Base de dados : MEDLINE
Pesquisa : J01.637.507 [Categoria DeCS]
Referências encontradas : 1649 [refinar]
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[PMID]:29238765
[Au] Autor:Varade V; Markus T; Vankayala K; Friedman N; Sheves M; Waldeck DH; Naaman R
[Ad] Endereço:Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel. ron.naaman@weizmann.ac.il.
[Ti] Título:Bacteriorhodopsin based non-magnetic spin filters for biomolecular spintronics.
[So] Source:Phys Chem Chem Phys;20(2):1091-1097, 2018 Jan 03.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We discuss spin injection and spin valves, which are based on organic and biomolecules, that offer the possibility to overcome some of the limitations of solid-state devices, which are based on ferromagnetic metal electrodes. In particular, we discuss spin filtering through bacteriorhodopsin in a solid state biomolecular spin valve that is based on the chirality induced spin selectivity (CISS) effect and shows a magnetoresistance of ∼2% at room temperature. The device is fabricated using a layer of bacteriorhodopsin (treated with n-octyl-thioglucoside detergent: OTG-bR) that is adsorbed on a cysteamine functionalized gold electrode and capped with a magnesium oxide layer as a tunneling barrier, upon which a Ni top electrode film is placed and used as a spin analyzer. The bR based spin valves show an antisymmetric magnetoresistance response when a magnetic field is applied along the direction of the current flow, whereas they display a positive symmetric magnetoresistance curve when a magnetic field is applied perpendicular to the current direction.
[Mh] Termos MeSH primário: Bacteriorodopsinas/química
Imãs
[Mh] Termos MeSH secundário: Eletrodos
Elétrons
Ouro
Campos Magnéticos
Tioglucosídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thioglucosides); 53026-44-1 (Bacteriorhodopsins); 7440-57-5 (Gold); 85618-21-9 (n-octyl-beta-D-thioglucopyranoside)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp06771b


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[PMID]:29206000
[Au] Autor:Murtojärvi S; Salonen J
[Ti] Título:Dislocation of cochlear implant magnet as a complication following MRI.
[So] Source:Duodecim;133(5):497-500, 2017.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:According to current best knowledge, an MRI scan can be performed for patients with cochlear implants. The warnings and recommendations of the implant manufacturers must be followed strictly to prevent complications, such as overheating, migration or demagnetization of the magnet in the implant. We report on a case of cochlear implant magnet dislocation as a complication for an MRI scan. The patient had a tight bandage around the head to hold the magnet in place as recommended by the manufacturer, but apparently the bandage was not in the correct place.
[Mh] Termos MeSH primário: Implantes Cocleares
Migração de Corpo Estranho/etiologia
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Falha de Equipamento
Seres Humanos
Imãs
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29224745
[Au] Autor:Helbig S; Stöver T; Burck I; Kramer S
[Ad] Endereço:Hearing Center, Ear Nose Throat Department, University Clinic Frankfurt, Frankfurt am Main, Germany. Electronic address: silke.helbig@kgu.de.
[Ti] Título:Cranial MRI in a young child with cochlear implants after bilateral magnet removal.
[So] Source:Int J Pediatr Otorhinolaryngol;103:1-4, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:A young bilateral cochlear implant (CI) user required magnetic resonance imaging (MRI) to determine the cause of hydrocephalus. The images obtained with the CIs in place were not diagnostically useful due to large artefacts generated by the CI magnets. We obtained useful images by bilaterally explanting the CI-magnets and replacing them with non-magnetic placeholder dummies then conducted the imaging. The artefact in the new images was greatly reduced and the images were diagnostically useful. Lastly, we explanted the dummies and reimplanted the CI-magnets. This procedure should be useful to obtain useful images in CI users.
[Mh] Termos MeSH primário: Implante Coclear/efeitos adversos
Implantes Cocleares/efeitos adversos
Imagem por Ressonância Magnética/métodos
Imãs/efeitos adversos
[Mh] Termos MeSH secundário: Artefatos
Implante Coclear/métodos
Remoção de Dispositivo
Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:29212690
[Au] Autor:Ahmad A; Subramanian T; Panteliadis P; Wilson-Macdonald J; Rothenfluh DA; Nnadi C
[Ad] Endereço:Oxford University Hospitals NHS Trust, Windmill Road, Headington, Oxford, UK.
[Ti] Título:Quantifying the 'law of diminishing returns' in magnetically controlled growing rods.
[So] Source:Bone Joint J;99-B(12):1658-1664, 2017 Dec.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Magnetically controlled growing rods (MCGRs) allow non-invasive correction of the spinal deformity in the treatment of early-onset scoliosis. Conventional growing rod systems (CGRS) need repeated surgical distractions: these are associated with the effect of the 'law of diminishing returns'. The primary aim of this study was to quantify this effect in MCGRs over sequential distractions. PATIENTS AND METHODS: A total of 35 patients with a maximum follow-up of 57 months were included in the study. There were 17 boys and 18 girls with a mean age of 7.4 years (2 to 14). True Distraction (TD) was determined by measuring the expansion gap on fluoroscopy. This was compared with Intended Distraction (ID) and expressed as the 'T/I' ratio. The T/I ratio and the Cobb angle were calculated at several time points during follow-up. RESULTS: The mean follow-up was 30 months (6 to 57). There was a significant decrease in the mean T/I ratio over time (convex rod at 3 months 0.81, sd 0.58 51 months 0.17, sd 0.16, p = 0.0001; concave rod at 3 months 0.93, sd 0.67 51 months 0.18, sd 0.15, p = 0.0001). A linear decline of the mean T/I ratios was noted for both convex rods (r = 0.90, p = 0.004) and concave rods (r = 0.81, p = 0.015) over 51 months. At the 24-month follow-up stage, there was a significant negative correlation between the mean T/I ratio of the concave rod with weight (r = -0.59, p = 0.01), age (r = -0.59, p = 0.01), and BMI of the child (r = -0.54, p = 0.01). CONCLUSIONS: The 'law of diminishing returns' is also seen after serial distraction using MCGR. Compared to previously published data for CGRS, there is a gradual linear decline rather than a rapid initial decline in lengthening. In older, heavier children a reduced distraction ratio in the concave rod of the MCGR device is noted over time. Cite this article: 2017;99-B:1658-64.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação
Osteogênese por Distração/instrumentação
Reoperação/métodos
Escoliose/cirurgia
Fusão Vertebral/instrumentação
Coluna Vertebral/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Adolescente
Pinos Ortopédicos
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Imãs
Masculino
Osteogênese por Distração/métodos
Estudos Prospectivos
Escoliose/diagnóstico por imagem
Escoliose/fisiopatologia
Fusão Vertebral/métodos
Coluna Vertebral/diagnóstico por imagem
Coluna Vertebral/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B12.BJJ-2017-0402.R2


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[PMID]:29180176
[Au] Autor:Vaena MLHT; Sinnecker JP; Vargas TJS; Serra-Guimarães F; Marques RG
[Ad] Endereço:Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: michel.vaena@hotmail.com.
[Ti] Título:Magnetic transcutaneous fixation: an experimental study in pigs.
[So] Source:J Surg Res;220:139-146, 2017 Dec.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Magnetic subdermal implants have never been studied in the context of magnetic fixation of an external device to the body's surface. Excessive attractive force between the implant and the external device may compromise local circulation due to mechanical compression, leading to necrosis. OBJECTIVE: To evaluate the feasibility of transcutaneous magnetic fixation and assess secondary skin changes when subjected to a continuous static magnetic field. METHODS: Using the pig as an animal model, 72 implants were introduced in 12 animals. After wound healing, ultrasonography was performed to measure implant depths. Computer simulations were applied to allow magnetic attachment between implants and external devices without impairing local blood flow. External devices of different magnetic strengths were applied over the skin for 7 days. Local skin was examined and collected for analysis. A senior dermatopathologist blindly examined skin specimens and controls for abnormal findings, measuring dermal and epidermal thickness. Statistical analysis (P <0.05) was performed over the data. RESULTS: Nineteen implants presented extrusion. The remaining 53 skin sites underwent magnetic compression, of which 43 (81%) evolved uneventfully. Implant depth varied between 4.6 mm and 8.3 mm (5.8 mm; ± 8.6 mm) with estimated pressure levels between 13.28 mmHg and 37.04 mmHg (27.6 mmHg; ±6.0 mmHg). Stronger magnets were associated with an increase in dermal thickness (P = 0.011) and neovascularization (P = 0.045). CONCLUSIONS: Transcutaneous magnetic fixation is compatible with skin viability in vivo, under experimental conditions. Skin interposition between two permanent magnets resulted in a continuous static magnetic field stimulation, which showed similar effects to pulsed electromagnetic fields reported on scientific literature.
[Mh] Termos MeSH primário: Imãs/efeitos adversos
Neovascularização Fisiológica
Próteses e Implantes/efeitos adversos
Pele/patologia
Estresse Mecânico
[Mh] Termos MeSH secundário: Animais
Estudos de Viabilidade
Campos Magnéticos/efeitos adversos
Masculino
Modelos Animais
Necrose/etiologia
Pele/irrigação sanguínea
Pele/diagnóstico por imagem
Suínos
Porco Miniatura
Ultrassonografia
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:28467324
[Au] Autor:Them K
[Ad] Endereço:Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg. Institute for Biomedical Imaging, Hamburg University of Technology, Schwarzenbergstrasse 95, 21073 Hamburg, Germany.
[Ti] Título:On magnetic dipole-dipole interactions of nanoparticles in magnetic particle imaging.
[So] Source:Phys Med Biol;62(14):5623-5639, 2017 Jun 14.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Magnetic dipole-dipole (MDD) interactions between iron oxide nanoparticles can influence the sensitivity, image resolution and quantification of magnetic particle imaging (MPI). For the first time, the Landau-Lifshitz-Gilbert equation (LLG) for MDD interactions has been solved to investigate the effect of MDD interactions on the MPI spectrum. It was found that at concentrations above 39 mmol(Fe) l , MDD interactions significantly influence MPI spectra. This influence increases with increasing harmonics, which means first harmonics should be preferred for iron quantification. Since ≈10 particles are neglected in the LLG compared to in an MPI experiment, the calculated limit below which MDD interactions can be neglected is only a bound. The true limit is therefore below the calculated limit of 39 mmol(Fe) l , because all other neglected particles also contribute to deviations in the MPI spectra via MDD interactions. Therefore, a quantum mechanical bound on the influence of MDD interactions is calculated, including up to 10 particles. Analysis of the bound as a function of the particle number provides a valuable insight into the influence of the large number of particles neglected in numerical simulations. Both results are compared with concentrations in biomedical MPI experiments. We conclude that the standard approximation of an absence of MDD interactions in MPI experiments must be handled more carefully. Our method of incorporating MDD interactions into the LLG can be easily implemented as part of model-based reconstruction to increase the sensitivity, image resolution and quantitative tracer detection during MPI.
[Mh] Termos MeSH primário: Compostos Férricos/química
Imãs/química
Nanopartículas
Fenômenos Físicos
Tomografia/métodos
[Mh] Termos MeSH secundário: Processamento de Imagem Assistida por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 1K09F3G675 (ferric oxide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6560/aa70ca


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[PMID]:29069553
[Au] Autor:Kazikdas KC; Dirik MA
[Ad] Endereço:Near East University, Nicosia, Cyprus ckazikdas@gmail.com.
[Ti] Título:Button Magnets in the Nasal Cavity.
[So] Source:N Engl J Med;377(17):1666, 2017 Oct 26.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Corpos Estranhos/diagnóstico por imagem
Imãs
Cavidade Nasal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Masculino
Radiografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1708934


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[PMID]:28985482
[Au] Autor:Wang GN; Wu NP; He X; Zhang HC; Liu J; Wang JP
[Ad] Endereço:College of Veterinary Medicine, Agricultural University of Hebei, Baoding, Hebei, 071000, China.
[Ti] Título:Magnetic graphene dispersive solid phase extraction-ultra performance liquid chromatography tandem mass spectrometry for determination of ß-agonists in urine.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1067:18-24, 2017 Nov 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, a magnetic graphene-based dispersive solid phase extraction method was first developed for extraction of ß-agonists in urine. During the experiments, the absorbent amount, sample pH, extraction time, elution solution and elution time were optimized respectively. The optimized extraction method was finished within 10min, and showed high enrichment factors for 9 ß-agonists (20-26 folds). Furthermore, this absorbent could be reused for at least 60 times. Then this extraction method was combined with ultra performance liquid chromatography triple quadrupole tandem mass spectrometry to determine the 9 drugs in urine. The limits of detection for the 9 drugs were in a range of 0.015-0.023ngmL , and the recoveries from the standards fortified blank urine were in a range of 60.2%-109.4%. Therefore, this method could be used as a simple, rapid, sensitive and accurate tool to determine trace level of ß-agonists in urine.
[Mh] Termos MeSH primário: Agonistas Adrenérgicos beta/urina
Cromatografia Líquida de Alta Pressão/métodos
Grafite/química
Imãs/química
Extração em Fase Sólida/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Resíduos de Drogas/análise
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-Agonists); 7782-42-5 (Graphite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28862836
[Au] Autor:Diner I; Dooyema J; Gearing M; Walker LC; Seyfried NT
[Ad] Endereço:Department of Biochemistry, ‡Yerkes National Primate Research Center, §Department of Pathology and Laboratory Medicine, and ∥Department of Neurology, Emory University , Atlanta, Georgia 30322, United States.
[Ti] Título:Generation of Clickable Pittsburgh Compound B for the Detection and Capture of ß-Amyloid in Alzheimer's Disease Brain.
[So] Source:Bioconjug Chem;28(10):2627-2637, 2017 Oct 18.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The benzothiazole-aniline derivative Pittsburgh Compound B (PiB) is the prototypical amyloid affinity probe developed for the in vivo positron emission tomography (PET) detection of amyloid beta (Aß) deposits in Alzheimer's disease (AD). Specific high-affinity binding sites for PiB have been found to vary among AD cases with comparable Aß load, and they are virtually absent on human-sequence Aß deposits in animal models, none of which develop the full phenotype of AD. PiB thus could be an informative probe for studying the pathobiology of Aß, but little is known about the localization of PiB binding at the molecular or structural level. By functionalizing the 6-hydroxy position of PiB with a PEG spacer and a terminal alkyne (propargyl) moiety, we have developed a clickable PiB compound that was derivatized with commercially available azide-labeled fluorophores or affinity-tags using copper-catalyzed azide-alkyne cycloaddition reactions, commonly referred to as "click" chemistry. We have determined that both the clickable PiB derivative and its fluorescently labeled conjugate have low nanomolar binding affinities for synthetic Aß aggregates. Furthermore, the fluorescent-PiB conjugate can effectively bind Aß aggregates in human AD brain homogenates and tissue sections. By covalently coupling PiB to magnetic beads, Aß aggregates were also affinity-captured from AD brain extracts. Thus, the clickable PiB derivative described herein can be used to generate a wide variety of covalent conjugates, with applications including the fluorescence detection of Aß, the ultrastructural localization of PiB binding, and the affinity capture and structural characterization of Aß and other cofactors from AD brains.
[Mh] Termos MeSH primário: Doença de Alzheimer/metabolismo
Peptídeos beta-Amiloides/química
Peptídeos beta-Amiloides/metabolismo
Compostos de Anilina/química
Encéfalo/metabolismo
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/metabolismo
Tiazóis/química
[Mh] Termos MeSH secundário: Animais
Química Click
Seres Humanos
Imãs/química
Microesferas
Agregados Proteicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole); 0 (Amyloid beta-Peptides); 0 (Aniline Compounds); 0 (Peptide Fragments); 0 (Protein Aggregates); 0 (Thiazoles); 0 (amyloid beta-protein (1-40))
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00500


  10 / 1649 MEDLINE  
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[PMID]:28817122
[Au] Autor:Kim JW; Seo D; Lee JU; Southard KM; Lim Y; Kim D; Gartner ZJ; Jun YW; Cheon J
[Ad] Endereço:Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea.
[Ti] Título:Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles.
[So] Source:Nat Protoc;12(9):1871-1889, 2017 Sep.
[Is] ISSN:1750-2799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Spatiotemporal interrogation of signal transduction at the single-cell level is necessary to answer a host of important biological questions. This protocol describes a nanotechnology-based single-cell and single-molecule perturbation tool, termed mechanogenetics, that enables precise spatial and mechanical control over genetically encoded cell-surface receptors in live cells. The key components of this tool are a magnetoplasmonic nanoparticle (MPN) actuator that delivers defined spatial and mechanical cues to receptors through target-specific one-to-one engagement and a micromagnetic tweezers (µMT) that remotely controls the magnitude of force exerted on a single MPN. In our approach, a SNAP-tagged cell-surface receptor of interest is conjugated with a single-stranded DNA oligonucleotide, which hybridizes to its complementary oligonucleotide on the MPN. This protocol consists of four major stages: (i) chemical synthesis of MPNs, (ii) conjugation with DNA and purification of monovalent MPNs, (iii) modular targeting of MPNs to cell-surface receptors, and (iv) control of spatial and mechanical properties of targeted mechanosensitive receptors in live cells by adjusting the µMT-to-MPN distance. Using benzylguanine (BG)-functionalized MPNs and model cell lines expressing either SNAP-tagged Notch or vascular endothelial cadherin (VE-cadherin), we provide stepwise instructions for mechanogenetic control of receptor clustering and for mechanical receptor activation. The ability of this method to differentially control spatial and mechanical inputs to targeted receptors makes it particularly useful for interrogating the differential contributions of each individual cue to cell signaling. The entire procedure takes up to 1 week.
[Mh] Termos MeSH primário: DNA/metabolismo
Imãs/química
Nanopartículas/metabolismo
Análise de Célula Única/métodos
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos/fisiologia
Linhagem Celular Tumoral
DNA/química
Técnicas Genéticas
Seres Humanos
Fenômenos Mecânicos
Nanopartículas/química
Nanotecnologia/métodos
Receptores de Superfície Celular/química
Receptores de Superfície Celular/genética
Receptores de Superfície Celular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Cell Surface); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1038/nprot.2017.071



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