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  1 / 11305 MEDLINE  
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[PMID]:29431949
[Au] Autor:Serebryakov PV; Khoshtariya NV; Mustafina IZ
[Ti] Título:[Retrospective analysis of primary disability among employees of enterprises for the production of technical ceramics].
[So] Source:Gig Sanit;95(11):1070-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:On the example of588 disability cases registered in employees of the plant for the production of technical ceramics during the 1975-2014 the analysis of the dynamics of illness, gender and age structure of disability indices on the main Origlnarartlcie and auxiliary units of the enterprise was executed for the interval of 10 years periods. There were followed trends in the alteration of the structure of the disability caused by the socio-economic, hygienic and demographic factors.
[Mh] Termos MeSH primário: Cerâmica
Pessoas com Deficiência/estatística & dados numéricos
Doenças Profissionais
Exposição Ocupacional
[Mh] Termos MeSH secundário: Indústria Química/estatística & dados numéricos
Demografia
Avaliação da Deficiência
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças Profissionais/diagnóstico
Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/estatística & dados numéricos
Saúde Pública/estatística & dados numéricos
Estudos Retrospectivos
Medição de Risco/métodos
Federação Russa/epidemiologia
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 11305 MEDLINE  
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[PMID]:29267670
[Au] Autor:Bellan MC; Cunha PFJSD; Tavares JG; Spohr AM; Mota EG
[Ad] Endereço:Pontifícia Universidade Católica da Universidade Federal do Rio Grande do Sul - PUC-RS, School of Dentistry, Graduate Program, Porto Alegre, RS, Brazil.
[Ti] Título:Microtensile bond strength of CAD/CAM materials to dentin under different adhesive strategies.
[So] Source:Braz Oral Res;31:e109, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the microtensile bond strength (µTBS) of novel computer-aided design/computer-aided manufacturing (CAD/CAM) restorative materials to dentin using different adhesive strategies. Thirty-two crowns were milled using CAD/CAM materials (Vita Mark II as control, Vita Suprinity, Vita Enamic and Lava Ultimate) and luted to dentin using different resin cements (RelyX ARC, RelyX Unicem 2 and RelyX Ultimate). The specimens were stored in 100% relative humidity at 37°C for 24 h and sectioned. The samples (n = 16) with cross-sectional areas of approximately 0.90 mm2, were submitted to a µTBS test in a universal testing machine with a crosshead speed of 0.5 mm/min. The samples were analyzed with SEM to determinate the failure mode. According to 2-way ANOVA and Tukey's test (α=0.05), the interaction effect (material x luting strategy) was significant (p=0.001). Regardless of the luting strategy, a higher µTBS was obtained with Lava Ultimate and Vita Enamic, which were significantly different from Vita Mark II and Vita Suprinity (p<0.05). For Vita Mark II, Vita Suprinity, Vita Enamic, and Lava Ultimate, the µTBS obtained with RelyX Unicem 2 was not significantly different from that obtained with RelyX ARC or RelyX Ultimate. All groups obtained at least three types of failure. The adhesive strategy with self-adhesive resin cement was comparable to conventional resin cement with total-etch or self-etch adhesive techniques in the bond of novel CAD/CAM materials to dentin.
[Mh] Termos MeSH primário: Cerâmica/química
Projeto Auxiliado por Computador
Colagem Dentária/métodos
Dentina/efeitos dos fármacos
Cimentos de Resina/química
[Mh] Termos MeSH secundário: Análise de Variância
Falha de Restauração Dentária
Dentina/química
Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Propriedades de Superfície/efeitos dos fármacos
Resistência à Tração
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resin Cements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  3 / 11305 MEDLINE  
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[PMID]:28459251
[Au] Autor:Spath A; Smith C
[Ad] Endereço:Lecturer, University of California, Los Angeles, California; Private Practice, Newport Beach, California; Mentor, Kois Center, Seattle, Washington.
[Ti] Título:Removal of Modern Ceramics.
[So] Source:Compend Contin Educ Dent;38(5):326-333, 2017 May.
[Is] ISSN:2158-1797
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With the overwhelming acceptance of lithium disilicate and zirconia, the frequency with which dentists have to remove these materials is increasing, and this can be difficult. Proper cement usage for full-coverage crowns with preparations that have retention and resistance can be helpful if in the future the restoration needs to be removed. When removing these modern materials, bur and laser techniques are both effective means, with each having specific benefits. Materials selection and preparation design are vital when considering areas of risk each patient exhibits and the potential need for removal.
[Mh] Termos MeSH primário: Cerâmica
Coroas
Materiais Dentários
Porcelana Dentária
Lasers
Zircônio
[Mh] Termos MeSH secundário: Cerâmica/química
Cimentos Dentários/química
Falha de Restauração Dentária
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Cements); 0 (Dental Materials); 0 (lithia disilicate); 12001-21-7 (Dental Porcelain); C6V6S92N3C (Zirconium); S38N85C5G0 (zirconium oxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  4 / 11305 MEDLINE  
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[PMID]:28459245
[Au] Autor:Magalhães APR; Decurcio RA; Ojeda GPD; Teixeira TR; Cardoso PC
[Ad] Endereço:Professor of Operative Dentistry, Brazilian Dental Association, Goiânia, Brazil.
[Ti] Título:Does Post-etching Cleaning Influence Bond Strength of Lithium Disilicate Laminate Veneers?
[So] Source:Compend Contin Educ Dent;38(5):e9-e12, 2017 May.
[Is] ISSN:2158-1797
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper aims to present a clinical case of laminate veneers in lithium disilicate (LD) reinforced ceramic, complemented with scanning electron microscopy and energy dispersive x-ray spectroscopy analysis of this ceramic's surfaces submitted to some of the different post-etching cleaning protocols proposed by literature. Many dentists are applying all-ceramic restorations, especially veneers, with the most applied material being LD, due to its good mechanical properties, esthetics, and ability to adhere to tooth substrate. The cementation process is critical to clinical success of indirect restorations. Combination of hydrofluoric acid and silane application on the inner surface of ceramic has been the most recommended method to increase bond strength between ceramic and tooth substrate. As a result of surface corrosion, residual subproducts are formed and precipitate on the ceramic surface, affecting the bonding process to the resin cement. Elimination of residue is recommended in the literature and can be done via 3 common techniques: thorough washing with air/water spray for 30 seconds, 37% phosphoric acid for 60 seconds, or ultrasonic bath for 4 to 10 minutes. Little information on LD ceramics post-etching cleaning methods is available in the literature. For this ceramic, the thorough washing with air/water spray for 30 seconds appeared to remove most of the residue without damaging the material. Being also the most practical and easiest of the reviewed procedures, it was, therefore, the protocol of choice for the clinical cases presented in this paper with success after 18 months.
[Mh] Termos MeSH primário: Ataque Ácido Dentário/métodos
Colagem Dentária
Porcelana Dentária
Facetas Dentárias
[Mh] Termos MeSH secundário: Adulto
Cerâmica
Feminino
Seres Humanos
Ácido Fluorídrico
Cimentos de Resina/química
Silanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resin Cements); 0 (Silanes); 0 (lithia disilicate); 12001-21-7 (Dental Porcelain); RGL5YE86CZ (Hydrofluoric Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  5 / 11305 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:29412222
[Au] Autor:Ayse Gozde T; Metin S; Mubin U
[Ad] Endereço:Ege University, Faculty of Dentistry, Department of Prosthodontics, Izmir, Turkey.
[Ti] Título:Evaluation of adaptation of ceramic inlays using optical coherence tomography and replica technique.
[So] Source:Braz Oral Res;32:e005, 2018 Feb 01.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Optical coherence tomography (OCT) has generally been used as a nondestructive technique to evaluate integrities of composite restorations. We investigated marginal and internal adaptations of ceramic inlay restorations with OCT and compared them to results with the silicone replica technique. Round-shaped class I cavities were prepared on 16 human maxillary first premolar teeth. Ceramic inlays were fabricated. Silicone replicas from inlays were obtained and sectioned to measure marginal and internal adaptations with a stereomicroscope (Leica Dfc 295, Bensheim, Germany). Inlays were cemented on respective teeth. Marginal and internal adaptations were then measured with the OCT system (Thorlabs, New Jersey, USA) in 200- µm intervals. Replica and OCT measurements were compared with independent samples t-tests. A paired t-test was used to evaluate the marginal and internal adaptations of each group (p < 0.05). Marginal and internal adaptations were 100.97 ± 31.36 and 113.94 ± 39.75 µm, respectively, using the replica technique and 28.97 ± 17.86 and 97.87 ± 21.83 µm, respectively, using OCT. The differences between the techniques were significant (p = 0.00 and p = 0.01, respectively). On evaluation within the groups, internal adaptation values were found to be significantly higher than the marginal adaptation values for the replica technique (p = 0.00) and OCT (p = 0.00). Therefore, the replica and OCT techniques showed different results, with higher values of marginal and internal adaptation found with the replica technique. Marginal and internal adaptation values of ceramic inlays, whether measured by replica or OCT techniques, were within clinically acceptable limits.
[Mh] Termos MeSH primário: Cerâmica/química
Adaptação Marginal Dentária
Restaurações Intracoronárias/métodos
Técnicas de Réplica/métodos
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Teste de Materiais
Padrões de Referência
Valores de Referência
Reprodutibilidade dos Testes
Cimentos de Resina/química
Propriedades de Superfície
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resin Cements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  6 / 11305 MEDLINE  
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[PMID]:29182216
[Au] Autor:Viitaniemi L; Abdulmajeed A; Sulaiman T; Söderling E; Närhi T
[Ad] Endereço:Department of Prosthetic Dentistry and Stomatognathic Physiology, University of Turku, FINLAND.
[Ti] Título:Adhesion and Early Colonization of S. Mutans on Lithium Disilicate Reinforced Glass-Ceramics, Monolithic Zirconia and Dual Cure Resin Cement.
[So] Source:Eur J Prosthodont Restor Dent;25(4):228-234, 2017 Dec 01.
[Is] ISSN:0965-7452
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Monolithic zirconia and glass ceramics are increasingly used in implant crowns. Limited data is available on bacterial adhesion and early biofilm formation on these materials. METHODS: Four different materials were investigated: (1) Lithium disilicate glass-ceramics (LDS), (2) Fully stabilized zirconia (FSZ), (3) Partially stabilized zirconia (PSZ), and (4) Dual curing cement (DCC). The materials' surfaces were characterized with spinning disc confocal microscopy and by water contact angle and surface free energy (SFE) measurements. For the adhesion tests the materials were rolled in suspensions of Streptococcus mutans. Early biofilm formation was studied on the materials and allowing the biofilms to form for 24 h. S. mutans cell counts were determined by plate culturing. ANOVA and post-hoc Tukey's tests (p⟨0.05) were used for statistical evaluation. RESULTS: The LDS surfaces were clearly hydrophilic with the highest SFE value (p⟨0.001). For S. mutans adhesion, the ranking of the materials from lowest to highest was: LDS = FSZ ⟨ DCC ⟨ PSZ (p⟨0.05). No significant differences among the materials were noticed in biofilm formation. CONCLUSIONS: LDS has lower S.mutans adhesion than other materials examined in this study, but the difference was not reflected in early biofilm formation.
[Mh] Termos MeSH primário: Aderência Bacteriana
Biofilmes
Cerâmica
Materiais Dentários
Porcelana Dentária
Cimentos de Resina
Streptococcus mutans/isolamento & purificação
Streptococcus mutans/fisiologia
Zircônio
[Mh] Termos MeSH secundário: Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DCR cement); 0 (Dental Materials); 0 (Resin Cements); 0 (lithia disilicate); 12001-21-7 (Dental Porcelain); 85422-94-2 (Glass ceramics); C6V6S92N3C (Zirconium); S38N85C5G0 (zirconium oxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1922/EJPRD_01711Viitaniemi07


  7 / 11305 MEDLINE  
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[PMID]:29182215
[Au] Autor:Abdulhameed N; Roulet JF; Chen C; Hussein H
[Ad] Endereço:PhD Student, Clinical Assistant Professor, University of Florida, College of Dentistry, Department of Restorative Dental Sciences, Center for Dental Biomaterials, 1395 Center Drive, Gainesville Fl 32608 USA.
[Ti] Título:A Measurement Protocol for the Marginal and Internal Fit of All-Ceramic Crowns.
[So] Source:Eur J Prosthodont Restor Dent;25(4):193-200, 2017 Dec 01.
[Is] ISSN:0965-7452
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To evaluate in vitro the influence of firing on marginal and internal fit of all-ceramic milled and pressed lithium-disilicate crowns. MATERIALS AND METHODS: One Standardized model with 1.6mm occlusal and 1.4mm axial reduction was used to fabricate 64 crowns. Using a factorial design, eight groups of lithium disilicate ceramics (n=8) using P=press, C=CAD/CAM, M=monolithic, O=coping, V=veneered, R=as produced: PMR, PMG, POR, PVG, CMR, CMG, COR, CVG. Crowns were produced and cemented on stone dies, then embedded in clear epoxy resin and sectioned into two plains. With a digital microscope, the distance between die and crowns was measured at the occlusal and axial walls. The horizontal/vertical fit at the finishing line of each section were measured as well. RESULTS: For the marginal fit, the analysis shows that the influence of material and design was significant on horizontal and vertical margins, and the influence of finish was significant with horizontal but not vertical margins (p=0.09). For the internal fit, the analysis showed that the axial gap was significantly influenced by material and finish but not by design (p=0.44). CONCLUSIONS: With a few exceptions, horizontal and vertical marginal discrepancies were below 100 µm. Additional firing increased the discrepancies.
[Mh] Termos MeSH primário: Cerâmica
Coroas
Materiais Dentários
Porcelana Dentária
Ajuste de Prótese/métodos
[Mh] Termos MeSH secundário: Planejamento de Prótese Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Materials); 0 (lithia disilicate); 12001-21-7 (Dental Porcelain)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1922/EJPRD_01735Abdulhameed08


  8 / 11305 MEDLINE  
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[PMID]:29180865
[Au] Autor:Zeng D; Zhang X; Wang X; Cao L; Zheng A; Du J; Li Y; Huang Q; Jiang X
[Ad] Endereço:Department of Prosthodontics, School of Medicine, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China.
[Ti] Título:Fabrication of large-pore mesoporous Ca-Si-based bioceramics for bone regeneration.
[So] Source:Int J Nanomedicine;12:8277-8287, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Our previous study revealed that mesoporous Ca-Si-based materials exhibited excellent osteoconduction because dissolved ions could form a layer of hydroxycarbonate apatite on the surface of the materials. However, the biological mechanisms underlying bone regeneration were largely unknown. The main aim of this study was to evaluate the osteogenic ability of large-pore mesoporous Ca-Si-based bioceramics (LPMSCs) by alkaline phosphatase assay, real-time PCR analysis, von Kossa, and alizarin red assay. Compared with large-pore mesoporous silica (LPMS), LPMSCs had a better effect on the osteogenic differentiation of dental pulp cells. LPMSC-2 and LPMSC-3 with higher calcium possessed better osteogenic abilities than LPMSC-1, which may be related to the calcium-sensing receptor pathway. Furthermore, the loading capacity for recombinant human platelet-derived growth factor-BB was satisfactory in LPMSCs. In vivo, the areas of new bone formation in the calvarial defect repair were increased in the LPMSC-2 and LPMSC-3 groups compared with the LPMSC-1 and LPMS groups. We concluded that LPMSC-2 and LPMSC-3 possessed both excellent osteogenic abilities and satisfactory loading capacities, which may be attributed to their moderate Ca/Si molar ratio. Therefore, LPMSCs with moderate Ca/Si molar ratio might be potential alterative grafts for craniomaxillofacial bone regeneration.
[Mh] Termos MeSH primário: Regeneração Óssea/fisiologia
Cálcio/química
Teste de Materiais/métodos
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Antraquinonas/análise
Antraquinonas/metabolismo
Materiais Biocompatíveis/química
Compostos de Cálcio/química
Diferenciação Celular
Cerâmica/química
Polpa Dentária/citologia
Seres Humanos
Masculino
Naftalenos/farmacologia
Nitratos/química
Osteogênese/efeitos dos fármacos
Fator de Crescimento Derivado de Plaquetas/genética
Fator de Crescimento Derivado de Plaquetas/metabolismo
Porosidade
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Crânio/lesões
Crânio/fisiologia
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Biocompatible Materials); 0 (Calcium Compounds); 0 (N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine); 0 (Naphthalenes); 0 (Nitrates); 0 (Platelet-Derived Growth Factor); 3F3AT0Q12H (Alizarin Red S); 7631-86-9 (Silicon Dioxide); EC 3.1.3.1 (Alkaline Phosphatase); NF52F38N1N (calcium nitrate); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S144528


  9 / 11305 MEDLINE  
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[PMID]:29253824
[Au] Autor:Swain B; Shin D; Joo SY; Ahn NK; Lee CG; Yoon JH
[Ad] Endereço:Institute for Advanced Engineering (IAE), Advanced Materials & Processing Center, Yongin-Si, 449-863, Republic of Korea. Electronic address: swain@iae.re.kr.
[Ti] Título:Synthesis of submicron silver powder from scrap low-temperature co-fired ceramic an e-waste: Understanding the leaching kinetics and wet chemistry.
[So] Source:Chemosphere;194:793-802, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The current study focuses on the understanding of leaching kinetics of metal in the LTCC in general and silver leaching in particular along with wet chemical reduction involving silver nanoparticle synthesis. Followed by metal leaching, the silver was selectively precipitated using HCl as AgCl. The precipitated AgCl was dissolved in ammonium hydroxide and reduced to pure silver metal nanopowder (NPs) using hydrazine as a reductant. Polyvinylpyrrolidone (PVP) used as a stabilizer and Polyethylene glycol (PEG) used as reducing reagent as well as stabilizing reagent to control size and shape of the Ag NPs. An in-depth investigation indicated a first-order kinetics model fits well with high accuracy among all possible models. Activation energy required for the first order reaction was 21.242 kJ mol for Silver. PVP and PEG 1% each together provide better size control over silver nanoparticle synthesis using 0.4 M hydrazine as reductant, which provides relatively regular morphology in comparison to their individual application. The investigation revealed that the waste LTCC (an industrial e-waste) can be recycled through the reported process even in industrial scale. The novelty of reported recycling process is simplicity, versatile and eco-efficiency through which waste LTCC recycling can address various issues like; (i) industrial waste disposal (ii) synthesis of silver nanoparticles from waste LTCC (iii) circulate metal economy within a closed loop cycle in the industrial economies where resources are scarce, altogether.
[Mh] Termos MeSH primário: Cerâmica/química
Nanopartículas Metálicas/química
Reciclagem
Prata/química
[Mh] Termos MeSH secundário: Resíduos Industriais/análise
Cinética
Pós/síntese química
Pós/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Industrial Waste); 0 (Powders); 3M4G523W1G (Silver)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  10 / 11305 MEDLINE  
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[PMID]:28457960
[Au] Autor:Nommeots-Nomm A; Labbaf S; Devlin A; Todd N; Geng H; Solanki AK; Tang HM; Perdika P; Pinna A; Ejeian F; Tsigkou O; Lee PD; Esfahani MHN; Mitchell CA; Jones JR
[Ad] Endereço:Department of Materials, Imperial College London, South Kensington Campus London, SW7 2AZ, UK.
[Ti] Título:Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration.
[So] Source:Acta Biomater;57:449-461, 2017 Jul 15.
[Is] ISSN:1878-7568
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted, employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation used previously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing, termed sintering. The original Bioglass® 45S5 composition crystallises upon sintering, altering its bioactivity, due to the temperature difference between the glass transition temperature and the crystallisation onset being small. Here, we optimised and compared scaffolds from three glass compositions, ICIE16, PSrBG and 13-93, which were selected due to their widened sintering windows. Amorphous scaffolds with modal pore interconnect diameters between 100-150µm and porosities of 75% had compressive strengths of 3.4±0.3MPa, 8.4±0.8MPa and 15.3±1.8MPa, for ICIE16, PSrBG and 13-93 respectively. These porosities and compressive strength values are within the range of cancellous bone, and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffold surfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone in a rabbit model according to X-ray micro tomography imaging. STATEMENT OF SIGNIFICANCE: This manuscript describes a new method for making scaffolds from bioactive glasses using highly bioactive glass compositions. The glass compositions have lower silica content that those that have been previously made into amorphous scaffolds and they have been designed to have similar network connectivity to that of the original (and commercially used) 45S5 Bioglass. The aim was to match Bioglass' bioactivity. The scaffolds retain the amorphous nature of bioactive glass while having an open pore structure and compressive strength similar to porous bone (the original 45S5 Bioglass crystallises during sintering, which can cause reduced bioactivity or instability). The new scaffolds showed unexpectedly rapid bone regeneration in a rabbit model.
[Mh] Termos MeSH primário: Regeneração Óssea
Cerâmica/química
Polpa Dentária/metabolismo
Vidro/química
Células-Tronco/metabolismo
Tecidos Suporte/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Polpa Dentária/patologia
Feminino
Seres Humanos
Porosidade
Coelhos
Células-Tronco/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (bioactive glass 45S5)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE



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