEDLINE  
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[PMID]:28782927
[Au] Autor:Piraner DI; Farhadi A; Davis HC; Wu D; Maresca D; Szablowski JO; Shapiro MG
[Ad] Endereço:Division of Chemistry and Chemical Engineering, ‡Division of Biology and Biological Engineering, and §Division of Engineering and Applied Sciences, California Institute of Technology , Pasadena, California 91125, United States.
[Ti] Título:Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function.
[So] Source:Biochemistry;56(39):5202-5209, 2017 Oct 03.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most cellular phenomena of interest to mammalian biology occur within the context of living tissues and organisms. However, today's most advanced tools for observing and manipulating cellular function, based on fluorescent or light-controlled proteins, work best in cultured cells, transparent model species, or small, surgically accessed anatomical regions. Their reach into deep tissues and larger animals is limited by photon scattering. To overcome this limitation, we must design biochemical tools that interface with more penetrant forms of energy. For example, sound waves and magnetic fields easily permeate most biological tissues, allowing the formation of images and delivery of energy for actuation. These capabilities are widely used in clinical techniques such as diagnostic ultrasound, magnetic resonance imaging, focused ultrasound ablation, and magnetic particle hyperthermia. Each of these modalities offers spatial and temporal precision that could be used to study a multitude of cellular processes in vivo. However, connecting these techniques to cellular functions such as gene expression, proliferation, migration, and signaling requires the development of new biochemical tools that can interact with sound waves and magnetic fields as optogenetic tools interact with photons. Here, we discuss the exciting challenges this poses for biomolecular engineering and provide examples of recent advances pointing the way to greater depth in in vivo cell biology.
[Mh] Termos MeSH primário: Bioquímica/métodos
Imagem por Ressonância Magnética/métodos
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Animais
Engenharia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00443


  10 / 3186 MEDLINE  
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[PMID]:28736950
[Au] Autor:Cho AN; Park NG
[Ad] Endereço:School of Chemical Engineering and Department of Energy Science, Sungkyunkwan University, SKKU, Suwon, 440-746, Korea.
[Ti] Título:Impact of Interfacial Layers in Perovskite Solar Cells.
[So] Source:ChemSusChem;10(19):3687-3704, 2017 Oct 09.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Perovskite solar cells (PCSs) are composed of organic-inorganic lead halide perovskite as the light harvester. Since the first report on a long-term-durable, 9.7 % efficient, solid-state perovskite solar cell, organic-inorganic halide perovskites have received considerable attention because of their excellent optoelectronic properties. As a result, a power conversion efficiency (PCE) exceeding 22 % was certified. Controlling the grain size, grain boundary, morphology, and defects of the perovskite layer is important for achieving high efficiency. In addition, interfacial engineering is equally or more important to further improve the PCE through better charge collection and a reduction in charge recombination. In this Review, the type of interfacial layers and their impact on photovoltaic performance are investigated for both the normal and the inverted cell architectures. Four different interfaces of fluorine-doped tin oxide (FTO)/electron-transport layer (ETL), ETL/perovskite, perovskite/hole-transport layer (HTL), and HTL/metal are classified, and their roles are investigated. The effects of interfacial engineering with organic or inorganic materials on photovoltaic performance are described in detail. Grain-boundary engineering is also included because it is related to interfacial engineering and the grain boundary in the perovskite layer plays an important role in charge conduction, recombination, and chargecarrier life time.
[Mh] Termos MeSH primário: Compostos de Cálcio/química
Fontes de Energia Elétrica
Óxidos/química
Energia Solar
Titânio/química
[Mh] Termos MeSH secundário: Engenharia
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Oxides); 12194-71-7 (perovskite); D1JT611TNE (Titanium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701095



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