Base de dados : MEDLINE
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[PMID]:29446298
[Au] Autor:Katamanova EV; Dyakovich MP; Kudaeva IV; Shevchenko OI; Eshchina IM; Rukavishnikov VS; Meshchakova NM
[Ti] Título:[Clinical and neurophysiological peculiarities of health disorders in workers in dependence on the vinyl chloride exposure load].
[So] Source:Gig Sanit;95(12):1167-71, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Results of the clinical and neurophysiological examinations of 42 workers with operating history at the chemical plant exposed to vinyl chloride (VC) are presented. The purpose of research was the identification ofpeculiarities of clinical manifestations and disorders of the functional activity of the brain in workers at the vinyl chloride production, with taking into account the exposure toxic load (ETL). There were made clinical and electroencephalographic examinations with the detection of cognitive evoked potentials (CEP) and statistical analysis of results with the use of the Mann-Whitney U-test, Fisher's F-test, calculation of Spearman's correlation coefficient. The features in clinical picture of the pathology of the nervous system were detected in the form of asthenic disorders with cognitive impairment and autonomic dysfunction syndrome. There was established the increase in the cognitive impairment rate (p = 0.03), the decline in a-EEG activity (p = 0.01) and the worsening of indices of the amplitude (p = 0.011) and latency (p = 0,05) of CEP in extremely high level of ETL in comparison with same indices in the group with moderately high ETL. In the first group there was revealed a statistically significant exceedance of the frequency of hypertension - by 1.6 times, skin diseases - by 9 times, chronic subatrophic rhino-pharyngitis by 1.4 times in comparison with cases from the second group. In the group with moderately high level of ETL there was established the statistically significant inverse correlationship between the ETL and the index of P300 amplitude from the left side (r = -0.38, p = 0.019) and in the group with extremely high level ETL - between ETL and index of the ß2 - rhythm (r = - 0.73, p = 0.0008).
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Indústria Manufatureira
Síndromes Neurotóxicas
Cloreto de Vinil
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Eletroencefalografia/métodos
Seres Humanos
Masculino
Indústria Manufatureira/métodos
Indústria Manufatureira/normas
Meia-Idade
Síndromes Neurotóxicas/diagnóstico
Síndromes Neurotóxicas/epidemiologia
Síndromes Neurotóxicas/etiologia
Síndromes Neurotóxicas/fisiopatologia
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Medição de Risco/métodos
Medição de Risco/estatística & dados numéricos
Fatores de Risco
Sibéria/epidemiologia
Fatores de Tempo
Cloreto de Vinil/análise
Cloreto de Vinil/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:29446294
[Au] Autor:Efimova NV; Rukavishnikov VS; Pankov VA; Perezhogin AN; Shayakhmetov SF; Meshchakova NM; Lisetskaya LG
[Ti] Título:[Assessment of carcinogenic risks to workers of the main enterprises of the Irkutsk region].
[So] Source:Gig Sanit;95(12):1163-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The purpose of research is the assessment of the individual cancer risk (ICR) for workers of the basic occupations in key branches of industry of the Irkutsk region. There was executed the calculation of ICR levels for workers of the basic occupations of the aircraft industry, aluminum smelters and vinyl chloride production plants. The estimation of the exposure for workers was carried out according to long-term time-weighted average concentrations in the air of the working area, for the population - on annual average concentrations in the ambient air. To assess the risk that is not associated with the profession, the dose was calculated for the period of life (70 years). When calculating the toxicant doses in the working area there were used the "standard" indices ofpulmonary ventilation for adults, body weight, the work experience in the contact with carcinogens of 30 years, the number of days in the contact of 240, the duration of the working time 8 or 12 hours (in accordance with the working hours) duration. ICR for the Irkutsk population amounted of 3.08E-04, in Shelekhov - 4.8E-05, Sayansk - 1.1E-05. The amount of risk depends on the content offormaldehyde in all territories and chromium VI in cities of Irkutsk and Shelekhov. ICR for workers of basic occupations of studied plants in dozens of times are higher than for the urban population. Priority carcinogens are: chromium VI, nickel, formaldehyde, silicon dioxide -for the aircraft plant employees; 1,2-dichloretan, vinyl chloride - for the workers of vinyl chloride production plant; benzopyrene - for the aluminum smelter workers.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Carcinogênese/induzido quimicamente
Cromo
Formaldeído
Indústria Manufatureira
Cloreto de Vinil
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Carcinógenos Ambientais/análise
Carcinógenos Ambientais/toxicidade
Cromo/análise
Cromo/toxicidade
Formaldeído/análise
Formaldeído/toxicidade
Seres Humanos
Indústria Manufatureira/métodos
Indústria Manufatureira/normas
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Medição de Risco/métodos
Medição de Risco/estatística & dados numéricos
Fatores de Risco
Sibéria/epidemiologia
Tempo
Cloreto de Vinil/análise
Cloreto de Vinil/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Carcinogens, Environmental); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion); 1HG84L3525 (Formaldehyde); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:29431320
[Au] Autor:Kudaeva IV; Dyakovich OA; Masnavieva LB; Popkova OV; Abramatets EA
[Ti] Título:[Features of the lipid exchange in workers employed in aluminium productions].
[So] Source:Gig Sanit;95(9):857-60, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Aluminum production can be referred to the category of industries of the increased health hazard for the workers. During technological process of receiving aluminum the air of a working zone is polluted by a large number of harmful substances. Workers are exposed to the complex of toxicants possessing a polytropic impact on the body. The most significant consequences are violations of different types of metabolism in the organism, including lipid metabolism. The purpose of the study is the investigation of the state of lipid metabolism in persons working in the production of aluminum. The object of research was 108 male workers of aluminum production suffering from occupational pathology of airways. The group of comparison was consisted of 103 men, apparently healthy, not exposed to toxicants. There was determined the content of the total cholesterol (TC), high and low density lipoprotein cholesterol (HDLC and LDLC), triglycerides (TG), phospholipids (PL), atherogenic index (AI). Statistical processing was performed with the use of software «Statistica 6.0¼. There were established statistically significant differences of indices of lipid exchange in the persons occupied in aluminum production when related to the group of comparison. IA values in persons from the study group proved to be higher than in the comparison group, due to elevated levels of TC and LDLC. The TG and PL level was also higher. The values of IA, TC and TG in workers of aluminum production in more than 50% cases exceeded the reference values. The average concentration of HDL cholesterol in both groups did not differ, and was above the lower reference boundary. Established features of lipid metabolism in workers of aluminum allow us to suggest the distinction in mechanisms of developing proatherogenic disorders from previously established ones for workers exposed to other chemicals. One of the causes of the shaping of these disorders can be oxidative stress, which in turn serves as a response to the exposure of complex of toxic substances to workers.
[Mh] Termos MeSH primário: Alumínio
Aterosclerose
Metabolismo dos Lipídeos/efeitos dos fármacos
Doenças Profissionais
Exposição Ocupacional
Local de Trabalho/normas
[Mh] Termos MeSH secundário: Adulto
Alumínio/efeitos adversos
Alumínio/análise
Aterosclerose/epidemiologia
Aterosclerose/etiologia
Aterosclerose/prevenção & controle
Seres Humanos
Masculino
Indústria Manufatureira/métodos
Indústria Manufatureira/normas
Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Saúde do Trabalhador/normas
Avaliação de Resultados (Cuidados de Saúde)
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29430903
[Au] Autor:Sycheva LP; Budarina OV; Sabirova ZF; Akhaltseva LV; Rosolovsky AP
[Ti] Título:[Cytogenetic status of children in the hygienic assessment of the air pollution by odorous substances].
[So] Source:Gig Sanit;95(8):765-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:For the first time the impact of odorous emissions from the enterprise for the production of chewing gum on the cytogenetic status of children, residing in the distance of 0,9 and 6 km, was studied. Specific weak mint and fruity odour in the air in the placement of the enterprise may be related to the presence of menthol, menthone, pinene, limonene, ethyl acetate and other compounds containing in the emissions. There were no differences in cytogenetic status of children in both groups (by frequency of micronuclei, protrusions, binucleated cells, apoptosis).
[Mh] Termos MeSH primário: Poluentes Atmosféricos
Mucosa Bucal/patologia
Odorantes
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/efeitos adversos
Poluentes Atmosféricos/análise
Poluentes Atmosféricos/classificação
Pré-Escolar
Análise Citogenética/métodos
Análise Citogenética/estatística & dados numéricos
Exposição Ambiental/efeitos adversos
Exposição Ambiental/prevenção & controle
Feminino
Seres Humanos
Masculino
Indústria Manufatureira/normas
Odorantes/análise
Odorantes/prevenção & controle
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29370201
[Au] Autor:Fang H; Jiang D; Yang T; Fang L; Yang J; Li W; Zhao J
[Ad] Endereço:Department of Military Logistics, Army Logistics University, Chongqing, China.
[Ti] Título:Network evolution model for supply chain with manufactures as the core.
[So] Source:PLoS One;13(1):e0191180, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Building evolution model of supply chain networks could be helpful to understand its development law. However, specific characteristics and attributes of real supply chains are often neglected in existing evolution models. This work proposes a new evolution model of supply chain with manufactures as the core, based on external market demand and internal competition-cooperation. The evolution model assumes the external market environment is relatively stable, considers several factors, including specific topology of supply chain, external market demand, ecological growth and flow conservation. The simulation results suggest that the networks evolved by our model have similar structures as real supply chains. Meanwhile, the influences of external market demand and internal competition-cooperation to network evolution are analyzed. Additionally, 38 benchmark data sets are applied to validate the rationality of our evolution model, in which, nine manufacturing supply chains match the features of the networks constructed by our model.
[Mh] Termos MeSH primário: Equipamentos e Provisões
Indústria Manufatureira
[Mh] Termos MeSH secundário: Comércio
Simulação por Computador
Marketing
Modelos Teóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191180


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[PMID]:29074628
[Au] Autor:Liu JJ; Bell CM; Matelski JJ; Detsky AS; Cram P
[Ad] Endereço:Department of Medicine, University of Toronto, Toronto, Ontario, Canada jessica.liu@uhn.ca.
[Ti] Título:Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study.
[So] Source:BMJ;359:j4619, 2017 Oct 26.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To estimate financial payments from industry to US journal editors. Retrospective observational study. 52 influential (high impact factor for their specialty) US medical journals from 26 specialties and US Open Payments database, 2014. 713 editors at the associate level and above identified from each journal's online masthead. All general payments (eg, personal income) and research related payments from pharmaceutical and medical device manufacturers to eligible physicians in 2014. Percentages of editors receiving payments and the magnitude of such payments were compared across journals and by specialty. Journal websites were also reviewed to determine if conflict of interest policies for editors were readily accessible. Of 713 eligible editors, 361 (50.6%) received some (>$0) general payments in 2014, and 139 (19.5%) received research payments. The median general payment was $11 (£8; €9) (interquartile range $0-2923) and the median research payment was $0 ($0-0). The mean general payment was $28 136 (SD $415 045), and the mean research payment was $37 963 (SD $175 239). The highest median general payments were received by journal editors from endocrinology ($7207, $0-85 816), cardiology ($2664, $0-12 912), gastroenterology ($696, $0-20 002), rheumatology ($515, $0-14 280), and urology ($480, $90-669). For high impact general medicine journals, median payments were $0 ($0-14). A review of the 52 journal websites revealed that editor conflict of interest policies were readily accessible (ie, within five minutes) for 17/52 (32.7%) of journals. Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research.
[Mh] Termos MeSH primário: Conflito de Interesses
Indústria Farmacêutica/economia
Políticas Editoriais
Equipamentos e Provisões
Indústria Manufatureira/economia
Publicações Periódicas como Assunto/economia
Publicações Periódicas como Assunto/ética
[Mh] Termos MeSH secundário: Pesquisa Biomédica/economia
Seres Humanos
Renda
Estudos Retrospectivos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171028
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j4619


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[PMID]:28830080
[Au] Autor:Liu Y; Zhou Y; Hnizdo E; Shi T; Steenland K; He X; Chen W
[Ti] Título:Total and Cause-Specific Mortality Risk Associated With Low-Level Exposure to Crystalline Silica: A 44-Year Cohort Study From China.
[So] Source:Am J Epidemiol;186(4):481-490, 2017 Aug 15.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The association between low-level crystalline silica (silica) exposure and mortality risk is not well understood. We investigated a cohort of 44,807 Chinese workers who had worked in metal mines or pottery factories for at least 1 year from January 1, 1960, to December 31, 1974, and were followed through 2003. Low-level silica exposure was defined as having a lifetime highest annual mean silica exposure at or under a permissible exposure limit (PEL). We considered 3 widely used PELs, including 0.05 mg/m3, 0.10 mg/m3, and 0.35 mg/m3. Cumulative silica exposure was estimated by linking a job exposure matrix with each participant's work history. For the 0.10-mg/m3 exposure level, Cox proportional hazards models showed significantly increased risk of mortality from all diseases (for each 1-ln mg/m3-years increase in logged cumulative silica exposure, hazard ratio (HR) = 1.05, 95% confidence interval (CI): 1.03, 1.07), malignant neoplasms (HR = 1.06, 95% CI: 1.03, 1.09), lung cancer (HR = 1.08, 95% CI: 1.02, 1.14), ischemic heart disease (HR = 1.09, 95% CI: 1.02, 1.16), pulmonary heart disease (HR = 1.08, 95% CI: 1.00, 1.16), and respiratory disease (HR = 1.20, 95% CI: 1.14, 1.26). The 0.05-mg/m3 and 0.35-mg/m3 exposure levels yielded similar associations. Long-term exposure to low levels (PELs ≤0.05 mg/m3, ≤0.10 mg/m3, or ≤0.35 mg/m3) of silica is associated with increased total and certain cause-specific mortality risk. Control of ambient silica levels and use of personal protective equipment should be emphasized in practice.
[Mh] Termos MeSH primário: Cardiopatias/induzido quimicamente
Neoplasias/induzido quimicamente
Doenças Profissionais/induzido quimicamente
Exposição Ocupacional/efeitos adversos
Transtornos Respiratórios/induzido quimicamente
Dióxido de Silício/efeitos adversos
[Mh] Termos MeSH secundário: Agricultura/estatística & dados numéricos
Causas de Morte
China/epidemiologia
Feminino
Cardiopatias/mortalidade
Seres Humanos
Estudos Longitudinais
Masculino
Indústria Manufatureira/estatística & dados numéricos
Mineração/estatística & dados numéricos
Neoplasias/mortalidade
Doenças Profissionais/mortalidade
Modelos de Riscos Proporcionais
Transtornos Respiratórios/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kwx124


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[PMID]:28759748
[Au] Autor:Zhao Z; Xing X; Ou X; Liu X; Zhou R; Zhang H; Yang L; Zhuang Z; Su X; Lu Y; Jiang J; Yang Y; Cui D; He Y
[Ad] Endereço:Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China.
[Ti] Título:DNA damage levels in electronics workers in Southern China: A micro-whole blood comet assay.
[So] Source:Mutat Res;803-805:17-21, 2017 Oct.
[Is] ISSN:1873-135X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We evaluated DNA damage levels of different categories of workers exposed to hazards inside electronics factories in Southern China. To find out the most dangerous risk factor, a cross-sectional study was conducted on a total of 584 exposed subjects and 138 controls in an electronics factory in Southern China, where the electronics industry is prevalent. The exposed hazards included isopropanol (IPO), lead, noise, video display terminals (VDT), lead in a high-temperature (high-temp) environment, and IPO in a high-temp environment. DNA damage detection was performed by the micro-whole blood comet assay using peripheral blood. DNA damage levels were estimated by percent tail DNA (%T). Linear regression models were used to test DNA damage differences between exposed groups and control group with adjustments for potential confounding factors. The level of DNA damage was more significant in both lead in a high-temp and IPO in a high-temp environment groups than in that of the controls (p<0.05). The differences remained significant after stratifying by smoking status (p<0.05). There were no significant differences between groups exposed to IPO, lead, noise, VDT environment and controls. In conclusion, we identified potential risk factors for DNA damage to electronics workers. Special attention should be paid to workers exposed to IPO and lead in a high-temp environment.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Substâncias Perigosas/toxicidade
Indústria Manufatureira
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: 2-Propanol/toxicidade
Acetona/toxicidade
Adolescente
Adulto
Benzeno/toxicidade
China
Ensaio Cometa
Estudos Transversais
Feminino
Temperatura Alta
Seres Humanos
Chumbo/toxicidade
Modelos Lineares
Masculino
Inquéritos e Questionários
Tolueno/toxicidade
Xilenos/toxicidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances); 0 (Xylenes); 1364PS73AF (Acetone); 2P299V784P (Lead); 3FPU23BG52 (Toluene); J64922108F (Benzene); ND2M416302 (2-Propanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE


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[PMID]:28601814
[Au] Autor:Bongers S; Slottje P; Kromhout H
[Ad] Endereço:Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
[Ti] Título:Hearing loss associated with repeated MRI acquisition procedure-related acoustic noise exposure: an occupational cohort study.
[So] Source:Occup Environ Med;74(11):776-784, 2017 Nov.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study the effects of repeated exposure to MRI-related acoustic noise during image acquisition procedures (scans) on hearing. METHODS: A retrospective occupational cohort study was performed among workers of an MRI manufacturing facility (n=474). Longitudinal audiometry data from the facility's medical surveillance scheme collected from 1973 to 2010 were analysed by studying the association of cumulative exposure to MRI-related acoustic noise from voluntary (multiple) MRI scans and the hearing threshold of the volunteer. RESULTS: Repeated acoustic noise exposure during volunteer MRI scans was found to be associated with a small exposure-dependent increased rate change of hearing threshold level (dB/year), but the association was only found related to the number of voluntary MRI scans and not to modelled cumulative noise exposure (dB*hour) based on MRI-system type. The increased rate change of hearing threshold level was found to be statistically significant for the frequencies 500, 1000, 2000, 3000 and 4000 Hz in the right ear. CONCLUSIONS: From our longitudinal cohort study, it appeared that exposure to noise from voluntarily MRI scans may have resulted in a slight amount of hearing loss. Mandatory use of hearing protection might have prevented more severe hearing loss. Lack of consistency in findings between the left and right ears and between the two exposure measures prohibits definitive conclusions. Further research that addresses the study's methodological limitations is warranted to corroborate our findings.
[Mh] Termos MeSH primário: Limiar Auditivo
Perda Auditiva Provocada por Ruído/etiologia
Audição
Imagem por Ressonância Magnética
Ruído Ocupacional
Doenças Profissionais/etiologia
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Audiometria
Estudos de Coortes
Orelha
Dispositivos de Proteção das Orelhas
Feminino
Seres Humanos
Masculino
Indústria Manufatureira
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103750


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[PMID]:28542539
[Au] Autor:Lyda TA; Wagner EL; Bourg AX; Peng C; Tomaraei GN; Dean D; Kennedy MS; Marcotte WR
[Ad] Endereço:Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America.
[Ti] Título:A Leishmania secretion system for the expression of major ampullate spidroin mimics.
[So] Source:PLoS One;12(5):e0178201, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spider major ampullate silk fibers have been shown to display a unique combination of relatively high fracture strength and toughness compared to other fibers and show potential for tissue engineering scaffolds. While it is not possible to mass produce native spider silks, the potential ability to produce fibers from recombinant spider silk fibers could allow for an increased innovation rate within tissue engineering and regenerative medicine. In this pilot study, we improved upon a prior fabrication route by both changing the expression host and additives to the fiber pulling precursor solution to improve the performance of fibers. The new expression host for producing spidroin protein mimics, protozoan parasite Leishmania tarentolae, has numerous advantages including a relatively low cost of culture, rapid growth rate and a tractable secretion pathway. Tensile testing of hand pulled fibers produced from these spidroin-like proteins demonstrated that additives could significantly modify the fiber's mechanical and/or antimicrobial properties. Cross-linking the proteins with glutaraldehyde before fiber pulling resulted in a relative increase in tensile strength and decrease in ductility. The addition of ampicillin into the spinning solution resulted in the fibers being able to inhibit bacterial growth.
[Mh] Termos MeSH primário: Materiais Biomiméticos
Fibroínas/biossíntese
Leishmania/metabolismo
[Mh] Termos MeSH secundário: Ampicilina/farmacologia
Antibacterianos/farmacologia
Materiais Biomiméticos/farmacologia
Reatores Biológicos
Western Blotting
Reagentes para Ligações Cruzadas/química
Escherichia coli
Fibroínas/química
Fibroínas/farmacologia
Fibroínas/ultraestrutura
Glutaral/química
Leishmania/genética
Indústria Manufatureira
Teste de Materiais
Microscopia Eletrônica de Varredura
Projetos Piloto
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/química
Proteínas Recombinantes/farmacologia
Proteínas Recombinantes/ultraestrutura
Soluções
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cross-Linking Reagents); 0 (Recombinant Proteins); 0 (Solutions); 7C782967RD (Ampicillin); 9007-76-5 (Fibroins); T3C89M417N (Glutaral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178201



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