Base de dados : MEDLINE
Pesquisa : J01.293.069 [Categoria DeCS]
Referências encontradas : 1313 [refinar]
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  1 / 1313 MEDLINE  
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[PMID]:29408942
[Au] Autor:Slipher GA; Hairston WD; Bradford JC; Bain ED; Mrozek RA
[Ad] Endereço:Vehicle Technologies Directorate, U.S. Army Research Laboratory, MD, United States of America.
[Ti] Título:Carbon nanofiber-filled conductive silicone elastomers as soft, dry bioelectronic interfaces.
[So] Source:PLoS One;13(2):e0189415, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soft and pliable conductive polymer composites hold promise for application as bioelectronic interfaces such as for electroencephalography (EEG). In clinical, laboratory, and real-world EEG there is a desire for dry, soft, and comfortable interfaces to the scalp that are capable of relaying the µV-level scalp potentials to signal processing electronics. A key challenge is that most material approaches are sensitive to deformation-induced shifts in electrical impedance associated with decreased signal-to-noise ratio. This is a particular concern in real-world environments where human motion is present. The entire set of brain information outside of tightly controlled laboratory or clinical settings are currently unobtainable due to this challenge. Here we explore the performance of an elastomeric material solution purposefully designed for dry, soft, comfortable scalp contact electrodes for EEG that is specifically targeted to have flat electrical impedance response to deformation to enable utilization in real world environments. A conductive carbon nanofiber filled polydimethylsiloxane (CNF-PDMS) elastomer was evaluated at three fill ratios (3, 4 and 7 volume percent). Electromechanical testing data is presented showing the influence of large compressive deformations on electrical impedance as well as the impact of filler loading on the elastomer stiffness. To evaluate usability for EEG, pre-recorded human EEG signals were replayed through the contact electrodes subjected to quasi-static compressive strains between zero and 35%. These tests show that conductive filler ratios well above the electrical percolation threshold are desirable in order to maximize signal-to-noise ratio and signal correlation with an ideal baseline. Increasing fill ratios yield increasingly flat electrical impedance response to large applied compressive deformations with a trade in increased material stiffness, and with nominal electrical impedance tunable over greater than 4 orders of magnitude. EEG performance was independent of filler loading above 4 vol % CNF (< 103 ohms).
[Mh] Termos MeSH primário: Bioengenharia
Carbono/química
Nanofibras
Elastômeros de Silicone
[Mh] Termos MeSH secundário: Eletroencefalografia
Seres Humanos
Microscopia Eletrônica de Varredura
Processamento de Sinais Assistido por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Silicone Elastomers); 7440-44-0 (Carbon)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189415


  2 / 1313 MEDLINE  
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[PMID]:29200855
[Au] Autor:Gerstenhaber JA; Barone FC; Marcinkiewicz C; Li J; Shiloh AO; Sternberg M; Lelkes PI; Feuerstein G
[Ad] Endereço:Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA.
[Ti] Título:Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II).
[So] Source:Int J Nanomedicine;12:8471-8482, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The aim of this feasibility study was to test the ability of fluorescent nanodiamond particles (F-NDP) covalently conjugated with bitistatin (F-NDP-Bit) to detect vascular blood clots in vivo using extracorporeal near-infrared (NIR) imaging. Specifically, we compared NIR fluorescence properties of F-NDP with N-V (F-NDP ) and N-V-N color centers and sizes (100-10,000 nm). Optimal NIR fluorescence and tissue penetration across biological tissues (rat skin, porcine axillary veins, and skin) was obtained for F-NDP with a mean diameter of 700 nm. Intravital imaging (using in vivo imaging system [IVIS]) in vitro revealed that F-NDP -loaded glass capillaries could be detected across 6 mm of rat red-muscle barrier and 12 mm of porcine skin, which equals the average vertical distance of a human carotid artery bifurcation from the surface of the adjacent skin (14 mm). In vivo, feasibility was demonstrated in a rat model of occlusive blood clots generated using FeCl in the carotid artery bifurcation. Following systemic infusions of F-NDP -Bit (3 or 15 mg/kg) via the external carotid artery or femoral vein (N=3), presence of the particles in the thrombi was confirmed both in situ via IVIS, and ex vivo via confocal imaging. The presence of F-NDP in the vascular clots was further confirmed by direct counting of fluorescent particles extracted from clots following tissue solubilization. Our data suggest that F-NDP -Bit associate with vascular blood clots, presumably by binding of F-NDP -Bit to activated platelets within the blood clot. We posit that F-NDP -Bit could serve as a noninvasive platform for identification of vascular thrombi using NIR energy monitored by an extracorporeal device.
[Mh] Termos MeSH primário: Bioengenharia/métodos
Diagnóstico por Imagem
Desintegrinas/química
Raios Infravermelhos
Nanodiamantes/química
Peptídeos/química
Trombose/diagnóstico
[Mh] Termos MeSH secundário: Animais
Artérias Carótidas/patologia
Modelos Animais de Doenças
Desintegrinas/administração & dosagem
Fluorescência
Seres Humanos
Infusões Intravenosas
Masculino
Peptídeos/administração & dosagem
Ratos Sprague-Dawley
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disintegrins); 0 (Nanodiamonds); 0 (Peptides); 124123-27-9 (bitistatin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S146946


  3 / 1313 MEDLINE  
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[PMID]:29179542
[Au] Autor:Zhao Y; Lv B; Feng X; Li C
[Ad] Endereço:Institute for Biotransformation and Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
[Ti] Título:Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents.
[So] Source:J Agric Food Chem;65(51):11147-11156, 2017 Dec 27.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Licorice, an important herbal medicine, is derived from the dried roots and rhizomes of Glycyrrhiza genus plants. It has been widely used in food, pharmaceutical, tobacco, and cosmetics industries with high economic value. However, overexploitation of licorice resources has severely destroyed the local ecology. Therefore, producing bioactive compounds of licorice through the biotransformation and bioengineering methods is a hot spot in recent years. In this perspective, we comprehensively summarize the biotransformation of licorice constituents into high-value-added derivatives by biocatalysts. Furthermore, successful cases and the strategies for de novo biosynthesizing compounds of licorice in microbes have been summarized. This paper will provide new insights for the further research of licorice.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Fungos/metabolismo
Glycyrrhiza/química
Extratos Vegetais/síntese química
[Mh] Termos MeSH secundário: Bactérias/genética
Bioengenharia
Biotransformação
Fungos/genética
Glycyrrhiza/genética
Glycyrrhiza/metabolismo
Extratos Vegetais/química
Extratos Vegetais/metabolismo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Plant Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04470


  4 / 1313 MEDLINE  
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[PMID]:28463802
[Au] Autor:Scholes NS; Isalan M
[Ad] Endereço:Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
[Ti] Título:A three-step framework for programming pattern formation.
[So] Source:Curr Opin Chem Biol;40:1-7, 2017 Oct.
[Is] ISSN:1879-0402
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The spatial organisation of gene expression is essential to create structure and function in multicellular organisms during developmental processes. Such organisation occurs by the execution of algorithmic functions, leading to patterns within a given domain, such as a tissue. Engineering these processes has become increasingly important because bioengineers are seeking to develop tissues ex vivo. Moreover, although there are several theories on how pattern formation can occur in vivo, the biological relevance and biotechnological potential of each of these remains unclear. In this review, we will briefly explain four of the major theories of pattern formation in the light of recent work. We will explore why programming of such patterns is necessary, while discussing a three-step framework for artificial engineering approaches.
[Mh] Termos MeSH primário: Padronização Corporal
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Bioengenharia
Regulação da Expressão Gênica no Desenvolvimento
Seres Humanos
Medicina Regenerativa
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  5 / 1313 MEDLINE  
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[PMID]:28898253
[Au] Autor:Belair DG; Wolf CJ; Wood C; Ren H; Grindstaff R; Padgett W; Swank A; MacMillan D; Fisher A; Winnik W; Abbott BD
[Ad] Endereço:Toxicity Assessment Division, US EPA, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, United States of America.
[Ti] Título:Engineering human cell spheroids to model embryonic tissue fusion in vitro.
[So] Source:PLoS One;12(9):e0184155, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epithelial-mesenchymal interactions drive embryonic fusion events during development, and perturbations of these interactions can result in birth defects. Cleft palate and neural tube defects can result from genetic defects or environmental exposures during development, yet very little is known about the effect of chemical exposures on fusion events during human development because of a lack of relevant and robust human in vitro assays of developmental fusion behavior. Given the etiology and prevalence of cleft palate and the relatively simple architecture and composition of the embryonic palate, we sought to develop a three-dimensional culture system that mimics the embryonic palate and could be used to study fusion behavior in vitro using human cells. We engineered size-controlled human Wharton's Jelly stromal cell (HWJSC) spheroids and established that 7 days of culture in osteogenesis differentiation medium was sufficient to promote an osteogenic phenotype consistent with embryonic palatal mesenchyme. HWJSC spheroids supported the attachment of human epidermal keratinocyte progenitor cells (HPEKp) on the outer spheroid surface likely through deposition of collagens I and IV, fibronectin, and laminin by mesenchymal spheroids. HWJSC spheroids coated in HPEKp cells exhibited fusion behavior in culture, as indicated by the removal of epithelial cells from the seams between spheroids, that was dependent on epidermal growth factor signaling and fibroblast growth factor signaling in agreement with palate fusion literature. The method described here may broadly apply to the generation of three-dimensional epithelial-mesenchymal co-cultures to study developmental fusion events in a format that is amenable to predictive toxicology applications.
[Mh] Termos MeSH primário: Bioengenharia
Técnicas de Cultura de Órgãos
Palato/embriologia
Esferoides Celulares
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Bioengenharia/métodos
Diferenciação Celular/genética
Análise por Conglomerados
Biologia Computacional/métodos
Proteínas da Matriz Extracelular
Perfilação da Expressão Gênica
Ontologia Genética
Seres Humanos
Técnicas In Vitro
Células Mesenquimais Estromais/citologia
Células Mesenquimais Estromais/metabolismo
Osteogênese/genética
Palato/metabolismo
Fatores de Tempo
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Extracellular Matrix Proteins); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184155


  6 / 1313 MEDLINE  
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[PMID]:28869589
[Au] Autor:Higuchi A; Ku NJ; Tseng YC; Pan CH; Li HF; Kumar SS; Ling QD; Chang Y; Alarfaj AA; Munusamy MA; Benelli G; Murugan K
[Ad] Endereço:Department of Chemical and Materials Engineering, National Central University, Jhongli, Taoyuan, Taiwan.
[Ti] Título:Stem cell therapies for myocardial infarction in clinical trials: bioengineering and biomaterial aspects.
[So] Source:Lab Invest;97(10):1167-1179, 2017 Oct.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiovascular disease remains the leading cause of death and disability in advanced countries. Stem cell transplantation has emerged as a promising therapeutic strategy for acute and chronic ischemic cardiomyopathy. The current status of stem cell therapies for patients with myocardial infarction is discussed from a bioengineering and biomaterial perspective in this review. We describe (a) the current status of clinical trials of human pluripotent stem cells (hPSCs) compared with clinical trials of human adult or fetal stem cells, (b) the gap between fundamental research and application of human stem cells, (c) the use of biomaterials in clinical and pre-clinical studies of stem cells, and finally (d) trends in bioengineering to promote stem cell therapies for patients with myocardial infarction. We explain why the number of clinical trials using hPSCs is so limited compared with clinical trials using human adult and fetal stem cells such as bone marrow-derived stem cells.
[Mh] Termos MeSH primário: Bioengenharia
Ensaios Clínicos como Assunto
Infarto do Miocárdio/terapia
Transplante de Células-Tronco
[Mh] Termos MeSH secundário: Animais
Materiais Biocompatíveis
Bioengenharia/métodos
Bioengenharia/tendências
Seres Humanos
Camundongos
Células-Tronco Pluripotentes/citologia
Células-Tronco Pluripotentes/transplante
Pesquisa com Células-Tronco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biocompatible Materials)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2017.100


  7 / 1313 MEDLINE  
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[PMID]:28708632
[Au] Autor:Chua KSG; Kuah CWK
[Ad] Endereço:From the Tan Tock Seng Hospital Rehabilitation Center, Center for Advanced Rehabilitation Therapeutics, Singapore.
[Ti] Título:Innovating With Rehabilitation Technology in the Real World: Promises, Potentials, and Perspectives.
[So] Source:Am J Phys Med Rehabil;96(10 Suppl 1):S150-S156, 2017 Oct.
[Is] ISSN:1537-7385
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this article, we discuss robotic-assisted therapy as an emerging and significant field of clinical rehabilitation and its value proposition for innovating rehabilitation clinical practice. Attempts to achieve integration among clinicians' practices and bioengineers' machines often generate new challenges and controversies. To date, the literature is indicative of a sizeable number and variety of robotic devices in the field of clinical rehabilitation, some are commercially available; however, large-scale clinical outcomes are less positive than expected. The following main themes related to integrating rehabilitation technology in real-world clinical practice will be discussed: the application of current evidence-based practice and knowledge in relation to treatment in the rehabilitation clinic, perspectives from rehabilitation professionals using robotic-aided therapy with regard to challenges, and strategies for problem solving. Lastly, we present innovation philosophies with regard to sustainability of clinical rehabilitation technologies.
[Mh] Termos MeSH primário: Prática Clínica Baseada em Evidências/tendências
Medicina Física e Reabilitação/tendências
Robótica/tendências
[Mh] Termos MeSH secundário: Bioengenharia/tendências
Previsões
Seres Humanos
Medicina Física e Reabilitação/métodos
Robótica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1097/PHM.0000000000000799


  8 / 1313 MEDLINE  
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[PMID]:28617405
[Au] Autor:Muraev AA; Ivanov SY; Ivashkevich SG; Gorshenev VN; Teleshev AT; Kibardin AV; Kobets KK; Dubrovin VK
[Ad] Endereço:Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia; Peoples Friendship University of Russia, Moscow, Russia.
[Ti] Título:[Orthotopic bone implants for bone regeneration].
[Ti] Título:Organotipichnye kostnye implantaty - perspektiva razvitiia sovremennykh osteoplasticheskikh materialov..
[So] Source:Stomatologiia (Mosk);96(3):36-39, 2017.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Biotechnology industry is rapidly developing. The elaboration of new biomaterials for bone reconstruction is one of the most perspective directions in tissue engineering. There are millions of surgical operations associated with use of bone graft materials every year. In this article we tried to analyze and systematize data about advanced technologies and modern trends in the preparation of bio-composite bone graft materials. Special attention is given to 3D-prototyping that allows making bone implants with individual form. Introduction of molecular biology technologies such as activating specific cytokines and growth factors at the right time makes it possible to optimize bone regeneration process. The article has also some suggestions on further improvement of the bone engineering technology.
[Mh] Termos MeSH primário: Processo Alveolar/anatomia & histologia
Regeneração Óssea
Substitutos Ósseos
Mandíbula/anatomia & histologia
Impressão Tridimensional
[Mh] Termos MeSH secundário: Bioengenharia
Simulação por Computador
Seres Humanos
Imagem Tridimensional
Modelos Anatômicos
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Substitutes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.17116/stomat201796336-39


  9 / 1313 MEDLINE  
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[PMID]:28514412
[Au] Autor:Bourzac K; Bender E; Dolgin E; Mullard A; Savage N; Gruber K
[Ti] Título:Therapeutic developments: Masters of medicine.
[So] Source:Nature;545(7654):S4-S9, 2017 05 17.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides/provisão & distribuição
Terapia Biológica
Biotecnologia
Contrato de Risco
Escherichia coli/metabolismo
Impressão Tridimensional
Células-Tronco/citologia
Células-Tronco/efeitos dos fármacos
Engenharia Tecidual
[Mh] Termos MeSH secundário: Analgésicos Opioides/efeitos adversos
Analgésicos Opioides/economia
Analgésicos Opioides/metabolismo
Animais
Bioengenharia
Reatores Biológicos
California
Diferenciação Celular/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos/economia
Avaliação Pré-Clínica de Medicamentos/métodos
Indústria Farmacêutica/tendências
Contrato de Risco/economia
Contrato de Risco/organização & administração
Escherichia coli/genética
Seres Humanos
Investimentos em Saúde
Erros Inatos do Metabolismo/metabolismo
Erros Inatos do Metabolismo/terapia
Microbiota/genética
Microbiota/fisiologia
Distrofia Muscular de Duchenne/tratamento farmacológico
Transtornos Relacionados ao Uso de Opioides/prevenção & controle
Impressão Tridimensional/economia
Impressão Tridimensional/instrumentação
Pele
Bibliotecas de Moléculas Pequenas/farmacologia
Bibliotecas de Moléculas Pequenas/uso terapêutico
Fatores de Transcrição/antagonistas & inibidores
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Small Molecule Libraries); 0 (Transcription Factors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1038/545S4a


  10 / 1313 MEDLINE  
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[PMID]:28489987
[Au] Autor:Baidal DA; Ricordi C; Berman DM; Alvarez A; Padilla N; Ciancio G; Linetsky E; Pileggi A; Alejandro R
[Ad] Endereço:University of Miami Leonard M. Miller School of Medicine, Miami, FL dbaidal@med.miami.edu.
[Ti] Título:Bioengineering of an Intraabdominal Endocrine Pancreas.
[So] Source:N Engl J Med;376(19):1887-1889, 2017 05 11.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/cirurgia
Transplante das Ilhotas Pancreáticas
[Mh] Termos MeSH secundário: Adulto
Bioengenharia
Glicemia/análise
Diabetes Mellitus Tipo 1/sangue
Feminino
Seres Humanos
Ilhotas Pancreáticas
[Pt] Tipo de publicação:CASE REPORTS; LETTER; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1613959



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